Phase I/II study of S-1 combined with weekly docetaxel in patients with metastatic gastric carcinoma

Park, S R,Kim, H K,Kim, C G,Choi, I J,Lee, J S,Lee, J H,Ryu, K W,Kim, Y-W,Bae, J-M,Kim, N K Cancer Research UK 2008 The British journal of cancer Vol.98 No.8

We designed a phase I/II trial of S-1 combined with weekly docetaxel to determine the maximum tolerated dose (MTD) and recommended dose (RD) and to evaluate the efficacy and toxicity in metastatic gastric carcinoma (MGC). Patients with measurable disease received S-1 orally b.i.d. on days 1–14 and docetaxel intravenously on days 1 and 8 every 3 weeks. In phase I (n=30), each cohort received escalating doses of S-1 (30–45 mg m<SUP>−2</SUP> b.i.d.) and docetaxel (25–40 mg m<SUP>−2</SUP>); MTD was 45 mg m<SUP>−2</SUP> b.i.d. S-1/35 mg m<SUP>−2</SUP> docetaxel and RD was 40 mg m<SUP>−2</SUP> b.i.d. S-1/35 mg m<SUP>−2</SUP> docetaxel. Dose-limiting toxicities included grade 3 elevated liver enzymes, gastric perforation, grade 3 diarrhoea/fatigue, febrile neutropenia with grade 3 anorexia/fatigue, and neutropenic infection with grade 3 stomatitis/anorexia. In phase II (n=52), the overall response rate was 66.7% (95% confidence interval (CI): 53.8–79.6%) and the median time to progression and overall survival were 6.5 months (95% CI: 4.9–8.1) and 13.7 months (95% CI: 9.9–17.5), respectively. The most common grade 3/4 toxicity was neutropenia (29.4%), and febrile neutropenia/neutropenic infection occurred in 19.6% of patients. Non-haematological toxicities were generally mild. There was one treatment-related death due to pneumonitis. S-1 combined with weekly docetaxel is active in MGC with moderate toxicities.British Journal of Cancer (2008) 98, 1305–1311. doi:10.1038/sj.bjc.6604312 www.bjcancer.com Published online 25 March 2008

Various supercritical carbon dioxide cycle layouts study for molten carbonate fuel cell application

Bae, S.J.,Ahn, Y.,Lee, J.,Lee, J.I. Elsevier Sequoia 2014 Journal of Power Sources Vol.270 No.-

Various supercritical carbon dioxide (S-CO<SUB>2</SUB>) cycles for a power conversion system of a Molten Carbonate Fuel Cell (MCFC) hybrid system are studied in this paper. Re-Compressing Brayton (RCB) cycle, Simple Recuperated Brayton (SRB) cycle and Simple Recuperated Transcritical (SRT) cycle layouts were selected as candidates for this study. In addition, a novel concept of S-CO<SUB>2</SUB> cycle which combines Brayton cycle and Rankine cycle is proposed and intensively studied with other S-CO<SUB>2</SUB> layouts. A parametric study is performed to optimize the total system to be compact and to achieve wider operating range. Performances of each S-CO<SUB>2</SUB> cycle are compared in terms of the thermal efficiency, net electricity of the MCFC hybrid system and approximate total volumes of each S-CO<SUB>2</SUB> cycle. As a result, performance and total physical size of S-CO<SUB>2</SUB> cycle can be better understood for MCFC S-CO<SUB>2</SUB> hybrid system and especially, newly suggested S-CO<SUB>2</SUB> cycle shows some success.

서울대학교 保健大學院 博士課程 敎育프로그램의 評價的 硏究

김정순,김성옥,문용,박은옥,박태진,배은영,정인숙 서울大學校 保健大學院 國民保健硏究所 1997 國民保健硏究所 硏究論叢 Vol.7 No.2

Predictive risk factors for Listeria monocytogenes meningitis compared to pneumococcal meningitis: a multicenter case–control study

Lim, S.,Chung, D. R.,Kim, Y. S.,Sohn, K. M.,Kang, S. J.,Jung, S. I.,Kim, S. W.,Chang, H. H.,Lee, S. S.,Bae, I. G. Springer Science + Business Media 2017 Infection Vol.45 No.1

<P>Patients with a prior history of receiving immunosuppressive therapy within 1 month and chronic liver disease have 8.1-fold and 5-fold increased risk of meningitis by L. monocytogenes compared to S. pneumoniae, respectively.</P>

서울대학교 保健大學院 博士課程 敎育프로그램의 評價的 硏究

정인숙,박태진,김성옥,배은영,박은옥,김정순,문 용 서울大學校保健大學院 1997 國民保健硏究所硏究論叢 Vol.7 No.2

The doctoral program of school of Public Health in Seoul National University was established in 1976 and about 100 students have graduated or completed the course. Even though there have been several studies on evaluating the educational programs of the school, both master's and doctorate's since early 1980s, this study was carried out to identify needs of students, their performance and perceived achievements, unmet needs and barriers in achieving their educational goals only on doctoral graduates. The study was done by the students of doctoral program taking 'evaluative research in public health services' course as a practice under the direction of the teaching staff. Out of 91 eligibles 51 persons responded to the mail and/or telephone interview, and the results obtained are as followings: 1) The goal of the doctoral program of the Public Health, SNU that was to produce competent public health specialists furnished with full abilities of performong research, education and administration(service)has not been changed since 1976 as was set on the program establishment. 2) The objective of enrollment to the program stated by the subjecs varied considerably; majority of them(47%) for expanding scope of public health sceience, for advanced degree(39%), for contribution to the progress of public health sceience(20%), for better job(20%) and for pure academic interest(2%). 3) The needs of students by area of concern, for instance research, theaching and administration, each classified into several performance is viewed as the proportion accomplished out of needs, which are quantified by 5-point Likert scale, most of the graduates indicated that they have accomplished their needs in 83-92% for research abilities, 75-92% for teaching sbilities and 72-96% for administration abilities, the average performance being the highes in research. 5) The barriers that hindered their performance were the school facilities, such as library(72.5%), deficient funds for research(39.2%), insufficient students' room(33.3%) and deficient laboratory supplies(25.5%). 6) The barrier related to student's characteristics were insufficient study time for part-time student(56.9%), deficient study motivation(45.1%), tendency to take easy curriculum(29.4%) and addmittence of less qualificated students(19.6%). 7) The barrier related to professor's characteristics were deficiency of self-development endeavour(62.7%), lack of professor majoring in some particular fields of public health(39.2%), infrequent collaborative researches/activities with students (17.6%), and absolutely deficient number of professors that are necessary for the program(17.6%). In general, however, the graduates appered to be satisfied in terms of what they have accomplished through the current educational program, which have been revised by the school from time to time to cope with the student's as well as community's demand.

Simulation study on effect of drain underlap in gate-all-around tunneling field-effect transistors

Lee, J.S.,Seo, J.H.,Cho, S.,Lee, J.H.,Kang, S.W.,Bae, J.H.,Cho, E.S.,Kang, I.M. Elsevier 2013 Current Applied Physics Vol.13 No.6

In this work, the effects of underlapping drain junction on the performances of gate-all-around (GAA) tunneling field-effect transistors (TFETs) have been studied in terms of direct-current (DC) characteristics including on-current (I<SUB>on</SUB>), off-current (I<SUB>off</SUB>), subthreshold swing (S), and I<SUB>on</SUB>/I<SUB>off</SUB> ratio. In addition, the dependences of intrinsic delay time (τ) and radio-frequency (RF) performances including cut-off frequency (f<SUB>T</SUB>) and maximum oscillation frequency (f<SUB>max</SUB>) on gate-drain capacitance (C<SUB>gd</SUB>) with the underlapping were investigated as the gate length (L<SUB>gate</SUB>) is scaled. A GAA TFET with asymmetric junctions, with an underlap at the drain side, demonstrated DC and RF performances superior to those of a device with symmetric junctions.

용융탄산염 연료전지용 스테인리스강 분리판의 부식거동

박형호,윤재식,배인성,김병일 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.12

In order to investigate the corrosion resistance at the anode side separator for molten carbonate fuel cell, STS310S and SC-STS310S (chromium and aluminum were simultaneously deposited by diffusion into STS310S austenitic stainless steel substrate by pack-cementation process) were used as the separator material. In case of STS310S, corrosion proceeded via three steps; a formation step of corrosion product, a protection step against corrosion, an advance step of corrosion after breakaway. From the standpoint of the behavior of the elements in the specimen, Fe, Cr and Ni were formed richly in the region of corrosion product, in the region of corrosion protection, and at the Cr-deplete zone respectively. Especially, STS310S would be impossible to be used as a separator without suitable surface modification because of rapid corrosion rate after formation of corrosion product, making the severe problem on stability of cell during long-time operation. Whereas, SC-STS310S showed higher corrosion resistance than the present separator, STS310S. And SC-STS 310S can be expected to use for an alternative separator at the anode side by developing coating and pre-treatment process which can lead to dense coating layer and very high corrosion resistance respectively.

[S9-1] Anti-diabetic Effects of Two Variants of Korean Arlemisia princeps Pampanini Cultivated in Ganghwa Island

U.J. Jung,N-I. Bae,H-G. Chung,M-H. Bang,J-S. Yoo,T-S. Jeong,K-T. Lee,Y-J. Kang,M-K. Lee,S-N. Ryu,M-S. Choi 한국식품영양과학회 2006 한국식품영양과학회 학술대회발표집 Vol.2006 No.10

Effects of mechanical stresses on the reliability of low-temperature polycrystalline silicon thin film transistors for foldable displays

Bae, M.S.,Park, C.,Shin, D.,Lee, S.M.,Yun, I. Pergamon Press 2017 Solid-state electronics Vol.133 No.-

This paper investigates the mechanical reliability of low temperature polycrystalline silicon (LTPS) thin film transistors (TFTs) for foldable display. Both compressive and tensile directions of mechanical stresses were applied for different types of mechanical stresses, such as dynamic and static mechanical stresses. The electrical characteristics of tested n-channel TFTs under mechanical stress conditions were analyzed based on several key parameters, including the threshold voltage (V<SUB>th</SUB>), field effect mobility (μ<SUB>FE</SUB>), maximum drain current (I<SUB>D.MAX</SUB>) and subthreshold swing (S<SUB>sub</SUB>). For both cases of dynamic and static mechanical stresses, increase of V<SUB>th</SUB> and decrease of μ<SUB>FE</SUB> and I<SUB>D.MAX</SUB> were observed in the compressive direction. This trend was inversed when tensile stress was applied. The degradation of electrical characteristics originates from the change of lattice constant after mechanical stress. However, S<SUB>sub</SUB> increases under dynamic tensile stress while it remains unchanged within 5% under static tensile stress. Transient analysis while bent condition was conducted to investigate the change of parameters in time.

원발성 간암에서 PIVKA-II 및 Lens Culinaris Agglutinin-A 반응성 Alpha-fetoprotein(AFP-L3)의 임상적 유용성

배시현,박두호,양진모,박영민,차상복,최종영,성광용,조세현,정규원,선희식,김부성,최상욱,변병훈,한남익 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.2

Background/Aims: Des-γ-carboxy prothrombin(DCP), a protein induced by vitamin K absence or antagonist-II(PIVKA-II), and Lens culinaris agglutinin-A reactive AFP-L3 have been reported to be useful markers for the diagnosis of hepatocellular carcinoma (HCC). In the present study, both the PIVKA-II and AFP-L3 were analyzed and compared with a conventional AFP to determine its usefulness, specificity and sensitivity in the diagnosis of HCC. Methods: Sera were collected from 108 patients consisting of 17 patients with chronic hepatitis, 22 patients with liver cirrhosis and 69 patients with HCC. The AFP-L3 was determined by an lectin affinity electrophoresis coupled with an antibody-affinity blotting. Level of DCP was measured by an enzyme immunoassay with an anti-DCP monoclonal antibody. Results: The sensitivity and specificity of PIVKA-II and AFP L3 were 49.3% and 89.5%, and 32.5% and 85.7%, respectively. No significant correlation was found between the PIVKA-II or AFP L3 and serum AFP. No correlation was found etween the PIVKA-II or AFP L3 and the characteristics of HCC. Conclusion: The determination of plasma DCP and AFP L3 levels combined with AFP levels may be useful especially for the differential diagnosis between HCC and chronic liver diseases without HCC.(Korean J HepatoBackground/Aims: Des-γ-carboxy prothrombin(DCP), a protein induced by vitamin K absence or antagonist-II(PIVKA-II), and Lens culinaris agglutinin-A reactive AFP-L3 have been reported to be useful markers for the diagnosis of hepatocellular carcinoma (HCC). In the present study, both the PIVKA-II and AFP-L3 were analyzed and compared with a conventional AFP to determine its usefulness, specificity and sensitivity in the diagnosis of HCC. Methods: Sera were collected from 108 patients consisting of 17 patients with chronic hepatitis, 22 patients with liver cirrhosis and 69 patients with HCC. The AFP-L3 was determined by an lectin affinity electrophoresis coupled with an antibody-affinity blotting. Level of DCP was measured by an enzyme immunoassay with an anti-DCP monoclonal antibody. Results: The sensitivity and specificity of PIVKA-II and AFP-L3 were 49.3% and 89.5%, and 32.5% and 85.7%, respectively. No significant correlation was found between the PIVKA-II or AFP-L3 and serum AFP. No correlation was found etween the PIVKA-II or AFP L3 and the characteristics of HCC. Conclusion: The determination of plasma DCP and AFP-L3 levels combined with AFP levels may be useful especially for the differential diagnosis between HCC and chronic liver diseases without HCC.(Korean J Hepatol 2000;6:205-214)l 2000;6:205-214)