Comparative evaluation of the algorithms for parametric mapping of the novel myocardial PET imaging agent ¹⁸ F-FPTP

Kim, Ji Who,Seo, Seongho,Kim, Hyeon Sik,Kim, Dong-Yeon,Lee, Ho-Young,Kang, Keon Wook,Lee, Dong Soo,Bom, Hee-Seung,Min, Jung-Joon,Lee, Jae Sung Springer Japan 2017 Annals of nuclear medicine Vol.31 No.6

<P><B>Objective</B></P><P>(<SUP>18</SUP>F-fluoropentyl)triphenylphosphonium salt (<SUP>18</SUP>F-FPTP) is a new promising myocardial PET imaging tracer. It shows high accumulation in cardiomyocytes and rapid clearance from liver. We performed compartmental analysis of <SUP>18</SUP>F-FPTP PET images in rat and evaluated two linear analyses: linear least-squares (LLS) and a basis function method (BFM) for generating parametric images. The minimum dynamic scan duration for kinetic analysis was also investigated and computer simulation undertaken.</P><P><B>Methods</B></P><P><SUP>18</SUP>F-FPTP dynamic PET (18 min) and CT images were acquired from rats with myocardial infarction (MI) (<I>n</I> = 12). Regions of interest (ROIs) were on the left ventricle, normal myocardium, and MI region. Two-compartment (<I>K</I><SUB>1</SUB> and <I>k</I><SUB>2</SUB>; 2C2P) and three-compartment (<I>K</I><SUB>1</SUB>–<I>k</I><SUB>3</SUB>; 3C3P) models with irreversible uptake were compared for goodness-of-fit. Partial volume and spillover correction terms (<I>V</I><SUB><I>a</I></SUB> and <I>α</I> = 1 − <I>V</I><SUB><I>a</I></SUB>) were also incorporated. LLS and BFM were applied to ROI- and voxel-based kinetic parameter estimations. Results were compared with the standard ROI-based nonlinear least-squares (NLS) results of the corresponding compartment model. A simulation explored statistical properties of the estimation methods.</P><P><B>Results</B></P><P>The 2C2P model was most suitable for describing <SUP>18</SUP>F-FPTP kinetics. Average <I>K</I><SUB>1</SUB>, <I>k</I><SUB>2</SUB>, and <I>V</I><SUB><I>a</I></SUB> values were, respectively, 6.8 (ml/min/g), 1.1 (min<SUP>−1</SUP>), and 0.44 in normal myocardium and 1.4 (ml/min/g), 1.1 (min<SUP>−1</SUP>), and 0.32, in MI tissue. Ten minutes of data was sufficient for the estimation. LLS and BFM estimations correlated well with NLS values for the ROI level (<I>K</I><SUB>1</SUB>: <I>y</I> = 1.06<I>x</I> + 0.13, <I>r</I><SUP><I>2</I></SUP> = 0.96 and <I>y</I> = 1.13<I>x</I> + 0.08, <I>r</I><SUP><I>2</I></SUP> = 0.97) and voxel level (<I>K</I><SUB>1</SUB>: <I>y</I> = 1.22<I>x</I> − 0.30, <I>r</I><SUP><I>2</I></SUP> = 0.90 and <I>y</I> = 1.26<I>x</I> + 0.00, <I>r</I><SUP><I>2</I></SUP> = 0.92). Regional distribution of kinetic parametric images (<I>αK</I><SUB>1</SUB>, <I>K</I><SUB>1</SUB>, <I>k</I><SUB>2</SUB>, <I>V</I><SUB>a</SUB>) was physiologically relevant. LLS and BFM showed more robust characteristics than NLS in the simulation.</P><P><B>Conclusions</B></P><P>Fast kinetics and highly specific uptake of <SUP>18</SUP>F-FPTP by myocardium enabled quantitative analysis with the 2C2P model using only the initial 10 min of data. LLS and BFM were feasible for estimating voxel-wise parameters. These two methods will be useful for quantitative evaluation of <SUP>18</SUP>F-FPTP distribution in myocardium and in further studies with different conditions, disease models, and species.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1007/s12149-017-1171-6) contains supplementary material, which is available to authorized users.</P>

연구보문 : 자연과학 ; 황산처리에 의한 불투수성 황근 종자의 발아촉진에 관한 연구

서상흠 ( Sang Heum Seo ),박민우 ( Min Woo Park ),장미하 ( Mi Ha Chang ),장일웅 ( Il Ung Jang ),심상인 ( Sang In Shim ),나영왕 ( Young Wang Na ),김수영 ( Soo Young Kim ),김석현 ( Seok Hyeon Kim ) 한국국제농업개발학회 2012 韓國國際農業開發學會誌 Vol.24 No.3

The reason of poor germination rate of hamabo mallow seed was speculated using TZ test to determine the viability of seed. Seeds showed high viability via TZ test were not germinated well. The quiescent seeds did not imbibed properly due to the hard seed coat and did not show further processes required for germination. Several well-known treatments for seed coat loosening and water uptake into seed were applied and compared for their efficiency. Stratification, hot water treatment, seed coat scarification, wet-cold treatment were revealed as less effective for improving germination although those treatments were common method for breaking dormant seed. Chemical scarification with sulfuric acid, however, effectively increased germinability and promptness index of hamabo mallow seeds. Optimal time for sulfuric acid treatment was 20 min. Seeds treated for 20 min showed improved germination percentage, germination speed, and promptness index of 80%, 13, and 1969 at 30 days after imbibition, respectively, in petri dish experiment. The values were greater than control seeds showed low values (12%, 1, and 183, respectively). The similar tendency was observed in the pot experiment that sulfuric acid treated seed were sown in artificially mixed soil (loamy soil:peatmoss:sand:compost = 5:2:2:1) and placed in greenhouse. Ultrastructure analysis of chemically scarified seed with sulfuric acid for 20 min by scanning electron microscopy did not show any noticeable changes in seed coat hardness and water uptake via hilum. But the only change after sulfuric acid treatment was removal of hilum cap that close the hilum and hider imbibition. Therefore, subsequent experiment was conducted to know the relationship between removal of hilum cap and facilitated imbibition by sulfuric acid treatment and whether the hilum cap removal directly influenced to the opening of micropyle. Water uptake velocity of seed treated for 20 min in concentrated sulfuric acid for was greater than control seed. This result implies that the crucial effect of sulfuric acid treatment is the removal of hilum cap that increase water uptake via micropyle in hamabo mallow.

성인 음낭수종의 치료로서 Window Operation의 효용성

서병욱,박영호,이남규,전윤수,김민의,김영호,송윤섭,구자현 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.1

We intended to determine the usefulness of window operation for adult hydrocele repair. We reviewed medical records of 132 patients from January 1995 to June 1998 with primary hydrocele and evaluated complications and recurrence rates of eversion and/or excision, plication, and internal drainage technique. Recurrence rate was highest in internal drainage technique as 85.2%, and those of eversion and/or excision and plication technique were 1.3% and 4%, respectively. Complication rate was highest in eversion and/or excision technique, and lowest in internal drainage technique. Although complication rate was lowest in window operation, this operation could not be successful due to high recurrence, and we suggest that this operation should be abandoned for hydrocele repair.

무증상의 현미경적 혈뇨의 비뇨기과적 고찰

구자현,서병욱,김영호,송윤섭,전윤수,김민의,이남규,박영호 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.2

We intended to know whether all of the patients with asymptomatic microscopic hematuria should be urologically investigated routinely. We reviewed the medical records with asmptomatic microscopic hematuria from January 1995 to December 1997. Urological studies included intravenous urography or ultrasonography, urine cytology, cystoscopy and biopsy, urine AFB smear and culture and urine PCR for AFB. The age with patients ranged from 9 to 74 years(mean age: 39.7 years). Benign diseases were found in elderly patients and patients with high degree of hematuria, but there was no patients who had urological malignant disease. According to the results, we suggest that follow-up with urine cytology is sufficient to younger patients or low degree of hematuria with asymptomatic microscopic hematuria.

단면형상변화에 따른 점용접 부재의 에너지흡수 특성

최영민,차천석,김지훈,서현경,양인영 한국공작기계학회 2006 한국공작기계학회 추계학술대회논문집 Vol.2006 No.-

The front-end side members of vehicles absorb the most of the energy during the front-end collision. These side members are mostly consist of single hat shape. The side members absorb more energy under axial load if they have higher strength, and stable folding capacity (local buckling). When structural members are subjected to axial loadings, stress is concentrated on their edges. Thus, in this study, the energy absorption characteristics of the member were analyzed according to change of sectional shape for increase of strength. The side members consist of single hat, double hat, single cap and double cap section member. Based on the static test result of these side member, the impact simulation were carried out and compared with test result.

자연의 아름다움과 고급스러움이 공존하는 마임 비에타 쇼룸 제안 -오감 (시각, 청각, 후각, 촉각, 미각)을 중심으로-

김보현,이서연,은다솜,엄연정,이진민,장미정,이성애 숙명여자대학교 산업디자인연구소 2017 숙명디자인학 연구 Vol.24 No.-

본 연구는 국내 브랜드 ‘마임'의 뷰티와 연계한 뷰티 쇼룸을 제안함에 있어서 공간속에 오감을 담아내는 일련의 프로세스를 밝히는데 목적이 있다. 이는 브랜드가 소유하고 있는 다양한 감각과 가치가 결여된 채 시각적 요소만이 담긴 브랜드 뷰티 쇼룸이 대다수를 차지하는 오늘날, 이에 대한 문제를 해결하기 위해 ’융합 연출 디자인'적 시점에서 폭넓게 바라보고 브랜드의 정신과 오감의 결합을 통해 이를 해결하고자 하였다. 이에 본 연구는 2017년 3월~6월 15주간 숙명여대 환경디자인학과 <융합연출 디자인>수업에서 진행된 수업의 결과물로서 산학 연계된 화장품 브랜드의 쇼룸디자인 개발 프로세스를 제안한다. 또한 본 연구의 범위는 오감을 담고 있는 뷰티 쇼룸(4D)이 되기까지의 과정 전체로 한다. 그 결과, 마임 뷰티쇼룸은 공간 디자인과 오감을 융합하여 영상에서 공간에 이르기까지 오감의 조화와 브랜드의 정신을 녹여내고 확장시켰다. 끝으로 본 연구는 뷰티 쇼룸 공간 디자인을 제안함에 있어서 오감을 활용하여 통합된 시점에서 그래픽·제품·공간을 개발 및 제시한 것에 의의가 있다. 또한 향후 이와 관련된 쇼룸 공간 개발에 있어서 기초 자료로 활용될 것으로 기대된다.

조기 발병 양극성 장애 환자의 임상적 특징 : 후향적 의무기록 조사 연구

우영섭,박민현,서호준,채정호,전태연,박원명 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.5

Objective : Bipolar disorder is a disease with diverse clinical profiles and outcomes. In recent years, it is suggested that if bipolar disorder occurs early in one's life, functional and symptomatic prognoses are poor. The prognoses include severe Symp-toms, frequent psychotic symptoms, comorbidity ofmental illnesses, slow improvement of the symptoms, and high suicide rate. We investigated the clinical characteristics of early onset bipolar inpatients. Method : The subjects of this study were selected from the patients who were discharged after hospitalization between January 1, 2001 and May 31, 2005 and diagnosed with bipolar disorder according to DSM-IV criteria. These patients were examined for the following data ; the type of bipolar disorder, comorbid psychiatric disorders, the age at onset of the illness, the acuteness of the disorder, and the duration of the disorder. The presence of four major clinical psychopathology, rapid cycling, Psychotic symptoms, comorbid psychiatric disorders, and suicide attempt, was also examined. The patients whose onset of the illness was before the age of 19 were classified as the early onset group and after the age of 19 were classified as the late onset group. Data on demographics, family histories, four major clinical psychopathologies and other clinical variables were compared between the early onset group and the late onset group. Results : Of the 53 patients, 19 patients belonged to the early onset group. There was higher incidence ofpsychotic Symp-toms in the early onset group than in the late onset group, and the difference was statistically significant according to the χ² - test (84.2% vs 44.1%, P=0.005). The incidence of comorbid psychiatric disorders was higher in the early onset group than in the late onset group, and the difference was also statistically significant according to the χ²-test (52.6% vs 23.5%, P=0.032).However, there was no statistically significant difFerence between the groups regarding the incidence of rapid cycling and suicide attempt. The result of logistics regression showed correlation of psychotic symptoms (0R=6.756 ; 1.655≤95% CI≤27.580) and comorbid psychiatric disorders (0R=3.611 ; 1.088≤95% CI≤11.984) with the early onset group. Conclusion : Early onset of bipolar disorder is related to the manifestation of psychotic symptoms and frequently accom-panies comorbid psychiatric disorders. The results of this study will help understand the mechanism of the onset of complexbipolar disorder and estimate the prognosis.

외안각 절제술과 경결막 절개에 의한 안와 접근법

정종철,김성범,서지훈,송민석,전창훈,최세훈,김현민 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.4

Various surgical approaches to the orbits have been used. But the transconjunctival approach, also called the inferior fornix incision, provides adequate access to the orbital floor with esthetic results. Additionally, transconjunctival approach with lateral canthotomy allows more wide surgical field and good access to the orbital area. Generally, preseptal approach is more used rather than postseptal approach in the transconjunctival incision for the prevention of fat herniation during surgery. There are some complications in transconjunctival approaches but these complications can be prevented with careful surgical techniques. We report clinical results in 12 patients who were treated by preseptal transconjunctival incision with lateral canthotomoy for the treatment of orbital trauma. We were satisfied with this technique for reduction and reconstruction of the orbital trauma and we could also observe relatively good esthetic results.

여성 하부요관석환자에서 무마취하 요관경하 배석술

박영호,송윤섭,임용순,김영호,이남규,구자현,서병욱,김민의,전윤수 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.2

Although ureteroscopy(URS) has been used widely to remove ureteral calculi, there is an argument against the belief that anesthesia or admission is needed for URS. We evaluated the experience of URS without anesthesia in female patients. From September 1997 to July 1998, URS was performed in 31 female patients without anesthesia. EHL(Electrohydraulic Lithotripsy) was used in 21 patients with impacted or large stone over 5mm. All patients were given oral antibiotics for 3 days and follow-up KUB was taken to confirm successful removal of the stone one week after the procedure. Successful treatment was defined as complete removal of the stone or residual fragments less than 2mm. Overall success rate was 96.7%(30 cases among 31 cases). All but one patient tolerated with analgesia through the entire procedures. There were only minimal complications such as mild flank pain and hematuria. So, we recommend that non-anesthetic ureteroscopic removal of stone as the first choice for treatment of lower ureteral stones in female based on the minimal morbidity, high success rate and low cost.

The environmental benefits of reducing thermal discharge from nuclear power generation

Min, Seo-Hyeon,Lim, Seul-Ye,Yoo, Seung-Hoon SAGE Publications 2017 Energy & environment Vol.28 No.8