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심한 정신병적 증상을 나타낸 전신성 홍반성 루푸스 3례
문혜원,강민희,송정수,박원,김철응,이정섭,배재남 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.3
전신성 홍반성 루푸스(systemic lupus erythematosus, 이하 SLE)는 원인을 알 수 없는 자가항체 및 면역복합체로 인하여 여러 장기의 손상을 초래하는 질환이다. SLE의 신경정신의학적 증상에 대하여는 1872년 Kaposi에 의해 처음 기술되었다. 이때에 나타나는 임상적 양상은 상당히 다양하여 정신증, 우울증, 뇌졸증과 인지기능장애등을 포함한다. 이들은 종합적인 정신과적 평가를 위해 종종 협의진료가 의뢰되고 있다. SLE의 정신병적 증상은 환자의 사망률을 높이고 좋지 않은 예후를 시사하는 지표가 될 수 있기 때문에 조기 진단 및 치료가 요구된다. 그러나 SLE의 중추신경계 침범에 대한 명확한 진단기준이 마련되어있지 않고, 증상의 다양성과 변동성은 진단을 더욱 어렵게한다. 저자들이 경험한 심한 정신병적 증상을 보인 SLE 3례의 경우, 이들은 지남력 장애, 환시, 환청, 망상, 불안정한 기분을 보였고 자주 충동적이 되거나 난폭해져 자신 또는 타인에게 위험을 초래할 수 있었다. 현재까지 SLE의 정신병적 증상에 대하여 잘 알려져 있지는 않지만, 문헌고찰을 통해 발병기전, 분류진단, 임사양상, 치료등에 대하여 알아보았다. Systemic lupus erythematosus(SLE) is a disease of unknown etiology in which multiple organs are damaged by pathogenic autoantibodies and immune complexes. Neuropsychiatric manifestations in SLE were first described by Kaposi in 1872. These are so diverse that they include psychosis, depression, stroke, seizure and cognitive dysfunction etc.These patients are frequently consulted for psychiatric evaluation. Neuropsychiatric manifestations in SEL re also among the leading causes of morbidity and mortality and associated with poor long-term outcome. So it is essential to recognize and intervene these symptoms early. But the clear diagnostic criteria for CNS involvement in SLE have not been formulated, and diversity and fluctuation of illness make it difficult to confirm it. The authors reported three cases of SLE with severe neuropsychiatric manifestation. These patients showed symptoms such as disorientation, auditory and visual hallucibation, delusion and mood instability. They became frequently impulsive and violent and had risks to injure themselves or others. Although CNS involvement in SLE is not well known, we reviewed the pathogenesis, classification, diagnosis, clinical manifestation and treatment of them.
국내 Fabry disease 환자의 a-Galatosidase A 유전자 돌연변이 검색
박기범,최지혜,강윤성,김선미,정향민,문영준,이광호 中央大學校 基礎科學硏究所 2001 基礎科學硏究所 論文集 Vol.15 No.-
Fabry disease(FD) is an X-linked recessive lysosomal disorder caused by a deficiency of a-galactosidase A(a-Gal A), localized at Xq22. Besides onset of pain and paresthesias in the extremities, FD was diagnosed by absence of a-Gal A activity. In this experiment the a-Gal A activity of Korean FD patients was spectrometrically analysed using an artificial substate, 4-Mrthylumbellifery1-a-D-galactoside. As expected, no a-Gal A activity was detected in lymphocytes and lymphoblastoid cells from FD patients. To screen the mutation in their a-Gal A genes, we performed single strand conformation polymorphism(SSCP) and PCR-direct sequencing form seven a-Gal A exons. The nonsense mutation was identified both in classically affected hemyzygotes and a heterozygote. They showed the C to T transition at nucleotide number 11,002, resulting in a arginine-to-stop(R342X). This result will be applicable for pre- and neonatal detection of FD and to define the genotype/phenotype correlation.
Actual situation and prescribing patterns of opioids by pain physicians in South Korea
Min Jung Kim,Ji Yeon Kim,Yun Hee Lim,Sung Jun Hong,Jae Hun Jeong,Hey Ran Choi,Sun Kyung Park,김정은,Min Ki Lee,Jae Hun Kim 대한통증학회 2022 The Korean Journal of Pain Vol.35 No.4
Background: Use of opioids for chronic intractable pain is increasing globally, and their proper use can improve patients’ quality of life. In contrast, opioid use disorders, such as abuse or addiction, caused by prescribing opioids, are a worldwide issue. This study aimed to understand current opioid prescribing patterns and pain physicians’ experiences with opioid use in South Korea. Methods: Pain physicians in 42 university hospitals in South Korea were asked to complete anonymous questionnaires regarding opioid prescriptions. Results: A total of 69 surveys were completed. Most pain physicians started prescribing opioids at a pain score of 7/10 and aimed to reduce pain by 50%. Most physicians (73.1%) actively explained the prescribed medications and possible side effects, and 61.2% of physicians preferred the prescription interval of 4 weeks. Immediate-release opioids were the most popular treatment for breakthrough pain (92.6%). The most common side effect encountered by physicians was constipation (43.3%), followed by nausea/vomiting (34.3%). Of the physicians, 56.5% replied that addiction and misuse prevalences were less than 5%. However, the most concerning side effect was addiction (33.0%). Conclusions: The survey results showed that the prescribing patterns of pain physicians generally followed Korean guidelines. Physicians were most interested in the safety and effectiveness of opioid prescriptions. They were most concerned about respiratory depression and abuse or addiction. A significant number of physicians agreed that the NHIS regulations needed improvement for patient convenience and safe and effective treatment, though there were pros and cons of the NHIS restrictions on prescription conditions.
전문건설업의 CEO특성, 회계정보이용, 경영성과의 관계
김민성(Min Sung Kim),정순여(Soonyeo Jung),박혜영(Hey Young Park) 한국관리회계학회 2022 관리회계연구 Vol.22 No.2
[연구목적] 본 연구는 CEO의 전문성과 리더십이 재무회계정보이용과 원가관리회계정보이용에 미치는 영향과 이들 회계정보이용이 재무성과 및 비재무성과에 미치는 영향을 살피는 것을 목적으로 한다. [연구방법] 연구대상은 제주도내 전문건설업 매출 순위 100위 업체이며, 설문조사법으로 데이터를 수집하였다. 최종 54부의 데이터가 분석에 사용되었다. 분석방법은 SPSS 18.0과 Smart PLS 3.0이다. [연구결과] 첫째, CEO특성(CEO 전문성, CEO 리더십)은 회계정보이용(재무회계정보의 이용과 원가관리회계정보의 이용)에 유의한 정의 관계가 있는 것으로 나타났다. 둘째, 회계정보의 이용(재무회계정보의 이용과 원가관리회계정보의 이용)이 경영성과에 미치는 영향도 긍정적으로 나타났다. 셋째, 경영자의 특성이 원가관리회계 정보사용을 통해 비재무적 성과에 유의한 간접효과를 미치고 있음을 확인하였다. [연구의 시사점] 본 연구는 제주도지역의 전문건설업에 관한 연구가 부족한 상황에서 실증연구를 수행하였다는 점에서 의의가 있다. 연구 결과는 전문건설업의 경영성과를 향상시키기 위한 회계정보시스템 수립 시의 기초자료로 활용될 수 있으며, 전문건설업의 특수성을 고려한 회계정보시스템의 설계에 도움이 될 것이다. [Purpose] The purpose of this study is to examine the effect of CEO’s expertise and leadership on the use of financial accounting information and cost management accounting information and the effect of the use of these accounting information on financial and nonfinancial performance. [Methodology] The subject of this study was the top 100 companies in the sales ranking of the professional construction industry in Jeju-do, and data was collected using a survey method. The final 54 copies of data were used for analysis. The analysis methods are SPSS 18.0 and Smart PLS 3.0. [Findings] First, it was found that CEO characteristics (CEO expertise, CEO leadership) had a significant positive relationship with the use of accounting information (the use of financial accounting information and the use of cost management accounting information). Second, the effect of the use of accounting information (use of financial accounting information and use of cost management accounting information) on business performance was also positive. Third, it was confirmed that the characteristics of managers had a significant indirect effect on non-financial performance through the use of cost management and accounting information. [Implications] This study is meaningful in that it conducted an empirical study in a situation where there is a lack of research on the specialized construction industry in Jeju Island. The research results can be used as basic data when establishing an accounting information system to improve the management performance of the professional construction industry, and will be helpful in designing an accounting information system considering the specificity of the professional construction industry.
김민영 ( Min Yeong Kim ),권오준 ( O Jun Kown ),추병길 ( Byung Kil Choo ),이가위 ( Chia Wei Lee ),박은혜 ( Eun Hey Park ),김홍준 ( Hong Jun Kim ) 대한본초학회 2016 大韓本草學會誌 Vol.31 No.3
Objectives:Arachidonic acid is control the thromboxane A2 (TXA2) and prostacycline (PGI2) synthesis, TXA2 increase lead to thrombus produced by induces platelet aggregation and vasoconstriction. Angelicae gigantis radix (RAR) is mainly used blood deficiency and stagnation. In previous studies, RAR has been reported that a vasodilating and blood clotting delay effects. In this study, investigate that anti-oxidant and anti-thrombotic effects of RAR by heat-process. Methods:The heated angelicae gigantis radix sample were made by 140, 180, and 220 ℃ and 4, 6, 9 and 12 min using water or 30% ethanol. The anti-oxidant effects were measured by total polyphenol, total flavonoid, DPPH and ABTS radical scavening activation. Anti-thrombotic effect conducted in samples that are determined to be effective through the anti-oxidant experiment such as angelicae gigantis radix roasted 180℃, and 220℃ and angelicae gigantis radix roasted with 30% ethanol 180℃, and 220℃. Results:Anti-oxidant parameters were efficacious in high temperature roasted AR. Also AR and EAR increased a inhibitory activity of FXa compared with RAR. The blood coagulation time of administration groups were significantly increased compare with control group. The TXB2 was significantly decreased in AR and EAR. Conclusions : We confirmed that whether AR and EAR administration has anti-oxidant and anti-thrombotic effect or not. As the results, AR and EAR were improved anti-oxidant effects and blood biochemistry compare with control group. This study provides scientific evidence that AR and EAR are have an anti-oxidant effect and anti-thrombotic effect, it expected that there is no difference between the two.