한국인 본태성 고혈압환자에서 Angiotensinogen M235T 유전자 다양성

양동호(Dong Ho Yang),홍세용(Sea Yong Hong),김홍수(Hong Soo Kim),방차옥(Cha Ok Bang),김철현(Chul Hyun Kim),최종순(Jong Soon Choi),하권수(Kwun Soo Ha) 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.3

N/A Background: Potential involvement of the angio-tensinogen gene(M235T) in the pathogenesis of essen-tial hypertension has been suggested by some inves- tigators. However, an association between M235T gene polymorphism and essential hypertension has been reported by some, but not by others. Since genetic diversity exists among different ethnic population, we addressed the question of whether there is an association between M235T gene poly-morphism and essential hypertension in the Korean. Methods: 100 patients with essential hypertension and 100 control subjects were recruited from out- patients at the Department of Internal Medicine, Soon-chunhyang Hospital, Chunan City. The criteria for hypertension was defined as systolic blood pressure higher than 160mmHg and/or diastolic blood pressure higher than 95mmHg. For detection of the M235T polymorphism at the angiotensinogen locus, the primer sequences were: sense primer : 5'-TGAAGGAG- AAGGTGTCTGCGGGA-3' and antisense primer : 5'- AGGACGGTGCGGTGAGAGTG-3'. The PCR product mixture was exposed to restriction enzyme Tthlll I and then submitted to electrophoresis in polyacryl-amide gel. Differences between the molecular variants of the gene in hypertensives and normotensives were com- pared by using the X²test. p<0.05 was considered statistically significant. The odds ratio and 95% confidence interval were calculated using Woolf's method. Results: Compared with the control subjects, hypertensives had higher values of three established risk factors for hypertension : age, BMI cholesterol (total and LDL). X analysis showed no difference in the distribution of genotype or allele frequency between the hypertensives and normotensives(X²=1.14, p=0.29). The crude odds ratio was 0.73 for CC over CT(95% confidence interval 0.41-1.30). The adjusted odds ratio with age, sex, lipid profilcs and BMI was 0.68 for CC over CT(9596 confidence interval 037-1,23). Conclusion : The molecular varient M235T of the angiotensinogen gene is not associated with essential hypertension in Korean population.

Antioxidant and cytoprotective effects of morin against hydrogen peroxide-induced oxidative stress are associated with the induction of Nrf-2-mediated HO-1 expression in V79-4 Chinese hamster lung fibroblasts

Lee, Moon Hee,Cha, Hee-Jae,Choi, Eun Ok,Han, Min Ho,Kim, Sung Ok,Kim, Gi-Young,Hong, Su Hyun,Park, Cheol,Moon, Sung-Kwon,Jeong, Soon-Jeong,Jeong, Moon-Jin,Kim, Wun-Jae,Choi, Yung Hyun Spandidos Publications 2017 International journal of molecular medicine Vol.39 No.3

<P>Natural phytochemicals of plant origin, including flavonoids, have been found to be potent antioxidants providing beneficial effects against oxidative stress-related diseases. The present study was carried out to investigate the antioxidant properties of morin, a flavonoid originally isolated from the flowering plants of the Moraceae family. Superoxide dismutase (SOD)-like activity and 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS(center dot+)) radical scavenging activity were determined. We also investigated the cytoprotective effects of morin against hydrogen peroxide (H2O2)-induced DNA damage and apoptosis in V79-4 Chinese hamster lung fibroblasts. Our results demonstrated that morin had strong scavenging effects against ABTS' radicals with enhanced SOD activity, which varied in a dose-dependent manner. Morin was found to reduce H2O2-induced intracellular reactive oxygen species generation and nuclear DNA damage, and it recovered cell viability damaged by H2O2 via inhibition of mitochondrial dysfunction-mediated apoptosis. Notably, the treatment of V79-4 cells with morin markedly enhanced the expression of heme oxygenase-1 (HO-1) but not quinone oxidoreductase-1, which was associated with the increased expression and phosphorylation of nuclear factor-erythroid 2-related factor 2 (Nrf2) and the downregulation of Kelch-like ECH-associated protein 1 expression. Based on our findings, we conclude that morin effectively ameliorated oxidative stress-induced DNA damage through intrinsic free radical scavenging activity and activation of the Nrf2/HO-1 pathway.</P>

KLEINE-LEVIN 증후군 2례

홍순형,정인과,김순범,한선호,곽동일,이병윤 大韓神經精神醫學會 1981 신경정신의학 Vol.20 No.2

The Kleine-Levin syndrome is composed of recurring episodes of sleepiness lasting days, associated with excessive appetite and often with abnormal behavior. The authors reported two cases of the Kleine-Levin syndrome. The results were as follows: 1. They were adolescent male patients. 2. The onsets were predisposed by psychological stresses of school examinations. 3. Their electroencephalograms revealed abnormal findings only during episodes of hypersomnolence. 4. One of them was improved by treatment with imipramine and lithium.

대장암에서 개복 대장절제술, 복강경 대장절제술 및 수부 보조 복강경 대장절제술의 단기 추적 관찰 결과의 비교

홍경숙,노경태,오보영,이령아,정순섭,김광호 이화여자대학교 의과학연구소 2011 EMJ (Ewha medical journal) Vol.34 No.2

Objectives: Hand-assisted laparoscopic surgery had both technical advantages of open surgery and better postoperative short-term follow-up results of laparoscopic surgery. We compared open colectomy, laparoscopic colectomy and hand-assisted laparoscopic colectomy, and tried to find the most effective operative modality. Methods: 90 patients, who were diagnosed with colorectal cancer and underwent colectomy in our institution, were categorized as 3 groups of open colectomy (OC) group, laparoscopic colectomy (LC) group and hand-assisted laparoscopic colectomy (HALC) group by the surgical modality. Results: In this study, ratio of male and female was 57:37, and mean age was 64.1 years old. LC group and HALC group showed longer operation time, shorter hospital stay after operation, lesser pain and earlier removal of closed drainage catheter than OC group. Amount of bleeding during operation, frequency of transfusion and incidence of complication showed no significant difference. In permanent pathologic results, the number of harvested lymph nodes had significant difference between OC group and other groups (P=0.030), but it was probably caused by the bias of the different distribution of the stages in each group. Overall 14 of the cases resulted in complications while there was no mortality. Conclusion: Laparoscopic colectomy and hand-assisted laparoscopic colectomy showed better short-term follow-up results rather than open colectomy. And hand-assisted laparoscopic surgery could provide tactile sensation to operator, which lacked in laparoscopic surgery. Hand-assisted laparoscopic colectomy could be an alternative surgical option for colorectal cancer with these advantages.

당뇨병 환자의 혈청 Lipoprotein에 관한 연구

홍영숙,성낙응,경난호,이순남 梨花女子大學校 醫科大學 醫科學硏究所 1984 EMJ (Ewha medical journal) Vol.7 No.3

Lipoprotein cholesterol and triglyceride levels have been determined innormal and diabetes. The abnormalities of lipoprotein were investigated by SDS-polyacrylamide gel electrophoresis in the serum and the 3 major lipoprotein classes for diabetes. HDL cholesterol levels were lower in the diabetes compared to the normals. VLDL triglyceride levels also elevated in the diabetes. There were significant shifts in the distribution of lipoprotein cholesterol, with an increase in LDL cholesterol and decrease in HDL cholesterol. The results of this study suggest that diabetes may be associated with changes in both lipoprotein triglyceride and cholesterol levels. The electrohoretic patterns of VLDL and HDL in diabetes showed the abnorm-al pattern in comparison to normal.

綜合科學으로서의 秘書學 硏究方法論 : 理論體係 確立을 위한 問題點을 中心으로 a preliminary sketch

洪淳鎬 이화여자대학교 법정대학 비서학과 1981 비서학연구 Vol.- No.1

The purpose of this study is to exiamne the possibility of a systematic theory and methodology for developing an interisciplinary apporach to secretarial science. As a branch of the applied social sciences, secretarial science has had problems which have resulted from disagreements on the concept of "secretary". As Professor Maurice Duverger of the University of Paris has observed, there is a striking contrast between the effectivemess of the applied social sciences and the anarchic state of their theory. As in the case of all other social sciences, secretarial science suffers from a confusion on its hiatory and philosophy. This has produced two results: firstly, a mixture of the analysis of objective facts with the affirmation of normative principles; secondly, the predominance of a priori "practically". Therefore, secretarial science, as a discipline, is seen both as a science(theory) and an art(practicality). Historically , in response to practical needs, social sciences have been developing logic, methodology and standard of relevance for scientific inquiry. In order further to refine the concept of secretary, it seems useful to begin by defining the concept of administration in generic terms, as a common social process involving certain common secretarial activities. These activities, which usually include decision-making, programming, staffing wothput supervision, may be seen in most forms of business or public adminintration as well. Indeed, to some extent, the differences betweem administration and secretarial service come to rest largly in the respective environment of each. The office of the secretary may be defined as that aspect of administration occuring under the formal aegis of administrative organization at every level. While reconizing the validity of secretarial science as a subfield in the study of public and business administration, we do not believe that it involves the analysis of administration(management) in all its forms and in all human groups. We must define a "Secretarial service" differently than the way it is commonly defined. For some, secretarial service mat be characterized by its ultimate practicality. For others, it may be seen as a administrative or managerial science. However, secretarial service should be seen as neithe of these. It should be defined as something falling between public and business administration, in other wprds, as staff service within the framework of organization. The study of secretarial science should start from this point. Because secretarial science is, as mentioned above, a generalized human activity concered with ordering the men and materials required to achieve organizational goals, it has drown widly from the various social sciences. However, it is impossible to gain any adequate perspective of the field without tracing its background in the areas of public and business administration. Traditionally, the analysis of the field has reflected certain dominant contemporary trends in public and business administrative sciences which are usually recongnized as the parent discioline of the field. Each of these to be superseded as analytical tools and fashions change. An interdisciplinary apptoach represents an amalgam of all such styles: as role structural approach, behavioral approach and social philosophical approach. A new secretarial science as one of the applied social sciences should be pursued at the university level by adopting this interdisciplinary approach.

보행시 하지체질의 내적일 분석

홍성표,이순호,김희수 忠南大學校體育科學硏究所 1995 體育科學硏究誌 Vol.13 No.1

This study is to represent basic data of biomechanical work of human body which has been data measured precisely and is to see on pathology and abnormal gaits patterns. And 5, 6th grade boys in Taejon city were attended in this experiment. Each student wore 8 landmarks on their lower leg joints and walked for 4 Km/h, 5 Km/h, and 6 Km/h on the treadmill Mechanical energy of lower extremity segment by lower joint (thigh and shank) movement were measured in stance phase and swing phase which were assessed internal work and energy of segment The conclusions were as following; 1. Increasing gait velocity cause toe off in early stage and swing of lower extremity happen early and quickly with angle of shank increasing in swing phase. 2. Children gait velocity grow rapidly above 5km/h, internal work of thigh mechanical energy showed value of work clearly and large. and internal work change represent greater in shank than in thigh 3. The stance period of gait is the period off set by two operated cocontracting muscles, and the later the speed of gait is, the lower the effect of the net torque.

탄소성 변형을 받는 냉간 압연강의 X선 잔류응력 특성에 관한 연구

홍순혁,이동우,양광호,조석수,주원식 동아대학교 생산기술연구소 2000 生産技術硏究所硏究論文集 Vol.5 No.1

In textured material, diffraction angle 2θ usually shows a nonlinear relation against sin^2Ψ due to elastic anisotropy of crystals. SPHD and SPCD steel is cold-rolled carbon steel for automobile. The characteristics X-ray for stress measurement is Cr K_α and Mo K_α1characteristic X-ray. The sin^2Ψ-2θ diagram under elastic strain seems to have a linear behavior using regression line of data but has a nonlinear behavior in distribution of data by Cr K_αcharacteristic X-ray. As the plastic strain of specimen increases, the nonlinearity of 2θ with respect to sin^2Ψ increases remarkably. On the other hand, the diffraction angle 2 θ by Mo K_α1 characteristic X-ray shows a good linearity on sin^2Ψ-2θ diagram under plastic strain as well as elastic strain. Therefore, This paper presents the measurement of residual stress in cold-rolled carbon steel for automobile using penetration depth of Mo K_α1 charateristic X-ray and multiplicity factor of crystal diffraction plane.

보행시 하지체절의 에너지 교환

홍성표,김희수,이순호 忠南大學校體育科學硏究所 1996 體育科學硏究誌 Vol.14 No.1

This study is to represent basic datas of biomechanical work of human body which has measured precisely and datas on pathology and abnormal gaits paterns. 5 6th grader boys in Taejon city were attended in this experiment. Each student wore 8 landmarks on their lower leg joints and walked for 4 Km/h, 5 Km/h, and 6 Km/h on the tread mill. Mechanical energy of lower extremity segment by lower joint(thigh and shank) movement were measured in stance phase and swing phase by using 2 dimentional image analyzer, and which were evaluated energy of segment The conclusions were as fllowing; 1. Rotational kinetic energy change slightly in lower extremity segment, translational kinetic energy change in the biggest, and value of energy creat greater in swing phase than in stance phase. 2. Energy change in gait cycle increas in swing phase and decrease in stance phase. 3. Perfect energy change of lower extremity segment is not do.

울산시 보건소 당뇨교실에 참가한 당뇨환자의 식습관 실태에 관한 연구

홍순명,황혜진,최순호,정은미 울산대학교 2000 생활과학논문집 Vol.2 No.1

본 연구의 목적은 당뇨환자의 특성, 식사조절, 운동여부와 그 외의 식습관을 조사함으로써, 이를 영양교육과 영양상담을 하는 데에 있어 기초자료로 이용하고자 한다. 울산시 동구 보건소를 내원한 당뇨환자 112명을 대상으로 조사한 결과를 요약하면 다음과 같다. 대상자의 당뇨보유기간은 7.58 ± 7.30년이었고, 공복시 혈당과 식후 2시간 후 혈당은 각각 180.92 ± 71.42mg/dl 247.64 ± 105.26mg/dl으며, 합병증 증세로는 저혈당 증세가 가장 많았으며, 심혈관질환, 망막장애, 백내장, 당뇨족, 신장장애, 말초신경장애 등 여러 합병증도 존재함을 알 수 있었다. 당뇨병으로 인한 증상으로는 눈흐림 50.5%, 피로 46.7%로 대부분의 조사대상자가 느끼는 증상이었고, 그 외 잦은 소변, 갈증, 짜증, 기타 증상(손발 절임, 어지러움, 몸이 무겁다, 변비, 가래)이 나타났다. 조사대상자들의 38%는 식사조절을 하였으나 대부분이 식품 교환표를 이용하지 않는 것으로 나타났고, 음주와 흡연을 한다는 경우는 각각 15.7%로 나타났다. 보건소를 이용하는 환자들은 대부분 고령인 점을 고려하여 이들이 쉽게 이해할 수 있으며 식생활에 적응할 수 있는 영양교육프로그램의 개발이 필요하다고 본다. The purpose of this study is to investigate the diabetes subject of health center for nutrition education. 112 subjects were evaluated with Questionnaire., Diabetic duration were 7.58 years and the fasting and 2-hour postprandial glucose level were 180.92 ±71.42mg/dl, 247.64 ± 105.26mg/dl. The complications were hypoglycemia > weakness in legs > renal, failure > peripheral neural disorder, and diabetic symptoms were sight disturbance > fatigue> polyuria. 62% of subjects were not executed diet therapy and 15.7% of subject had drinking and smoking habit. The most influential referents were medical professionals including doctors, nurses, dieticians, so their role in diet therapy should be emphasized. Since diabetic patients commuting to a local health center were mainly illiterate and received little formal education, it is very important to develop and assess appropriate nutrition education for them.