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이중의,신상도,표창해,서길준,정성은,윤여규 대한응급의학회 1999 대한응급의학회지 Vol.10 No.4
Background : Multi-organ failure from sepsis is very lethal disease entity, which is suspected to be caused by activated inflammatory cells. Inflammatory cells activated by endotoxins generate oxidants and cytokines such as TNF-α and IL-6, which in turn stimulate macrophages and neutrophils. Augmented inflammation makes an organ-injury deteriorate into an organ-failure, which may progress to multi-organ failure. This study is designed to evaluate the therapeutic effects of vitamin-C, a scavenger of oxidants, in sepsis. Methods : Male Sprague-Dawley rats were divided into 3 groups : a control group, a group injected intrapetoneally with LPS(lipopolysaccharide), and a group injected intraperitoneally with LPS and vitamin-C. Each eight rats were sacrified 24 hours and 48 hours after injection, and samples of the blood, the liver and the lung were obtained. Biochemical assays of TNF-α level in the blood and malondialdehyde(MDA)level, catalase activity and nitric oxide synthase(NOS)activity in the liver and the lung tissues were performed. Results : Serum TNF-α level, tissue lipid peroxidation and tissue i-NOS activity were dramatically increased, and tissue catalase activity was exhausted rapidly in sepsis. High dose vitamin-C administration decreased serum TNF-α level, tissue lipid peroxidation and tissue i-NOS induction, and protected against catalase exhaustion. Conclusion : high dose vitamin-C therapy was proved to have definite antioxidant effect in septic condition.
Kinetic Study of Recycled Newspaper Liquefaction in Polyol Solvent
Hae Joong Shin,김창준,김성배 한국생물공학회 2009 Biotechnology and Bioprocess Engineering Vol.14 No.3
The kinetics of liquefaction of recycled newspaper was investigated. Liquefaction was carried out in the presence of polyhydric alcohols and ethylene carbonate under acidic conditions. The liquefaction yield was found to be a function of the solvent type, sulfuric acid concentration, temperature, and the ratio of solvent to newspaper. The total liquefaction rate and degradation rates of cellulose, hemicelluloses, and lignin, which are the major components of newspaper, were measured. From the results, it was found that the total liquefaction rate did not follow first order reaction kinetics, because of the difference in the degradation rate of each component and the condensation of lignin. The degradation rates of lignin and hemicellulose were approximately 13 and 7 times greater than that of cellulose, respectively
Hae Joong Shin,김창준,김성배 한국생물공학회 2008 Biotechnology and Bioprocess Engineering Vol.13 No.3
The purpose of this research was to study the enhancement of rifamycin SV (RSV) yield according to the feeding method of a carbon source for Amycolatopsis mediterranei MM2. RSV produced during fermentation dropped sharply after reaching a maximum, and it was found that this trend of RSV production resulted from simultaneous production and degradation of RSV. To reduce RSV degradation during incubation, the effect of carbon source on cell growth was investigated. Based on the results, glucose was a better carbon source than glycerol for cell growth, although glycerol was better than glucose for RSV production, as reported in our previous study. To confirm this, RSV yield and dry cell weight (DCW) were measured according to the feeding method of carbon source using a 5-L size bioreactor. Results showed that initial cell growth rate and RSV yield were significantly increased regardless of the addition method of glucose into glycerol, provided glucose was present in the initial stage of cell growth.
Shin, Hae-Joong,Kim, Chang-Joon,Kim, Sung-Bae Korean Society for Biotechnology and Bioengineerin 2007 Biotechnology and Bioprocess Engineering Vol.12 No.4
In this paper, we conducted a statistical optimization of the medium components for the production of rifamycin SV by Amycolatopsis mediterranei MM2. In order to maximize the yield of rifamycin SV, a Plakett-Burman experimental design (PBD) was initially utilized in the screening of the medium components among 11 nutrients. Glycerol and yeast extract were determined to influence significantly the yield of rifamycin SV. Then, a central-composite experimental design (CCD) was utilized in order to optimize the concentrations of the screened components accqired using the PBD and to predict the mutual interactions occurring between the screened components. The predicted optimal glycerol and yeast extract concentrations were determined to be 43.8 and 9.5g/L, respectively. At this optimum point, the predicted rifamycin SV yield was 490.5 mg/L, whereas the corresponding experimental yield was $480.3{\pm}43.8 mg/L$.
NO 환원반응을 위한 V₂O?/TiO₂계 촉매필터의 MnO₂ 조촉매 효과
신해중(Hae Joong Shin),최재호(Jae Ho Choi),송영환(Young Hwan Song),이주영(Ju Young Lee),장성철(Sung Cheol Jang),최주홍(Joo Hong Choi) 대한설비공학회 2008 대한설비공학회 학술발표대회논문집 Vol.2008 No.2
Nitrogen oxides (NO, NO₂ and N₂O) have been controlled effectively by the SCR catalysts coated on monolith or honeycomb in commercial sites with ammonia as reductant at high temperature range 300~400℃. However, the catalytic filter has much merit on the point of controlling the particles and nitrogen oxides simultaneously. It will be more advanced-system if the catalytic working temperature is reduced to the normal filtration temperature of under 200℃. This study has focus on the development of the catalytic filter working at the low temperature. So the additive effect of the components such as Pt and Mn (which are known the catalytic component of V₂O5/TiO₂ was investigated. The V₂O?-WO₃ catalytic filter exhibited high activity and selectivity at 250~320℃ showing more than 95% NO conversion for the treatment of 600 ppm NO at face velocity 2 cm/s. The Pt-V₂O?-WO₃ catalytic filter shifted the optimum working temperature towards the lower temperature (170~200℃). And NO conversion was 100% and higher than that of V₂O?-WO₃ catalyst at 250~320℃. The MnOX-V₂O?-WO₃ catalytic filter showed the wide temperature range of 220~330℃ for more than 95% NO conversion. This is a remarkable advantage when considered the MnOX catalytic filter presents the maximum activity at 150~250℃ and V₂O?-WO₃ catalytic filter shows the maximum activity at 250~320℃.