Generalized weighted composition operators from area Nevanlinna spaces to weighted-type spaces

Yang Weifeng,Yan Weiren 대한수학회 2011 대한수학회보 Vol.48 No.6

Let H(D) denote the class of all analytic functions on the open unit disk D of the complex plane C. Let n be a nonnegative integer, φ be an analytic self-map of D and u∈ H(D). The generalized weighted composition operator is defined by [수식]=uf^(n)Οφ, f∈H(D). The boundedness and compactness of the generalized weighted composition operator from area Nevanlinna spaces to weighted-type spaces and little weighted-type spaces are characterized in this paper.

GENERALIZED WEIGHTED COMPOSITION OPERATORS FROM AREA NEVANLINNA SPACES TO WEIGHTED-TYPE SPACES

Weifeng, Yang,Weiren, Yan Korean Mathematical Society 2011 대한수학회보 Vol.48 No.6

Let $H(\mathbb{D})$ denote the class of all analytic functions on the open unit disk $\mathbb{D}$ of the complex plane $\mathbb{C}$. Let n be a nonnegative integer, ${\varphi}$ be an analytic self-map of $\mathbb{D}$ and $u{\in}H(\mathbb{D})$. The generalized weighted composition operator is defined by $$D_{{\varphi},u}^nf=uf^{(n)}{\circ}{\varphi},\;f{\in}H(\mathbb{D})$$. The boundedness and compactness of the generalized weighted composition operator from area Nevanlinna spaces to weighted-type spaces and little weighted-type spaces are characterized in this paper.

Zearalenone exposure affects the Wnt/β-catenin signaling pathway and related genes of porcine endometrial epithelial cells in vitro

Song Tingting,Yang Weiren,Huang Libo,Yang Zaibin,Jiang Shuzhen 아세아·태평양축산학회 2021 Animal Bioscience Vol.34 No.6

Objective: Zearalenone (ZEA) has estrogen-like effects. Our previous study has shown that ZEA (0.5 to 1.5 mg/kg) could induce abnormal uterine proliferation through transforming growth factor signaling pathway. To further study the other regulatory networks of uterine hypertrophy caused by ZEA, the potential mechanism of ZEA on porcine endometrial epithelial cells (PECs) was explored by the Illumina Hiseq 2000 sequencing system. Methods: The PECs were treated with ZEA at 0 (ZEA0), 5 (ZEA5), 20 (ZEA20), and 80 (ZEA80) μmol/L for 24 h. The collected cells were subjected to cell cycle, RNA-seq, real-time quantitative polymerase chain reaction, immunofluorescence, and western blot analysis. Results: The proportion of cells in the S and G2 phases decreased (p<0.05), but the proportion of cells in the G1 phase increased (p<0.05) in the ZEA80 treatment. Data analysis revealed that the expression of Wnt pathway-related genes, estrogen-related genes, and mitogen-activated protein kinase pathway-related genes increased (p<0.05), but the expression of genetic stability genes decreased (p<0.05) with increasing ZEA concentrations. The relative mRNA and protein expression of WNT1, β-catenin, glycogen synthase kinase 3β (GSK-3β) were increased (p<0.05) with ZEA increasing, while the relative mRNA and protein expression of cyclin D1 (CCND1) was decreased (p<0.05). Moreover, our immunofluorescence results indicate that β-catenin accumulated around the nucleus from the cell membrane and cytoplasm with increasing ZEA concentrations. Conclusion: In summary, ZEA can activate the Wnt/β-catenin signaling pathway by upregulating WNT1 and β-catenin expression, to promote the proliferation and development of PECs. At the same time, the up-regulation of GSK-3β and down-regulation of CCND1, as well as the mRNA expression of other pathway related genes indicated that other potential effects of ZEA on the uterine development need further study. Objective: Zearalenone (ZEA) has estrogen-like effects. Our previous study has shown that ZEA (0.5 to 1.5 mg/kg) could induce abnormal uterine proliferation through transforming growth factor signaling pathway. To further study the other regulatory networks of uterine hypertrophy caused by ZEA, the potential mechanism of ZEA on porcine endometrial epithelial cells (PECs) was explored by the Illumina Hiseq 2000 sequencing system.Methods: The PECs were treated with ZEA at 0 (ZEA0), 5 (ZEA5), 20 (ZEA20), and 80 (ZEA80) μmol/L for 24 h. The collected cells were subjected to cell cycle, RNA-seq, real-time quantitative polymerase chain reaction, immunofluorescence, and western blot analysis.Results: The proportion of cells in the S and G2 phases decreased (p<0.05), but the proportion of cells in the G1 phase increased (p<0.05) in the ZEA80 treatment. Data analysis revealed that the expression of Wnt pathway-related genes, estrogen-related genes, and mitogen-activated protein kinase pathway-related genes increased (p<0.05), but the expression of genetic stability genes decreased (p<0.05) with increasing ZEA concentrations. The relative mRNA and protein expression of WNT1, β-catenin, glycogen synthase kinase 3β (GSK-3β) were increased (p<0.05) with ZEA increasing, while the relative mRNA and protein expression of cyclin D1 (CCND1) was decreased (p<0.05). Moreover, our immunofluorescence results indicate that β-catenin accumulated around the nucleus from the cell membrane and cytoplasm with increasing ZEA concentrations.Conclusion: In summary, ZEA can activate the Wnt/β-catenin signaling pathway by up-regulating WNT1 and β-catenin expression, to promote the proliferation and development of PECs. At the same time, the up-regulation of GSK-3β and down-regulation of CCND1, as well as the mRNA expression of other pathway related genes indicated that other potential effects of ZEA on the uterine development need further study.

Protective effect of Macleaya cordata isoquinoline alkaloids on lipopolysaccharide-induced liver injury in broilers

Jiaxin Chen,Weiren Yang,Hua Liu,Jiaxing Niu,Yang Liu,Qun Cheng Asian Australasian Association of Animal Productio 2024 Animal Bioscience Vol.37 No.1

Objective: This experiment aimed to explore the protective action of dietary supplementation with isoquinoline alkaloids (IA) from Macleaya cordata on lipopolysaccharide (LPS)-induced liver injury in broilers. Methods: Total 216 healthy broilers were selected in a 21-d trial and assigned randomly to the following 3 treatments: control (CON) group, LPS group, and LPS+IA group. The CON and LPS groups were provided with a basal diet, whereas the LPS+IA group received the basal diet supplemented with 0.6 mg/kg Macleaya cordata IA. Broilers in LPS and LPS+IA groups were intraperitoneally injected with LPS (1 mg/kg body weight) at 17, 19, and 21 days of age, while those in CON group were injected with equivalent amount of saline solution. Results: Results showed LPS injection caused systemic and liver inflammation in broilers, inhibited immune function, and ultimately lead to liver injury. By contrast, supplementation of IA ameliorated LPS-induced adverse change in serum parameters, boosted immunity in LPS+IA group. Furthermore, IA suppressed the elevation of hepatic inflammatory cytokines and caspases levels induced by LPS, as well as the expressions of genes related to the toll-like receptor 4 (TLR4)/myeloid differentiation primary response 88 (MyD88)/nuclear factor-kappa B (NF-κB) pathway. Conclusion: Dietary inclusion of 0.6 mg/kg Macleaya cordata IA could enhance immune function of body and inhibit liver damage via inactivating TLR4/MyD88/NF-κB signaling pathway in broilers.

Neuromonitoring in Cervical Spine Surgery: When Is a Signal Drop Clinically Significant?

Decruz Joshua,Kaliya-Perumal Arun-Kumar,Wong Kevin Ho-Yin,Kumar Dinesh Shree,Yang Eugene Weiren,Oh Jacob Yoong-Leong 대한척추외과학회 2021 Asian Spine Journal Vol.15 No.3

Study Design: Retrospective cohort study. Purpose: To identify the clinical significance of different patterns of intraoperative neuromonitoring (IONM) signal alerts. Overview of Literature: IONM is a long-established valuable adjunct to complex spine surgeries. IONM for cervical spine surgery is in the form of somatosensory evoked potential (SSEP) and motor evoked potential (MEP). The efficacy of both modalities (individually or in combination) to detect clinically significant neurological compromise is constantly being debated and requires conclusive suggestions. Methods: Clinical and neuromonitoring data of 207 consecutive adult patients who underwent cervical spine surgeries at multiple surgical centers using bimodal IONM were analyzed. Signal changes were divided into three groups. Group 0 had transient signal changes in either MEPs or SSEPs, group 1 had sustained unimodal changes, and group 2 had sustained changes in both MEPs and SSEPs. The incidences of true neurological deficits in each group were recorded. Results: A total of 25% (52/207) had IONM signal alerts. Out of these signal drops, 96% (50/52) were considered to be false positives. Groups 0 and 1 had no incidence of neurological deficits, while group 2 had a 29% (2/7) rate of true neurological deficits. The sensitivities of both MEP and SSEP were 100%. SSEP had a specificity of 96.6%, while MEP had a lower specificity at 76.6%. C5 palsy rate was 6%, and there was no correlation with IONM signal alerts (p=0.73). Conclusions: This study shows that we can better predict its clinical significance by dividing IONM signal drops into three groups. A sustained, bimodal (MEP and SSEP) signal drop had the highest risk of true neurological deficits and warrants a high level of caution. There were no clear risk factors for false-positive alerts but there was a trend toward patients with cervical myelopathy.

Numerical Simulation of Prestressed Precast Concrete Bridge Deck Panels Using Damage Plasticity Model

Wei Ren,Lesley H. Sneed,Yang Yang,Ruili He 한국콘크리트학회 2015 International Journal of Concrete Structures and M Vol.9 No.1

This paper describes a three-dimensional approach to modeling the nonlinear behavior of partial-depth precast prestressed concrete bridge decks under increasing static loading. Six full-size panels were analyzed with this approach where the damage plasticity constitutive model was used to model concrete. Numerical results were compared and validated with the experimental data and showed reasonable agreement. The discrepancy between numerical and experimental values of load capacities was within six while the discrepancy of mid-span displacement was within 10 %. Parametric study was also conducted to show that higher accuracy could be achieved with lower values of the viscosity parameter but with an increase in the calculation effort.