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( Lam Nguyen-ho ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Background More evidence showed that corticosteroid, an immunomodulatory agent, reduces both the need of invasive mechanical ventilation and the mortality in severe COVID-19 patients. However, its optimal therapeutic duration is still ambiguous. There is no study to evaluate progress in disease after stopping the treatment course of corticosteroid in COVID-19 patients with ARDS. Method Case report Results We reported a 61 year-old female patient with past history of atrial fibrillation and prosthetic bicuspid valve. She presented with a one-week history of fever, cough and fatigue and her result of the real-time polymerase chain reaction for SARS-Cov-2 was positive. Her peripheral capillary oxygen saturation was 89% with 15 l/min of oxygen via reservoir mask. Chest X-ray (CXR) showed bilateral diffuse infiltration predominant in the lower half fields. She was treated with oxygen via high flow nasal cannula (HFNC), ceftriaxone, moxifloxacin, remdesivir, unfractionated heparin, and methylprednisolone (80 mg/day) according to national guideline. On the sixth hospitalized day her respiratory failure worsened with right pneumothorax to require endotracheal intubation and chest drainage. On the eleventh hospitalized day, chest tube removal and extubation was conducted and supplement of oxygen via HFNC (flow 50 L/min and FiO2: 40%) was indicated with the result of PaO2/FiO2 (P/ F) 232. Methylprednisolone was stopped after the 10-day course of treatment. However, her respiratory condition aggravated with the higher need of oxygen (P/F 96) and progressive parenchymal infiltration on CXR (figure 1.D15). Follow-up data of inflammatory biomarkers showed in figure 1 with the high inflammatory response on the fifteenth hospitalized day (4 days after stopping corticosteroid). Restarting methylprednisolone was indicated and her condition improved spectacularly. Conclusion Evaluation of inflammatory response after stopping corticosteroid in COVID-19 patients with ARDS should be considered. Further studies on this topic are required to provide more knowledge relating to specific therapeutic duration of corticosteroid.
Survey of the management of patients with bronchiectasis: a pilot investigation in Asian populations
( Ho Cheol Kim ),( Masaru Suzuki ),( Hui Fang Lim ),( Le Thi Tuyet Lan ),( Ho Lam Nguyen ),( Jeng-Shing Wang ),( Kang-Yun Lee ),( Jae Seung Lee ),( Yeon-Mok Oh ),( Sang Do Lee ),( Hayoung Choi ),( Hyu 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.6
Background/Aims: Although international guidelines for bronchiectasis management have been published in Western countries, there is a lack of data about their application in Asian populations including patients with different phenotypes. We aimed to investigate the current status of bronchiectasis management in Asian populations. Methods: A nationwide questionnaire survey was performed of Asian respiratory specialists from South Korea, Japan, Taiwan, Singapore, Vietnam, and Sri Lanka. Participants were invited by e-mail to answer a questionnaire comprising 25 questions based on international guidelines for the management of bronchiectasis. Results: A total of 221 physicians participated in the survey. About half of them were Korean (50.2%), with the next most common nationalities being Japanese (23.1%), Taiwanese (13.6%), and Singaporean (7.7%). Only 18 (8.1%) responders had local guidelines for bronchiectasis. While 85 (38.5%) responders checked sputum acid-fast bacillus smear/culture about 1 to 3 times per year, only a small proportion of responders routinely performed a serum immunoglobulin test (36/221, 16.3%) or evaluated for allergic bronchopulmonary aspergillosis (41/221, 18.6%). Less than half (43.4%) of responders performed eradication treatment in patients with drug-sensitive Pseudomonas aeruginosa infection, mainly due to the limited availability of inhaled antibiotics (34.8%). In addition, 58.6% of responders considered physiotherapy such as airway clearance and pulmonary rehabilitation. Conclusions: Discrepancies might exist between guideline recommendations and practice for bronchiectasis management in Asian populations, partly due to the limited availability of treatment in each country. The development of local guide-lines that consider the phenotypes and situation will help to standardize and improve the management of bronchiectasis.
정희호 ( Hui Ho Jeong ),김동우 ( Dong Wu Kim ),( Nguyen Hoang Lam ),최태봉 ( Tae Bong Choi ),조현서 ( Hyeon Seo Cho ) 한국환경분석학회 2017 환경분석과 독성보건 Vol.20 No.2
Gamak Bay, Deukryang Bay, and Doam Bay were designated as Environmental preservation sea areas for conservation of fishery resources by the Korean government. It is essential to maintain the chemical status of these environments, particularly for heavy metals that pose potential risks to fishery resources. This study was, therefore, carried out to investigate the concentration distribution and potential risk of seven heavy metals, namely Cd, Cr, Cu, Zn, Pb, As, and Hg present in the surface sediments (n = 116) of these sea areas during March and August 2009. The metal concentrations in the sampling sites was found to be highly variable. The dominant metals were Zn (mean = 118.22 mg/kg) for Gamak Bay, Cr (mean = 19.07 mg/kg) for Dyukryang Bay, and Zn (mean = 39.07 mg/kg) for Doam Bay. Overall, the order of the target metals was Zn > Cr > Pb > Cu > As > Hg > Cd. Additionally, the metal concentrations were categorized as less than Igeo Class 2 `Moderately polluted`; except for As determined during March in Gamak Bay. As had concentrations that categorized it under Igeo Class 3 `Moderately/strongly polluted`.
The V. Ho,Lam N. Nguyen 한국해양과학기술원 2014 Ocean science journal Vol.49 No.3
Three epiphytic dinoflagellate species of the genus Coolia isolated from Vietnamese coastal waters were identified and described. Among the three Coolia species, Coolia monotis, C. tropicalis and C. canariensis, the latter two are recorded for the first time in Vietnam. The morphology of these species is illustrated by light and scanning electron micrographs. The heavily areolated thecal surface of C. areolata and the apical quadrangular 3′ plate of C. malayensis have been reported in original descriptions. The two species C. areolata and C. malayensis were not found in this study.
Huynh Quynh Thi Vu,Ho Ban Tran,Le Nguyen Quoc Khanh,Trinh Tung Huu,Lam Luu Ho Thanh,Nguyen Ngan Thi Kim,Huang Shih-Yi 대한소아내분비학회 2022 Annals of Pediatirc Endocrinology & Metabolism Vol.27 No.2
Purpose: Cranial magnetic resonance imaging (MRI) is recommended to identify intracranial lesions in girls with central precocious puberty (CPP). Yet, the use of routine MRI scans in girls with CPP is still debatable, as pathological findings in girls 6 years of age or older with CPP are limited. Therefore, we aimed to identify the prevalence of brain lessons in CPP patients stratified by age group (0–2, 2–6, and 6–8 years). Methods: This retrospective cross-sectional study recruited 257 girls diagnosed with CPP for 6 years (2010–2016). MRI was used to detect brain abnormalities. Levels of luteinizing hormone, follicle-stimulating hormone, and sex hormones in blood samples were measured. Results: Most girls had no brain lesions (82.9%, n=213), and of the minor proportion of girls with CPP that exhibited brain lesions (17.1%, n=44), 32 girls had organic CPP. Pathological findings were detected in 33.3% (2 of 6) of girls aged 0–2 years, 15.6% (5 of 32) of girls aged 2–6 years, and 3.6% (8 of 219) of girls aged 6–8 years. Hypothalamic hamartoma and tumors in the pituitary stalk were the most common pathological findings. The likelihood of brain lesions decreased with age. Girls with organic CPP were more likely to be younger (6.1±2.4 vs. 7.3±1.3 years, P<0.01) than girls with idiopathic CPP. Conclusion: Older girls appeared to have a lower prevalence of organic CPP. Clinicians should cautiously use cranial MRI for girls aged 6–8 years with CPP.
Huynh Quynh Thi Vu,Ho Ban Tran,Le Nguyen Quoc Khanh,Trinh Tung Huu,Lam Luu Ho Thanh,Nguyen Ngan Thi Kim,Huang Shih-Yi 대한소아내분비학회 2022 Apem Vol.27 No.2
Purpose: Cranial magnetic resonance imaging (MRI) is recommended to identify intracranial lesions in girls with central precocious puberty (CPP). Yet, the use of routine MRI scans in girls with CPP is still debatable, as pathological findings in girls 6 years of age or older with CPP are limited. Therefore, we aimed to identify the prevalence of brain lessons in CPP patients stratified by age group (0–2, 2–6, and 6–8 years).Methods: This retrospective cross-sectional study recruited 257 girls diagnosed with CPP for 6 years (2010–2016). MRI was used to detect brain abnormalities. Levels of luteinizing hormone, follicle-stimulating hormone, and sex hormones in blood samples were measured.Results: Most girls had no brain lesions (82.9%, n=213), and of the minor proportion of girls with CPP that exhibited brain lesions (17.1%, n=44), 32 girls had organic CPP. Pathological findings were detected in 33.3% (2 of 6) of girls aged 0–2 years, 15.6% (5 of 32) of girls aged 2–6 years, and 3.6% (8 of 219) of girls aged 6–8 years. Hypothalamic hamartoma and tumors in the pituitary stalk were the most common pathological findings. The likelihood of brain lesions decreased with age. Girls with organic CPP were more likely to be younger (6.1±2.4 vs. 7.3±1.3 years, p<0.01) than girls with idiopathic CPP.Conclusion: Older girls appeared to have a lower prevalence of organic CPP. Clinicians should cautiously use cranial MRI for girls aged 6–8 years with CPP.