신경아세포종 : 전산화단층촬영소경

윤춘식 대한영상의학회 1994 대한영상의학회지 Vol.30 No.1

목 적: 소아에서 가장 많은 복부악성종양중의 하나인 신경아세포종의 진단에 도움을 주고자 전산화단층촬영소견의 특징을 분석하였다. 대상 및 방법: 1983년부터 1990년 9월 사이에 조직병리학적으로 확진된 51예의 신경아세포종중 전산화단층촬영소견분석이 가능하였던 25예를 대상으로 하였다. 결 과: 가장 많이 발생한 부위는 부신(40%)였고, 후복막(32%), 후종격동(16%) 순이었다. 특징적인 CT소견은 석회화는 복부종양의 경우 86%, 종격동 종양의 경우50%에서 보였고 종양내 괴사나 출혈성 괴사는 복부종양(86%), 종격동 종양(25%)에서 보였다. 조영증강후에는 종괴내 연부조직의 조영증강뿐아니라 작은 격막상의 조영증강 소견들이 빈번해 보였다. 복부 종양의 90%에서 종괴나 전이된 림프절에의해 주요 혈관들인 하대정맥이나 대동맥 등의 encasement가 있었고 림프절의 전이소견은 복부종양의 95%, 종격동종양의 경우 25%에서 보였다. 가장 흔히 침습을 보인 장기는 신장으로 6예에서 있었다. 결 론: 신경아세포종의 진단은 이상의 전산화단층촬영의 특징적인 소견들을 보이는 종양에서 비교적 쉽게 얻을 수 있을 것으로 생각된다. Purpose : To evaluate the characteristic CT findings of neuroblastoma, we studied neurobalstomas.Materials and Methods : We analysed CT findings of available 25 cases among pathologically proved 51 neurobalstomas from Jan. 1983 to Sept. 1990.Results : The most frequent site of origin is adrenl gland (40%) and the second is retroperitoneurn (32%) and the third ismediastinum (16%). Characteristic CT findings are as follows : Calcifications within the tumor is detected in 86% of abdominal neuroblastomas and 50% of mediastinal origin. Hemorrhagic and necrotic changes within the tumor is noted at 86% in the tumor of abdominal origin and 25% in mediastinal neuroblastomas. Contrast enhanced study showed frequently septated enhanced appearance with/without solid contrast enhancement. Encasements of major great vessels such as aorta and IVC with/without displacement by metastatic lymphnodes or tumor are frequently seen in 90% of abdominal neuroblastomas. Multiple lymphadenopathy are detected in 95% of abdominal neurobalstomas and 25% of mediastinal neuroblastomas. The most common organ of contiguous direct invasion is kidney in 6 cases and the next one is liver but intraspinal canal invasion is also noted in 2 cases.Concusion : We concluded that diagnosis of neuroblastoma would be easily obtained in masses of pediatric group from recognition of above characteristic findings.

Trichophyton verrucosum에 의한 두부독창 2예

윤춘식,문승현,김정애,김규한,조광현,강성하 대한의진균학회 2000 대한의진균학회지 Vol.5 No.2

In Korea, kerion celsi caused by Trichophyton(T.) verrucosum was first reported in the Honam area in 1986. Since then, more cases have been reported in the Youngnam and Chungcheong areas but there has been no report in Seoul and Kyonggido until now. Recently, two patients with kerion celsi visited Seoul National University Hospital and T. verrucosum was isolated from the scalp lesions of these patients. Case 1 was a 52 year-old female living in Kapyoung, Kyonggido and she showed l0×10 cm and 5×3 cm sized, indurated alopecic masses on the scalp which were developed 2 months ago. Case 2 was a 50 year-old female living in Youngju, Kyongsangbukdo and a 10×7 cm sized, purulent alopecic plaque was developed on the scalp 1 month ago. They were farmers raising cows with gray or whitish plaques on their skins. These patients were successfully treated with terbinafine 250 mg per day for 7 weeks and 8 weeks, respectively. We report these cases to call more attention to detect this species even in urban areas such as in Seoul. Therapeutic effect of terbinafine on kerion celsi has not been reported in Korea so far and our cases demonstrated the excellent therapeutic effect of terbinafine on kerion celsi cause by T. verrucosum. [Kor J Med Mycol 5(2): 60-65]

[미션칼럼] 담장안의 성경과 목적있는 스토커 : "천하에 범사가 기한이 있고…" (전도서3:1)

윤춘식 ACTS 북한선교학회 2001 북한선교 Vol.1 No.-

장애인기업의 연구개발 지원 방안 연구

윤춘식,고은영,최유화 국제문화기술진흥원 2020 The Journal of the Convergence on Culture Technolo Vol.6 No.3

The purpose of this study is to examine the current status and R&D activities of disabled enterprise, and to find ways to support R&D. Through this study, the company's demand for R&D and the characteristics of companies with active R&D activities were derived, and the research and development support plan was proposed by integrating them. As a result of comparing the location quotient (LQ) of small and medium-sized businesses and disabled enterprise by industry, the number of workers with disabilities showed great specialization by business type. R&D was active in companies with sales of over 2 billion won in four industries including manufacturing. As a result of the research, R&D support for disabled enterprise needs to be supported by categorizing them into field-hardened technology-oriented and innovative technology-oriented, depending on the type of business and the size of the company. 본 연구는 장애인기업에 대한 현황과 연구개발활동을 살펴보고 연구개발 지원 방안을 찾는데 그 목적이 있다. 본 연구를 통해 연구개발에 대한 기업의 수요와 연구개발활동이 활발한 기업의 특성을 도출하였으며, 이를 종합하여 연구개발지원 방안을 제안하였다. 중소기업과 장애인기업의 업종별 입지계수(LQ) 비교결과 장애인종사자수는 업종별 큰 특화를 보였다. 연구개발은 제조업을 비롯한 4개 업종의 매출액 20억원 이상 기업에서 활발하였다. 연구결과 장애인기업에 대한 연구개발 지원은 업종 및 기업의 규모에 따라 현장애로기술중심과 혁신기술중심으로 구분하여 지원할 필요가 있다.

북한 문학연구를 통한 북한선교 전략 - 남한에 소개된 북한문학의 한 단편적 연구 -

윤춘식 ACTS 북한선교학회 2001 북한선교 Vol.1 No.-

전산화단층촬영을 이용한 정상인 뇌하수체의 방사선학적 고찰

윤춘식 대한영상의학회 1987 대한영상의학회지 Vol.23 No.3

Direct coronal computed tomography with 1.5mm contiguous scanning was done in total 95 cases, who had o clinical evidence of pituitary and hypothalamic disease. The evaluation of pituitary height, width, upper surface contour and density was done and the pituitary stalk was also evaluated. RESULT : 1. Total 95 cases were 45 males and 50 females. 2. The average height of mormal pituitary gland was 5.72$\pm$1.44mm in female and 5.37$\pm$1.17mm in male. There was no significant difference of pituitary height between male and female. 3. The pituitary height was decreased according to the increased age both in male ad female except prepubertal age. 4. The group between 15-30 year old age showed significantly increased pituitary height comparingto the remained age group both in male and female. 5. The upper limit of mormal pituitary height in 95% confidence level was 7.95-0.011xage infemale and 7.4-0.013xage in male. 6. The upper surface contour of normal pituitary gland were convex in 14 cases, flat in 58 cases adn concave in 23 cases. There was a significant correlation between the height and upper surface contour of putuitary gland. 7. The average width of normal pituitary gland was 13.4$\pm$1.74mm in female and 13.69$\pm$2.3mm in male. There was o significant difference between those of female and male. 8. The focal low density of normal pituitary gland was noted in only 8.4% and its size was always below 3mm. 9. Te pituitary stalk can be seen in 94.7% by direct coronal CT scanning and it was located at the midline. 10. There were nosignificant difference in pituitary height and width accordig to the menopause or the marrige.

초파리 rdgC 돌연변이체 단안 시각계의 퇴행현상

윤춘식,Yoon, Chun-Sik 한국현미경학회 1998 Applied microscopy Vol.28 No.3

The morphological phenotype on ocellus of Drosophila rdgC mutant was observed with electron microscope. The result showed the particular phenotype that was not found in other retinal degenarative mutants. The most distinct difference was the orientation of photoreceptor cells. The photoreceptor cells did not attached to corneagenous cells but dropped under corneagenous cells and assembled around newly formed space. Enormous multivesicle bodies caused by the degeneration of photoreceptor cells were frequently found. Rhabdomeres were also severely degenerated in consequence of the mutant. Another degeneration was found in a part of photoreceptor cell, but the degeneration of subrhabdomeric cisternae (SRC) was not found. It was a ovious difference of rdgC comparing with other two retinal degenerative mutants, rdgA and rdgB. As a result, rdgC mutant was affected on the attachment between photoreceptor cells and corneageneous cells, and it suggested the defect of cell-cell attachment. In addition, rdgC mutant was accompanied by the defect not only in retina but nerve system. The results were agreed to the reference discussion that the rdgC molecule is exist in the nerve.

아르헨티나 가톨릭교 사회·문화·신학의 분석과 그 모델들 - 1990년 이후 2013년 교황 프란시스꼬 1세 등장까지 -

윤춘식 아세아연합신학대학교 세계지역연구소 2013 ACTS 세계선교연구 Vol.3 No.-

선교교육과 오순절 프락시스

윤춘식 고신대학교 선교연구소 2001 고신선교 Vol.- No.-

골단일 형질세포종 : 방사선학적 소견

윤춘식,김명준,안창수,서진석,신규호,Yoon, Choon-Sik,Kim, Myung-Joon,Ahn, Chang-Soo,Suh, Jin-Suck,Shin, Kyoo-Ho 대한근골격종양학회 2000 대한골관절종양학회지 Vol.6 No.2

목적 : 골단일 형질세포종의 방사선 소견을 알아보고자 하였다. 대상 및 방법 : 최근 5년동안 골단일 형질세포종으로 진단받았던 9례의 방사선 소견을 후향적으로 검토하였다. 이 중 2례는 골수검사 소견의 이상으로 대상에서 제외되었고 다른 2례는 전산화단층촬영(1례)와 자기공명영상(1례) 소견의 이상 소견에 의해 대상에서 제외되었다. 결과 : 5례 중 4례에서 단순방사선검사상 경화성 변연이 없는 지도 모양의 골파괴 소견을 보였으며 대퇴골에서 발생한 1예는 골경화증 병변을 보였다. 전산화단층촬영과 자기공명영상 검사는 단순방사선검사에 비해 소주형성을 한 골파괴와 연부조직 침범 등 보다 많은 정보를 보여주었다. 4례의 자기공명영상에서 T 1강조영상에서는 비교적 고신호강도, T2강조영상에서 는 근육보다 약간 높은 중등도 신호강도를 보여주었다. 1례에서는 광범위한 연부조직 침범이 있었고, T1강조영상에서 같거나 저신호강도로, T2강조영상에서는 비균일한 고신호강도를 보이는 다발성 괴사가 있었다. 조영증상 T 1강조영상에서는 괴사부위를 제외한 병변의 강한 조영증강소견이 보였다. 결론 : 전산화단층촬영과 자기공명영상 검사는 골단일 형질세포종의 특징적인 소견의 일부를 보여줄 수 있고 형질세포 침윤이 있는 다른 부위를 찾을 수 있다. 이러한 것들이 골단일 형질세포종의 진단과 치료에 도움을 줄 수 있을 것이다. Purpose : We examined the patients to evaluate the radiologic findings of solitary plasmacytoma of the bone. Materials and Methods : We retrospectively reviewed radiologic findings of 9 cases with solitary plasmacytoma of the bone (SPB) for recent 5 years, but 2 cases were not included this study due to an abnormal finding of bone marrow and another 2 cases were not included due to an abnormal manifestations of computed tomography (n=1) and MRI (n=1). Results : Among 5 cases, 4 cases had an osteolytic bone destruction and 1 case had an osteosclerotic bone destruction on the plain radiograph. Computed tomography and MRI showed more informations about trabeculated bone destruction and the soft-tissue extension of the lesion comparing to plain radiographs. The MRI finding of SPB in 4 cases showed a relatively high signal intensity on T1-weighted image and intermediate signal intensity on T2-weighted image, on which the signal intensity of the lesion is slightly higher than that of the muscle. One case had an extensive soft-tissue involvement and multiple necrosis, which presented iso to low signal intensity on T1-weighted image and high heterogeneous signal intensity on T2-weighted image. The Gadolinium-enhanced T1-weighted images of 5 cases showed diffusely strong enhancement of the lesion except on the necrosis areas. Conclusion : Computed tomography and MRI may present some characteristics of SPB and demonstrate another foci of plasma cell infiltrates, so these can be helpful for the diagnosis and treatment of SPB.