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3′‐Sialyllactose protects against osteoarthritic development by facilitating cartilage homeostasis
Jeon, Jimin,Kang, Li‐,Jung,Lee, Kwang Min,Cho, Chanmi,Song, Eun Kyung,Kim, Wook,Park, Tae Joo,Yang, Siyoung John Wiley and Sons Inc. 2018 JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Vol.22 No.1
<P><B>Abstract</B></P><P>3′‐Sialyllactose has specific physiological functions in a variety of tissues; however, its effects on osteoarthritic development remain unknown. Here, we demonstrated the function of 3′‐sialyllactose on osteoarthritic cartilage destruction. <I>In vitro</I> and <I>ex vivo</I>, biochemical and histological analysis demonstrated that 3′‐sialyllactose was sufficient to restore the synthesis of Col2a1 and accumulation of sulphated proteoglycan, a critical factor for cartilage regeneration in osteoarthritic development, and blocked the expression of Mmp3, Mmp13 and Cox2 induced by IL‐1β, IL‐6, IL‐17 and TNF‐α, which mediates cartilage degradation. Further, reporter gene assays revealed that the activity of Sox9 as a transcription factor for Col2a1 expression was accelerated by 3′‐sialyllactose, whereas the direct binding of NF‐κB to the <I>Mmp3</I>,<I> Mmp13</I> and <I>Cox2</I> promoters was reduced by 3′‐sialyllactose in IL‐1β‐treated chondrocytes. Additionally, IL‐1β induction of Erk phosphorylation and IκB degradation, representing a critical signal pathway for osteoarthritic development, was totally blocked by 3′‐sialyllactose in a dose‐dependent manner. <I>In vivo</I>, 3′‐sialyllactose protected against osteoarthritic cartilage destruction in an osteoarthritis mouse model induced by destabilization of the medial meniscus, as demonstrated by histopathological analysis. Our results strongly suggest that 3′‐sialyllactose may ameliorate osteoarthritic cartilage destruction by cartilage regeneration <I>via</I> promoting Col2a1 production and may inhibit cartilage degradation and inflammation by suppressing Mmp3, Mmp13 and Cox2 expression. The effects of 3′‐sialyllactose could be attributed in part to its regulation of Sox9 or NF‐κB and inhibition of Erk phosphorylation and IκB degradation. Taken together, these effects indicate that 3′‐sialyllactose merits consideration as a natural therapeutic agent for protecting against osteoarthritis.</P>
Mercury exposure is associated with obesity: a systematic review and meta-analysis
Jeon Jimin,박경 대한지역사회영양학회 2023 대한지역사회영양학회지 Vol.28 No.3
Objectives: Previous studies have evaluated the association between mercury exposure and obesity but have yielded mixed conclusions. The aim of this study was to systematically review and summarize scientific evidence regarding the association between mercury exposure and obesity in the human population. Methods: We conducted a systematic search of PubMed, Web of Science, Scopus, and Science Direct for articles related to mercury exposure and obesity. Meta-analyses of the highest and lowest categories of mercury levels were evaluated using a random effects model. Begg’s test was used to detect publication bias. Results: A total of 9 articles were included. The pooled random effects odds ratio (OR) for mercury exposure and obesity of all 9 studies was 1.66 (95% confidence interval [CI]: 1.16-2.38). This positive association was evident in adults (OR: 1.61, 95% CI: 1.02-2.54) and among studies with Asian populations (OR: 2.00, 95% CI: 1.53-2.59), but not among those with North America/African populations (OR: 0.90, 95% CI: 0.50-1.65). Conclusions: The present meta-analysis identified a positive association between mercury exposure and obesity. These findings suggest that toxic environmental metals such as mercury may be an important risk factor for obesity along with dietary habits and lifestyles.
Park, Jimin,Du, Ping,Jeon, Jin‐,Kyung,Jang, Gun Hyuk,Hwang, Mintai Peter,Han, Hyung‐,Seop,Park, Kwideok,Lee, Kwan Hyi,Lee, Jee‐,Wook,Jeon, Hojeong,Kim, Yu‐,Chan,Park, Jong Woon WILEY‐VCH Verlag 2015 Angewandte Chemie Vol.127 No.49
<P><B>Abstract</B></P><P>Although the use of reactive oxygen species (ROS) has been extensively studied, current systems employ external stimuli such as light or electrical energy to produce ROS, which limits their practical usage. In this report, biocompatible metals were used to construct a novel electrochemical system that can spontaneously generate H<SUB>2</SUB>O<SUB>2</SUB> without any external light or voltage. The corrosion of Mg transfers electrons to Au‐decorated oxidized Ti in an energetically favorable process, and the spontaneous generation of H<SUB>2</SUB>O<SUB>2</SUB> in an oxygen reduction reaction was revealed to occur at titanium by combined spectroscopic and electrochemical analyses. The controlled release of H<SUB>2</SUB>O<SUB>2</SUB> noticeably enhanced in vitro angiogenesis even in the absence of growth factors. Finally, a new titanium implant prototype was developed by Mg incorporation, and its potential for promoting angiogenesis was demonstrated.</P>
전산유체역학을 활용한 킬른 회전 방향에 따른 염소 By-pass 위치 선정에 관한 연구
전지민(Jimin Jeon),이명종(Myeongjong Lee),고형탁(Hyeongtak Ko),오세천(Seacheon Oh),이구회(Guhoe Lee),김재형(Jaehyeong Kim),김우태(Wootae Kim) 한국환경에너지공학회 2023 한국열환경공학회 학술대회지 Vol.2023 No.2
시멘트 산업은 탄소중립 시나리오에 따라 소성 공정 에서 발생하는 이산화탄소 배출량을 줄이고자 대체 연료로써 폐합성수지의 사용량을 중가시키 고 있다. 폐합성수지의 염소 성분은 원료에 포함된 칼륨과 반용하여 염화칼륨을 생성한다. 염화칼륨은 소성로 내부에서 휘발과 응축을 반복 순환하며 코팅 현상으로 인한 하소로 막 둥의 문제를 발생시킨다. 따라서, 연료 대체율 향상과 안정된 시멘트 공정을 위한 염소 By-pass 시스템을 통해 염화칼륨을 우회해야 한다 염소 By-pass 설비는 염화칼륨이 고농도로 휘발되며 유속이 낮아 비산하는 양이 적은 구역에 설치해야 한다. 또한, 내부 유동장은 고온의 가스가 회전하며 유입되어 킬른의 회전 방향에 따라 다른 양상을 보인다. 본 연구는 전산유체역학 해석 프로그램인 ANSYS 2021 R2를 활용하여 킬론 회전 방향에 따 염소 By-pass 설비의 설치 위치를 선정 하는 연구를 수행하였다.
Jin‑Kyung Jeon,Hyunseon Seo,Jimin Park,Soo Ji Son,Yeong Rim Kim,Eun Shil Kim,Jong Woong Park,Woong‑Gyo Jung,Hojeong Jeon,Yu‑Chan Kim,Hyun‑Kwang Seok,Jae Ho Shin,Myoung‑Ryul Ok 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.4
The excessive initial corrosion rate of Mg is a critical limitation in the clinical application of biodegradable Mg implantsbecause the device loses its fi xation strength before the fractured bone heals. This study suggests a new approach to overcomethis hurdle by accelerating tissue regeneration instead of delaying the implant biodegradation. As angiogenesis is anessential process in early bone regeneration, a Mg implant coated with electrospun nanofi bers containing nitric oxide (NO),which physiologically promotes angiogenesis, is designed. The integrated device enables adjustable amounts of NO to bestored on the NO donor-conjugated nanofi ber coating, stably delivered, and released to the fractured bone tissue near theimplanted sites. An in vitro corrosion test reveals no adverse eff ect of the released NO on the corrosion behavior of the Mgimplant. Simultaneously, the optimal concentration level of NO released from the implant signifi cantly enhances tube networkformation of human umbilical vein endothelial cells without any cytotoxicity problem. This indicates that angiogenesis canbe accelerated by combining NO-releasing nanofi bers with a Mg implant. With its proven feasibility, the proposed approachcould be a novel solution for the initial stability problem of biodegradable Mg implants, leading to successful bone fi xation.
Risk Factors of Failure to Rescue in Unplanned ICU Admitted Patients after Elective Pancreatectomy
Jimin Son,Ki Byung Song,Ye Won Jeon,Janghun Han,Min Kyu Sung,Yuna Lee,Younghoon Roh,Sarang Hong,Yejong Park,Bong Jun Kwak,Woohyung Lee,Jae Hoon Lee,Dae Wook Hwang,Song Cheol Kim,Suk-kyung Hong 대한외과학회 2022 대한외과학회 학술대회 초록집 Vol.2022 No.11