심근경색 모델 흰쥐에서 스트레스가 B-type Natriuretic Peptide 발현 및 심박변이율 변화에 미치는 영향

이삼윤(Sam Youn Lee),이미경(Mi Kyoung Lee),김남호(Nam-ho Kim),주민철(Min Cheol Joo),조항정(Hyang Jeong Jo),강지숙(Ji Sook Kang),김병숙(Byung Sook Kim),윤선식(Sun Sik Yoon),최을식(Eul Sig Choi),이문영(Moon Young Lee) 대한스트레스학회 2010 스트레스硏究 Vol.18 No.3

심박변이율의 감소는 심근 경색 환자에서 예후의 악화와 관련되어 있다. 심박변이율 중 very low frequency가 심부전환자의 예후를 판단할 수 있는 독립적 인자로서 사용이 가능하다고 보고된 바 있으며, 심실의 압력 증가에 반응해서 생성되는 B-type natriuretic peptide가 심근 경색의 예후 인자로서 사용할 수 있음 역시 보고된 바 있다. 본 연구에서는 심근경색 모델을 제작하여 일정의 회복 기간을 거친 다음 다시 일정 기간의 스트레스를 겪게 한 후 심박변이율의 변화 및 심실 조직에서의 BNP 발현 정도를 비교하여 스트레스에 의한 영향을 관찰하고자 하였다. Sprague-Dawley계 수컷 흰쥐 15마리를 대상으로 하였다. 실험동물은 인위적 스트레스 및 수술을 받지 않은 대조군(CON, n=5), 심근경색 수술을 받은 후 restraint stress를 받지 않은 군(MI+No Stress, n=5), 심근경색 수술을 받은 후 1주일 동안 restraint stress를 받은 군(MI+Stress, n=5)으로 분류하였다. 심근경색 모델 제작 직후 15분 이상 심전도의 변화를 기록하였으며, 2개월 정도 후 심근경색 수술을 받은 동물을 두 군으로 나누어 그 중 한 군에는 1주일 동안 restraint stress를 가한 후 restraint stress를 가하지 않은 동물과 심박변이율을 비교 분석하였다. 심실 조직은 좌심실 전벽 부위의 위축을 관찰할 수 있었고, 대식세포에 의하여 응고, 괴사된 심근세포의 탐식과 혈관이 풍부한 육아조직 및 섬유 변화를 볼 수 있었다. 심박변이율은 심근경색 수술을 받은 직후 심박수는 유의한 증가를 보였고, standard deviation of the normal to normal intervals (SDNN), very low frequency (VLF) 및 low frequency (LF)의 유의한 감소를 보였다. 심근경색 수술을 받았던 동물에서 두 달 정도의 회복 기간을 거친 후 스트레스를 받지 않은 군은 심박수 및 기타 심박변이율 분석에서 SDNN 값을 제외하고는 정상군과 유의한 차이를 관찰할 수 없었던 반면 1주일 동안 스트레스를 받은 군에서는 심박수가 다시 유의하게 증가했을 뿐만 아니라 SDNN, VLF 및 LF 역시 정상군과 유의한 차이를 보였다. 이상의 결과를 종합하면 심근경색 동물에 대해 1주일 동안 스트레스를 가한 결과 심박변이율이 감소하고 심실에서의 BNP 발현은 더욱 증가하여 악화함을 보여주고 있다. Diminished heart rate variability (HRV) is associated with less favorable prognosis after myocardial infarction (MI). It has been reported that very low frequency (VLF) power in HRV analysis is an independent risk predictor in patients with congestive heart failure and B-type natriuretic peptide (BNP) can be used as a prognostic factor of MI. The purpose of this study was to investigate whether stress has an effect to the changes of BNP expression and/or heart rate variability in MI model in rats. Male Sprague-Dawley rats were divided into 3 groups: control group (CON), MI group (MI+No Stress), and MI followed by stress group (MI+Stress). MI+Stress group rats were raised for a two month recovery period after the operation, followed by being exposed to restraint stress for 2 hours per day for 1 week. Electrocardiogram was recorded after the operation and the last day after 1 week of stress. The frequency components of HRV were calculated in the frequency domain such as VLF, low frequency (LF), high frequency (HF) and so on. In HRV analysis, standard deviation of the normal to normal intervals (SDNN) was significantly reduced in both groups compared to the control group. VLF and LF also were significantly reduced in MI+Stress group compared to the control groups. In addition, BNP expression in western blotting was shown the strongest bands in MI+ Stress group among experimental groups. These results suggest that BNP and HRV were aggravated by stress in MI rat model. (Korean J Str Res 2010;18:275∼285)

김채원의 〈겨울의 환〉에 나타난 문학치료적 성격 분석

류미향(Ryu, Mi-Hyang) 한국어문학회 2017 語文學 Vol.0 No.137

This article redefines the significance of motherhood expressed in Kim Ch’ae-Wǒn’s novel entitled Kyǒul ǔi hwan , which represents motherhood as a force of vitality, transcendence, and spirituality. By employing the bibliotherapic approach toward literature, I observed that the literary representation of motherhood is connected to heal human wounds. The contemporary society prevails with the mental and psychological problems, as epitomized in the concept of “fatigue society” in Han Byǒng-Ch’ǒl’s writing. Han argues for the positive side of the “fatigue society” in which people focus on deliberation and contemplation. Such pursuit of the contemplative life is suggested in Illusion of winter. Specifically, this article focuses on the expression of motherhood as an instrument of healing, and I concentrate on the two particular scenes concerning the representation of motherhood: The mother who prepares a meal and sets the table, and the mother patiently waits for her family at the door. Specifically, the mother’s preparation of food symbolizes the vitality of life, while her waiting at the door captures the transcendental personality or spirituality of the mother character. Such portrayals serve to wrap and heal the wounds and scars, since motherhood occupies the inherent and sacred realm of humanity, where pain can never reach. The vitality and spiritual nature of life and nourishment in the Illusion of winter therefore suggests its significance in modern society. Conclusively, this study illuminates the literary representation of motherhood as a site of healing.

자궁경부 상피내 병변 환자에서 LEETZ 원추절제술 후 HPV DNA Test 추적 검사의 임상적 의의

김미향,이태화,오영림,이천준,김원규 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2

Objective: This study was performed to investigate the clinical significance and timing of HPV test for follow up of patients after LEETZ treatment in CIN lesion Methods: From January 2005 to December 2008, 105 patients with CIN were treated with LLETZ at Kosin university gospel hospital, Busan, Korea. After LEETZ, HPV test and Pap smear were done after 3months. Every HPV typing was done by HPV DNA chip. Results: A total of 105 cases were enrolled in this study. There were 25 patients with CINⅠ, 38 with CINⅡ, 42 with CINⅢ. Mean age was 41.95 years (range, 23-71 years) at the time of LEETZ. Positive HPV DNA was found about 72.4% before LEETZ procedure and subtype 16 was the most common type (10.5%), follow by subtype 18 (6.6%) and subtype 58 (6.6%). During follow up after LEETZ, 65.6% had negative result after 3 month, 72.1% after 6 month, 73.9% after 9 month, 77.1% after 12 month, 79.2% after 15 month, 79.6% after 18 month, and 80.4% after 24 month. There were 2 cases of abnormal pap smear among persistent positive HPV DNA cases and no abnormal pap smear results in negative HPV DNA cases during follow up. Conclusion: Positive HPV DNA was found about 72.4% before LEETZ procedure and subtype 16 was the most common type (10.5%), follow by subtype 18 (6.6%) and subtype 58 (6.6%). We suggest that HPV DNA test is recommended per 6 Months, and close observation is recommended in persistent positive HPV DNA test cases.

어패럴 패턴구조에 관한 연구(3) : 각 부위별 벌어짐량을 중심으로 Focusing on broadening volume per each part

나미향,민유숙 청주대학교 학술연구소 2005 淸大學術論集 Vol.5 No.-

I have developed a human body into body surface shell in order to find out the characteristics when the dimensional shape of human body is developed on a plane. I have reviewed characteristics of pattern with broadened and folded surface of front, side, and back part shaped along with winding of a human body, I have come to the following result. 1. In light of a front section, there has been a change on a hip for a breast dart volume, upper breast dart volume, under breast No. 1 and 2 dart volume, and abdomen from the aspect of relation among breast volume and type, and breast inclination and structural of a hip. 2. In light of a side section, its pattern structure is classified into three types of folded type, broadened type, and collected type. A broadened type is for a big hip physical shape, folded type for small hip physical shape, and collected type for same gap between waist and hip or no such a gap. 3. In light of a back section, its pattern structure varies depending upon structural characteristics of bending degree; dart volume of rear shoulder was classified into three types of large, medium, and small. A structural pattern of dart volume of a hip on a back abdomen was classified into hip-protruding physical shape, common physical shape, small hip physical shape, and its shaping characteristics were observed in the presence of a type collected to three types, broadened type, and folded type.

샐러드 드레싱에 대한 소비자의 기호도와 이용 실태 조사 연구 : 대구지역을 중심으로

김미향,이수진,김향희 동아시아식생활학회 2001 동아시아식생활학회지 Vol.11 No.5

This study was conducted to evaluate the consumers' preferences and perceptions on the salad and its dressings, via a total of 401 subjects in the Taegu area on the basis of 5-point Likert scale. Anthropometric data included the total subjects consisted of 66 females and 335 males: categorized by age, 20's (103), 30's (135). 40's (83), over 50's (80). The average size of family was 4.2 persons. According to BMI, 64.8% of the subjects belonged to the normal group. The age group that liked salad most was the 20's group, which was also the group that ate salad most frequently. The salad was perceived as food item which is convenient to eat(3.83), healthy(3.63), easy to prepare(3.63) and delicious(3.61) but rarely as a expensive item(2.44). The ingredients, used for salad preparation included fruits and vegetables (3.19) such as tomato and cucumber, Among the salad dressings, the fruit dressing was preferred the most(4.59), while the mayonnaise the least(3.59). The mayonnaise was perceived as an item with highest calories(4.1). and hardly perceived as a luxury item(2.78). The preference for the fruits dressing was highly correlated with the degree of education (p<0.05), age(p<0.001) and BMI(p<0.001). The higher the degree of education, the lower the level of age group, and the lower the BMI, the higher preference for the fruit salad dressing was demonstrated.

가공쌀가루 대체량을 달리한 백설기의 저장기간과 온도에 따른 관능적 및 기계적특성

오미향,김경자 한국조리과학회 2003 한국식품조리과학회지 Vol.19 No.1

Backsulgi, the most basic type of rice cake, were prepared with the addition of process rice flour at 0%, 10%, 20%, 30%, 40% and their sensory quality and mechanical characteristics were compared. In addition, the changes in the sensory and textural characteristics of Backsulgi were determined while storing them at the temperatures of 4℃ and 20℃ for 0, 1, 2, and 3 days. As a result of sensory evaluation, Backsulgi with 30% process rice flour showed the highest score in overall quality, and the one with 10% process rice flour showed higher scores than controls. Backsulgi with process rice flour did not show significant differences in whiteness, graininess, sweet aroma, roasted nutty taste, sweet taste compared with the control even in the longer storage time at 4℃ and 20℃. In the measurement of color changes, L value (lightness) was not significantly different, but a value (redness) and b value (yellowness) were increased as the addition of process rice flour increased.

맞벌이 가족의 아동복지감 척도에 대한 타당화 연구

도미향 한국영유아보육학회 2003 한국영유아보육학 Vol.0 No.33

The purpose of this study was to examine the validating the child well-being sense of the Dual Income Family scale to children. As the result, the child well-being sense scale contained 4variables (sense of child emotional well-being, satisfaction sense of child on the mother's role, satisfaction sense of child on the father's role, satisfaction sense of child on the mother's working) and 4 rating scale of 32items. Almost every items had high discriminating power. The reliability was satisfactory on the total readiness score. After the scale development, various validation procedures was using sample of 632. Three examples are concurrent validity, related validity, and. contrasted group validity. There appeared to be, sufficient evidence for validity of child psychological well-being instrument form the validity procedures. The present investigations contributed to understanding of child psychological well-being of the Dual Income Family. And the practical significance of the present study lied in the validation on the development of specific instrument for the measurement of the particular aspects of child well-being of the Dual Income Family. The validation of an instrument for the measurement of such variables provides the opportunity for assessing child well-being of the Dual Income Family scale.

Bacillus subtilis BK-17이 난소를 절제한 흰쥐의 혈 중 지질 함량 변화에 미치는 영향

박미화,김미향 신라대학교 자연과학연구소 2006 自然科學論文集 Vol.15 No.-

여성은 폐경 시 estrogen에 의해 정상여성보다 심혈관련 질환의 발병률이 높아진다. 따라서 본 연구에서는 혈관관련 질환의 예방에 사용되는 혈전용해제 개발의 목적의 일환으로 갱년기 장애 시 유발되는 체내의 지질 함량 증가에 있어서 Bacillus subtilis BK-17이 미치는 영향을 조사하기 위해 흰쥐에 인위적 폐경을 유도하여 Bacillus subtilis BK-17를 투여함으로써 그에 따른 혈 중 지질 함량에 미치는 영향을 검토하였다. 그 결과 난소절제 후 Bacillus subtilis BK-17추출물 투여는 난소 절제에 의해 야기되는 total-cholesterol 의 증가를 감소시키고, 중성지질을 감소시키며, HDL-cholesterol의 감소를 증가시키는결과, Bacillus subtilis BK-17이 갱년기 장애 시 발생찰 수 있는 지질변화에 효과가 있는 것으로 나타나 혈전 용해제로서의 기능이 있는 것으로 사료되어 진다. Bacillus subtilis BK-17, which was isolated from a decaying rice plant, known as fibrinolytic enzyme. The ovariectomized rat is proposed as an experimental model for the rapid development of menopausal symptoms. Following loss of ovarian function, postmenopausal women display an increased incidence of hypertension and coronary heart disease, which is at least partially attributable to an increase in the total cholesterol, LDL-cholesterol and triglyceride levels, as well as a reduction in the HDL-cholesterol levels. Two groups were surgically ovariectomized (OVX). The third group was sham operated. Sprague- Dawley female rats were randomly assigned to the following groups : sham-operated rats (Sham), ovariectomized control rats (OVX-Control), ovariectomized rats supplemented with Bacillus subtilis BK-17 (OVX-BK17). The aim of this study was to evaluate the effects of the purified fibrinolytic enzyme from Bacillus subtilis BK-17 on the lipid on serum in ovariectomized rats.

단백질 대체량을 달리한 백설기의 저장기간과 온도에 따른 관능적 및 기계적특성

오미향,김경자 한국조리과학회 2003 한국식품조리과학회지 Vol.19 No.1

Backsulgi were prepared with the addition of nutriprotein powder at 0%, 2%, 4%, 6%, 8%, and their sensory quality and mechanical characteristics were compared. In addition, the changes in the sensory and textural characteristics of Backsulgi were determined while storing them at the temperatures of 4℃ and 20℃ for 0, 1, 2, and 3 days. In the sensory evaluation, Backsulgi with 4% nutriprotein powder showed the highest score in overall quality. In the measurement of color changes, L value (lightness) was decreased, but a value (redness) and b value (yellowness) increased as the addition of nutriprotein powder increased. In textural characteristics, the hardness, gumminess and cohesiveness of Backsulgi were decreased by the increase of nutriprotein powder. The hardness and gumminess were increased as the storage time increased.

합리적·장서적 상담(RET)프로그램 : 중·고등 학생용

吳美香,金晟會 경북대학교 학생생활연구소 1987 學生指導硏究 Vol.20 No.1

The purpose of this program, which is based on Ellis' Rational Emotive Therapy, is to experience desirable emotions by changing irrational beliefs into rational beliefs, resulting in a joyful and effiecient-living student. This program is made up of seven parts : (1) the purpose of this program (2) principle of ABCDE (3) Irrational beliefs (4) undesirable emotions (5) disputing of Irrational beliefs (6) practice of ABCDE (7) evaluation of this program. This program consists of twelve sessions. There are three or four sections in each session: explanation, exercises, activities, and evaluation. Twelve sessions of this program are : (1) Orientation of this program, under standing of purpose of program, and Self-Instruction. (2) Understanding of ABCDE principle. (3) Discriminating of Irrational beliefs and Rational beliefs. (4) Discriminating of undesirable emotions and desirable emotions. (5) Understanding of disputing Irrational beliefs. (6) Irrational belief Ⅰ-Demand for approval. (7) Irrational belief Ⅱ-High self-expectation. (8) Irrational belief Ⅲ-Blame proneness. (9) Irrational belief Ⅳ-Emotional Irresponsibility. (10) Irrational belief Ⅴ-Frustration Reactivity. (11) Irrational beliefⅥ -Perfectionism. This RET program, which is carried out 2 hours a week for 12 weeks by group training procedures, may come into effect to junior and high school students.