사체간이식 환자와 생체간이식 환자들의 삶의 질 비교 연구

김금희,윤석준,안형식,이준영,박형근,서경석 한국의료QA학회 2004 한국의료질향상학회지 Vol.11 No.1

Objective : The aim of this study were to measure quality of life(QOL) in liver transplant recipicnts, to ocmpare QOL between living donor liver transplant recipicnts and cadavcric live transplant recipients and to investgatre whether SF-36 may be used as a disease-specific instrument in liver transplant recipients. Methods : We conducted a single-center cross-sectional study of 133 LT recipients ages 13 to 65 years, all of whom had had Liver Transplantion(LT) at least 1 months previously. QOL was assessed using a self-completion questionnaire consisting of the Bang Whal Ran(1991) instruments and the 36-Item Short-Firm Health Survey(SF-36) health status profile measure. We investigated whether the SF-36 instrument may be used as a disease-specific instrument in LT recipients. Individual scale scores range from 0 to 100 , with higher score reflecting better health. Data on demograpics, clinical status at pre transplantation 1 day, post transplantation clinical statns, and graft gunction were collected to identify predictors of post transplantation QOL. Results : Standard measures for test-rtest reliability, internal consistency, and discriminant and concurrent validity were examined. The reliability of the SF-36, as measured by test-retest correlation(Pearson coeffocoents: 0.729, p=0.002) and by internal consistency (Cronbach's alpha: 0.9431) exceeded conbentional acceptability criteria. The correlation between domain scores of SF-36 and the Bang Whal Ran(1991) was clear and logical in that the clinical characteristics of SF-36 strongly correlated with the clinical component summary score of the Bang Whal Ran(1991)(r = 0.8155, P<01). SF-36 scale scores were compared between Cadaveric Liver Transplant recipients and Living Donor Liver Transplant recipients. Donor types of post LT did not influence HRQOL(P >0.05). 87% of the liver transplant recipients were safisfied to get LT. Satisfaction of post LT showed significantly greater HRQOL(p<0.001). Conclusion : SF-36 is found reliable and valid. This study indicates thet Donor Type did not influence HRQOL after LT. The information gained from this study will help us to better define expectations and the colinical course after liver transplantation to patients and their families.

진로,직업교육을 위한 특수교육기관과 관련기관 간의 협력에 관한 연구

정인숙 ( In Suk Jeong ),김형일 ( Hyeung-il Kim ),박재국 ( Jea Kook Park ) 한국특수교육문제연구소 2008 특수교육저널 : 이론과 실천 Vol.9 No.4

이 연구는 진로.직업 교육을 위한 특수교육기관과 관련기관간의 협력에 있어서 투입요인과 과정요인으로 분류하여 그 실태를 분석하는데 목적을 두었다. 이를 위해 전국 특수학교(급), 특수교육지원센터에 재직하고 있는 1,005명의 교사를 대상으로 설문조사를 실시하였다. 연구결과, 첫째, 진로.직업교육을 위한 관련기관 간 협력에 있어서 투입요인으로, 인적 자원의 협력은 극히 미미한 것으로 나타났으며, 지역에서 활용하고 있는 관련기관은 주로 정신지체.정서장애학교 및 특수학급의 경우는 장애인복지관, 감각장애학교는 장애인고용촉진공단인 것으로 나타났다. 둘째, 과정요인으로, 관련 기관과 연계한 교육내용에 따른 주된 활동은 ‘현장견학’과 현장실습이었고, 평가는 대부분 학교자체에서 이루어지고 있는 것으로 나타났다. 평가의 효율성을 위한 요구사항은 외부 직업 관련기관과의 연계 요구가 가장 높았으며, 기관간 연계를 위한 바람직한 협력 방법에 관해서는 각 부처(교육인적자원부, 보건복지부, 노동부)의 통합된 통합고용지원팀의 구성을 요구하고 있었다. The purpose of this research is to anaylze the statue of cooperation between special education institutes and related agency for career and vocational education according to the input and process factor. For this, we used a question survey as the general study method. The recipients are 1,005 people in charge of special education schools, special education classes, or special education support center. Those are as follows. First, as an input factors of the cooperation in related agency for career ; vacational education, a cooperation of human resource are appeared very dull. especially, in case of the schools for mentally retardation and emotional disturbance, they used mostly The Local Community Welfare Agency for The Disabled, but other schools for sensory impairment used mostly Korea Employment Promotion Agency for the Disabled Second, as a process factor, the major activation according to the curriculum linked lelated agency are field trip and on-the-job training, the schools conducted the evaluation by themselves. so they are needed linked evaluation methods to the related agencies for establishment of effective evaluation. and as an effective cooperation method for interagency linking, totally, they are needed organizing ‥integrated employment team…through the cooperation with each ministry of departments(Ministry of Education Science and Technology, Ministry of Health Welfare and Family Affairs, Ministry of Labor).

화분의 영양생화학적 연구 - Aniline이 유도한 간 독성에 미치는 진달래 화분의 영향 -

권정숙(Chong-Suk Kwon),조수열(Soo-Yeul Cho),정형재(Hyeung-Jae Chung),박종민(Jong-Min Park),허근(Keun Huh) 한국식품영양과학회 1989 한국식품영양과학회지 Vol.18 No.3

진달래 화분의 해독 작용을 연구할 목적으로 aniline을 model 약물로 하여 간 조직에 대한 병태 생리학적 동태를 대사 효소의 활성과 관련지어 검토하였다. 진달래 화분 각 추출물을 투여한 군이 대조군에 비해 간 aniline hydroxylase의 활성이 증가되었으며, 진달래 화분 물 추출물 투여에 의한 간 aniline hydroxylase 활성 증가를 동력학적인 측면에서 관찰하였을 때 Km치는 변하지 않았으나 Vmax가 증가하는 점으로 보아 본 효소의 단백 합성이 촉진될 결과라고 사료된다. 또한 aniline만 투여한 군에 비해 진달래 화분 각 추출물을 투여한 실험군이 aniline의 혈중 농도와 간 손상을 현저히 감소시켰고, 이러한 작용한 물 추출물에서 가장 강하게 나타났다. 이로써 진달래 화분 투여에 의한 aniline의 간독성 예방 효과는 진달래 화분 추출물에 의한 간 aniline hydroxylase의 활성증가와 관련되어 나타난 것으로 사료되어진다. Preventive effect of azalea pollen extracts against aniline-induced hepatic toxicity in mice was investigated in this experiment. When the biochemical and histological changes were measured, preventive effect was more striking by treatment with water extract. After treatment with azalea pollen extracts, hepatic microsomal aniline hydroxylase activity increased as compared to control. Whereas, aniline level in serum and liver significantly decreased. The Vmax value without affecting Km value increased by the water extract treatment, the results obtained suggest that the characteristics of increase in the aniline hydroxylase activity may include induction of enzyme proteins. These data indicate that the observed preventive effects of azalea pollen extracts against hepatotoxicity is due to the induction of aniline metabolizing enzyme.

VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy

Kim, Minah,Park, Hyeung Ju,Seol, Jae Won,Jang, Jeon Yeob,Cho, Young-Suk,Kim, Kyu Rae,Choi, Youngsok,Lydon, John P,DeMayo, Francesco J,Shibuya, Masabumi,Ferrara, Napoleone,Sung, Hoon-Ki,Nagy, Andras,Al Blackwell Publishing Ltd 2013 EMBO molecular medicine Vol.5 No.9

<P>The features and regulation of uterine angiogenesis and vascular remodelling during pregnancy are poorly defined. Here we show that dynamic and variable decidual angiogenesis (sprouting, intussusception and networking), and active vigorous vascular remodelling such as enlargement and elongation of ‘vascular sinus folding’ (VSF) and mural cell drop-out occur distinctly in a spatiotemporal manner in the rapidly growing mouse uterus during early pregnancy — just after implantation but before placentation. Decidual angiogenesis is mainly regulated through VEGF-A secreted from the progesterone receptor (PR)-expressing decidual stromal cells which are largely distributed in the anti-mesometrial region (AMR). In comparison, P<SUB>4</SUB>-PR-regulated VEGF-A-VEGFR2 signalling, ligand-independent VEGFR3 signalling and uterine natural killer (uNK) cells positively and coordinately regulate enlargement and elongation of VSF. During the postpartum period, Tie2 signalling could be involved in vascular maturation at the endometrium in a ligand-independent manner, with marked reduction of VEGF-A, VEGFR2 and PR expressions. Overall, we show that two key vascular growth factor receptors — VEGFR2 and Tie2 — strikingly but differentially regulate decidual angiogenesis and vascular remodelling in rapidly growing and regressing uteri in an organotypic manner.</P>

특수교육대상자의 졸업 후 지역사회 고용에 따른 진로,직업교육 개선방안

정인숙 ( In Suk Jeong ),김형일 ( Hyeung Il Kim ),박재국 ( Jea Kook Park ) 한국특수아동학회 2008 특수아동교육연구 Vol.10 No.2

수산물의 콜레스테롤함량과 가공중의 변화

이용우,박영호,강진훈,천석조,이병일 한국수산학회 1984 한국수산과학회지 Vol.17 No.4

水産物을 加工處理할 때 콜레스테롤含量이 어떻게 變化하는가를 알기 위하여 살오징어, 뱀장어, 고등어, 바지락 및 미역 등 5종류를 試料로 하여 살오징어는 日乾, 뱀장어는 焙燒, 고등어는 鹽乾, 바지락은 煮乾, 미역은 鹽藏 등의 處理를 하였을 때의 콜레스테롤含量의 變化를 調査檢討하였다. 1. 生試料에 있어서의 콜레스테롤含量은 살오징어가 761㎎/100g(乾物量)으로 가장 높았고, 이어 뱀장어, 바지락, 미역의 順이었으며, 生試料의 콜레스테롤含量과 脂質含量과의 關聯性은 찾아 볼 수가 없었다. 2. 살오징어, 뱀장어, 고등어 및 미역 등 4종류의 試料는 加工處理에 의하여 콜레스테롤含量이 감소하였는데, 살오징어는 日乾에 의하여 生試料 때의 66.4%로 감소하였으며, 뱀장어는 焙燒處理에 의하여 43.6%로, 고등어는 鹽乾處理에 의하여 41.0%로 미역은 鹽藏處理에 의하여 58.1%로, 각각 감소하였다. 3. 바지락은 煮乾處理에 의하여 콜레스테롤含量이 生試料 때의 1.6倍로 증가하여 다른 試料와 對照的인 結果를 나타내었다. 4. 加工處理에 의한 콜레스테롤含量의 變化는 脂質含量의 變化와 相關關係가 있어 脂質含量의 감소가 큰 것일수록 콜레스테롤含量의 감소도 많았다. This experiment was carried out to investigate the changes of cholesterol contents during the processing of various marine products. For the above purpose, squid, eel, mackerel, baby clam and sea mustard were sun-dried, roasted, salted-dried, boiled-dried and salted, respectively. In raw samples, the highest content of cholesterol was 761㎎/100g in squid, following by eel, baby clam, mackerel and sea mustard in order, and there was no significant relationship between cholesterol and lipid contents. The cholesterol contents of the used samples were decreased during the processing except baby clam. The decreasing ratios of the cholesterol contents during the processing were 66.4% in squid, 43.6% in eel, 41% in mackerel and 58% in sea mustard. While the cholesterol content of baby clam was increased by 1.6 times compared with that of raw sample. Considered from the results, it seems that the changes of cholesterol content during processing depended upon the changes of lipid content in the sample.

외부온도 변화에 따른 인체의 생리적 반응(1)

김유진(Yu-Jin Kim),박승한(Sung-Han Park),최창렬(Chang-Ryeul Choi),김형국(Hyeung-Kuk Kim),김유영(You-Young Kim),권용훈(Yong-Hoon Kwon),김현정(Hyun-Jung Kim),우숙향(Suk-Hyang Woo),정혁(Hyuk Jung),천영신(Young-Shin Chon),김종기(Jong-Ki 한국생활환경학회 1998 한국생활환경학회지 Vol.5 No.1

청주지역 거주 중국 유학생들의 식행동, 식태도 및 식품섭취실태

김기남(Ki Nam Kim),박은혜(Eun Hye Park),오은희(Eun Hee Oh),이미경(Mee Kyeung Lee),최형호(Hyeung Ho Choi),조진숙(Jin Suk Cho) 충북대학교 생활과학연구소 2013 생활과학연구논총 Vol.17 No.1

The purposes of this study were to investigate dietary behavior, dietary attitude, and food frequency of Chinese students studying in the university of Cheongju area and collect basic data for their nutrition education in future. The subjects include total 161 college students(male: 54, female: 107). The survey lasted for about six months from April 1 to June 30, 2011. In dietary behavior, 64.8% of male students and 72.1% of female students skipped a meal. They skipped "breakfast" the most. The most popular reason for skipping a meal was "lack of time." Of male students, 14.8% took them less than ten minutes to finish a meal, and 46.3% of male students and 48.6% of female students did not check the nutrition label. The male students recorded the highest points on two items of dietary attitude, which were "I have interest in information about nutrition and health"(3.6 points) and "I value nutrition more than high consumption of what I want to have"(3.6 points). The female students recorded the highest points on "I always have interest in what to eat"(3.8 points). Both the groups scored low points on "I should pay attention to my health even when I take vitamins or restoratives." In food frequency, the male students consumed pork(p<0.05) more frequently than their female counterparts, who consumed boiled fish paste(p<0.05) and chocolate(p<0.05) more frequently than their male counterparts. Both duration and type of stay turned out to affect the dietary behavior, dietary attitude, and food frequency of the two groups. Those findings suggest that it will be effective to develop content by taking the duration and type of stay into account when providing nutrition education to Chinese students living and studying in the nation and further to develop menus and cooking practice to suit their taste.

가임기 여성의 유방암 토모치료 시 난소선량 평가비교

이수형,박수연,최지민,박주영,김종석,Lee, Soo Hyeung,Park, Soo Yeun,Choi, Ji Min,Park, Ju Young,Kim, Jong Suk 대한방사선치료학회 2014 대한방사선치료학회지 Vol.26 No.2

목 적 : 최근 시행되고 있는 가임기 여성의 유방암 토모치료 시 치료영역 외에서 발생되는 산란 및 누설에 의한 난소산란선량을 측정하여 평가하고자 한다. 대상 및 방법 : 인체모형팬텀(Aldorson Rando phantom, USA)을 대상으로 전산화단층영상 2.5 mm 획득 후, Tomotherapy Planning station(Tomotherapy, Inc, USA)을 이용하여 좌측 유방암 환자의 토모테라피 치료계획(Tomotherapy Helical & Tomotherapy Direct)을 수립하였다. 난소의 산량 선량 측정을 위한 측정 지점은 치료계획면적의 30 cm 아래 떨어진 골반의 좌우 위치로 직경 1.5 mm, 길이가 12mm인 저에너지용 보상필터가 들어있는 종류의 유리선량계 (GD-352M, ASAHI TECHNO GLASS CO, Japan)를 이용하여 각 5회씩 측정하여 평균하였으며, 선형지수-선량반응모델을 이용한 장기등가선량(organ equivalent dose: OED)으로 평가하였다. 결 과 : 토모 Helical 및 토모 Direct의 두 가지 방식으로 측정된 난소의 산란선량은 좌측 난소부위가 각각 평균 $64.94{\pm}0.84mGy$, $37.64{\pm}1.20mGy$이고, 우측 난소부위가 평균 $64.38{\pm}1.85mGy$, $32.96{\pm}1.11mGy$로 나타났다. 이는 토모치료 시 비교적 모니터 단위(MU)가 크고 조사 시간이 긴 토모Helical 방식이 토모Direct에 비하여 측정된 산란선량의 양이 보다 약 1.8배 높은 경향을 보였다. 결 론 : 가임기 여성의 유방암 토모테라피 시 발생하는 좌우측 난소의 산량선량은 ICRP 권고 선량이하로, 불임 및 2차 암 발생에 대한 우려 수준은 현저히 낮지만 향후 유방암 발생 연령층이 낮아지고, 토모테라피와 같이 고정밀 영상유도장치를 이용한 방사선치료가 발달할수록, 가임기 여성 환자의 난소산란선량에 대한 임상적 추적조사가 더욱 필요할 것으로 사료된다. Purpose : The aim of this study is to evaluate unwanted scattered dose to ovary by scattering and leakage generated from treatment fields of Tomotherapy for childbearing woman with breast cancer. Materials and Methods : The radiation treatments plans for left breast cancer were established using Tomotherapy planning system (Tomotherapy, Inc, USA). They were generated by using helical and direct Tomotherapy methods for comparison. The CT images for the planning were scanned with 2.5 mm slice thickness using anthropomorphic phantom (Alderson-Rando phantom, The Phantom Laboratory, USA). The measurement points for the ovary dose were determined at the points laterally 30 cm apart from mid-point of treatment field of the pelvis. The measurements were repeated five times and averaged using glass dosimeters (1.5 mm diameter and 12 mm of length) equipped with low-energy correction filter. The measures dose values were also converted to Organ Equivalent Dose (OED) by the linear exponential dose-response model. Results : Scattered doses of ovary which were measured based on two methods of Tomo helical and Tomo direct showed average of $64.94{\pm}0.84mGy$ and $37.64{\pm}1.20mGy$ in left ovary part and average of $64.38{\pm}1.85mGy$ and $32.96{\pm}1.11mGy$ in right ovary part. This showed when executing Tomotherapy, measured scattered dose of Tomo Helical method which has relatively greater monitor units (MUs) and longer irradiation time are approximately 1.8 times higher than Tomo direct method. Conclusion : Scattered dose of left and right ovary of childbearing women is lower than ICRP recommended does which is not seriously worried level against the infertility and secondary cancer occurrence. However, as breast cancer occurrence ages become younger in the future and radiation therapy using high-precision image guidance equipment like Tomotherapy is developed, clinical follow-up studies about the ovary dose of childbearing women patients would be more required.

Oral Administration of Hot Water Extracts of<i> Chlorella vulgaris</i> Increases Physical Stamina in Mice

An, Hyo-Jin,Choi, Hyun-Myung,Park, Hyeung-Suk,Han, Jae-Gab,Lee, Eun-Hee,Park, Young-Sig,Um, Jae-Young,Hong, Seung-Heon,Kim, Hyung-Min Karger 2006 Annals of nutrition & metabolism Vol.50 No.4

<P><I>Background/Aims:</I> A unicellular algae, <I>Chlorella vulgaris</I>, was used as a biological response modifier. Although hot water extracts of <I>C. vulgaris</I> (CVE) are thought to augment immune responses, the effect of CVE on fatigue and physical stamina has not been studied. <I>Methods:</I> In the present study, we investigated the effect of CVE on forced swimming test and blood biochemical parameters related to fatigue, blood urea nitrogen (BUN), creatine kinase (CK), lactic dehydrogenase (LDH), glucose (Glc), and total protein (TP). CVE (0.05-0.15 g/kg/day) was orally administered to mice. <I>Results:</I> After 7 days, the immobility time was decreased in the 0.1- and 0.15-g/kg CVE-treated groups (179 ± 8.3 and 175 ± 2.1 s) in comparison with the control group (223 ± 5.4 s). In addition, the contents of BUN, CK, and LDH in the blood serum were decreased in the CVE-fed group. However, they had no effect on the elevation of Glc and TP level. <I>Conclusions:</I> The results predict a potential benefit of CVE for enhancing immune function and improving physical stamina.</P><P>Copyright © 2006 S. Karger AG, Basel</P>