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Min Jin-Young,Kim Jin Youp,성충만,Kim Seon Tae,조현진,문수진,Cho Sung-Woo,Hong Sang Duk,Ryu Gwanghui,Cho Kyoung Rai,Kim Young Hyo,Park Soo-Kyoung,Kim Dong-Kyu,Lee Dong Hoon,Heo Sung Jae,Lee Ki-Il,Kim Su Jin,Le 대한천식알레르기학회 2023 Allergy, Asthma & Immunology Research Vol.15 No.4
Purpose: Cluster analyses on inflammatory markers of chronic rhinosinusitis (CRS) in Asians from multicenter data are lacking. This multicenter study aimed to identify the endotypes of CRS in Koreans and to evaluate the relationship between the endotypes and clinical parameters. Methods: Nasal tissues were obtained from patients with CRS and controls who underwent surgery. The endotypes of CRS were investigated by measuring interleukin (IL)-5, interferon (IFN)-γ, IL-17A, IL-22, IL-1β, IL-6, IL-8, matrix metalloproteinase-9, eotaxin-3, eosinophil cationic protein, myeloperoxidase (MPO), human neutrophil elastase (HNE), periostin, transforming growth factor-β1, total immunoglobulin E (IgE), and staphylococcal enterotoxin (SE)-specific IgE. We performed hierarchical cluster analysis and evaluated the phenotype, comorbidities, and Lund-Mackay computed tomography (LM CT) score in each cluster. Results: Five clusters and 3 endotypes were extracted from 244 CRS patients: cluster 1 had no upregulated mediators compared to the other clusters (mild mixed inflammatory CRS); clusters 2, 3, and 4 had higher concentrations of neutrophil-associated mediators including HNE, IL-8, IL-17A, and MPO (T3 CRS); and cluster 5 had higher levels of eosinophil-associated mediators (T2 CRS). SE-specific IgE was undetectable in T3 CRS and had low detectable levels (6.2%) even in T2 CRS. The CRS with nasal polyps (CRSwNP) phenotype and LM CT scores showed no significant differences between T2 and T3 CRS, while the incidence of comorbid asthma was higher in T2 CRS than T3 CRS. In T3 clusters, higher levels of neutrophilic markers were associated with disease severity and CRSwNP phenotype. Conclusions: In Koreans, there is a distinct T3 CRS endotype showing a high proportion of CRSwNP and severe disease extent, along with T2 CRS.
Kim, Hee Man,Park, Jeong Youp,Kim, Kyung Sik,Park, Mi-Suk,Kim, Myeong-Jin,Park, Young Nyun,Bang, Seungmin,Song, Si Young,Chung, Jae Bock,Park, Seung Woo Blackwell Publishing Asia 2010 Journal of gastroenterology and hepatology Vol.25 No.2
<P>Abstract</P><P>Background and Aim: </P><P>In hilar cholangiocarcinoma, an accurate assessment of preoperative resectability is important to optimize surgical resection. We investigated the accuracy of the combination of intraductal ultrasonography (IDUS) and percutaneous transhepatic cholangioscopy (PTCS) for evaluating longitudinal extent in hilar cholangiocarcinoma.</P><P>Methods: </P><P>Patients diagnosed with hilar cholangiocarcinoma underwent multidetector computed tomography (MDCT) and magnetic resonance cholangiography (MRC) for tumor staging and Bismuth type. Percutaneous transhepatic biliary drainage was performed at the left or right bile duct of the liver section that was anticipated to be preserved in the surgical treatment. After tract dilation, PTCS with cholangioscope-directed biopsy and IDUS were sequentially performed to evaluate Bismuth type. Surgical treatment was executed according to tumor staging and longitudinal tumor extent. Postoperative histological Bismuth types were compared to preoperative Bismuth types based on MDCT, MRC, PTCS with biopsy, and IDUS.</P><P>Results: </P><P>From June 2006 to November 2008, 25 patients with hilar cholangiocarcinoma were enrolled, with 20 of these patients evaluable. The accuracy of MDCT, MRC, PTCS with biopsy, and IDUS for the evaluation of Bismuth type was 80%, 84.2%, 90%, and 85.0%, respectively, in 20 patients, and 82.4%, 82.4%, 94.1%, and 88.2%, respectively, in 18 patients with Bismuth type IIIa, IIIb, or IV cancer. The accuracy of the combination of IDUS and PTCS with biopsy was 95% in 20 patients, and 100% in 18 with Bismuth type IIIa, IIIb, or IV cancer.</P><P>Conclusions: </P><P>The combination of IDUS and PTCS with biopsy was highly accurate for assessing Bismuth type and may help in the identification of an optimal surgical plan for the treatment of hilar cholangiocarcinoma, especially in Bismuth type IIIa, IIIb, or IV. </P>
내시경으로 확진된 위선암의 VATER 팽대부 림프선 전이 1 예
김영호,김경호,김남훈,김규식,김진범,김배영,이영록,추무엽,황교승,곽재영,이명기,조연회,이주택 대한내과학회 1997 대한내과학회지 Vol.53 No.4
Cancer of the stomach is responsible for approximately 650,000 deaths globally each year and is probably second only to lung cancer worldwide as an overall cause of cancer-related mortality. Similar to the situation with most adenocarcinomas of the gastointestinal tract, carcinomas of the stomach can spread by local extension to adjacent normal structures and can develop lymphatic, peritoneal, and distant metastases. The tumor cells, can also permeate diffusely into the lymphatic plexus of the bowel, more often at the level of the upper duodenum hut sometimes down into the distal ileum and the large bowel. We report a case of lymphatic metastasis of gastric adenocarcinoma to the ampulla of Vater with review of the literature.
Distinct Endotypes of Pediatric Rhinitis Based on Cluster Analysis
Kim Jin Youp,Lee Sangjun,서동인,Kim Dae Woo,Yoon Hyung-Jin,Park Sue K.,Rhee Chae-Seo,Han Doo Hee 대한천식알레르기학회 2022 Allergy, Asthma & Immunology Research Vol.14 No.6
Purpose: Despite the wide spectrum of pediatric rhinitis, endotyping of rhinitis based on type 2 inflammation and bronchial hyper-responsiveness (BHR) is lacking. This study aimed to investigate endotypes of pediatric rhinitis using cluster analysis. Methods: Cluster analysis was performed on data from 241 children with rhinitis by using 12 variables reflecting clinical characteristics of skin prick, laboratory, and pulmonary function tests. After extracting clusters, between-cluster differences in clinical features, such as nasal symptom scores and asthma comorbidity, were assessed to investigate the association between the endotypes and clinical features. Results: Four clusters were extracted by hierarchical cluster analysis. Cluster 1 (n = 32 [13.3%]) was the non-allergic rhinitis dominant cluster with low type 2 inflammation and the lowest rate of BHR. Patients in cluster 1 had the mildest nasal symptoms and no asthma comorbidity. Cluster 2 (n = 114 [47.3%]) was the largest cluster and exhibited intermediate type 2 inflammation and low BHR. Cluster 3 (n = 65 [27.0%]) showed high type 2 inflammation and intermediate BHR. However, the severity of nasal symptoms and asthma comorbidity in this cluster were comparable with those in cluster 2. Cluster 4 (n = 30 [12.4%]) revealed high type 2 inflammation and BHR with potential functional airway impairment. Additionally, cluster 4 displayed the most severe nasal symptoms and frequent asthma comorbidity. Conclusions: Four distinct endotypes of pediatric rhinitis based on allergen sensitization, type 2 inflammation, and BHR correlate to symptoms and asthma comorbidity. These endotypes may aid clinicians in understanding the wide spectrum of pediatric rhinitis.
Fabrication of coupled GaAs quantum dots and their optical properties
Kim, Jong Su,Song, Jin Dong,Byeon, Clare C.,Kang, Hoonsoo,Jeong, Mun Seok,Cho, Nam Ki,Park, Sung Jun,Choi, Won Jun,Lee, Jung Il,Kim, Jin Soo,Leem, Jae-Young,Yim, Sang-Youp,Ko, Do-Kyeong,Lee, Jongmin Wiley (John WileySons) 2009 Physica Status Solidi C Vol.6 No.4
첨단 과학수사 정책 및 포렌식 기법 종합발전방안 연구(Ⅲ) - 수사효과성 증진을 위한 유관 법제도 및 정책 평가
김한균(Kim, Han-Kyun),김대원(Kim, Dae-Won),이경렬(Lee, Kyung-Lyul),김기범(Kim, Gi-Bum),김면기(Kim, Myeonki),조은경(Jo, Eunkyung),승재현(Seung, Jae-Hyun),도규엽(Do, Gyu-Youp),김민이(Kim, Min-Yi),차종진(Cha, Jong-Jin),이관희(Lee, Kwan- 한국형사법무정책연구원 2020 형사정책연구원 연구총서 Vol.- No.-
현대 건축에 나타난 랜드스케이프 건축의 공공공간(公共空間)에 관한 연구
김진엽(Kim, Jin-Youp),김정곤(Kim, Jung-Gon) 한국실내디자인학회 2012 한국실내디자인학회논문집 Vol.21 No.5
This study starts from the question about the possibility of landscape, especially the possibility to give a new vision in the aspect of publicity. Such a concept of landscape architecture made its appearance in the last decade of the 20th century, as the flexible network to include the changes and the specificity of the surroundings, which simultaneously focuses on the temporality-the uncertainty. Moreover landscape architecture can be defined as the architecture in which the interest on human activities lie in the center of the concept. By analyzing concrete examples, the landscape architecture can be defined in 3 aspects : unity of building and nature, void and public space, space of expansion. As a result of the analysis of landscape architects" statements, it can be said that the issues of publicity are always put at the starting point of landscape architecture with its attention to the way to associate an individual with the others.
김진성 ( Jin Sung Kim ),이종범 ( Jong Bum Lee ),서완석 ( Wan Seok Seo ),구본훈 ( Bon Hoon Koo ),배대석,김이영 ( Yi Youg Kim ),김정엽 ( Jung Youp Kim ) 영남대학교 기초/임상의학연구소 2005 Yeungnam University Journal of Medicine Vol.22 No.2
Purpose: This study was conducted to investigate the prognostic factors of postpsychotic depressive symptoms in patients with schizophrenia. Materials and Methods: Eighty patients were selected based on the diagnostic criteria from the DSM-IV, PANSS and ESRS. For all patients information was collected on demographic and clinical characteristics. The subjective depressive symptoms and the objective depressive symptoms, as well as patients insight regarding psychosis were evaluated. The subjective depressive symptoms were evaluated by BDI and ZDS; the objective depressive symptoms were evaluated by HDRS and CDSS, and patient insight into the psychosis was evaluated by KISP. Results: The comparisons using demographic and clinical characteristics showed that HDRS and CDSS had significant difference with regard to gender and suicide attempts; the BDI was associated with difference in education level and age of onset. The patients with scores above cuff-off score for each scale were 20(25.0%) for the BDI, 16(20.0%) for the ZDS, 18(22.5%) for the CDSS and 6(7.5%) for the HDRS. The results of the stepwise multiple regression analysis showed that the scores for the KISP, education levels, gender and suicide attempts were the main prognostic factors in patients with the psychotic depressive disorder of schizophrenia. Conclusion: The main prognostic factors in psychotic depressive disorder of schizophrenia included: insight into psychosis, suicidal attempts. Insight into the psychosis was the most reliable prognostic factor but this characteristic had a negative relationship to the with depressive symptoms.