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한국인 제2형 당뇨병 환자에 있어 지속적 피하 인슐린 주입법 치료시 Lispro insulin와 Regular insulin의 효과 비교
유재등,박봉안,류하근,류주성,김정수,김치훈,박선민,최수봉 건국대학교 의과학연구소 2001 건국의과학학술지 Vol.11 No.-
Objective: The Lispro insulin has faster onset of effects and shorter duration than the human regular insulin, an analog of human insulin. The differences in the pharmacodynamics between the two types of insulin in the continuous subcutaneous insulin infusion(CSII) with insulin pump for treating the Korean Type 2 DM patients were analyzed. The effects on the regulation of blood sugar, the amount of insulin injected, and the frequency of hypoglycemia were compared between the lispro insulin and the regular human insulin. Method and Material: One hundred and three Korean Type 2 DM patients were randomly divided into two groups, 49 Lispro insulin and 54 Regular insulin.(Table 1) Both groups were treated for 14 days. Also at a set time before meal, insulin was injected as bolus, using a portable insulin pump, in both groups, 15 minutes before for lispro insulin and 30 minutes before for human insulin The HbA1C, C-peptide, AC/PC, height and weight were measured for each patients at the time of admission. The peripheral blood sugar level and insulin injection profile were recorded 7 times per day for each patients. Results: After treating for 7 days and 14 days, the blood sugar level normalized in both groups. There weren't any significant differences in blood sugar levels in both groups at point of the study, and also there weren't any differences in the frequency of hypoglycemia. In order to maintain the normalized blood sugar level, the lispro insulin group had higher total daily insulin requirement than the regular insulin group after 14 days of treatment (0.90±0.35 vs 0.73±0.39u/kg/day, p<0.05) This difference is probably due to the difference in basement insulin requirements rather than prandial insulin requirements (0.32±0.1 vs 0.43± 0.09u/kg/day, p<0.001). Discussion: In the hospitalized Korean Type 2 DM patients with CSII treatment, continuous subcutaneous insulin infusion therapy using lispro insulin has convenience in usage compared to the regular insulin. However, there were not any differences in the blood sugar levels. Also lispro insulin requires more insulin in order to maintain normal blood sugar level, which is probably due to the increase in the basal requirement. Also there were not any difference in the frequency of hypoglycemia.
한상우,유진홍,권순석,김성훈,박지찬,홍은정,최경성,박용완,장준희,안지원,박유경,강지영,박상미,신완식 대한감염학회 2004 감염과 화학요법 Vol.36 No.5
We experienced a 25 year-old male patient with typhoid fever complicated with massive hemoptysis. Pulmonary complication in typhoid fever is very rare and to our knowledge, there has been no report of hemoptysis as a main cause of death with this disease. We herein report a rare case of typhoid fever.
Jung, Jae Hun,Yoon, Hyun Sik,Kim, Yu Lee,Song, Man Suk,Kim, Yong,Chen, Zhi Gang,Zou, Jin,Choi, Duk Yong,Kang, Jung Hyun,Joyce, Hannah J,Gao, Qiang,Hoe Tan, H,Jagadish, Chennupati IOP Pub 2010 Nanotechnology Vol.21 No.29
<P>We demonstrate a method to realize vertically oriented Ge nanowires on Si(111) substrates. Ge nanowires were grown by chemical vapor deposition using Au nanoparticles to seed nanowire growth via a vapor–liquid–solid growth mechanism. Rapid oxidation of Si during Au nanoparticle application inhibits the growth of vertically oriented Ge nanowires directly on Si. The present method employs thin Ge buffer layers grown at low temperature less than 600 °C to circumvent the oxidation problem. By using a thin Ge buffer layer with root-mean-square roughness of ∼ 2 nm, the yield of vertically oriented Ge nanowires is as high as 96.3%. This yield is comparable to that of homoepitaxial Ge nanowires. Furthermore, branched Ge nanowires could be successfully grown on these vertically oriented Ge nanowires by a secondary seeding technique. Since the buffer layers are grown under moderate conditions without any high temperature processing steps, this method has a wide process window highly suitable for Si-based microelectronics. </P>
Yu-Hun Jung,Woo-Suk Song,Dong-Chan Eun,Sang-Jun Park 대한정형외과 스포츠의학회 2017 Arthroscopy and Orthopedic Sports Medicine Vol.4 No.2
Background: This study aims to compare the results between antibiotic therapy alone and combined with arthroscopic lavage in patients with low-grade pyogenic arthritis of the knee. Methods: Patients with low-grade pyogenic arthritis of the knee were defined as those with symptoms of acute pyogenic arthritis but with a white blood cell count of 20,000 to 50,000/mm3 in the synovial fluid and a polymorphonuclear neutrophil level of 50% to 90%. We analyzed a total of 124 patients retrospectively. Patients treated using antibiotic monotherapy were categorized as Group A, and those treated using antibiotic therapy combined with arthroscopic lavage, as Group B. We compared parameters such as the duration of antibiotic injection, length of hospitalization, and recovery of the range of motion. Clinical outcome, measured as the Lysholm score and the visual analogue scale (VAS) score, was also compared. Results: We found that the parameters duration of antibiotic injection, length of hospital stay, and recovery of range of motion of the knee were significantly better in Group A than in Group B. However, the clinical outcome, denoted by the Lysholm knee score and the VAS score, did not significantly differ between the two treatment groups. Conclusion: We conclude that in patients with low-grade pyogenic arthritis of the knee early antibiotic therapy alone shows more satisfactory results than antibiotic therapy combined with arthroscopic lavage. Thus, our findings suggest that antibiotic monotherapy should be considered without any adjunct procedures such as arthroscopic lavage.
Jung, Hun Soon,Erkin, Ozgur Cem,Kwon, Mi Jeong,Kim, Seok Hyung,Jung, Jae In,Oh, Yu‐,Kyoung,Her, Song Wook,Ju, Woong,Choi, Yoon‐,La,Song, Sang Yong,Kim, Joong Kyu,Kim, Young Deug,Shim, Ga Y Wiley Subscription Services, Inc., A Wiley Company 2012 International journal of cancer: Journal internati Vol.130 No.8
<P><B>Abstract</B></P><P>Human papillomavirus (HPV) types 16 and 18 are the major etiologic factors in the development of cervical epithelial neoplasia. Our study was designed to validate antiviral short interfering RNA (siRNA) targeting the <I>E6</I> and <I>E7</I> oncogenes as a potential chemosensitizer of cisplatin (<I>cis</I>‐diaminedichloroplatinum II; CDDP) in cervical carcinoma. Specifically, the therapeutic efficacy of combination of CDDP and E6/E7‐specific siRNA was assessed in an <I>in vivo</I> cervical cancer xenograft models. The combination of CDDP and E6/E7‐specific siRNA had greater efficacy than the combination of CDDP and E6‐specific siRNA especially in terms of inducing cellular senescence. Through <I>in vitro</I> and <I>in vivo</I> experiments, the mechanism of synergy between these two treatments was revealed, demonstrating that the combination of E6/E7‐specific siRNA and CDDP therapy was significantly superior to either modality alone. <I>In vitro</I>, long‐term exposure of HeLa cells to the combination of CDDP and E6/E7‐specific siRNA induced apoptosis and cellular senescence. <I>In vivo</I>, E6/E7‐specific siRNA potentiated the antitumor efficacy of CDDP <I>via</I> induction of apoptosis, senescence and antiangiogenesis. Our results suggest that E6/E7‐specific siRNA may be an effective sensitizer of CDDP chemotherapy in cervical cancer.</P>
정유훈(Yu-Hun Jung),송우석(Woo-Suk Song),박섭리(Sub-Ri Park),백소야(So-Ya Paik) 대한정형외과학회 2016 대한정형외과학회지 Vol.51 No.4
신경 림프종증(neurolymphomatosis)은 림프종세포가 말초 신경계를 침범하는 것을 일컫는다. 일반적으로 림프종은 여러 연구에서 보고된 것처럼 말초 신경계를 침범하는 경우는 드문 것으로 알려져 있다. 신경 림프종증은 그 증상이 비특이적이고, 진단하는 데 있어서도 명확하게 정립된 바가 없어 치료하는 데에도 어려움이 많다. 특별한 증상 없이 전완 피부신경에 발생한 종괴에 대해 적출술을 시행하고 미만성 큰 B세포 림프종 진단 후 추가 치료하면서 경과관찰하였으나 동측 전완부 척골 신경에 재발한 림프종 1예를 경험하여 문헌 고찰과 함께 이를 보고하는 바이다. The term neurolymphomatosis has included infiltration of the peripheral nervous system by lymphoma. In generally, direct invasion of the peripheral nervous system is rare. The difficulty in treatment of neurolymphomatosis is due to unclassified characteristic symptoms and diagnosis. We performed excision of mass on the antebrachial cutaneous nerve with no specific symptoms. After diagnosis of diffuse large B cell lymphoma, further treatment and observation were followed. However, recurrence of the lymphoma was found in the ipsilateral forearm ulnar nerve, therefore we described a case of neurolymphomatosis with a brief review of the literature.
태양광 발전 시스템의 최적 설치 각도 예측에 관한 연구
김정환(Jung-Hwan Kim),유권종(Gwon-Jong Yu),소정훈(Jung-Hun So),차한주(Han-Ju Cha),유병규(Byung-Gyu Yu) 대한전기학회 2009 대한전기학회 학술대회 논문집 Vol.2009 No.7
The measured solar radiation on tilted surfaces by all directions has been widely used as important solar radiation data in installing photovoltaic system. The photovoltaic systems is much affected by angle and direction of incident rays. The results obtained in this research could be used in installing optimal photovoltaic systems.