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Jiaxin Chen,Weiren Yang,Hua Liu,Jiaxing Niu,Yang Liu,Qun Cheng Asian Australasian Association of Animal Productio 2024 Animal Bioscience Vol.37 No.1
Objective: This experiment aimed to explore the protective action of dietary supplementation with isoquinoline alkaloids (IA) from Macleaya cordata on lipopolysaccharide (LPS)-induced liver injury in broilers. Methods: Total 216 healthy broilers were selected in a 21-d trial and assigned randomly to the following 3 treatments: control (CON) group, LPS group, and LPS+IA group. The CON and LPS groups were provided with a basal diet, whereas the LPS+IA group received the basal diet supplemented with 0.6 mg/kg Macleaya cordata IA. Broilers in LPS and LPS+IA groups were intraperitoneally injected with LPS (1 mg/kg body weight) at 17, 19, and 21 days of age, while those in CON group were injected with equivalent amount of saline solution. Results: Results showed LPS injection caused systemic and liver inflammation in broilers, inhibited immune function, and ultimately lead to liver injury. By contrast, supplementation of IA ameliorated LPS-induced adverse change in serum parameters, boosted immunity in LPS+IA group. Furthermore, IA suppressed the elevation of hepatic inflammatory cytokines and caspases levels induced by LPS, as well as the expressions of genes related to the toll-like receptor 4 (TLR4)/myeloid differentiation primary response 88 (MyD88)/nuclear factor-kappa B (NF-κB) pathway. Conclusion: Dietary inclusion of 0.6 mg/kg Macleaya cordata IA could enhance immune function of body and inhibit liver damage via inactivating TLR4/MyD88/NF-κB signaling pathway in broilers.
Shaomei Liu,Jiaxin Li,Yuan Wu,Yanna Ren,Qi Liu,Qiyao Wang,Xiangshan Zhou,Menghao Cai,Yuanxing Zhang 한국유전학회 2017 Genes & Genomics Vol.39 No.3
Aspergillus glaucus HB1-19 is a typical marinederived fungus preferring the dependence on sea water for its growth, asexual development and polyketides biosynthesis. Therein, salt stress greatly functions even in superior to light illumination, which is also a critical regulation signal for fungi. Here, comparative RNA-seq analysis of this strain was performed under conditions of saltstress ? dark (group A), non salt-stress ? dark (group B), salt-stress ? light (group C). The RNA-seq generated a total of 19,024 unigenes with an average length of 1415 bp. Differentially expressed genes were very similar between group A and group C but greatly differed between group A and group B, proving that salt stress functioned superior to light illumination globally. Salt stress highly enhanced primary metabolism and activated Ras and MAPK signaling pathways. There seems no direct interaction between asexual development and polyketides biosynthesis. Salt stress inhibited terpenoids biosynthesis but showed little influences on polyketide pathway as well as other secondary metabolism pathways. These findings provide a better understanding of marine fungi adapting to marine environment. Also, it indicates that the so-called ‘salt stress-induced’ may truly be a ‘metal ions-induced’ for biosynthesis of secondary metabolites in marine fungi.
Experimental and Numerical Research on the Laser Impact Welding of Ti/SS
Jiaxin Lu,Huixia Liu,Hao Jin,Feng Li,Xiaojun Wang,Xiao Wang 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.22 No.5
The welding of Ti/SS metal foil was realized by laser impact welding. The interface morphology and mechanical properties of welding specimens were studied by systematic experiments, and the experimental phenomena were revealed by smoothed particle hydrodynamics numerical simulation. Results indicated that the plastic deformation of the composite plate and the springback of the welding spot center were small under low laser pulse energy and enlarged under high laser pulse energy. Impinging jet, interface wave, and interface cracking were found at the micro-interface of the welding specimens. Increasing the laser pulse energy resulted in the transition of the interface waveform from straight to microwave and finally to wave primarily because of the change in interfacial impact pressure and effective plastic strain. Energy dispersive spectroscopy analysis showed that the trace element diff used at the welding interface, and no intermetallic compounds were formed. SPH simulation revealed that the thickness of the high-temperature layer was related to the thickness of the diffusion layer. As the distance between the test point and welding interface increased, the hardness decreased. The maximum tensile force of the welding specimens increased with laser pulse energy. The failure mode of the interface was welding spot edge fracture failure.
Jiaxin Wena,Xin Zhang,Jinlong Chen,Ting Liu,Yi Zhou,Lingjie Li 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.107 No.-
To exploit the advanced corrosion inhibitor for mild steel in acidic solution, N, N, N, N, N′-pentakis (2-hydroxyethyl)-1,4,7-triazaheptane (PHET) was synthesized by a facile process, which was confirmed by FT-IR, NMR and EI-MS. Inhibition effect of PHET was examined on mild steel in 1.0 M HCl solution by using weight loss, electrochemical tests and surface analyses. The results showed that the optimal concentration of PHET in HCl solution was 400 mg/L corresponding to the inhibitive efficiency of 93% at 293 K. PHET presented superior and durable corrosion inhibition performance for mild steel. Meanwhile, PHET acted as a mixed-type inhibitor which affects both anodic and cathodic reactions of the corrosion process. PHET could be absorbed on mild steel through forming complexes with ferrous ions that acted as protective film, which was supported by UV–vis and XPS analyses. The adsorption process of PHET molecules on mild steel, following Langmuir adsorption isotherm, was an exothermal process and belonged to mixed adsorption mechanisms ( =-31.78 kJ mol−1, 293 K) between physisorption and chemisorption. Besides, theoretical calculations were conducted to give further investigation on the inhibition mechanism of PHET and elucidated the adsorption behaviour of PHET. PHET synthesized in this work also can be extended to use for the corrosion protection of other metals in acidic medium.
Qianying Zhao,Jiaxin Yang,Dongyan Cao,Jiangna Han,Kaifeng Xu,Yongjian Liu,Keng Shen 대한부인종양학회 2016 Journal of Gynecologic Oncology Vol.27 No.3
Objective: To explore the appropriate treatment of malignant germ cell tumor (MGCT) in thefemale genital system, and to analyze the factors influencing both therapeutic response andsurvival outcome. Methods: A cohort of 230-Chinese women diagnosed with MGCT of the genital systemwas retrospectively reviewed and prospectively followed. The demographic and pathologicalfeatures, extent of disease and surgery, treatment efficiency, recurrence and survival wereanalyzed. Results: MGCTs from different genital origins shared a similar therapeutic strategy andresponse, except that all eight vaginal cases were infantile yolk sac tumors. The patients’ curerate following the initial treatment, 5-year overall survival and disease-free survival (DFS)were 85.02%, 95.00%, and 86.00%, respectively. Although more extensive excision couldenhance the remission rate; it did not improve the patients’ survival. Instead, the level of themedical institution, extent of surgery and disease were independent prognostic factors forrelapse (p<0.05). Approximately 20% of patients had recurrent or refractory disease, morethan half of whom were in remission following secondary cytoreductive surgery with salvagechemotherapy. Conclusion: Fertility-sparing surgery with or without standardized PEB/PVB (cisplatin,etoposide/vincristine, and bleomycin) chemotherapy is applicable for female MGCTsof different origins. Comprehensive staging is not required; nor is excessive debulkingsuggested. Appropriate cytoreduction by surgery and antineoplastic medicine at anexperienced medical institution can bring about an excellent prognosis for these patients.
Analytical modeling of axial stiffness of tensile bolted joints under concentric external load
Peng He,Jiaxin Liu,Chengyuan Zhang,Zhansheng Liu 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.11
Stiffness of bolted joints is a critical parameter for determining deformations and natural frequencies of assemblies. In this study, the effect of external load on axial stiffness of bolted joints is clarified theoretically for the first time. The stiffness of stress zones between and beyond load planes is derived on the basis of the strain energy method and used to formulate the stiffness of bolted joints. The influence of the distance between the load planes of the external load, axial positions of the external load, and difference in the material of the clamped parts on the stiffness of the bolted joints are investigated by applying the proposed formulations and finite element method. Comparisons with finite element results indicate that the proposed formulation can accurately predict the stiffness of the bolted joints.
HALF-METALLIC SILICENE AND GERMANENE NANORIBBONS: TOWARDS HIGH-PERFORMANCE SPINTRONICS DEVICE
YANGYANG WANG,JIAXIN ZHENG,ZEYUAN NI,RUIXIANG FEI,QIHANG LIU,RUGE QUHE,CHENGYONG XU 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2012 NANO Vol.7 No.5
By using first-principles calculations, we predict that an in-plane homogenous electrical ¯eld can induce half-metallicity in hydrogen-terminated zigzag silicene and germanene nanoribbons (ZSiNRs and ZGeNRs). A dual-gated ¯nite ZSiNR device reveals a nearly perfect spin-¯lter e±ciency (SFE)of up to 99% while a quadruple-gated ¯nite ZSiNR device serves as an effective spin ¯eld e®ect transistor (FET) with an on/o® current ratio of over 100 from ab initio quantum transport simulation. This discovery opens up novel prospect of silicene and germanene in spintronics.