Non-Contrast Cine Cardiac Magnetic Resonance Derived-Radiomics for the Prediction of Left Ventricular Adverse Remodeling in Patients With ST-Segment Elevation Myocardial Infarction

A Xin,Liu Mingliang,Chen Tong,Chen Feng,Qian Geng,Zhang Ying,Chen Yundai 대한영상의학회 2023 Korean Journal of Radiology Vol.24 No.9

Objective: To investigate the predictive value of radiomics features based on cardiac magnetic resonance (CMR) cine images for left ventricular adverse remodeling (LVAR) after acute ST-segment elevation myocardial infarction (STEMI). Materials and Methods: We conducted a retrospective, single-center, cohort study involving 244 patients (random-split into 170 and 74 for training and testing, respectively) having an acute STEMI (88.5% males, 57.0 ± 10.3 years of age) who underwent CMR examination at one week and six months after percutaneous coronary intervention. LVAR was defined as a 20% increase in left ventricular end-diastolic volume 6 months after acute STEMI. Radiomics features were extracted from the oneweek CMR cine images using the least absolute shrinkage and selection operator regression (LASSO) analysis. The predictive performance of the selected features was evaluated using receiver operating characteristic curve analysis and the area under the curve (AUC). Results: Nine radiomics features with non-zero coefficients were included in the LASSO regression of the radiomics score (RAD score). Infarct size (odds ratio [OR]: 1.04 (1.00–1.07); P = 0.031) and RAD score (OR: 3.43 (2.34–5.28); P < 0.001) were independent predictors of LVAR. The RAD score predicted LVAR, with an AUC (95% confidence interval [CI]) of 0.82 (0.75–0.89) in the training set and 0.75 (0.62–0.89) in the testing set. Combining the RAD score with infarct size yielded favorable performance in predicting LVAR, with an AUC of 0.84 (0.72–0.95). Moreover, the addition of the RAD score to the left ventricular ejection fraction (LVEF) significantly increased the AUC from 0.68 (0.52–0.84) to 0.82 (0.70–0.93) (P = 0.018), which was also comparable to the prediction provided by the combined microvascular obstruction, infarct size, and LVEF with an AUC of 0.79 (0.65–0.94) (P = 0.727). Conclusion: Radiomics analysis using non-contrast cine CMR can predict LVAR after STEMI independently and incrementally to LVEF and may provide an alternative to traditional CMR parameters.

Risk of Treatment-related Mortality with Sorafenib in Patients with Cancer

Zhang, Xin-Ji,Zhang, Tian-Yi,Yu, Fei-Fei,Wei, Xin,Li, Ye-Sheng,Xu, Feng,Wei, Li-Xin,He, Jia Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

Background: Fatal adverse events (FAEs) have been reported with sorafenib, a vascular endothelial growth factor receptor kinase inhibitor (VEGFR TKI). We here performed an up-to-date and detailed meta-analysis to determine the overall risk of FAEs associated with sorafenib. Methods: Databases, including PubMed, Embase and Web of Science, and abstracts presented at the American Society of Clinical Oncology annual meetings were searched to identify relevant studies. Eligible studies included randomized controlled trials evaluating sorafenib effects in patients with all malignancies. Summary incidence rates, relative risks (RRs), and 95% confidence intervals (CIs) were calculated for FAEs. In addition, subgroup analyses were performed according to tumor type and therapy regimen. Results: 13 trials recruiting 5,546 patients were included in our analysis. The overall incidence of FAEs with sorafenib was 1.99% (95%CI, 0.98-4.02%). Patients treated with sorafenib had a significantly increased risk of FAEs compared with patients treated with control medication, with an RR of 1.77 (95%CI 1.25-2.52, P=0.001). Risk varied with tumour type, but appeared independent of therapy regimen. A significantly increased risk of FAEs was observed in patients with lung cancer (RR 2.26; 95% CI 1.03-4.99; P= 0.043) and renal cancer (RR 1.84; 95% CI 1.15-2.94; P= 0.011). The most common causes of FAEs were hemorrhage (8.6%) and thrombus or embolism (4.9%). Conclusions: It is important for health care practitioners to be aware of the risks of FAEs associated with sorafenib, especially in patients with renal and lung cancer.

OsMSR15 encoding a rice C2H2-type zinc finger protein confers enhanced drought tolerance in transgenic Arabidopsis

Xin Zhang,Bin Zhang,Ming Juan Li,Xu Ming Yin,Li Fang Huang,Yan Chun Cui,Man Ling Wang,Xin Jie Xia 한국식물학회 2016 Journal of Plant Biology Vol.59 No.3

Zinc nger proteins (ZFPs) play important roles in plant responses to biotic and abiotic stresses. Through microarray analysis, an Oryza sativa L. multi-stress-responsive gene, OsMSR15, was identied and subsequently cloned from rice Pei’ai 64S (Oryza sativa L.). Expression of OsMSR15 was strongly up-regulated by cold, drought and heat stresses in different tissues at different developmental stages of rice. OsMSR15 contains two C2H2-type zinc nger motifs, a nuclear localization signal (B box), a Leu-rich domain (L-box) and a conserved EAR-motif close to its C-terminus. The OsMSR15-GFP fusion protein was localized to the nucleus. Yeast-one hybrid assay showed that OsMSR15 possesses transcriptional activation ability. Expression of OsMSR15 in Arabidopsis conferred drought tolerance, and transgenic plants showed hypersensitivity to exogenous ABA during the seed germination and post-germination stages. Transgenic plants also showed higher levels of free proline, less electrolyte leakage and increased expressions of a number of stress-responsive genes, including LEA3, RD29A, DREB1A and P5CS1 under drought stress. The obtained results indicate that OsMSR15 is an important regulator involved in plant response to drought stress.

Baseline Total Metabolic Tumor Volume and Total Lesion Glycolysis Measured on 18F-FDG PET-CT Predict Outcomes in T-Cell Lymphoblastic Lymphoma

Xiaoyan Feng,Xin Wen,Ling Li,Zhenchang Sun,Xin Li,Lei Zhang,Jingjing Wu,Xiaorui Fu,Xinhua Wang,Hui Yu,Xinran Ma,Xudong Zhang,Xinli Xie,Xingmin Han,Mingzhi Zhang 대한암학회 2021 Cancer Research and Treatment Vol.53 No.3

Purpose There is no optimal prognostic model for T-cell lymphoblastic lymphoma (T-LBL). Here, we discussed the predictive value of total metabolic tumor volume (TMTV) and total lesion glycolysis (TLG) measured on 18F-fluorodeoxyglucose positron emission tomography–computed tomography (PET-CT) in T-LBL.Materials and Methods Thirty-seven treatment naïve T-LBL patients with PET-CT scans were enrolled. TMTV was obtained using the 41% maximum standardized uptake value (SUVmax) threshold method, and TLG was measured as metabolic tumor volume multiplied by the mean SUV. Progression-free survival (PFS) and overall survival (OS) were analyzed by Kaplan-Meier curves and compared by the log-rank test.Results The optimal cutoff values for SUVmax, TMTV, and TLG were 12.7, 302 cm3, and 890, respectively. A high SUVmax, TMTV, and TLG indicated a shorten PFS and OS. On multivariable analysis, TMTV ≥ 302 cm3, and central nervous system (CNS) involvement predicted inferior PFS, while high SUVmax, TLG and CNS involvement were associated with worse OS. Subsequently, we generated a risk model comprising high SUVmax, TMTV or TLG and CNS involvement, which stratified the population into three risk groups, which had significantly different median PFS of not reached, 14 months, and 7 months for low-risk group, mediate-risk group, and high-risk group, respectively (p < 0.001). Median OS were not reached, 27 months, and 13 months, respectively (p < 0.001).Conclusion Baseline SUVmax, TMTV, and TLG measured on PET-CT are strong predictors of worse outcome in T-LBL. A risk model integrating these three parameters with CNS involvement identifies patients at high risk of disease progression.

Fabrication of Photopolymer Hierarchical Micronanostructures by Coupling Electrospinning and Photolithography for SERS Substrates

Wen-Yi Zhang,Xin-Ze Xiao,Chao Lv,Jia Zhao,Gong Wang,Xuan Gu,Ran Zhang,Bin-Bin Xu,Dan-Dan Zhang,Ai-Wu Li,Yong-Lai Zhang,Hong-Bo Sun 한국고분자학회 2013 Macromolecular Research Vol.21 No.3

Reported here is the fabrication of photopolymer hierarchical micronanostructures through a combinative process of electrospinning and subsequent photolithography. Electrospun SU-8 (epoxy-based negative photoresist)nanofiber films have been patterned into gratings with periods of 100, 200, 300, and 400 μm, respectively. Deposition of a silver nanolayer on these interlaced nanofiber films would lead to the formation of various plasmonic nanostructures,and therefore, giving rise to abundant surface-enhanced Raman scattering (SERS) “hot spots”. In the detection of Rhodamine 6G (R6G), probing molecule, the resultant SERS substrates show both high sensitivity and good reproducibility. The SERS enhancement factor could reach as high as ~108, indicating high efficiency. The fabrication of patterned, highly efficient SERS substrates may hold a great promise for the integration of SERS substrates in various microdevices such as microfluidic chips.

Investigation on the wind-induced instability of long-span suspension bridges with 3D cable system

Zhang, Xin-Jun Techno-Press 2011 Wind and Structures, An International Journal (WAS Vol.14 No.3

The cable system is generally considered to be a structural solution to increase the spanning capacity of suspension bridges. In this work, based on the Runyang Bridge over the Yangtze River, three case suspension bridges with different 3D cable systems are designed, structural dynamic characteristics, the aerostatic and aerodynamic stability are investigated numerically by 3D nonlinear aerostatic and aerodynamic analysis, and the cable system favorable to improve the wind-induced instability of long-span suspension bridges is also proposed. The results show that as compared to the example bridge with parallel cable system, the suspension bridge with inward-inclined cable system has greater lateral bending and tensional frequencies, and also better aerodynamic stability; as for the suspension bridge with outward-inclined cable system, it has less lateral bending and tensional frequencies, and but better aerostatic stability; however the suspension bridge is more prone to aerodynamic instability, and therefore considering the whole wind-induced instability, the parallel and inward-inclined cable systems are both favorable for long-span suspension bridges.

A New Multi-View and Controllable Community-Uncovering Algorithm

Zhang Xin,Wang Xiaolong,Liu Bingquan 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.7

This paper introduces a new multi-view and controllable community-uncovering algorithm, an achievement of improving PageRank algorithm and Spin-glass model, which can avoid the overlapping community structure in the process of detecting communities by means of other algorithms and also helps to improve the usual community-expansion model.The process of uncovering communities by the introduced algorithms can be divided into three steps: first, identifying the nuclear one among nodes ranked by the advanced PageRank algorithms; Second, through using multi-view recognition modularity provided by Potts spin-glass model, optimizing the expansion model of local community that is found by applying the improved Iterative Greedy algorithm to eliminate the traditional modularity’s limits in the resolution limit and the following negative effects. Finally, grasping the overlapping structure and notes carefully. By analyzing and comparing the two results of respectively using PRSGMFCA and traditional technical schemes in both computer simulation network and the real network, it proves that the former enjoys stronger stability and higher accuracy than the latter, and its computation complexity is also acceptable.

Investigation on the wind-induced instability of long-span suspension bridges with 3D cable system

Xin-Jun Zhang 한국풍공학회 2011 Wind and Structures, An International Journal (WAS Vol.14 No.3

The cable system is generally considered to be a structural solution to increase the spanning capacity of suspension bridges. In this work, based on the Runyang Bridge over the Yangtze River, three case suspension bridges with different 3D cable systems are designed, structural dynamic characteristics, the aerostatic and aerodynamic stability are investigated numerically by 3D nonlinear aerostatic and aerodynamic analysis, and the cable system favorable to improve the wind-induced instability of long-span suspension bridges is also proposed. The results show that as compared to the example bridge with parallel cable system, the suspension bridge with inward-inclined cable system has greater lateral bending and tensional frequencies, and also better aerodynamic stability; as for the suspension bridge with outward-inclined cable system, it has less lateral bending and tensional frequencies, and but better aerostatic stability; however the suspension bridge is more prone to aerodynamic instability, and therefore considering the whole wind-induced instability, the parallel and inward-inclined cable systems are both favorable for long-span suspension bridges.

Study of seismic performance of cable-stayed-suspension hybrid bridges

Xin-Jun Zhang,Zhou-Jun Yu 국제구조공학회 2015 Structural Engineering and Mechanics, An Int'l Jou Vol.55 No.6

By taking a cable-stayed-suspension hybrid bridge with main span of 1400 m as example, seismic response of the bridge under the horizontal and vertical seismic excitations is investigated numerically by response spectrum analysis and time history analysis, its seismic performance is discussed and compared to the cable-stayed bridge and suspension bridge with the same main span, and considering the aspect of seismic performance, the feasibility of using cable-stayed-suspension hybrid bridge in super long-span bridges is discussed. Under the horizontal seismic action, the effects of structural design parameters including the cable sag to span ratio, the suspension to span ratio, the side span length, the subsidiary piers in side spans, the girder supporting system and the deck form etc on the seismic performance of the bridge are investigated by response spectrum analysis, and the favorable values of these design parameters are proposed.

Study of design parameters on flutter stability of cable-stayed-suspension hybrid bridges

Zhang, Xin-Jun Techno-Press 2006 Wind and Structures, An International Journal (WAS Vol.9 No.4

The cable-stayed-suspension hybrid bridge is a cooperative system developed from the traditional cable-stayed and suspension bridges, and takes some advantages of the two bridge systems. It is also becoming a competitive design alternative for some long and super long-span bridges. But due to its great flexibility, the flutter stability plays an important role in the design and construction of this bridge system. Considering the geometric nonlinearity of bridge structures and the effects of nonlinear wind-structure interaction, method and its solution procedure of three-dimensional nonlinear flutter stability analysis are firstly presented. Parametric analyses on the flutter stability of a cable-stayed-suspension hybrid bridge with main span of 1400 meters are then conducted by nonlinear flutter stability analysis, some design parameters that significantly influence the flutter stability are pointed out, and the favorable structural system of the bridge is also discussed based on the wind stability.