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자색고구마가 사염화탄소 투여에 의한 흰쥐의 간손상 보호에 미치는 영향
조영자,김현아,방미애,오용비,정병춘,문윤호,정우진 한국식생활문화학회 2003 韓國食生活文化學會誌 Vol.18 No.3
The purpose of this study was to investigate the effects of dietary purple sweet potato(lpomoea batatas) powder on serum lipid levels and antioxidative enzymes in normal and pretective effect on hepatotoxicity rats induced by carbon tetrachlolide. Four groups of rats (3-week-old inbred Sprague-Dawley male rats) were normal rats fed control diet(C)_(1) induced hepatotoxicity rats fed control diet(EC)_(1) normal rats fed purple sweet potato diet(P), and induced hepatotoxicity rats fed purple potato sweet diet(EP). Rats were induced by single injection of 50% carbon tetrachloide(0.1 mL/100 g B.W., i.p.). The rats were fed ad libitum each of the experimental diet for 5 weeks. After 5 weeks the rats were sacrificed and activities of antioxidant enzymes and lipid peroxidation products were determined in their liver homogenates. But serum concentrations of lipid was not significant in all groups. Serum alanine aminotransferase(ALT/GPT) and aspartate aminotransferase(ALT/GPT)of the EC and EP groups were heigher than the C and P groups. The hepatic glucose 6-phosphatase(G9Pase) activity of the group fed purple potato diet(P) was lower than the other groups(p<0.05). However, The glutathione peroxidase(GPx) activities was not statistically different between the groups. Renal glutathione S-transferase(GST) activity of the EC and EP groups were lower than the C and P groups(p<0.05). In conclusion, these results suggest that purple sweet potato is believed to be possible protective effect on hepatotoxicity rats induced by carbon tetrachlolide.
Cho, Seok-Cheol,Choi, Woon-Yong,Oh, Sung-Ho,Lee, Choon-Geun,Seo, Yong-Chang,Kim, Ji-Seon,Song, Chi-Ho,Kim, Ga-Vin,Lee, Shin-Young,Kang, Do-Hyung,Lee, Hyeon-Yong Hindawi Publishing Corporation 2012 Journal of biomedicine & biotechnology Vol.2012 No.-
<P>Marine microalga, <I>Scenedesmus</I> sp., which is known to be suitable for biodiesel production because of its high lipid content, was subjected to the conventional Folch method of lipid extraction combined with high-pressure homogenization pretreatment process at 1200 psi and 35°C. Algal lipid yield was about 24.9% through this process, whereas only 19.8% lipid can be obtained by following a conventional lipid extraction procedure using the solvent, chloroform : methanol (2 : 1, v/v). Present approach requires 30 min process time and a moderate working temperature of 35°C as compared to the conventional extraction method which usually requires >5 hrs and 65°C temperature. It was found that this combined extraction process followed second-order reaction kinetics, which means most of the cellular lipids were extracted during initial periods of extraction, mostly within 30 min. In contrast, during the conventional extraction process, the cellular lipids were slowly and continuously extracted for >5 hrs by following first-order kinetics. Confocal and scanning electron microscopy revealed altered texture of algal biomass pretreated with high-pressure homogenization. These results clearly demonstrate that the Folch method coupled with high-pressure homogenization pretreatment can easily destruct the rigid cell walls of microalgae and release the intact lipids, with minimized extraction time and temperature, both of which are essential for maintaining good quality of the lipids for biodiesel production.</P>
The Effects of Muscle Forces on Ankle Joint Kinetics during Postural Balance Control
Choi, Hyeon Ki,Seo, Min Jwa,Koo, Ja Choon,Choi, Hyeon Chang,Cho, Won Hak Trans Tech Publications, Ltd. 2006 Key Engineering Materials Vol.326 No.-
<P>We assessed the effects of muscle forces on ankle joint kinetics during postural balance control of human boy. Nine male subjects (mean age of 25.8 yrs) participated in the experiment. An ankle joint model assumed ball and socket joint was used, which was capable of three dimensional rotations. A six-camera VICON system was used for motion analysis. Waist pulling system and force platform were adopted for forward sway and GRF (ground reaction force) measurement. We used linear optimization programs to calculate the variation of muscle forces and angular displacements of shank and foot segments. With the experimental data and linear programs, we could calculate joint reaction forces, and bone-on-bone forces. The results presented in this study give us the insights to understand the roles of lower limb muscles during postural balance control and ankle injury mechanism.</P>
Jun Hyeon Cho,Jong Hee Lee,Ji Yun Lee,Young Bo Son,Soo Kwon Park,Sang Yeol Kim,Choon Woo Lee,Un Sang Yeo,Dong Soo Park,You Cheon Song,Min Hee Nam 한국육종학회 2012 한국육종학회 심포지엄 Vol.2012 No.07
Geneally, rice seeds regardless indica or japonica are showing low germination ratio or completely lost germination ability together with lost of good eating quality under high temperature and humidity conditions. Thus, this study was designed to evaluate a longevity for conservation of good eating quality during long term storage in rice. For the longevity evaluation, germination ability was studied after 5 days of high temperature and humidity stress (50℃/RH 95%). Dharial, originated from Bangladesh and showing weedy type with red pericarp, was selected as a good donor for longevity genes. A mutant was developed from Dharial through EMS mutagenesis and two populations of Dharial/4*Ilmibyeo and Dharial/4*Gopumbyeo were also developed for genetic study. In the 2-DE analysis followed by MALDI-TOF MS with wild and mutant lines, several candidate genes were identified. In the longevity test of two populations, a few lines showing good germination ability after high temperature and humidity stress were selected and subjected to confirm the relationships between longevity and conservation of good eating quality under long term storage.
Operative Method for Transverse Colon Carcinoma : Transverse Colectomy Versus Extended Colectomy
Chong, Choon Seng,Huh, Jung Wook,Oh, Bo Young,Park, Yoon Ah,Cho, Yong Beom,Yun, Seong Hyeon,Kim, Hee Cheol,Lee, Woo Yong Ovid Technologies (Wolters Kluwer) - Lippincott Wi 2016 Diseases of the colon and rectum Vol.59 No.7
<P>BACKGROUND: The type of surgery performed for primary transverse colon cancer varies based on tumor characteristics and surgeon perspective. The optimal oncological outcome following different surgical options has not been clearly established, and transverse colectomy has shown oncological equivalence only in small cohort studies. OBJECTIVE: Our aim was to compare long-term oncological outcomes after transverse colectomy versus extended resection for transverse colon cancer. DESIGN: This study is a retrospective review of prospectively collected data. SETTING: This study was conducted at a tertiary care hospital. METHOD: All patients treated for transverse colon cancer at the Samsung Medical Center between 1995 and 2013 were included. MAIN OUTCOME MEASURES: Oncological outcomes were compared between 2 groups of patients: a transverse colectomy group and an extended colectomy group (which included extended right hemicolectomy and left hemicolectomy). RESULTS: A total of 1066 patients were included, of whom 750 (70.4%) underwent extended right hemicolectomy, 127 (11.9%) underwent transverse colectomy, and 189 (17.7%) underwent left hemicolectomy. According to univariate analysis, surgical approach, histological type, tumor morphology, cancer T and N stage, cancer size, and lymphovascular invasion were significant factors contributing to disease-free survival (DFS). However, as seen in multivariate analysis, only node-positive disease (HR = 2.035 (1.188-3.484)), tumors with ulcerative morphology (HR = 3.643 (1.132-11.725)), and the presence of vascular invasion (HR = 2.569 (1.455-4.538)) were significant factors for DFS. Further analysis with a propensity-matched cohort between the transverse and extended colectomy groups demonstrated no significant differences in DFS and overall survival. LIMITATIONS: This study was limited because it was performed at a single institution and it was retrospective in nature. CONCLUSION: In terms of perioperative and oncological outcomes, transverse colectomy and extended colectomy did not differ despite a shorter specimen length and fewer lymph nodes harvested in the transverse colectomy group. Independent prognostic factors for DFS were node-positive disease, the presence of vascular invasion, and ulcerative morphology.</P>
Kim, Hyeon-Joong,Shin, Eun-Joo,Lee, Byung-Hwan,Choi, Sun-Hye,Jung, Seok-Won,Cho, Ik-Hyun,Hwang, Sung-Hee,Kim, Joon Yong,Han, Jung-Soo,Chung, ChiHye,Jang, Choon-Gon,Rhim, Hyewon,Kim, Hyoung-Chun,Nah, S Korean Society for Molecular and Cellular Biology 2015 Molecules and cells Vol.38 No.9
Gintonin is a novel ginseng-derived lysophosphatidic acid (LPA) receptor ligand. Oral administration of gintonin ameliorates learning and memory dysfunctions in Alzheimer's disease (AD) animal models. The brain cholinergic system plays a key role in cognitive functions. The brains of AD patients show a reduction in acetylcholine concentration caused by cholinergic system impairments. However, little is known about the role of LPA in the cholinergic system. In this study, we used gintonin to investigate the effect of LPA receptor activation on the cholinergic system in vitro and in vivo using wild-type and AD animal models. Gintonin induced $[Ca^{2+}]_i $ transient in cultured mouse hippocampal neural progenitor cells (NPCs). Gintonin-mediated $[Ca^{2+}]_i $ transients were linked to stimulation of acetylcholine release through LPA receptor activation. Oral administration of gintonin-enriched fraction (25, 50, or 100 mg/kg, 3 weeks) significantly attenuated scopolamine-induced memory impairment. Oral administration of gintonin (25 or 50 mg/kg, 1 2 weeks) also significantly attenuated amyloid-${\beta}$ protein ($A{\beta}$)-induced cholinergic dysfunctions, such as decreased acetylcholine concentration, decreased choline acetyltransferase (ChAT) activity and immunoreactivity, and increased acetylcholine esterase (AChE) activity. In a transgenic AD mouse model, long-term oral administration of gintonin (25 or 50 mg/kg, 3 months) also attenuated AD-related cholinergic impairments. In this study, we showed that activation of G protein-coupled LPA receptors by gintonin is coupled to the regulation of cholinergic functions. Furthermore, this study showed that gintonin could be a novel agent for the restoration of cholinergic system damages due to $A{\beta}$ and could be utilized for AD prevention or therapy.
조준현(Jun-Hyeon Cho),이종희(Jong-Hee Lee),김춘송(Choon-Song Kim),이지윤(Ji-Yoon Lee),오성환(Sung-Hwan Oh),박노봉(No-Bong Park),전명기(Myeong-Gi Jeon),곽도연(Do-Yeon Kwak),박동수(Dong-Su Park),여운상(Un-Sang Yeo),하운구(Woon-Goo Ha) 한국육종학회 2015 한국육종학회지 Vol.47 No.2
Recently, concerns have been voiced about the high eating quality rice in the market. To cope the high quality demands in rice market, a rice cultivar ‘Jinsumi’ which is showing high grain quality and multi-resistant to diseases was developed by the National Institute of Crop Science, RDA, Miryang, Korea. ‘Jinsumi’ was derived from a three-way cross of ‘Milyang165’ and F1 plant of YR16195-B-B-B-21-1/Milyang169. The pedigree of ‘Jinsumi’ was YR21999-B-B-B-17-3-1 and designated as ‘Milyang 218’ in 2005. Heading date of ‘Jinsumi’ was August 15 as mid-late maturing ecotype. ‘Jinsumi’ showed multi resistant to rice stripe virus (RSV), bacterial blight races of K1, K2, K3 and moderately resistant to leaf blast disease. The grain appearance of ‘Jinsumi’ was translucent and showed 96.6% of head rice ratio. The milled rice yield of ‘Jinsumi’ was 5.74 MT/ha at ordinary transplanting of local adaptability test. ‘Jinsumi’ would be adaptable to the plain area of Yeongnam province in Korea.