Multi‑tissue lipotoxicity caused by high‑fat diet feeding is attenuated by the supplementation of Korean red ginseng in mice

Seon‑A Jang,Seung Namkoong,이성률,Jin Woo Lee,Yuna Park,Gyeongseop So,Sung Hyeok Kim,Mi‑Ja Kim,Ki‑Hyo Jang,Alberto P. Avolio,Sumudu V. S. Gangoda,Hyun Jung Koo,Myung Kyum Kim,Se Chan Kang,Eun‑Hwa Sohn 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.1

Background Excessive intake of fat, one of the causes of obesity, is associated with low-grade infammation in various susceptible organs and eventually causes tissue toxicity. This study examines the multifaceted suppressive efects of Korean red ginseng extract (KRG) on high-fat diet (HFD)-induced lipotoxicity and infammatory responses in the aorta, liver, and brain. Methods Male C57BL/6 mice were fed HFD with or without KRG for 12 weeks. The improvement efect in KRG on lipotoxicity and infammatory potential was determined in the blood and the aorta, liver, and brain tissues. Results KRG signifcantly inhibited 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity by >20% in vitro. KRG supplementation suppressed HFD-associated body weight gain, lipid profle changes, and excessive fat deposition in the liver and increased leptin, insulin, and ALT levels in the blood. Infammatory markers in the aorta, liver, and brain were also signifcantly reduced by KRG treatment. In microvascular endothelial cells, the 15% cyclic stretch-mediated upregulation of ICAM-1 and vascular cell adhesion protein-1 (VCAM-1) expression was signifcantly attenuated in the presence of KRG. Conclusion KRG supplementation attenuates HFD-mediated body weight gain, lipid profle changes, and multi-tissue infammatory responses.

청소년이 지각한 가족기능과 희망과의 관계

우선혜,노지영,박영숙 韓國學校保健學會 2005 韓國學校保健學會誌 Vol.18 No.1

Purpose: This Study a descriptive correlation survey with the purpose of identifying the relationship between family function and hope in adolescents. It was done to provide basic data for developing family centered nursing strategies to promote adolescents' hope. Methods: The subjects of this study were 1030 high school students in J city. Data were analyzed with SPSS 10.0 program. Frequencies and percentages were used to compare the subjects' general characteristics. Minimum values, maximum values, mean scores and mean grades were used to identify the level of family function and hope. Pearson's correlation coefficient was used to analyze the relationship between family function and hope in adolescents, and t test, ANOVA, and Scheffe test were used to examine the level of family function and hope by general characteristics. Results: 1. The level of adolescents' family function ranged from 26 to 97, the mean score was 66.85±13.16, and the mean grade was 2.76±0.52. 2. The level of adolescents' hope ranged from 55 to 153, the mean score was 111.48±17.64 and the mean grade was 2.78±0.44. 3. It showed that there is a significantly positive correlation (r=0.546, p=.000) between adolescents' family function and hope. That is, the better family function adolescents have, the higher level of hope they have. 4. Adolescents' family function showed significant differences according to school record (F=6.363, p=.002), school life satisfaction (F=4.922, p=.007), father's education (F=2.640, p=.048), mother's education (F=3.586, p=.013) and domestic economy status(F=3.022, p=.049). 5. Adolescents' hope showed significant differences according to religion (t=2.018, p=.044), school type (t=2.567, p=.010), school record (F=9.712, p=.000), school life satisfaction (F=11.367,p=.000), father's education (F=4.632, p=.003), mother's education (F=4.709, p=.003), domestic economy status (F=4.235, p=.015), relationship with friends (F=8.187, p=.000), and subjective health condition (F=5.490, p=.001). Conclusion: First, in order to improve adolescents' family function, which encourages hope in adolescents, it is necessary to develop nursing interventions and to make further studies. Second, it is necessary to develop instruments for improving Korean adolescents' family function and hope. Third, further studies are required to improve adolescents' family function and hope in special situations such as disease, drug abuse and juvenile delinquent.

신경인성 방광의 치료에서 요도부목 설치의성공례와 실패례 -증례 보고-

임선희,나은우,이일영,문혜원,임신영,정도영 大韓再活醫學會 2000 Annals of Rehabilitation Medicine Vol.24 No.1

척수 손상인의 상부 운동원성 신경인성 장의대장 통과 시간과 배변 관리

임선희,나은우,이일영,조기홍 大韓再活醫學會 2000 Annals of Rehabilitation Medicine Vol.24 No.3

유산소 리듬 운동프로그램이 노인의 혈압, 심박수 및 생활만족도에 미치는 효과

우선혜,김효정,박영숙 대한보건협회 2001 대한보건연구 Vol.27 No.3

The purpose of this study was to test the effects of aerobic rhythmical exercise program on blood pressure, pulse and the life satisfaction of the elderly. This quai-experimental study was designed as a non-equivalent control group pretest-posttest study. The subjects were 36 subjects(experimental group: 19 subjects, control group: 17 subjects), aged between 65 and 73 years who have normal cognition, sensory function and cerebellum function. Aerobic rhythmical exercise program was developed on the basis of aerobic exercise, Korean tradititional dance and music by the author. The blood pressure, pulse rate and life satisfaction were measured prior to and following the experimental treatment. Data were analyzed with x^2-test, t-test, mean, standard deviation, percentage of change and ANCOVA test using SAS program. The results were as follows. 1. There was no significant difference of systolic blood pressure between experimental and control group following the aerobic rhythmical exercise program(F=1.39, P=0.247). 2. The diastolic blood pressure of the experimental group was significantly lower than that of control group following the aerobic rhythmical exercise program(F=2.96, p<0.1). 3. There was no significant difference of resting heart rate between experimental and control group following the aerobic rhythmical exercise program(F=0.07, P=0.793). 4. The life satisfaction of the experimental group was significantly higher than that of control group following the aerobic rhythmical exercise program(F=9.94, p<0.01). On the basis of the above findings, aerobic rhythmical exercise program is effective in reducing diastolic blood pressure and promoting life satisfaction of the elderly. Thus, this program can be recommended as an effective nursing intervention for the elderly.

엘리트 태권도선수의 영양지도 분석

선우진,박수복 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.2

We also developed food group allowances for the players based on their nutrient allowances and current young-aged Korean dietary styles; cereals 400g, potatoes and starches 60g, sugars 20g fats and oils 30g, pulses 120g, meats 150g, fishes and shellfishes 150g, eggs 80g, milks 600g, green and yellow vegetables 300g, the other vegetables 350g, fruits 400g and algae 20g per day. For the experimental period of 45 days, daily diets adjusted to approximate 120% of the dietary allowances were served to the players who were free talking snacks and drinks. Dietary guidances for the players were assessed by monitors of their dietary intakes, physical constitution and clinical examinations in blood. Means of the dietary intakes of the players were 96~99% of the dietary allowances, determined by a nutritional survey with the 24hours recall method. There were less changes in the physical constitution of the players before, during and after the experimental period; body weight 57±3㎏ and body fat 8.9±1.8%, Values of the clinical marks in the blood cells 509±4×104 cells/㎚3, hemoglobin 15±0.4g/dl and hematocrit 46.6±0.7%.

남자 태권도 선수에서 고비중 리포단백 콜레스테롤 (HDL-c)과 체력 및 성호르몬 종합단백 (SHBG)과의 관련성 분석

선우진,박수복 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.2

A study was conducted to investigate the contribution of physical fitness evaluated by speed at onset of blood lactate accumulation (OBLA-SP), sex hormones and sex hormone-binding globulin(SHBG) on high-density lipoprotein cholesterol (HDL-c) in 12young male players. These players has a higher level and wide range of intraindividual variance (44 to 93㎎/㎗) for HDL-c. The serum estradiol level was significantly and positively correlated with the level of approtein AI(ApoAI), and serum testosterone level was significantly and positively associated with the levels of both HDL3-C and apoprotein AⅡ(ApoAⅡ). The SHBG level was positively associated with the levels of both HDL-c and HDL2-C. Age, certain anthropometric parameters such as percentage body fat, body mass index, and body fat distribution evaluated by waist to hip ratio, and physical fitness levels were not associated with HDL-c and other lipids and apoproteins. Three results suggest that the HDL-c level in Taekwondo players are strongly associated with not only male but also female hormones, and SHBG, being independent of age, body composition and physical fitness level.

거제도 구천호와 연초호의 곤충과 저서성 대형무척추동물의 분포

정선우,박정원,전세근,윤춘식 7개 국립대학교 환경연구 논문집 공동발행 위원회 2004 공업기술연구 Vol.4 No.-

The community structures of benthic macroinvertebrates and insects of reservoirs Yeoncho and Gucheon in Is. Geoje were studied. The surveyed sites were three streams and waterfronts each lake. The Collection was performed from May to October of 2004. As a result, total macroinvertabrates collected in the reservoir Yeoncho were 2 phyla, 2 classes, 8 orders, 15 families, 17 genera and 18 species. IN insects, 12 orders, 52 families, 89 genera and 95 species were identifies. Total macroinvertabrates collected in the reservoir Gucheon were 3 phyla, 4 classes, 10 orders, 15 families, 18 genera and 18 species. In insects, 8 orders, 45 families, 92 genera and 101 species were identified. Dominant species of benthic macroinvertebrates and insects in reservoir Yeoncho were Macrobrachium nipponense and Nysius(Nysius) plebejus respectively. The total species richness and species diversity of benthic macroinvertebrates in the reservoir Yeoncho was 32.78 and 1,77 respectively. The total species richness and species diversity of benthic macroinvertertebrates in the reservoir Gucheon was 36.48 and 1.88 respectively.

주남저수지의 곤충분포

정선우 昌原大學校 基礎科學硏究所 1998 基礎科學硏究所論文集 Vol.10 No.-

The distribution of aquatic and terrestrial insects form Junam reservoir was surveyed. Junam reservoir locate at Dong-Up, Changwon-city, and various insects were collected from 10 serveying sites. Specimens were collected from May to October of 1997 by various collecting methods. Total insect taxa collected from reservoirs were 10 orders, 63 families, 143 genera, 170 species and 4295 individuals. In Odonata, 6 families, 16 genera, 25 species were identified. From order Mentodea, 1 families, 2 species were identified. From Dermaptera, 2 families, 3 species were recorded. In Orthoptera, 4 families, 8 genera, 10 species were identified, and 13 families, 29 genera, 35 species were collected in Hemiptera. On Homoptera, 6 families, 8 species were collected, and 13 families, 37 species were contained in Coleoptera. In Hymenoptera, 6 families, 19 species were classified, and 8 families, 20 species were identified in Diptera. In Lepidoptera, 4 families, 10 species were classified. From the faunal data, diversity index(H′), richness index(RI), relative density(RD), and dominance to the species(D) were calculated respectively. Ischnura asiatica showed the highest dominance index, and richness index of Junam reservoir was 46.52. Diversity index was highest at the site of D.

합천군 정양지와 박실지의 곤충 및 저서성 대형무척추동물의 분포

정선우,전세근,김인택,박정원,윤춘식 7개 국립대학교 환경연구논문집 공동발행 위원회 2005 공업기술연구 Vol.5 No.-

The community structures of benthic macro-invertebrates and insects of reservoirs Jeongyang and Pakasil in Hapcheon-gun were studied. The surveyed sites were three streams and waterfronts of each lake. The Collection was performed from April to October of 2005. As a result, total macreo-invertebrates collected in the reservoir Jeongyang were 3 phyla, 4 classes, 12 orders, 29 families and 56 species. In insects, 12 orders, 71 families and 167 species were identified. Total macro-invertebrates collectd in the reservoir Paksil were 2 phyla, 3 classes, 8 orders, 19 families and 36 species. In insects, 11orders, 50 families and 137 species were identified.Dominant species of benthic macro-invertebrates and insects in reservoir Jeongyang were Chiromomus sp and Nysius plebejus respectively. Dominant species of benthic macro-invertebrates and insects in reservoir Paksil were Physella acuta and Nysius plebejus respectively. The total species richness and species diversity of benthic macro-invertebrates in the reservoir Jeongyang was 16.88 and 1.43 respectively. The total species richness and species diversidty of benthic macro-invertebrates in the reservoir Paksil was 12.12 and 1.10 respectively. The total species richness and species diversity of insects in the reservoir Jeongyang was 56.65 and 1.99 respectively. The total species richness and species diversity of benthic macro-invertebrates in the reservoir Paksil was 47.65. and 0.90 respectively.