급성 골수성 백혈병에서의 병적 비장파열 1 예

이순남,한운섭,경난호,성연아,손현주,박응범,임양희,박이갑 대한내과학회 1987 대한내과학회지 Vol.33 No.3

Spontaneous splenic rupture is a rare complication of hematologic malignancies. A case of spontaneous rupture of spleen in 31-year-old man with acute myelacytic leukemia, M2 is presented, Splenectomy was carried out successfully and he is alive in remission status without any complication.

악성종양 환자에서 A. Port Implantation의 유용성과 합병증

이순남,김광호 梨花女子大學校 醫科大學 醫科學硏究所 1993 EMJ (Ewha medical journal) Vol.16 No.4

Reliable venous access is increasing serious problem in cancer chemotherapy Patients. Thiry six implantable second generation catheter system(A. Port) were placed subcutaneouslyin 35 patients with cancer. A Port were in place f3r an ave.age of 158 days(range 10-731^+ days). Complicationsincluded infections in 3 cases, thrombosis in 1 case, skin laceration in 1 case and pneurnothoraxin 1 case. Five ports were removed due to complication. One pneumothorax was managedconservatively; It is concluded that A. Port implantation constitute a safe and convenient access with alow rate of complication for long term intravenous chemotherapy in cancer patients.

진행성 비소세포폐암 환자의 Ifosfamide, Etoposide와 Cisplatin(IEP) 복합화학요법

이순남 梨花女子大學校 醫科大學 醫科學硏究所 1993 EMJ (Ewha medical journal) Vol.16 No.4

To evaluste the efficacy and toxicity of IEP chemotherapy in locally advanced and metastaticnon-small cell lung cancer, nineteen previously untreated patients with non-small cell lungcancer were studied. Patients received ifosfamide 1000mg/m^2 with mesna, 20% of ifosfamide dose at 0,4, 8 hoursafter ifosfamide, etoposide 100mg/m^2, and cisplatin 20mg/m^2 with full hydration and mannitoldiuresis intravenously on days 1-3 every 4 weeks. Eighteen male and one female, two stage ⅢA, 10 stage ⅢB and 7 stage Ⅳ patients havebeen treated. The response rate of IEP was 26% with no complete remission, 53% of stable disease, and23% of progressive diasease. The overall median survival was not reaced yet and 20 month survival rate was 51.4%, The duration of remission was at the range of 4^+ to 40 weeks. The toxicities were alopecia (100%), nausea and vomiting(47%), leukopenia(14%), infection(6%), renal dysfunction(6%) and oral mucositis(5%). This phase Ⅱ study of IEP in advanced non-small cell lung cancer is not superior to another combinatiori regimens in terms of response but toxicity was tolerable. Other new chemothera-peutic drugs and newer trials should be developed further.

장티푸스에 동반된 Hypoplastic Anemia의 1예

이순남,경난호 梨花女子大學校 醫科大學 醫科學硏究所 1983 EMJ (Ewha medical journal) Vol.6 No.3

The authors experienced a 29 year old female patient with hypoplastic anemia during her illness of typhoid fever. Because that is very rare and unreported, we are reporting this patient. She was promptly recovered from hypoplastic anemia with antibiotics for typhoid fever.

악성종양환자의 호중구기능에 관한 연구

이순남,박이갑 梨花女子大學校 醫科大學 醫科學硏究所 1989 EMJ (Ewha medical journal) Vol.12 No.4

It has been recognized for a long time that human malignant diseases are associated with immune deficiency states. Impaired phagocytic function, low levels of plasma opsonins, impaired bactericidal activity of granulocytes and macrophages, deficiency of myeloperoxydase, reduced migration of polymorphonuclear leukocytes and granulocytopenia have all been found in malignant condition primarily or secondarily. Especially neutrophils are crucial to the body's defenses against infection. Defects in phagocytes can contribute to the local establishment and systemic spread of serious bacterial infection. The authors studied neutrophil function in 40 control and 15 patients with acute myelogenous leukemia, 10 with non-Hodgkin's lymphoma, 40 with stomach cancer, 10 with hepatoma, 10 with pancreas cancer and 25 with other organ tumor to prove the mechanism of increased risk and the severity of infection using a battery of simple and reproducible neutrophil function tests as adherence to nylon wool fiber, migration under agarose method and nitrobule tetrazolium reduction test. The results obtained are as follows; 1) On adherence to nylon wool fiber, the adherence was significantly decreased in patients with acute myelogenous leukemia, but increased in patients with lymphoma. In patients with other solid tumors, there were no significant differences from those of controls. After chemotherapy with Cisplatin and 5-FU, the adherence was significantly decreased than that of prior to therapy. 2) On migration under agarose, the chemotactic differential was significantly decreased in patients with acute myelogenous leukemia but increased in patients with hepatoma and pancreas cancer. Presence of factors of those increment was suspected. After infusion of Cisplatin, chemotactic differential was decreased significantly but after infusion of 5-FU, it was decreased but there was no significance. 3) On NBT reduction test, NBT reduction was diminished in patients with acute myelogenous leukemia but increased in patients with hepatoma and pancreas cancer. It is assumed that some unidentified factors would be present to enhance chemotaxis and NBT reduction in patients with hepatoma and pancreas cancer. After infusion of Cisplatin, NBT reduction was significantly decreased, but after infusion of 5-FU it was decreased but not significantly. In patients with acute myelogenous leukemia, neutrophil functions were much impaired but in patients with solid tumors, there were no neutrophil function defects. After chemotheraphy with Cisplatin and 5-FU, neutrophil functions were much compromised and this would predispose to increased risk of infection.

급성백혈병과 고형종양 환자에서 피하 중심정맥포트의 비교

이순남,김광호 大韓血液學會 1994 大韓血液學會誌 Vol.29 No.3

대장암의 증상과 치료

이순남 약업신문사 1996 의약정보 Vol.1996 No.2

당뇨병환자에서의 Treadmill Exercise Test의 임상적 의의

이순남,경난호 梨花女子大學校 醫科大學 醫科學硏究所 1983 EMJ (Ewha medical journal) Vol.6 No.4

The maximum exercise testing using treadmill walking was performed in 36 patients of diabetes mellitus who were admitted to the Ewha Womans University Hospital from March, 1983 to August, 1983 and 30 normal control subjects to evaluate the efficacy of significance to detect latent coronary artery disease in diabetes mellitus as a chronic complication. Among 36 patients of diabetes mellitus, ten(27.8%) were treadmill exercise test positive, of whom two had ST depression in resting electrocardiogram but eight didn't have any changes in resting electrocardiogram. Since treadmill exercise test can be a useful sensitive diagnostic tool for early detection of latent coronary artery disease in the patients of diabetes mellitus as a chronic complication.

고기질도 소비자 위주로$\cdots$

이순남 대한양계협회 1987 월간 양계 Vol.19 No.9

국소진행된 비소세포 폐암의 선행화학요법후 방사선 병용요법 : 장기추적 결과 Long Term Results

이순남 梨花女子大學校 醫科大學 醫科學硏究所 1994 EMJ (Ewha medical journal) Vol.17 No.4

To evaluate the long term results of sequential neoadjuvant chemotherapy followed by radiotherapy in locally advanced non small ciell lung cancer(NSCLC), 32 patients with stage Ⅲ NSCLC were atudied. Neoadjuvanjt chemotherapy was performed with 2-3 cycles of cisplatin containing combination at the interval of 3-4 weeks, and then radiotherapy to and primary tumor, mediastinum and both supaclavicular lymph nodes was followed. The results were as follows: 1) After neoadjuvant chemotherapy, partial remission(PR) rate was 59.4% without complete remission(CR). At completion of radiotherapy, CR rate was 28.1%, PR rate 50.0% and overall response rate was 78.1%. 2) The median survival of all patients was 14.4 months, for stage ⅢA NSCLC patients was 22 months compared to 11.4 month in stage ⅢB NSCLC patients without significance. For responder of neoadjuvant chemotherapy, median survival was 16.6 months, and 9.3 months for the non responder(p<0,05). Median survival of responders at completion of chemotherapy was 26.8 months at the rangd of 4-48 months. Overall survival rate at 2 year was 27.1% and continued plateau till 50 months without late relapse. 3) The acute toxicities were tolerable in all patients and not fatal, but late complications of three restricitive pneumonitis and one cough induced syncopal attack compromise the quality of life among the 8 long term survivors who lived over 2 years. 4) The relapse rate was 58.1%(18 out of 31 cases) and the pattern of relapse was local in 14 cases(45.2%), systemic in 3 cases(9.7%) and local plus systemic in 1 case(3.2%). The sites of systemic relapse were brain in 3 cases and brain combined with bone in 1 case. In conclusion, sequential neoadjuvant chemotherapy and radiotherapy can prolong the survival and diminish the systemic relapse in locally advanced non small cell lung cancer patients but local failure was the main problem in these patients. To enhance the local control, other trials such as concurrent chemoradiotherapy, hyperfractionated radiotherapy combined with developing more effective new chemotherapeutic agents and combined regimens should be further investigated.