동일한 환자에서 조혈모세포이식 전후의 호중구감소 기간 중 감염양상에 대한 비교연구 : 중심정맥관 관련 패혈증을 중심으로 Based on Central Venous Catheter Related Septicemia

류재호,노규태,이영석,이영호,권혁찬,김재석,김효진,이영민,박혜원,박근희 대한조혈모세포이식학회 2002 대한조혈모세포이식학회지 Vol.7 No.1

연구배경: 동일한 환자를 대상으로 조혈모세포이식 전 일반 병실에서의 관해유도 항암제치료 및 강화요법으로 인한 호중구감소 기간의 감염양상과 고용량 항암제치료 후 무균실에서의 조혈모세포이식 시 호중구감소 기간의 감염양상을 중심정맥관 관련 패혈증을 중심으로 비교 연구함으로써 효율적인 감염관리지침을 마련하고자 하였다. 대상 및 방법: 1999년 1월부터 2001년 7월까지 2년 7개월간 동아대학교병원 일반병실에서 악성혈액질환으로 항암제 치료를 받다가 조혈모세포이식을 시행받았던 22명을 대상으로 중심정맥관 관련 패혈증의 형태를 비교분석하였다. 결과: 대상 환자들의 일반병실과 무균실에서의 입원기간은 각각 32±13일, 33±19일, 호중구 감소기간은 15±12일, 17±18일, 호중구 감소기간의 발열 횟수는 14회, 14회로서 입원병실의 종류에 따른 차이는 없었다. 환자들의 중심정맥관 사용일수는 일반병실에서 29일(7~545일), 무균실에서 100.5일(25~606일)이었으며, 총 사용일수는 각각 1,515일, 3,250일로서 무균실에서의 중심정맥관 사용일수가 의미 있게 길었다(P=0.001). 중심정맥관 사용 일수에 대한 감염률은 각각 5.28/1,000일, 3.08/1,000일로서 일반병실에서 그 빈도가 높았으나 통계적 유의성은 보이지 않았다(P=0.141). 결론: 중심정맥관 삽입 후 일반병실에서 항암제 치료를 받던 환자가 조혈모세포이식을 위하여 무균실에 입원하는 경우, 중심정맥관을 교체하는 것이 감염관리를 위하여 바람직할 것으로 생각된다. Background: We compared the incidence of central venous catheter (CVC) related septicemia during neutropenic period in the same patient, which developed following chemotherapy for remission induction and consolidation, or hematopoietic stem cell transplantation (HSCT). Methods: We retrospectively reviewed the medical records and laboratory data of 22 patients with hematologic malignancies who received anticancer chemotherapy followed by HSCT at Dong-A University Hospital between January, 1999 and July, 2001. We investigated the duration of hospitalization, duration of neutropenic period, duration of catheterization, microbiologically documented organisms and incidence of CVC related septicemia. Results: The data in general ward (before HSCT) and laminar air flow room (after HSCT) were as follows: duration of hospitalization was 32±13 days and 33±19 days, duration of neutropenic period was 15±12 days and 17±18 days, median duration of catheterization was 29 days (7~545 days) and 100.5 days (25~606 days) (P=0.001), and incidence of CVC related septicemia was 5.28/1000 days and 3.08/1000 days, respectively. In the CVC related septicemia, the most common etiologic organism was coagulase negative staphylococcus. Conclusion: We suggest that the exchange of CVC before admission to laminar air flow room could decrease the incidence of CVC related septicemia in HSCT recipients.

3차 의료기관에 입원한 노숙환자에서 감염질환의 유병율

함세운,남기석,노혜진,홍경득,황래석,방지환,신형식 대한감염학회 2007 감염과 화학요법 Vol.39 No.4

목적 : 3차 의료기관에서 입원치료를 받았던 노숙자를 대상으로 감염성 질환의 유병율을 알아보고자 하였다. 재료 및 방법 : 2002년 1월부터 2004년 8월 사이에 국립의료원에서 입원 치료를 받았던 269명의 노숙자 환자들을 대상으로 의무기록을 조사하였다. 결과 : 연구 기간동안 입원치료를 받은 총 269명의 노숙자 환자 중 남자가 249명(92.9%), 여자가 19명(7.1%)이었다. 감염질환의 유병율은 B형 간염이 228명 중 15명(6.6%), C형 간염 113명 중 8명(7.1%), 결핵은 269명중 19명(7.1%), VDRL 양성인 경우는 234명 중 25명(10.7%), 항사람면역결핍바이러스항체 양성은 130명중 2명(1.5%)이었다. B형 간염표면항원에 대한 항체 형성자는 118명(51.7%), 항체 미형성자는 95명(41.7%)이었다. 결핵으로 진단된 19명 중 객담도말 및 배양검사와 조직검사로 확인된 경우가 14명, 균음성이나 임상적으로 의심되는 경우가 5명이었다. 간질환 및 관련된 합병증으로 입원한 환자 28명 중 B형 및 C형 간염바이러스에 관련된 경우는 5명(17.9%)에불과하였고 결핵은 19명중 13명(68.4%)이 폐결핵 및 림프절종대의 증상으로 입원치료를 받았다. 복합 감염의 경우는 총 9명이었는데 후천면역결핍증후군 환자였던 2명중 1명이 결핵에 이환되어 있으면서 VDRL 양성소견을 보였고 다른 1명이 HIV와 결핵의 동시감염이었다. 결론 : 노숙자 입원환자에서 결핵, C형 간염 및 매독의 유병율이 일반 인구에 비해 높았다. 노숙자환자를 담당하는 의료인력를 보호하고 환자의 감염질환 유무를 파악하기 위해 적절한 선별검사가 필요하며 감염질환의 확산을 방지하기 위한 정부의 적극적인 대책이 필요하다. Background : Despite the expected high prevalence of several infectious diseases among the homeless, a majority of them have not received screening test and early treatment. Materials and Methods : The subjects of this study were 269 homeless patients who had been hospitalized in the National Medical Center (Korea) between January 2002 and August 2004. Their medical histories and records were reviewed to analyze the prevalence and clinical characteristics of hepatitis B and C, syphilis, tuberculosis and HIV infection among them. Results : The entire 269 homeless patients being hospitalized during the period of this study consist of 249 male patients and 19 female patients. For the prevalence of infectious diseases, HBV was seen in 15 of 228 patients (6.6%); HCV in 8 of 113 patients (7.1%); VDRL positive in 25 of 234 patients (10.7 %); HIV antibody positive in 2 of 130 (1.5%); and tuberculosis in 19 of 269 (7.1%). The number of patients who had the antibody to hepatitis B was 118 (51.7%). Of 28 patients hospitalized with the chief complaints of liver diseases and/or their complications, the number of cases infected with hepatitis B and C viruses was only 5 (17.9%). On the other hand, for patients with tuberculosis, 13 of 19 cases (68.4%) were hospitalized with the chief complaints associated with symptoms of pulmonary tuberculosis or enlarged lymph nodes. The number of patients with multiple infectious diseases was 9 in total. Conclusion : As expected, the prevalence of some infectious diseases were higher among the homeless inpatients, than non-homeless population. Proper screening tests in order to determine the presence of any infectious diseases among the patients and protect involved medical staff are necessary. Further, the government should take proactive measures to prevent the spread of infectious diseases in the aspect of public health.

[시설운영 및 기타] Glaucoma-therapeutic effects of exosome-rich conditioned media from human amniotic membrane stem cells

Hye-Rim Seong,Sangryong Park,Chan Ho Noh,Cuicui Wang,Sumin Cho,Seok Jin Hong,Tae Myoung Kim,Ehn-Kyoung Choi,Yun-Bae Kim 한국실험동물학회 2022 한국실험동물학회 학술발표대회 논문집 Vol.2022 No.1

PEBP1, a RAF kinase inhibitory protein, negatively regulates starvation-induced autophagy by direct interaction with LC3

Noh, Hae Sook,Hah, Young-Sool,Zada, Sahib,Ha, Ji Hye,Sim, Gyujin,Hwang, Jin Seok,Lai, Trang Huyen,Nguyen, Huynh Quoc,Park, Jae-Yong,Kim, Hyun Joon,Byun, June-Ho,Hahm, Jong Ryeal,Kang, Kee Ryeon,Kim, D Informa UK (TaylorFrancis) 2016 AUTOPHAGY Vol.12 No.11

<P>Autophagy plays a critical role in maintaining cell homeostasis in response to various stressors through protein conjugation and activation of lysosome-dependent degradation. MAP1LC3B/LC3B (microtubule- associated protein 1 light chain 3 ) is conjugated with phosphatidylethanolamine (PE) in the membranes and regulates initiation of autophagy through interaction with many autophagy-related proteins possessing an LC3-interacting region (LIR) motif, which is composed of 2 hydrophobic amino acids (tryptophan and leucine) separated by 2 non-conserved amino acids (WXXL). In this study, we identified a new putative LIR motif in PEBP1/RKIP (phosphatidylethanolamine binding protein 1) that was originally isolated as a PE-binding protein and also a cellular inhibitor of MAPK/ERK signaling. PEBP1 was specifically bound to PE-unconjugated LC3 in cells, and mutation (WXXL mutated to AXXA) of this LIR motif disrupted its interaction with LC3 proteins. Interestingly, overexpression of PEBP1 significantly inhibited starvation-induced autophagy by activating the AKT and MTORC1 (mechanistic target of rapamycin [serine/threonine kinase] complex 1) signaling pathway and consequently suppressing the ULK1 (unc-51 like autophagy activating kinase 1) activity. In contrast, ablation of PEBP1 expression dramatically promoted the autophagic process under starvation conditions. Furthermore, PEBP1 lacking the LIR motif highly stimulated starvation-induced autophagy through the AKT-MTORC1-dependent pathway. PEBP1 phosphorylation at Ser153 caused dissociation of LC3 from the PEBP1-LC3 complex for autophagy induction. PEBP1-dependent suppression of autophagy was not associated with the MAPK pathway. These findings suggest that PEBP1 can act as a negative mediator in autophagy through stimulation of the AKT-MTORC1 pathway and direct interaction with LC3.</P>

Buffer and Anode Combined Ta Doped In₂O₃ Electrodes Prepared by Co-sputtering for PEDOT

Hye-Min Lee,Yong-Jin Noh,Seok-In Na,Hyun-Woo Park,Kwun-Bum Chung,Han-Ki Kima 한국진공학회 2014 한국진공학회 학술발표회초록집 Vol.2014 No.2

Rapid thermal annealing effect on the electrical, optical, and structural properties of Ta-doped In₂O₃ films

Hye-Min Lee,Sin-Bi Kang,Yong-Jin Noh,Seok-In Na,Han-Ki Kim 한국표면공학회 2013 한국표면공학회 학술발표회 초록집 Vol.2013 No.11

Aortic valve replacement surgery for a case of infantile Takayasu arteritis

Kwon, Hye-Won,Suh, Yoon-Jung,Bang, Ji-Seok,Kwon, Bo-Sang,Kim, Gi-Beom,Bae, Eun-Jung,Kim, Woong-Han,Noh, Chung-Il The Korean Pediatric Society 2012 Clinical and Experimental Pediatrics (CEP) Vol.55 No.7

Takayasu arteritis is a chronic inflammatory disease of unknown etiology primarily affecting the aorta and its major branches and usually occurring in the second or third decade of life. Here, we report a case of Takayasu arteritis in a 10-month-old patient. The infant presented with signs of congestive heart failure and severe aortic regurgitation. Echocardiography and computed tomography angiography showed an abnormally dilated thoracic and abdominal aorta. The infant was initially treated with prednisolone, followed by commissuroplasty of the aortic valve but neither approach ameliorated the heart failure. The patient was eventually treated with a mechanical aortic valve replacement surgery at the age of 12 months, and her condition stabilized. Although unusual, this case indicates that the diagnosis of Takayasu arteritis should be considered in children with unexplained systemic symptoms, aortic valve regurgitation, and heart failure. Because severe aortic regurgitation may be a fatal complication of Takayasu arteritis, early aortic valve replacement surgery should be considered, even in very young children.

Poster Session:PS 1095 ; Gastroenterology (Gastrointestinal Tract) : A Case of Ulcerative Colitis with Prolonged Remission Following Azathioprine-Induced Aplastic Anemia

( Eun Hye Kim ),( Seok Won Jung ),( Yu Jin Yang ),( Jin Hee Noh ),( Tae Young Park ),( Hwung Rae Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Azathioprine (AZA) is an established medication for the treatment of infi ammatory bowel disease(IBD) as a second line therapy for refractory and steroid dependent case and for remission maintenance. However, bone marrow suppression is a common side effect with azathioprine treatment. On the other hand, several investigators have been reported that neutropenia during AZA therapy decreased relapse rates of IBD patients. It is unclear, but may explain that modifi cation of host immunity plays an important role in IBD activity. We report a case of a patient who presented prolonged remission following AZA induced aplastic anemia. A 19-year-old female who had been diagnosed as ulcerative colitis visited to outpatient clinic for diarrhea and abdominal pain. Her symptoms were persisted despite of treatment with prednisolone (20 mg/ day) and mesalazine (3. 6 g/day). And her colonoscopic fi nding showed erythematous mucosa and multiple ulcerations from the anal verge to sigmoid colon. Hence, AZA was administered at a starting dose of 25 mg, this was increased up to 50mg after 3 weeks. After 1 month start of azathioprine, she revisited an outpatient clinic for fever and vomiting. Her labora￢tory data showed pancytopenia (leukocyte count 480/mm3, absolute neutrophil count 9/mm3, hemoglobin 7. 9 g/dl, platelet count 3,100/mm3). She was admitted in the hospital and treated for neutropenic fever with broad spectrum antibiotics and cessation of azathioprine, prednisolone, mesalazine. After 3 days with transfusion of blood and intravenous antibiotics, she underwent a bone marrow biopsy. Bone marrow biopsy was consistent with a diagnosis of aplastic anemia. High dose G-CSF (Grasin® 450 μg) was initiated. Two weeks after treatment of G-CSF, the neutrophil count returned to normal range. Moreover, colonoscopy showed healing of diffuse active ulcers following recovery from aplastic anemia and maintenance of remission more than 2 years.

좋은 돌봄의 필요조건과 저해요인에 관한 연구

석재은(Seok, Jae-Eun),노혜진(Noh, Hye-Jin),임정기(Lim, Jeong-Gi) 한국사회복지학회 2015 한국사회복지학 Vol.67 No.3

노인장기요양보험 도입으로 돌봄서비스는 크게 성장하였지만, ‘우리가 과연 충분히 좋은 돌봄을 하고 있는가’라는 질문에 대해서는 긍정적 대답을 하기 어렵다. 이 연구는 우리 사회가 좋은 돌봄을 실현하기 위해서는 어떠한 조건이 필요한가를 파악하는 데 목적이 있다. 이 연구에서는 좋은 돌봄을 창출하는 필요조건과 저해하는 상황이 무엇인지에 대하여 현실적인 지식을 습득하기 위한 방안으로 포커스그룹 인터뷰(FGI)를 활용하였다. 포커스그룹 인터뷰는 요양보호사와 기관장을 대상으로 2014년 1월부터 3월까지 총 3회에 걸쳐서 진행하였으며, 인터뷰마다 3시간 정도 소요되었다. 분석 결과, 좋은 돌봄의 필요조건은 적극적 소통을 통한 상호 이해와 인정, 상호신뢰하고 존중하는 좋은 관계 맺기, 요양보호사의 전문성, 센터 관리자의 전문성, 가족-노인-요양보호사의 3각 파트너십으로 분석되었다. 반면, 좋은 돌봄의 저해요인은 사회적 인정을 받지 못하는 돌봄노동, 돌봄노동의 무정형성과 남용, 요양보호사 및 관리자의 비전문성, 가족의 부적절한 간섭과 무관심, 장기요양환경의 구조적 제약으로 분석되었다. Social care service has grown much with the introduction of Long-Term Care Insurance, but it remains difficult to answer in the affirmative to the question: are we providing sufficiently good care? This study has its purpose in figuring out what conditions are necessary to realize good care in our society. The study has used focus group interview (FGI) as a way to acquire realistic knowledge on the conditions that create good care and its deterring factors. The focus group interview, which targeted long-term care workers and facility heads, was conducted three times from January through March 2014, with each session taking about 3 hours. The analysis showed that the components of good care were mutual understanding and recognition through active interaction, making a good relationship based on mutual trust and respect, professionalism of care worker with flexible judgment that provides customized services, professionalism of center manager with appropriate intermediation, and the tripartite partnership among family, elderly, and care worker. Meanwhile, the deterring factors of good care were identified as devaluation of care labor, ambiguous job description and abuse, unprofessionalism of care worker and manager, inappropriate interference and indifference of family, and the structural constraints on long-term care environment.

라멜라 액정상 메이크업 클렌징 제형

여혜림 ( Hye Lim Yeo ),이지현 ( Ji Hyun Lee ),김수지 ( Su Ji Kim ),노민주 ( Minjoo Noh ),장지희 ( Ji Hui Jang ),김연준 ( Youn Joon Kim ),윤명석 ( Moung Seok Yoon ),유권종 ( Kweon Jong Yoo ),이준배 ( Jun Bae Lee ) 대한화장품학회 2017 대한화장품학회지 Vol.43 No.1

본 연구는 두 개의 편광판 사이에서 홀로그램과 같은 독특한 외관을 갖는 라멜라 액정상 메이크업 클렌징 제형에 관한 것이다. 라멜라 액정상을 갖는 메이크업 클렌징 제형 연구는 오래전부터 많이 시도되어 왔지만, 탁도 증가 및 점도 상승 등의 문제로 실제 상용화에는 한계가 있었다. 본 연구에서는 이러한 문제를 해결하기 위해 계면활성제의 알킬 체인에 의한 액정상의 유동성 증가와 음이온 계면활성제 도입에 따른 정전기적 반발력 증가를 이용하였다. 이를 통해 액정상의 결정화를 억제하여 안정한 액정상 제형을 확보할 수 있었다. 또한, 본 연구에서는 객관적이고 정량적인 클렌징력 평가를 위해 형광물질과 in vivo imaging system (IVIS) 장비를 이용하여 in vitro 클렌징력 평가법을 새롭게 도입하였다. 이렇게 개발된 클렌징력 평가법을 이용하여 라멜라 액정상 메이크업 클렌징 제형의 우수한 메이크업 클렌징력을 확인할 수 있었다. 한편, 본 연구에서 개발된 라멜라 액정상 메이크업 클렌징 제형을 직교 배열된 두 편광판 사이에 두면 홀로그램과 유사한 특이적인 무늬를 관측할 수 있다. 이러한 현상은 액정상 제형을 통과하는 가시광선과 라멜라 구조 사이의 간섭현상에 의한 것으로 추정된다. 클렌징 제형에서의 라멜라 구조는 소각 X선 산란분석(SAXS)을 이용하여 Bragg spacing ratio가 1 : 2의 정수 비로 관찰되는 것을 통해 확인하였다. 본 연구를 통해 개발된 라멜라 액정상 메이크업 클렌징 제형은 우수한 경시 안정성과 클렌징력, 그리고 편광판 사이에서 관찰되는 홀로그램과 유사한 독특한 외관으로 인해 향후 새로운 메이크업 클렌징 제품 개발에 도움이 될 것으로 기대된다. This study is related to a lamellar liquid crystal make-up cleansing formulation with a hologram-like unique appearance between two polarizing plates. Make-up cleansing formulations with a lamellar liquid crystal phase have been extensively studied for a long time, but there have been limitations in practical commercialization because of increasing turbidity and viscosity. In this study, to solve this problem, alkyl chains of surfactants were modified to increase the fluidity of the liquid crystal phase, and electrostatic repulsion force was increased by introducing anionic surfactant. The lamellar liquid crystal make-up cleansing formulation which introduced anionic surfactants can easily inhibit crystallization through electrostatic repulsion force, thereby showing excellent stability overtime, maintaining transparent appearance and viscosity. In addition, we have newly introduced an in vitro cleansing evaluation method using fluorescent material and in vivo imaging system (IVIS) for objective and quantitative cleansing ability evaluation. The excellent cleansing ability of lamellar liquid crystal cleansing formulation has been confirmed by newly developed evaluation method. On the other hand, when lamellar liquid crystal make-up cleansing formulation was placed between orthogonally arranged two polarizing plates, a specific pattern like a hologram can be observed. This phenomenon is presumably interpreted as the interference between the visible light passing through the liquid crystal formulation and the lamellar structure. The lamellar structure of cleansing formulation was confirmed by SAXS analysis, exhibiting Bragg spacing ratio of 1 : 2. The lamellar liquid crystal make-up cleansing formulation prepared in this study would be useful for future application in make-up cleansing due to its excellent stability, cleansing ability, and unique hologram-like pattern placed between two polarizing plates.