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        • KCI등재

          초파리 단안의 발생시기에 따른 각막형성세포의 형태

          윤춘식,Yoon,,Chun-Sik 한국현미경학회 1999 Applied microscopy Vol.29 No.2

          초파리 단안의 발생단계에 따른 각막형성세포의 형태적인 변화를 관찰하고, 생산된 단백질의 이동방향을 조사하였다. 그 결과 우화 후 수일이 지나면서 각막형성세포는 그 기능이 급격하게 감소하는 것으로 보인다. 반면 우화 직후의 각막형성세포는 왕성한 분비활동을 하는 것으로 생각된다. 특히 자기방사섭의 결과에서는 각막형성세포에서 생산된 대부분의 단백질이 랜즈쪽으로 가는 것을 볼 때, 이 시기에서 이들 세포는 시세포에 기능하기보다는 렌즈형성에 주 기능을 할 것으로 사료된다. 번데기시기의 각막형성세포는 더욱 잘 발달되어 있었다. 렌즈가 형성되고 있는 시기의 각막형성세포에는 rER이 잘 발달되어 물질생산이 왕성하게 일어나고 있음을 보여주었다. 또한 분비과립과 미세소관이 많이 관찰되는데, 후자는 물질이 이동하는 통로를 제공하기 때문이다. 발생도중의 단안에서 새롭게 만들어진 렌즈의 가장 아래층의 저밀도의 불연속적 라멜라구조를 이루고 있고, 이 부분의 각막형성세포는 미세융모가 잘 발달되어 있어 물질을 분비하는 조직의 일반적인 특징을 보여준다. 결론적으로 각막형성세포는 렌즈가 왕성하게 형성되는 시기에는 잘 발달하고, 우화 후 완전히 형성된 추에는 그 기능이 급격하게 감소하면서 세포의 크기도 작아진 다는 것을 알 수 있었다. Morphological changes of Drosophila ocellar corneagenous cells were studied to the development with electron microscopy, and the movement of produced proteins was traced with autoradiography. Corneagenous cells of immediate postemergence showed very active secretion pattern. However, a few days after the emergence, the secretory activity of corneagenous cell was supposed to be dropped suddenly. In autoradiography, almost of proteins that produced by corneagenous cells moved toward lens. From this, it was supposed that the corneagenous cells do not function in photoreceptor cells rather in the formation of lens at the postemergence stage. Corneagenous cells of pupal stage were well developed. In the period of lens formation, rER of corneagenous cells were well developed and it suggested very active material metabolism. Granules and microtubules were also frequently observed and the later would be a pathway of the movement of materials. In conclusion, corneagenous cells were well developed at vigorous lens forming stage. After emergence, when the lens formation was completed, both the function and the size of corneagenous cells were reduced.

        • KCI등재

          Wilms씨 종양 : 화학약물요법후 CT 소견의 변화

          윤춘식 대한영상의학회 1993 대한영상의학회지 Vol.29 No.6

          When the tumor is advanced with distant metastasis or unresectable initially, preoperative chemotherapy could be applied in the treatment of Wilms' tumor We experienced 6 cases of favorable type of Wilms' tumor, 1 case of clear cell sarcoma and 1 case of renal cell carcinoma. They were treated with preoperative chemotherapy and underwent CT Scans before and after the therapy. Pathologic changes after chemotherapy in Wilms' tumor were known from previous reports as subtotal hemorrhagic necrosis, cystic change, clusters of foamy histiocytes, granulation tissue formation, primitive nephrogenic tissues and peripherally remained focal areas of blastemal infltration. Changes of CT finding after chemotherapy were internal necrosis (6/6), decrease in size (5/6) decrease and absence of regional lymph node enlargement (4/6) and improved or disappered metastatic lesions (3/3). Although our study had some limitations such as small numbers of cases and cases were favorable types, we thought that there were good correlations between change of CT findings and subtotal hemorrhagic necrosis after preoperative chemotherapy in Wilms' tumor.

        • KCI등재

          신경아세포종 : 전산화단층촬영소경

          윤춘식 대한영상의학회 1994 대한영상의학회지 Vol.30 No.1

          목 적: 소아에서 가장 많은 복부악성종양중의 하나인 신경아세포종의 진단에 도움을 주고자 전산화단층촬영소견의 특징을 분석하였다. 대상 및 방법: 1983년부터 1990년 9월 사이에 조직병리학적으로 확진된 51예의 신경아세포종중 전산화단층촬영소견분석이 가능하였던 25예를 대상으로 하였다. 결 과: 가장 많이 발생한 부위는 부신(40%)였고, 후복막(32%), 후종격동(16%) 순이었다. 특징적인 CT소견은 석회화는 복부종양의 경우 86%, 종격동 종양의 경우50%에서 보였고 종양내 괴사나 출혈성 괴사는 복부종양(86%), 종격동 종양(25%)에서 보였다. 조영증강후에는 종괴내 연부조직의 조영증강뿐아니라 작은 격막상의 조영증강 소견들이 빈번해 보였다. 복부 종양의 90%에서 종괴나 전이된 림프절에의해 주요 혈관들인 하대정맥이나 대동맥 등의 encasement가 있었고 림프절의 전이소견은 복부종양의 95%, 종격동종양의 경우 25%에서 보였다. 가장 흔히 침습을 보인 장기는 신장으로 6예에서 있었다. 결 론: 신경아세포종의 진단은 이상의 전산화단층촬영의 특징적인 소견들을 보이는 종양에서 비교적 쉽게 얻을 수 있을 것으로 생각된다. Purpose : To evaluate the characteristic CT findings of neuroblastoma, we studied neurobalstomas.Materials and Methods : We analysed CT findings of available 25 cases among pathologically proved 51 neurobalstomas from Jan. 1983 to Sept. 1990.Results : The most frequent site of origin is adrenl gland (40%) and the second is retroperitoneurn (32%) and the third ismediastinum (16%). Characteristic CT findings are as follows : Calcifications within the tumor is detected in 86% of abdominal neuroblastomas and 50% of mediastinal origin. Hemorrhagic and necrotic changes within the tumor is noted at 86% in the tumor of abdominal origin and 25% in mediastinal neuroblastomas. Contrast enhanced study showed frequently septated enhanced appearance with/without solid contrast enhancement. Encasements of major great vessels such as aorta and IVC with/without displacement by metastatic lymphnodes or tumor are frequently seen in 90% of abdominal neuroblastomas. Multiple lymphadenopathy are detected in 95% of abdominal neurobalstomas and 25% of mediastinal neuroblastomas. The most common organ of contiguous direct invasion is kidney in 6 cases and the next one is liver but intraspinal canal invasion is also noted in 2 cases.Concusion : We concluded that diagnosis of neuroblastoma would be easily obtained in masses of pediatric group from recognition of above characteristic findings.

        • KCI등재

          초파리 rdgA 시각돌연변이체 단안의 형태적 연구

          윤춘식 한국생명과학회 1999 생명과학회지 Vol.9 No.3

          Ocellar morphological abnormality was studied in Drosophila rdgA mutant. In the mutant, ocellar photoreceptor cells were generally affected by the defection of rdgA molecules. Among organelles of photoreceptor cell, rhabdomeres were remarkably degenerated. The rdgA molecule, diacylglycerol kinase, was localized around SRC just below the rhabdomeric region. As a secondary phenomenon of photoreceptor degeneration, rER, multivesicular body and multilamella body were appeared in cytoplasm and these were known as to clean the cellular debris. These morphological abnormality was generally observed in degenerating cells. In Drosophila mutant, the degeneration of ocellar photoreceptor cell was facilitated to time. More intense morphological defection was observed in rdgA^{ks60} rather than in yw;rdgApc47.

        • KCI등재

          초음파로 진단한 Trichobezoar : 증례보고

          윤춘식 대한영상의학회 1993 대한영상의학회지 Vol.29 No.4

          The author experienced a case of gastroduodenojejunal trichobezoar detected by ultrasongraphic examination. We though that tricholbezoar had relatively specific ultrasonographic findings such as a broad hyperechogenic superficial bandlike rim with a complete posterior sonic shadowing and multiple linear echogenic strands on its surface representing hairs, which were better seen after water ingestion. So we were able to get the correct diagnosis of trichobezoar prior to conventional barium studies in a patient who could not be suspected clinically.

        • KCI등재

          장애인기업의 연구개발 지원 방안 연구

          윤춘식,고은영,최유화 국제문화기술진흥원 2020 The Journal of the Convergence on Culture Technolo Vol.6 No.3

          본 연구는 장애인기업에 대한 현황과 연구개발활동을 살펴보고 연구개발 지원 방안을 찾는데 그 목적이 있다. 본 연구를 통해 연구개발에 대한 기업의 수요와 연구개발활동이 활발한 기업의 특성을 도출하였으며, 이를 종합하여 연구개발지원 방안을 제안하였다. 중소기업과 장애인기업의 업종별 입지계수(LQ) 비교결과 장애인종사자수는 업종별 큰 특화를 보였다. 연구개발은 제조업을 비롯한 4개 업종의 매출액 20억원 이상 기업에서 활발하였다. 연구결과 장애인기업에 대한 연구개발 지원은 업종 및 기업의 규모에 따라 현장애로기술중심과 혁신기술중심으로 구분하여 지원할 필요가 있다. The purpose of this study is to examine the current status and R&D activities of disabled enterprise, and to find ways to support R&D. Through this study, the company's demand for R&D and the characteristics of companies with active R&D activities were derived, and the research and development support plan was proposed by integrating them. As a result of comparing the location quotient (LQ) of small and medium-sized businesses and disabled enterprise by industry, the number of workers with disabilities showed great specialization by business type. R&D was active in companies with sales of over 2 billion won in four industries including manufacturing. As a result of the research, R&D support for disabled enterprise needs to be supported by categorizing them into field-hardened technology-oriented and innovative technology-oriented, depending on the type of business and the size of the company.

        • KCI등재

          전산화단층촬영을 이용한 정상인 뇌하수체의 방사선학적 고찰

          윤춘식 대한영상의학회 1987 대한영상의학회지 Vol.23 No.3

          Direct coronal computed tomography with 1.5mm contiguous scanning was done in total 95 cases, who had o clinical evidence of pituitary and hypothalamic disease. The evaluation of pituitary height, width, upper surface contour and density was done and the pituitary stalk was also evaluated. RESULT : 1. Total 95 cases were 45 males and 50 females. 2. The average height of mormal pituitary gland was 5.72$\pm$1.44mm in female and 5.37$\pm$1.17mm in male. There was no significant difference of pituitary height between male and female. 3. The pituitary height was decreased according to the increased age both in male ad female except prepubertal age. 4. The group between 15-30 year old age showed significantly increased pituitary height comparingto the remained age group both in male and female. 5. The upper limit of mormal pituitary height in 95% confidence level was 7.95-0.011xage infemale and 7.4-0.013xage in male. 6. The upper surface contour of normal pituitary gland were convex in 14 cases, flat in 58 cases adn concave in 23 cases. There was a significant correlation between the height and upper surface contour of putuitary gland. 7. The average width of normal pituitary gland was 13.4$\pm$1.74mm in female and 13.69$\pm$2.3mm in male. There was o significant difference between those of female and male. 8. The focal low density of normal pituitary gland was noted in only 8.4% and its size was always below 3mm. 9. Te pituitary stalk can be seen in 94.7% by direct coronal CT scanning and it was located at the midline. 10. There were nosignificant difference in pituitary height and width accordig to the menopause or the marrige.

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