스피로노락톤의 한국인 지원자에서의 약물속도론적 연구

심희옥,이선영,지웅길,김동출 충남대학교 약학대학 의약품개발연구소 2005 藥學論文集 Vol.20 No.-

A reversed phase HPLC method was developed and validated for the determination of spironolactone in human plasma. Fenoprofen was used as an internal standard. Calibration curves were linear in the concentration range of 2.5~200 ng/㎖. The coefficient of variation of the intra- and inter-day precision were below 15%. The coefficient of variation of the accuracy were below 15% in the concentration range investigated. A bioavailability study was performed using the validated HPLC method. Eight healthy male volunteers were orally administered 100 ㎎ of spironolactone. The pharmacokinetic parameters were calculated using WinNonlin. The mean values of AUC_(12hr) was 158.9±69.9 ngㆍhr/㎖, C_(max) was 42.2±14.9 ng/㎖, T_(max)was 1.79±0.60 hr, t_(1/2) was 2.72±0.87 hr. The pharmacokinetic parameters and the HPLC method can be used for the design of bioequivalence study of spironolactone.

간호사를 위한 재활간호 교육의 효과

소희영,김봉옥,송재금,심희숙 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.1

To explore the effects of the rehabilitation nursing education on registered nurses, this study was designed quasi-experimentally for one group pre-test and post-test respectively. The study employed the Client Satisfaction Questionnaire, Positive Feeling Questionnaire, Self-Attitude (Confidence) Inventory, and Nurses Attitude Scale. The study found that only the positive feeling of professional nurses toward their rehabilitation clientele increased after rehabilitation nursing education, which means both that nurses showed inadequate awareness of the disabled and that a change of nursing awareness was critical if a change in popular awareness was to be realized. One influence on positive feeling was the current job position of the nurse subjects, with the position of head nurse especially affecting positive feeling. Considering experiences and career of head nurse, the positive feeling could be the influence of professional life. Another influence on the self-confidence of the nurse subjects was the working ward, specifically the rehabilitation ward. Because the level of self-confidence in rehabilitation nurses should increase the level of rehabilitation nursing received by the clients, rehabilitation nursing education must continue in future. Since a significant positive correlation was found between rehabilitation nursing education and positive feeling, the higher satisfaction about rehabilitation nursing education could result more positive feeling of nurses toward the disabled. Therefore there should be further educational programming to increase client satisfaction. The opinions of educational participants should be considered in instituting improved educational programs for rehabilitation nurses.

쌍태임신중 일측태아 사망 5 예에 대한 임상적 고찰

신정옥,심일구,이항재,김희범 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.1

Objective : Our purpose of this study was to evaluated the incidence of twin pregnancy with one fetal demise, predisposing factors and the maternal complications and perinatal outcomes. Patients : From January 1993 to December 1997, 5 twin pregnancy with single fetal demise after 28 weeks gestation by gestational age were observed in Soonchunhyang Kumi Hospital. Results : 1. The incidence of one fetal demise was 3.01% in twin pregnancy. 2. Maternal disseminated intravascular coagulation has not been demonstrated. 3. The predisposing factors of twin pregnancy with single fetal demise are umbilical cord torsion (40%), congenital anomaly(20%) and unknown(40%). 4. According to chorionicity, it seems that the perinatal mortality rate of monochorionic group was higher than dichorionic. Conclusion : This study suggests that monochorionic placentation is associated with increased risks of twin pregnancy with single fetal demise. But it may be partially explained due to small numbers of cases in this study.

한국인 지원자에서 니모디핀의 생체이용율연구

강원호,심희옥,남진경,김동출 忠南大學校 生命科學硏究院 醫藥品開發硏究所 2006 藥學論文集 Vol.21 No.-

A reversed phase HPLC method was developed and validated for the determination of nimodipine in human plasma. Nitrendipine was used as an internal standard. Calibration curves were linear in the concentration range of 5~300 ng/ml. The coefficient of variation of the intra- and inter-day precision was below 15%. The coefficient of variation of the accuracy was below 15% in the concentration range investigated. A bioavailability study was performed using the validated HPLC method. Eight healthy male volunteers were orally administered 30 mg of nimodipine. The pharmacokinetic parameters were calculated using WinNonlin. The mean values of AUC_(24hr) was 64.0±31.3 ng·hr/ml, C_(max) was 46.5±31.2 ng/ml, T_(max) was 0.54±0.17 hr and t_(1/2) was 3.03±2.26 hr. The pharmacokinetic parameters and the HPLC method can be used for the design of bioequivalence study of nimodipine.

프리미돈의 한국인에서의 생체이용율시험

권광일,윤민혁,윤희열,박희찬,권준택,심희옥,김동출 충남대학교 약학대학 의약품개발연구소 2004 藥學論文集 Vol.19 No.-

A reversed phase HPLC method was developed and validated for the determination of primidone in human plasma. Propylthiouracil was used as an internal standard. Calibration curves were linear in the concentration range of 10-120 ng/㎖. The coefficient of variation of the intra- and inter-day precision were below 15%. The coefficient of variation of the accuracy were below 15% in the concentration range investigated. A bioavailability study was performed using the validated HPLC method. Twenty four healthy human male volunteers were orally administered 20 mg of primidone. The pharmacokinetic parameters were calculated using WinNonlin. The mean values of AUC_(LAST) was 85.0±17.7 ㎍ hr/㎖, C_(max) was 4.22±1.04 ㎍/㎖, T_(max) was 1.85±1.13 hr, t_(1/2) was 17.7±2.4 hr. The pharmacokinetic parameters and the HPLC method can be used for the desigm of bioequivalence study of primidone.

The Interaction of Barley Acetolactate Synthase with 4,6-Dimethoxypyrimidine Inhibitors

Shim, Hee-Ok,Kim, Dae-Whang,Chang, Soo-Ik,Choi, Jung-Do Korean Society for Biochemistry and Molecular Biol 1995 Journal of biochemistry and molecular biology Vol.28 No.6

Acetolactate synthase (ALS) catalyzes the first common step in the biosynthesis of valine, leucine, and isoleucine. ALS is the target enzyme for several classes of structually diverse herbicides. We have synthesized 4,6-dimethoxypyrimidine derivatives as ALS inhibitors, and their inhibitory activities on barley ALS were determined. $IC_{50}$ values for the derivatives are 0.2~200 ${\mu}m$. K11570, the most potent ALS inhibitor with $IC_{50}$ of 0.2 ${\mu}m$, showed mixed-type inhibition with respect to substrate pyruvate, and the progress curves for ALS inhibition by K11570 indicated that the amount of inhibition increased with time. Inhibition-competition experiments were carried out and indicated that three different classes of inhibitors, K11570, a sulfonylurea Ally, and leucine, bind to ALS in a mutually exclusive manner. Chemical modification of tryptophanyl and tyrosyl residues of ALS decreased the sensitivity of ALS to K11570, while cysteine modification did not affect the sensitivity. These results suggest that tryptophanyl and tyrosynyl residues are probably located at or near the inhibitor binding site.

확장된 DNS 보안 베커니즘의 설계 및 구현

심희원(Shim Hee Won),김진성(Kim Jin Sung),심영철(Shim Young Chul),임찬순(Lim Chan Soon),변옥환(Byeon Ok Hwan) 한국정보처리학회 1999 정보처리학회논문지 Vol.6 No.1

The DNS provides naming services which are the basis for the application of the Internet and the security of the DNS should be provided for the security of the internet. Recently IETF proposed a method which guarantees the integrity of DNS database contents and DNS queries/replies and distributes host public keys. In this paper we describe the design and implementation of the secure DNS which is built based on the IETF proposal and extended to facilitate its use and management. In the extended secure DNS, DNS servers are used as the directory system in a public key infrastructure and stores/distributes user public key certificates. The Web-based management interface and security log functions are added and the extended secure DNS is being built so that new cryptographic algorithms can be easily added.

안전한 DNS 에서의 효율적인 동적 갱신과 존 전송 기능의 설계와 구현

심희원(Hee Won Shim),심영철(Young Chul Shim),임찬순(Chan Soon Im),이만희(Man Hee Lee),변옥환(Ok Hwan Byeon) 한국정보처리학회 2000 정보처리학회논문지 Vol.7 No.1

In the secure DNS the amount of information that should be managed greatly increased and the interdependency in the information became very complex. Therefore, it became necessary to develop a mechanism which can manage zone information efficiently. Moreover, a consistent interface became also necessary so that a secure DNS may be efficiently interconnected with other Internet application services. In this paper we explain the design and implementation of a secure DNS extended with two functions(1) a dynamic update function which enables to add and remove zone information dynamically and (2) a zone transfer function that efficiently transfers updated zone information among DNS servers. We developed a method which integrates two zone transfer mechanisms, full zone transfer and incremental zone transfer, and also proposed a method to compress data in the zone transfer message. We also introduced a data structure called a delta file to integrate the zone transfer function and the dynamic update function.

낙상 peer review group 운영을 통한 낙상발생률 감소

성일순,송미라,김희선,김은숙,정미아,이수미,하국희,김성화,이혜란,안경진,심미옥,김낙희,성영희 한국의료QA학회 2008 한국의료질향상학회지 Vol.14 No.1

Background : This study was to reduce incidence of falls by analyzing actual problem and drawing out improvement plan applicable to the clinical practice throughoperation of the staff nurses-centeredfall peer review group. Method: The fall peer review group was composedof 8 nurseshavingpatient nursing experience for over 5years, and each of fall cases was reviewed and the root cause was analyzed. As a result, it was found that the patients and their families did not fully understandthe content of the education, and the staff nurses did not completely inspect the risk factors of falls and performimmediate intervention whenpatient's condition changed. Based on the above-mentioned results, improvement activity was conducted for the purposes of consolidating patients education methodand supplementing computerized systemto supportnurses' decision making as wellas devicesand facilities. Result: As a resultof conducting improvement activity in the aspects of education forpatients, support of nurse's decision-making, and devicesand facilities through operation of the staff nurses-centered fall peer review group, falls decreased by 9.5% comparedto beforeimprovement activity. Conclusion : It is concluded that operation of the clinical nurses-centered fall peer review group played a roleof promoter to draw out practical and applicable improvement plan to the clinicalpractice and apply directions of the field-centered, and increased nurses' interest in falls and ultimately, reduced incidence of falls. Therefore the Center willcontinue to operate the staff nurses-centered peer review group, and recommends participation of nurseswhoactually take the charge of nursingpatients in furtheranalysis ofpatients' safety accidents.

Increased Cutaneous Lymphocyte Antigen(CLA)+T Cells in the Peripheral Blood of Children with Severe Atopic Dermatitis

Shim, Jung-Yeon,Lee, So-Yeon,Kim, Hyo-Bin,Kim, Bong-Seong,Kim, Ja-Hyung,Seo, Ji-Hye,Jang, Seong-Ok,Jung, Seo-Hee,Hong, Soo-Jong 대한 소아알레르기 및 호흡기학회 2004 소아알레르기 및 호흡기학회지 Vol.14 No.2