절수에 의한 Mongolian Gerbil 장기중량변화에 관한 분석연구

김무강,이기훈,이강이,송치원,이경열,권효정,박미선,정승혁,이행연,김명철 충남대학교 수의과대학 동물의과학연구소 2000 動物醫科學硏究誌 Vol.8 No.-

In this study, authors measured the each organ weight of the long term water deprived Mongolian gerbil, after then we calculated the mean, standard deviation, variance coefficient of the real measured organ weight and induced the organ weight change quantity, rate of quantity, deviation between measured and theological organ weight, deviation rate, sum of deviation rate, organ weight change rate, rate of organ weight by the mathematical formula. The results obtained as follow 1. The weight of the brains, lung, and testis were abruptly decreased after water deprived until the 5th day, after then slowly decreased until the 20th day. 2. The weight of the heart was decreased gradually from the first day until the 20th day. 3. The weight of the liver was abruptly decreased until the 10th day, after then the more slowly decreased until the 20th day. 4. The weight of the thymus, spleen, kidney, and pancreas were abruptly decreased until the 15th day, after then increased slowly until 20th day but the weight of the kidney was abruptly increased from the 10th day. 5. The organ weight change rate and the rate of the each day organ weight were very diversified.

오염토양에서의 생명공학기법을 이용한 Bioremediation에 관한 연구

김무훈,오종민 경희대학교 환경연구소 1997 環境硏究 論文集 Vol.7 No.-

The purpose of this research is to assess and determine the application of molecular tools in soil bioremediation. If useful, some of these applications may result in more predictabillity for hazardous waste management in the environmental field. Isolation of DNA from contaminated soil become a useful tool to study function of microbial systems. Cleaning up contaminated soils and sediments is one of the most difficult problems found at hazardous waste sites. No current technologies are adequate to handle soil cleanup usually because of cost involved or the unsuitability of the technology to the site environment. The biodegradation of pollutants is a complicated process, depending on the nature and amount of pollutant present, and the condition of indigenous microbial communities. Established or emerging biotechnological approaches can remove environmental pollutants. However, the rates of pollutant biodegradation are often limited by environmental constraints or possible by the lack of suitable microbial populations. It is possible to carry out bioremediation program to overcome these limitation.

窒素施用과 根瘤菌接種이 飼料作物의 收量에 미치는 影響

金武成,朴薰,金侊來 慶熙大學校 1983 論文集 Vol.12 No.-

The yield of dry matter and total nitrogen content of forage crops which were sown grown alone and in mixture with orchardgrass and legumes such as alfalfa, red clover, birdsfoot trefoil were studied using nitrogen fertilization and inoculation, and the results are as follows; 1) With-nitrogen for the yield of dry matter of forage crops was highly effective only to orchardgrass and was also effective to the early stages of alfalfa and birdsfoot trefoil in case of a mixed sowing. 2) In accordance with inoculation, the yield of dry matter of forage legumes on without-nitrogen increased as compared with that of orchardgrass. 3) Alone and mixed sowings showed the yield of dry matter and total nitrogen content in a decreasing order of alfalfa>red clover>orchardgrass>birdsfoot trefoil, and orchardgrass+alfalfa>orchardgrass+red clover>orchardgrass+birdsfoot trefoil, respectively. 4) The total nitrogen content and yield of dry matter revealed a positive correlation, and nitrogen was found to be a major factor for the dry matter productivity.

극단적인 가격점프를 고려한 옵션가격결정모형의 유용성에 관한 실증연구 : Camara-Heston(2008) 모형을 중심으로

김무성,강태훈 釜山 大學校 經營 經濟 硏究所 2008 經營 經濟 硏究 Vol.27 No.2

막성 하공 정맥 폐색에 의한 Budd-Chiari Syndrome : 증례 보고

김영훈,한상영,김무현,우종수 동아대학교의과대학 1997 동아의대학술지 Vol.9 No.1

窒素施用과 根瘤菌接種이 飼料作物의 收量에 미치는 影響

金武成,朴薰,金侊來 경희대학교 부설 식량자원개발연구소 1983 硏究論文集 Vol.4 No.-

The yield of dry matter and total nitrogen content of forage crops which were sown grown alone and in mixture with orchardgrass and legumes such as alfalfa, red clover, birdsfoot trefoil were studied using nitrogen fertilization and inoculation, and the results are as follows: 1) With-nitrogen for the yield of dry matter of forage crops was highly effective only to orchardgrass and was also effective to the early stages of alfalfa and birdsfoot trefoil in case of a mixed sowing. 2) In accordance with inoculation, the yield of dry matter of forage legumes on without-nitrogen increased as compared with that of orchardgrass. 3) Alone and mixed sowings showed the yield of dry matter and total nitrogen content in a decreasing order of alfalfa>red clover>orchardgrass>birdsfoot trefoil, and orchardgrass+alfalfa>orchardgrass+red clover>orchardgrass+birdsfoot trefoil, respectively. 4) The total nitrogen content and yield of dry matter revealed a positive correlation, and nitrogen was found to be a major factor for the dry matter productivity.

Geotextile Filter의 특수성능 분석

權武南,李相昊,金勝勳 慶北大學校 1992 論文集 Vol.52 No.-

In order to lock stability of geotextile filer to clogging or blocking, small scale laboratory tests were accomplished, considering to drainage conditions, on domestic and foreign nonwoven geotextile products used for filter, and permeable capacity of the geotextile filter was analyzed. The results obtained are as follows: 1. The permeable flow rate through the geotextile filter appears to be decrease remarkably in the initial stage of duration time but gradually afterward and is stabilized at 300 hours∼400 hours of duration time. 2. The increase ratio of permeable flow rate through the geotextile filter due to rising hydraulic head appears to be higher with protected soil having lower comparative content of fine particles, and the effect of rising hydraulic head finds to be higher with that protected soil. 3. The permeable flow rate through the geotextile filter appears to be higher with protected soil having lower content of fine particles and the increase of it trends to be considerable and to be decrease according to the elapse of time. From the fact, the flow rate finds to be more influenced by clogging or blocking with protected soil layer having lower content of fine particles. 4. It seems generally that the thicker the geotextile filter is, the higher the permeable flow rate is, but the decrease ratio of it in the initial stage finds to be lower in the case of thicker geotextile.

忠南地域 屠畜豚의 肺病變으로부터 分離한 Actinobacillus pleuropneumoniae의 生物學的 및 免疫學的 特性

이종훈,장경수,장치훈,김일택,정용성,김귀현,전무형 충남대학교 수의과대학 동물의과학연구소 1996 動物醫科學硏究誌 Vol.4 No.-

An epidemiologic study on pleuropneumonia in the slaughter pigs(Chonan and Asan area, Chungnam province, Korea) during the period of January 1994 through December 1995 was conducted. Isolation of A. pleuropneumoniae was attempted in 425 pigs with pneumonic lesions. Biochemical properties, antimicrobial susceptibility, serotypes and pathogenicity of A. pleuropneumoniae isolates were investigated. In addition, outer membrane protein(OMP) of the isolates were extracted to determine its properties and immunogenicity in both mice and piglets. Of 3,395 slaughter pigs, pleuropneumonia was observed in 425 pigs(10.6%). A. pleuropneumoniae was isolated from 22 pigs(5.2%) out of 425 pigs with pneumonic lesions. The biochemical properties of all isolates were same as those of reference A. pleuropneumoniae strain. Among 22 isolates, 9, 1 and 12 isolates were serovar 2, 3 and 5, respectively. The results of antimicrobial susceptibility test revealed that the isolates showed high susceptibility to ciprofloxacin and cephalothin, moderate susceptibility to amikacin, gentamicin, kanamycin and streptomycin, and low susceptibility to erythromycin, tylosin and sulfadimethoxin. The isolates were varied in pathogenicity to mice. Median lethal dose of LE9402(serovar 2) and LE9511(serovar 5) were 9.2×10^7CFU and 2.8×10^7CFU, respectively. Specific pneumonic lesions were observed from the infected mice with clinical signs. Bacteria recovery rate was high in the lung, but low in heart blood and tracheas. Serovar 2 was found to be more pathogenic than serovar 5 in guinea pig. Mortality on guinea pigs inoculated with serovar 2(5.4×10^8 - 5.4×10^6CFU) abd serovar 5(2.8×10^8 - 2.8×10^6CFU) was 20-40% and 40-80%, respectively. A severe hemorrhagic lesions and focal pneumonic lesions were observed from dead guinea pigs. Bacteria recovery rate was relatively higher in the lung than that of other organs. In the SDS-PAGE analysis, OMP-enriched fractions of both isolates and reference strains contain common peptide bands equivalent to molecular weight of 17, 27, 42, 52 and 95Kd. In addition to common peptide bands, the bands which are specific to each isolate were also observed. The profiles of Sephadex G25 fractions showed 3 major peaks. The common peptide bands which were observed by SDS-PAGE of the crude OMPs were found i the peaks 1 and 2. The OMPs extracted from serovar 2(LE9402) and serovar 5(LE9511) provided high level of protection in mice(70-80%) and pigs(100%). All animals inoculated with OMPs were seroconverted, showing micro-agglutination titer of 640 to 1280.

Cisplatin의 이독성 발견에 있어 초고주파 청각검사에 대한 연구

우훈영,김갑무,노윤성,김성록 인제대학교 1994 仁濟醫學 Vol.15 No.1

Cisplatin은 비뇨생식기 영역의 악성종양 및 두경부 편평상피암에 효과적인 항암제로 이에 의한 이독성은 주로 와우의 기저부에 영향을 미쳐 고음역 난청을 초래한다고 알려져 있다. 본 연구의 목적은 Cisplatin의 이독성을 발견하는데 있어 일반적인 순음청력검사와 비교하여 초고주파 청각검사의 유용성을 평가하는데 두었다. Cisplatin을 단독 혹은 타항암제와 병용하여 투여한 11명의 환자, 총 22귀를 대상으로 순음청각검사 및 초고주파 청각검사를 실시하여 다음과 같은 결과를 얻었다. 청각손실이 없었던 경우는 5귀(23%), 저주파 영역(125∼8,00Hz)의 청각손실이 있었던 경우는 17(5%), 초고주파 영역(10,000∼20,000Hz)의 청각손실이 있었던 경우는 67(27%), 저주파 및 초고주파 영역 모두에서 청각손실이 있었던 경우는 107(45%)였다. 결론적으로 Cisplatin에 의한 이독성을 발견하는데 있어 초고주파 청각검사가 순음청각검사보다 유용함을 알 수 있었다. Cis-diaminedichloroplatinum, or cisplatin, is an effective antineoplastic agent against genitourinary cancers and squamous cell carcinoma of head and neck. Ototoxicity of cisplatin is cochlear damage with a predilection for involvement of higher frequencies. The purpose of this study is to evaluate the usefulness of high frequecy audiometry in detection of cisplatin ototoxicity compared with conventional audiometry. The auditory function of 22 ears of 11 subjects receiving cisplatin alone or combined with other antineoplastic agents for lung, esophgeal, and cervical cancers was sarially monitored with conventional audiometry and high frequency audiometry. The results are as follows : no damage, 5 ears(23%) ; low frequency(125∼8,000Hz) damage, 1 ear(5%) ; high frequency(10,000∼20,000Hz) damage, 6 ears (27%) ; and both low and high damage, 10 ears(45%). In conclusion, high frequency audiometry is more useful than conventional audiometty in detection of cisplatin ototoxicity.

전신 진동이 Mouse의 기억상실에 미치는 영향에 과한 실험적 관찰

이무훈,김창주 공군본부 의무감실 1992 항공의학 Vol.40 No.1-2