Methylation Status and Expression of E-cadherin in Oral Squamous Cell Carcinomas Compared to Benign Oral Epithelial Lesions

Son, Hyun-Jin,Chu, Jung-Youb,Cho, Eui-Sic,Lee, Dong-Geun,Min, Myung-Gee,Lee, Suk-Keun,Cho, Nam-Pyo The Korean Academy of Oral Biology 2006 International Journal of Oral Biology Vol.31 No.2

Expression of invasion/metastasis suppressor, E-cadherin, is reduced in many types of human carcinomas. Although somatic and germline utations in the CDH1, which encodes the human E-cadherin, have frequently been reported in cases with diffuse gastric and lobular breast ancers, irreversible genetic inactivations are rare in other human carcinomas. Recently, it has been well documented that some genes in human cancers may be inactivated by altered CpG methylation. Herein, we determined the expression and methylation status of E-cadherin in oral squamous cell carcinoma (SCC) by immunohistochemistry and methylation-specific PCR. The expression of E-cadherin was significantly higher in the well-differentiated oral SCCs than the moderately or poorly differentiated ones. None of eight tested benign pithelial hyperplasias showed aberrant methylation, whereas five of 12 oral squamous cell carcinomas showed aberrant methylation. When we compared E-cadherin expression with methylation status, oral SCCs with normal methylation showed a higher expression of E-cadherin than those with methylation. These findings suggest that aberrant CpG methylation of CDH1 promoter region is closely associated with transcriptional inactivation and might be involved in tumor progression of the oral mucosa.

Chemical-Looping Combustion을 위한 금속산화물 매체들의 산화 환원 반응특성

이진배,송영욱,박주식,최상일,김영호,양현수 忠南大學校 産業技術硏究所 2003 산업기술연구논문집 Vol.18 No.2

Chemical-looping combustion has been focused as a very promising combustion technology from the viewpoint of high energy efficiency, easy separation of CO_(2) and no formation of NO_(x). The key of this combustion technology is to develop oxygen carrier mediums with high oxygen capacity, and high machanical and thermal stability. In this study, various kinds of mediums were prepared by the combination of active metal oxides, such as NiO, CoO, Fe_(2)O_(3) or NiO-Fe_(2)O_(3), with YSZ(yttria stabilized zirconia) as a binder. The redox reactions on the mediums were also carried out by using the thermogravimetric reactor. The redox reaction rates on a NiO/YSZ medium were found to be most superior in comparison with those of other mediums. In addition, durability of the medium was also found to be appropriate for UC. For the purpose of high redox reaction rates, the optimum reaction temperatures of reduction and oxidation on a NiO/YSZ medium were observed as 600℃ and l000℃, respectively.

木花 收量構成形質의 遺傳分析

崔周浩,李信雨,全鉉植,李喆浩 진주산업대학교 농업기술연구소 2005 農業技術硏究所報 Vol.18 No.-

2001년부터 2003년까지 木花 10개 品種을 二面交配하여 얻은 F_(1), F_(2) 45개 組合을 재료로 生育形質의 交配集團에 따른 遺傳分析한 結果를 요약하면 다음과 같다. 1. 각 형질에 대한 분산분석 결과는 전형질에서 고도의 유의성을 나타내었다. 2. 유전자의 상가적효과의 값은 우성효과의 값보다 높게 나타났고, F_(1)세대의 株當□數에서 가장 높았으며, 百粒重은 F_(2)세대에서 오히려 높아 세대간에는 일정한 경향을 보이지 않았다. 3. 유전력은 섬유장을 제외한 전 형질에서 0,80이상으로 평가되었고, 그 중 섬도는 F_(1)세대에서 0.97로 조사된 형질 중 가장 높았다. The quantitative inheritance of some yield characters in Gosyium spp was carried out by means of a 10×10 diallel cross. This study was genetically analyzed through diallel cross population among 10 different cultivars of cotton (Gosyium spp) at an experimental field in Jinju National University. According to research from April 2001 to December 2003, the results of genetic analysis were summarized as follow: 1. The high significance was observed from the genetic variance analysis in the all examined characters. 2. In the component of genetic variance analysis, additive effects were relatively higher than dominant effects. The number of boll in F_(1) generation was higher than F_(2), whereas no significant difference was seen in the dominance degree and gene arrangement between F_(1) and F_(2) generations because 100 seeds weight in F_(2) generation was much higher F_(1). 3. The progeny of F_(1) heritability was found to exceed a suggested minimum of 0.80 excepting fiber length. The heritability of F_(1) in fiber fineness was 0.97 relatively higher than other all examined characters.

유치열과 혼합치열기 어린이의 상악 절치부 외상

정주현,이제호,김성오,최병재 大韓小兒齒科學會 2004 大韓小兒齒科學會誌 Vol.31 No.2

현대인의 생활양식과 환경이 도시화 및 인공화되고 취미활동이 다양화됨에 따라 외상을 받을 수 있는 요인들을 증가하고, 특히 어린이 활동량이 많아져 외상의 기회가 잦아지고 있다. 어린이에서 외상이 발생하는 경우, 어린이의 일상적인 활동 뿐 아니라, 사회성 및 정서 발달에도 영향을 미칠 수 있으며, 그 보호자에게도 부정적인 영향을 미칠 수 있기에 외상의 발생 빈도를 줄이고 예방하는 것이 중요하다. 본 연구는 유지열과 혼합치열기에 발생하는 치아 외상을 예방하기 위한 기초 자료를 얻기 위하여, 특히 구강악안면부의 외상시 치아 외상을 가장 많이 받는 상악 유절치와 영구절치를 연구하기 위하여, 2002년 6월부터 2003년 5월까지 연세대학교 치과대학병원 소아치과에 내원한 유치열과 혼합치열기의 신환 8.799명중 상악 절치부 외상을 주소로 내원한 어린이 487명(남자 316명, 여자 171명)의 상악 절치 955개(유절치543개, 영구절치 412개)를 조사하여 다음과 같은 결과를 얻었다. 1. 상악 절치부 외상이 호발하는 나이는 유절치에서 1~3세, 영구절치에서 7세였으며 남자대 여자의 비율은 1.85:1이었다. 2. 상악 절치부 외상은 유절치와 영구절치 모두 오후 시간에 많이 발생하였으며, 유절치는 외상 장소로 집이 가장 많았고 (44.1%), 영구절치는 길에서 다치는 경우가 가장 많았다(17.5%). 3. 외상의 원인으로 유절치와 영구절치 모두 넘어져 다치는 경우가 가장 많았으며(39.8%, 12.9%), 다음으로 부딪히는 경우가 많았다(22.2%, 6.0%). 유절치에서는 다음으로 떨어져 다치는 경우, 교통사고, 폭력과 운동에 의한 외상 순이었으며, 영구절치에서는 폭력, 운동, 교통사고, 떨어져 다치는 순이었다. 4. 조사대상 어린이 1명당 유절치는 1.6개, 영구절치는 2.8개에 외상을 입었다. 5. 유절치와 영구절치 모두에서, 치관 파절 양상은 치수미노출 치관 파절이 많았고, 치주조직 외상 양상은 아탈구가 가장 많았다. 최근 어린이의 단체 생활이나 운동과 취미 활동에 참여하는 나이가 예전에 비하여 점차 낮아지고 있어, 이번 연구 결과와 같이, 외상이 발생하는 나이 역시 지속적으로 낮아질 수 있다. 나이에 따른 어린이의 외상을 받는 장소는 특별한 곳이 아닌, 집이나 학교와 같은 일상의 생활공간이기 때문에 단순한 주의만으로도 외상의 발생을 예방할 수 있을 것으로 사료된다. In children, change in lifestyles such as an increase in participation of physical activities has increased the chance of receiving an injury, harming the child and their parents. This study was carried out to give basic information of traumatic injuries to the upper anterior teeth which can be used in prevention of future complications that may arise. From June, 2002 to May, 2003, of the 8,799 children in their primary and mixed dentition visiting Department of Pediatric Dentistry, College of Dentistry, Yonsei University. 955 upper anterior teeth(primary 543, permanent 412) of 487 children(ma1e 316, female 171) with traumatic injures to the upper incisors were studied. The results were as follows: 1. Trauma to the primary teeth prevailed at the age of 1-3 and to the permanent teeth at the age of 7. The male to female ratio was 1.851. 2. Trauma to the upper incisors for both the primary and permanent teeth occurred in the afternoon. Primary teeth were injured most frequently in the home(44.1%) and the permanent teeth outdoors, in the street(l7.5%). 3. Both the primary and permanent teeth were most injured by fall-down injuries(39.8%, 12.9%), and next were collisions(22.2%, 6.0%) :For the primary teeth, high fall, traffic accident, violence and sports are next in order, and for the permanent teeth, violence, sorts, traffic accidents were next. 4. Average number of 1.6 primary teeth and 2.8 permanent teeth were injured with the right central incisor most prevailing. 5. Crown fracture without pulpal exposure and subluxation injures were highest in frequency in both the primary and permanent teeth.

이온주입이 금속의 일함수에 미치는 영향(Ⅰ)

김현경,강석태,황정남,이철주,최대선,정병두 연세대학교 자연과학연구소 1984 學術論文集 Vol.13 No.-

이온 주입이 일함수 차이에 미치는 영향을 연구하기 위하여 낮은 에너지 이온 가속기, 전자총과 기타 일함수 차이를 측정하기 위한 장치를 설계, 제작하였다. 제작된 이온 가속기의 집속 특성은 이론적인 값과 일치하였다. 즉, 집속 렌즈의 확대율이 이론값은 2.0인데 비하여 1.2로 상당히 작은 값이었다. 또한 집속 렌즈의 전압 V_L과 추출 전압 V_e에 의한 집속 특성 역시 이론값과 매우 잘 일치하였다 . 제작된 장치를 사용하여 다결정 Cu와 Ni의 일함수 차이를 측정한 결과 0.45eV임을 알았다. 그리고 전자선을 이용하여 억제 전위차로 일함수를 측정할때 입사 전자의 반사율을 고려해야 함을 알았다. Low energy ion accelerator, electron gun, and apparatus for measuring work function difference are designed and constructed in order to study the effect of ion implantation on the work function. The focusing properties of accelerator is coincided with theoretical results; the magnification of Einzel lens is found to be 1.2, while theoretical value is 2.0, and the focal properties as a function of V_L/V_e are in good agreement with theory. Using these systems, the work function difference between polycrystalline Cu and Ni is found to be 0.45eV, and the experimental retarding potential plots indicate close agreement with the theoretical values modified by electron reflection.

글루콘산 생산을 위한 최적 배양조건

홍성란,이현절,정봉우,김춘영 全北大學校 1995 論文集 Vol.39 No.-

The production of gluconic acid by Aspergillus niger KCTC 2119 was studied. The Optimal culture conditions, such as initial pH, temperature, inoculum size and medium composition were established. Maximum overall gluconic acid productivity, 0.13g/L · hr was obtained when the cultivation was carried out at 33℃ and initial pH 5.5 for 72 hrs, with medium containing 110g/L glucose, 0.5g/L (NH_4)_2SO_4, 0.2g/L KH_2PO_4, 1.0g/L MgSO_4·7H_2O, and 0.1g/L corn steep liquor. The metabolic parameters such as specific growth rate, cell and gluconic acid yields were estimated for process improvement.

이온 주입이 금속의 일함수에 미치는 영향(Ⅱ)

백영환,김현경,강석태,황정남,이철주,최대선,정병두 연세대학교 자연과학연구소 1985 學術論文集 Vol.15 No.-

낮은 에너지 가속기를 제작하여 순도가 99.99%인 다결정 Ni에 Li^+ 이온을 7 keV의 에너지로 각 시료에 대한 이온주입율이 1.3×10^16atoms/㎠, 4.0×10^15atoms/㎠, 2.0×10^15atoms/㎠, 1.0×10^15atoms/㎠, 2.0×10^14atoms/㎠ 가 되도록 주입시킨 후 전자총과 억제 전위차형 에너지 분석기를 이용하여 일함수의 변화를 측정하였다. 이온 주입율이 2×10^15atoms/㎠보다 작을 때는 일함수가 1.9 eV까지 감소하였고 이온주입율이 4.0×10^15atoms/㎠보다 많을 때는 일함수가 2.8 eV까지 증가하였다. 이것은 Topping의 이론 및 Bauer의 실험결과와 일치함을 보였다. The changes in the work function of polycrystalline Ni with a purity of 99.99% due to Li^+ ions implanted using a low energy ion accelerator and retarding potential energy analyser(RPEA) have been studied. The implantation energy of the Li^+ ions is 7 keV and the implanted ion dose for the various samples are 1.3×10^16 atoms/㎠, 4.0×10^15 atoms/㎠, 2.0×10^15 atoms/㎠, 1.0×10^15 atoms/㎠ and 2.0×10^14 atoms/㎠. When the ion dose is less than 2×10^15 atoms/㎠ the, work function decreases to 1.9 eV, but when the ion dose is more than 4×10^15 atoms/㎠, the work function increses to 2.8 eV. These results are in good agreement with Topping's theory and Bauer's experiment.

신장 이식 후 발생한 골수 이형성 증후군 1예

이철우,이현아,박민선,김진국,김원배,이희발,황승덕,이유경,강문수,추원석 대한신장학회 1999 Kidney Research and Clinical Practice Vol.18 No.1

A 44-year-old man treated with azathioprine, cyclosporine and prednisolone for 7.5 years after allogeneic renal transplantation was admitted because of exertional dyspnea, fatigue and pancytopenia which were found 3 months ago. He had been on hemodialysis for renal failure of unknown cause for 8 months before the renal transplantation. Bone marrow examination showed hypercellularity, erythroid hyperplasia and 7% of myeloblast, consistent with the diagnosis of myelodysplastic syndrome. Cytogenetic study showed chromosomal abnormalities:deletion of chromosome 5, monosomy 7, trisomy 8, monosomy 14 and deletion of chromosome 17. Immunosuppressive agents were discontinued and he was treated with transfusion, G-CSF, and combination chemotherapy including topotecan and Ara-C. Graft kidney function was normal before and after the treatment, but the clinical course was fatal because of leukemic transformation and eventually sepsis. Although therapy induced myelodysplastic syndrome was rare in renal allograft recipients, thorough evaluations including bone marrow biopsy and cytogenetic study are recommended in patients with anemia of unknown etiology.

Effects of the histamine H1 receptor antagonist hydroxyzine on hERG K+ channels and cardiac action potential duration

Lee, Byung Hoon,Lee, Seung Ho,Chu, Daehyun,Hyun, Jin Won,Choe, Han,Choi, Bok Hee,Jo, Su-Hyun Springer Science and Business Media LLC 2011 Acta pharmacologica Sinica. Vol.32 No.9

<P>To investigate the effects of hydroxyzine on human ether-a-go-go-related gene (hERG) channels to determine the electrolphysiological basis for its proarrhythmic effects.</P>

Research Trends in Sustainable Manufacturing: A Review and Future Perspective based on Research Databases

Hyun-Taek Lee,송지현,Soo-Hong Min,Hye-Sung Lee,Ki Young Song,Chong Nam Chu,Sung-Hoon Ahn 한국정밀공학회 2019 International Journal of Precision Engineering and Vol.6 No.4

Sustainable manufacturing has become of great importance in various fields include manufacturing, mechanical engineering, materials science, environmental science, and energy science. In this paper, we analyzed and reviewed the research trends of sustainable manufacturing technologies and suggested future perspective. Specifically, the state-of-the-art and historical trajectory of sustainable manufacturing are analyzed using data obtained from the Web of Science library and the Journal Citation Reports (JCR). Selected journals and research categories are evaluated by the number of publications, the number of citations, impact factor (IF), and H-indices. To suggest future perspectives on sustainable manufacturing research, growth rate of each research objects are evaluated and historically followed. Sustainable manufacturing is likely to be change in its nature in the era of digital transformation. It is expected to provide the status and future of research trends of sustainable manufacturing to the both manufacturing researchers and journal publishers.