자가골 이식과 골유착상 임프란트를 이용한 하악골 개선

전주홍,박기광,조경엽,이상대,송정록 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.1

Bony defects of mandible caused by trauma, infection, or tumor resection have been reconstructed by autologous bone graftings. These reconstruction can restore facial contour and integrity of the oral cavity. However, it is often necessary to reduce the bulk of bone to allow soft tissue coverage of the graft. Therefore, the construction of removable dentures in this situation is fraught with frustation. The use of osseointegrated implants is a method to allow improved anchorage and support for the successful fabrication of dental protheses. We report two cases of the use of osseointegrated implants of the Branemark type(3i), in conjunction with bone grafting to the lower jaw.

대구시 하수도 설계를 위한 기본 조사연구

조병하,이상렵,이순탁,함능수,나인엽,오창언,김자홍 경북대학교 1971 生産技術 Vol.5 No.-

This study is a "reconnaissance" of "preliminary" grade survery with the objectives of compiling and analyzing drainage systems, river pollution, hydraulic and hydrologic characteristics of sewage, and conservation of public water supplies for design of sewer systems in Taegu. In addition, it contains basis information for design of new sanitary sewage and drainage systems for Taegu. The results are shown as follows;1) Before attempting to design a sewage system, it was necessary to set up reliable standards for estinating sewage amounts. 2) The results of analysis and examination of Taegu's drainage systems. 3) The investigation of "sewage quality and river pollution in Taegu. 4) In order to maintain the B.O.D. value of the Kumho River below 8 ppm, a sewage treatment plant will be necessary. The basic information necessary in planning a treatment plant is given. This study is a summary of reseach that was conducted jointly by Kyung-Pook National Univ ersity's Insttute of Industrial Sciences and Young-Nam Universty's Institute of Industrial Sciences and Young-Nam University's Department of Civil Engineering. The study was begun on Novemver 4,1969 and completed on November 3,1970. By an agreement between the United States Agency for International Development and the Ministry of Science and Technology of the Republic of Korea, the work was financial out of the MO ST/USAID Trust Fnnd.

우리 나라 보건관리대행서비스 평가 연구

하은희,조수헌,김선민,주영수,한상환,하미나,권호장,홍윤철,김창엽 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.1

Group occupational health service programme started in 1990 is one of the measures to cope with limited human and financial resources in occupational health. The programme has expanded rapidly to include 52 institutions, private as well as public, all over the country. In spite of its potential impact on health of employees and practice of occupational health in small and medium sized industries, comprehensive evaluation in terms of quality has not been tried. This study has aims to develop the criteria to assess the quality of newly developed group occupational health service programme, and to investigate the quality of institutions, and finally to develop policies for the quality improvement. 1) Criteria development : By defining occupational health services, in particular for small and medium sized industries, as one of the primary health care, followings are included as core elements of qualitative occupational health programme; accessibility, continuity, comprehensiveness, technical quality, intersectoral collaboration, emphasis on preventive services, community participation, and adequacy. Again each element is divided into five major components of national health system infrastructure developed by the World Health Organization; development of health resources, organized arrangement of resources, delivery of health care, economic support, and management. In turn, each component is categorized into three aspects of quality assessment, structure, process and outcome. Expert panel selected several criteria for each category to evaluate the programme. Criteria were modified according to each group of interviewees, to produce two sets of questionnaire, one for chief operating officer and another for nurses in the institutions, and the chief operating officer and workers in the workplace. 2) Subject : Of all 52 institutions, 25 voluntarily participated in the survey. At individual institution, chief operating officer and practicing nurses were interviewed in depth. After intensive education for interviewees, every interviewees, every interview was performed with standardized guideline and questionnaire. The quality of the 'Group occupational health service programme' was found to be lower than expected. Especially in continuity, comprehensiveness, technical quality, community participation and adequacy, lower quality in structural aspect was commonly identified throughout all the institutions,. Quality in terms of accessibility and continuity highly varied among institutions., To improve quality of the programme, more comprehensive and systematic programme such as accreditation has to be introduced. In addition, human resources, governmental fund and information systems for individual workers are to be developed. As a long range plan, integration of occupational health services into the national health systems and pooling of financial resources and planned allocation should be considered.

Prognostic Factors of Mid- to Long-term Clinical Outcomes after Arthroscopic Partial Meniscectomy for Medial Meniscal Tears

Sung Yup Hong,Woosol Han,Junhyuk Jang,Joonhee Lee,Du Hyun Ro,Myung Chul Lee,Hyuk-Soo Han 대한정형외과학회 2022 Clinics in Orthopedic Surgery Vol.14 No.2

Background: Arthroscopic partial meniscectomy (APM) continues to be the popular treatment for meniscal tears, but recent randomized controlled trials have questioned its efficacy. To provide more evidence-based criteria for patient selection, we undertook this study to identify prognostic factors associated with clinical failure after APM for medial meniscus tears. Methods: Medical records of 160 patients followed up for at least 5 years after APM for medial meniscal tears were retrospectively reviewed. Demographic data (age, sex, and body mass index), radiographic variables (Kellgren-Lawrence [K-L] grade and hip-knee-ankle [HKA] angle), and clinical scores (International Knee Documentation Committee score, Tegner activity scale score, Lysholm score, and Knee injury and Osteoarthritis Outcome Score) were recorded. Clinical failure was defined as the need for an additional surgical procedure (arthroscopy, osteotomy, or arthroplasty) or the presence of intolerable pain. Survivorship analysis with clinical failure as an end point was performed using Kaplan-Meier survival curves. Factors related to clinical failure were analyzed using a Cox proportional hazard model. Cutoff values were determined using areas under receiver operating characteristic (ROC) curves. Radiographic progression of osteoarthritis was analyzed using the chi-square test, and serial changes of clinical scores were analyzed using a linear mixed model. Results: Clinical success rates were 95.7% at 5 years, 75.6% at 10 years, and 46.3% at 15 years. Age, HKA angle, and K-L grade (p = 0.01, p = 0.02, and p = 0.04, respectively) were found to be significant risk factors of clinical failure. Cutoff values at 10 years postoperatively as determined by ROC analysis were 50 years for age (sensitivity = 0.778, 1-specificity = 0.589), grade 2 for K-L grade (sensitivity = 0.778, 1-specificity = 0.109), and 5.5° for HKA angle (sensitivity = 0.667, 1-specificity = 0.258). In patients who had clinical success until 10 years after APM, radiological osteoarthritis progressed gradually. However, the clinical scores of patients who achieved clinical success did not decrease significantly over the 10-year follow-up. Conclusions: The poor prognostic factors found to be related to clinical failure after APM for a medial meniscal tear were patient age (≥ 50 years), preoperative K-L grade (≥ grade 2), and preoperative HKA angle (≥ varus 5.5°).

말초혈관질환이 있는 인슐린비의존형 당뇨병 환자에 있어서 혈액 내 Plasminogen Activator Inhibitor-1(PAI-1)및 lipoprotein(a)농도

김상기,최희진,박재홍,한승엽,우상균,이인규,조성래,남성진,김추성,김정철,한승범 대한당뇨병학회 1999 Diabetes and Metabolism Journal Vol.23 No.1

Activity, Selectivity, and Durability of Ruthenium Nanoparticle Catalysts for Ammonia Synthesis by Reactive Molecular Dynamics Simulation: The Size Effect

Kim, Sung-Yup,Lee, Hong Woo,Pai, Sung Jin,Han, Sang Soo American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.31

<P>We report a molecular dynamics (MD) simulation employing the reactive force field (ReaxFF), developed from various first-principles calculations in this study, on ammonia (NH<SUB>3</SUB>) synthesis from nitrogen (N<SUB>2</SUB>) and hydrogen (H<SUB>2</SUB>) gases over Ru nanoparticle (NP) catalysts. Using ReaxFF-MD simulations, we predict not only the activities and selectivities but also the durabilities of the nanocatalysts and discuss the size effect and process conditions (temperature and pressure). Among the NPs (diameter = 3, 4, 5, and 10 nm) considered in this study, the 4 nm NPs show the highest activity, in contrast to our intuition that the smallest NP should provide the highest activity, as it has the highest surface area. In addition, the best selectivity is observed with the 10 nm NPs. The activity and selectivity are mainly determined by the hcp, fcc, and top sites on the Ru NP surface, which depend on the NP size. Moreover, the selectivity can be improved more significantly by increasing the H<SUB>2</SUB> pressure than by increasing the N<SUB>2</SUB> pressure. The durability of the NPs can be determined by the mean stress and the stress concentration, and these two factors have a trade-off relationship with the NP size. In other words, as the NP size increases, its mean stress decreases, whereas the stress concentration simultaneously increases. Because of these two effects, the best durability is found with the 5 nm NPs, which is also in contrast to our intuition that larger NPs should show better durability. We expect that ReaxFF-MD simulations, along with first-principles calculations, could be a useful tool in developing novel catalysts and understanding catalytic reactions.</P> [FIG OMISSION]</BR>

전환기의 한국형 과학기술혁신 시스템

홍성주(Sung Joo HONG),이정원(Jung Won Lee),엄미정(Mi Jung Um),이상엽(Sang Yup Lee),오승환(Seung Hwan Oh),홍창의(Chang Ui Hong) 과학기술정책연구원 2015 정책연구 Vol.- No.-

The paradigm of Korean economy is transforming from catch-up to advanced style. The creative economy of President Park Geun Hye set a national strategy to evolve into an advanced economy. Under the situation, Science and Technology Policy Institute(STEPI) put together the study to define new roles and direction of changes of the National Science, Technology and Innovation System (NIS) to make sure the system to live up to the needs of the creative economy. NIS is the most comprehensive policy framework to understand macro environments, surrounding science, technology and innovation, as well as cooperative network of industry, academic and research sectors, involved in science and technology innovation and infrastructure to support them. Despite its huge policy potentials, NIS has not been widely utilized in science and technology policies in Korea as macro policy framework to cover entire spectrum of science, technology and innovation has not been established with frequent changes in science and technology policies and governance over the past 10 years. The study asked three questions to diagnose NIS of Korea in transition and explore the models. First, what are the challenges of the transitional time that call for change of NIS of Korea? Second, how NIS of Korea is diagnosed? Third, how and in what direction should NIS of Korea in transition change itself? To answer these question, the study reviewed both domestic and overseas environments of science, technology and innovation in 2014 and 2015, outlined science, technology and innovation policies of several advanced nations, defined new approaches and view points to better understand NIS, diagnosed NIS of Korea with collective knowledge of experts and set the direction of NIS upgrade. We hope the study can be a starting point to facilitate and expand comprehensive assessment reports to serve as a beacon to guide to new direction for science and technology innovation of Korea to go.

Enhanced Production of Succinic Acid by Metabolically Engineered Escherichia coli with Amplified Activities of Malic Enzyme and Fumarase

Hong, Soon-Ho,Lee, Sang-Yup The Korean Society for Biotechnology and Bioengine 2004 Biotechnology and Bioprocess Engineering Vol.9 No.4

A pfl ldhA double mutant Escherichia coli strain NZN 111 was used to produce succinic acid by overexpressing the E. coli malic enzyme gene (sfcA). This strain, however, produced a large amount of malic acid as well as succinic acid. After the analyses of the metabolic pathways, the fumB gene encoding the anaerobic fumarase of E. coli was co-amplified to solve the problem of malic acid accumulation. A plasmid, pTrcMLFu, was constructed, which contains an artificial operon (sfcA-fumB) under the control of the inducible trc promoter. From the batch culture of recombinant E. coli NZN 111 harboring pTrcMLFu, 7 g/L of succinic acid was produced from 20 g/L of glucose, with no accumulation of malic acid. From the metabolic flux analysis the strain was found under reducing power limiting conditions by severe reorientation of metabolic fluxes.

Characteristics of seismic velocities in the carbonate rocks

Hong Lee,Young Seok So,Hye Ra Son,Sang Yup Jang 대한지질학회 2014 대한지질학회 학술대회 Vol.2014 No.10

Thickness-controllable electrospun fibers promote tubular structure formation by endothelial progenitor cells

Hong, Jong Kyu,Bang, Ju Yup,Xu, Guan,Lee, Jun-Hee,Kim, Yeon-Ju,Lee, Ho-Jun,Kim, Han Seong,Kwon, Sang-Mo Dove Medical Press 2015 International journal of nanomedicine Vol.10 No.-

<P>Controlling the thickness of an electrospun nanofibrous scaffold by altering its pore size has been shown to regulate cell behaviors such as cell infiltration into a three-dimensional (3D) scaffold. This is of great importance when manufacturing tissue-engineering scaffolds using an electrospinning process. In this study, we report the development of a novel process whereby additional aluminum foil layers were applied to the accumulated electrospun fibers of an existing aluminum foil collector, effectively reducing the incidence of charge buildup. Using this process, we fabricated an electrospun scaffold with a large pore (pore size >40 μm) while simultaneously controlling the thickness. We demonstrate that the large pore size triggered rapid infiltration (160 μm in 4 hours of cell culture) of individual endothelial progenitor cells (EPCs) and rapid cell colonization after seeding EPC spheroids. We confirmed that the 3D, but not two-dimensional, scaffold structures regulated tubular structure formation by the EPCs. Thus, incorporation of stem cells into a highly porous 3D scaffold with tunable thickness has implications for the regeneration of vascularized thick tissues and cardiac patch development.</P>