Urapidil, Labetalol의 투여가 기관내 삽관시 심혈관계에 미치는 영향

신용섭,윤석화,손수창,이원형,이정은,황원재,김만수,김영주,김혜자,최세진 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

We have examined the comparative efficacy of small doses of intravenous urapidil and labetalol in blunting hemodynamic response to endotracheal intubation and surgical incision in 30 patients without cardiovascular diseases. After intravenous urapidil 0.2 mg/kg or labetalol 0.2 mg/kg anesthesia was induced with thiopental 5mg/kg. Endotracheal intubation was facilitated by vecuronium 0.15 mg/kg with priming principle and anesthesia was maintained with enflurane and nitrous oxide in oxygen. Systolic, diastolic and mean arterial pressure and heart rate were measured before administration of the drugs, 5 minute after administration, just prior to endotracheal intubation and 1, 3, 5, 10 minute after intubatin. Also the peak blood pressures and heart rate within 10 minutes after surgical incision were measured. Endotracheal intubation and surgical stimulation were associated with significant increases in blood pressures and heart rate in both urapidil and labetalol group. Comparison of the changes in systolic, diastolic, and mean artrial pressures and heart rate between urapidil and labetalol group showed no significant difference except peak systolic pressure after surgical incision. It is concluded that the pressor response to endotracheal intubation and surgical stimulation are not influenced significantly by urapidil 0.2 mg/kg or labetalol 0.2 mg/kg. However, urapidil and labetalol preloading may be similarly effective in the blunting of the increases in blood pressures with larger doses of the durgs during anesthetic induction.

두경부 암환자의 항암화학요법에 따른 삶의 질 변화

신혜숙,박혜자,박명희,연기순,김훈교,문한림,송혜향 가톨릭대학교 가톨릭대학교 간호대학 호스피스 교육연구소 1999 호스피스논집 Vol.4 No.-

The purpose of this study was to assess the changes in quality of life wish elapse of chemotherapy in head and neck cancer patients. This study was a longitudinal descriptive design. The subjects were 9 patients who had stage III and stage IV head and neck cancer and received neoadjuvant cisplatin and 5-fluorouracil chemotherapy. Linear Analogue Self Assessment Scale (LASA) of the QOL which it includes eleven items(seven physical items appetite, nausea/vomiting, physical well-being, vigor activity, energy, sleepiness, fatigue and four mental items anger, anxiety, depression & vital power) were used to assess the quality of life eleven times(once in the prechemotherapy period and from the 1st day to 10th day postchemotherapy). The means of scores at each time were analyzed by repealed measures of ANOVA and Bonferroni multiple comparison method. The results are as follows : 1. The degree of appetites decreased significantly on the period between third and sixth day compared with that of appetites on the prechemotherapy day (p<0.001). 2. The degree of physical well-being decreased significantly on the period between first and fifth day compared with that of physical well-being on the prechemotherapy day (p<0.001). 3. The degree of nausea/vomiting decreased significantly on the period between first and fourth day compared with that of appetites on the prechemotherapy day (p<0.001). 4. The degree of anger decreased significantly on the second, fourth, eighth and ninth day after chemotherapy compared with that of anger on the prechemotherapy day(p<0.001). 5. The degree of fatigue decreased significantly on the fourth day compared with that of fatigue on the prechemotherapy day(p<0.001). 6. The increment of nausea/vomiting and poor appetite started on the 2.89th day and 3.67th day after chemotherapy, respectively. 7. The increment of sleepiness started on the 2.56th day after chemotherapy. 8. The increment of depression and anxiety started on the 2.33th day and 3.33th day after chemotherapy, respectively. 9. The lowest degrees of nausea/vomiting and poor appetite were 37.00±17.9 % and 28.64±14.94 % after chemotherapy compared with those of nausea/vomiting and poor appetite on the prechemotherapy day, respectively. 10. The lowest degrees of anger and vigor activity were 48.12±28.3 % and 39.83±24.9 % after chemotherapy compared with those of anger and vigor activity on the prechemotherapy day, respectively. 11. The recovery rates of eight items of quality of life (appetite, vigor activity, energy, fatigue, anger, anxiety, depression & vital power) were shown to reach a peak on the tenth day after chemotherapy and be reached to almost 84 % compared with those of quality of life on the prechemotherapy day. 12. The recovery rates of physical well-being and sleepiness were shown to reach to 67.75 % and 95.68 % on the 10th day after chemotherapy compared with those of physical well-belong and sleepiness on the prechemotherapy day. 13. The recovery rates of seven physical items were faster than those of four mental items on the 10th day after chemotherapy. In conclusion, it is suggested that nursing care strategies to improve the quality of life in patients with chemotherapy would be established both physically and mentally, and be extended at least ten days when patients stayed their home after chemotherapy.

大學生活指導의 專門的 正體

崔海春,申海雨,宋明子 東亞大學校 學生指導硏究所 1978 學生硏究 Vol.9 No.-

大學敎育의 理念과 學生指導

崔海春,申海雨,姜永三,宋明子 東亞大學校 學生指導硏究所 1978 學生硏究 Vol.9 No.-

三日酒와 三日 基以內로 빚어지는 우리나라의 速成酒 : Ⅱ. 찹쌀로 빚은 速成酒 Ⅱ. About Brewing from Glutinous Rice

錢精日,申敏子,崔榮辰,金賢淑,李惠靜,鄭在洪,白淑殷 동아시아식생활학회 1999 東아시아食生活學會誌 Vol.9 No.3

This study was carried out to understand the brewing and processing methods of rapid-brew alcoholic beverage. In the contents of 45 classical records, there were 68 items about rapid-brew alcoholic beverage and single and double brew alcoholic beverage. Those alcoholic beverage of 68 items above, were made from green grown at that time-rice, glutinous rice, regular rice. Selected 38 items among those brewages, alcoholics from glutinous rice, were distributed into 4 patterns. Four patterns, grounded on rapid-brewing and processing methods, were set one thing to another and analyzed.

Midazolam의 백서 기관평활근 이완효과와 Flumazenil의 길항작용

윤석화,신용섭,손수창,이원형,김혜자,최세진 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2

Midazolam have been used widely as adjuvants in both regional and general anesthesia and in high risk patients in the intensive care unit. In the present study we evaluated the effect of midazolam and antagonistic effect of flumazenil on isolated rat tracheal preparations mounted for recording isometric contractile force. Trachea smooth muscle were contracted with acetylcholine (10^-5M, Ach) and potassium chloride (40mM KC1). Midazolam 5x10 exp (-6)M and 5x10 exp (-5)M produced dose-dependent relaxation and flumazenil (3.2 x 10 exp (-7)M), central antagonist of benzodiazepine, pretreatment had no significant change midazolaminduced relaxation. Midazolam probably did not relax airway smooth muscle by activatong central benzodiazepine receptors, as flumazenil did not block the concentration-related relaxation of midazolam. Our study suggests that flumazenil may be used satety for asthmatic patients who have been with midazolam, as flumazenil did not antagonize airway relaxation elicited by midazolam.

일 간호대학의 지역사회 방문간호사업 사례

강윤숙,최양자,고영애,전시자,조갑출,이옥철,주혜경,신기수,안은숙 적십자간호전문대학 2000 적십자간호전문대학논문집 Vol.22 No.-

트립토판 중합효소 알파 소단위체의 in vitro 구조재형성시 Ca^2+과 Mg^2+이온의 단백질 응집체 형성 촉진 효과

천광호,김종원,신혜자,임운기 부산대학교 유전공학연구소 1999 분자생물학 연구보 Vol.15 No.-

The effect of cations on the formation of protein aggregates was examined by in vitro refolding of mutant tryptophan synthase α-subunit in which Pro 24 was replaced by Leu. NH^+_4, K^+ and NA^+ had no effect, but Mg^2+ and Ca^2+ stimulated the formation of protein aggregates in dose-dependent manner. It is suggested that Mg^2+ and Ca^2+ may be implicated in the formation of protein aggregates in vivo.

신안 상서고분군 석재에 대한 암석학적 특성과 석재 유통 고찰

윤석태 ( Youn Seok-tai ),고영구 ( Koh Yeong-koo ),오강호 ( Oh Kang-ho ),김해정 ( Kim Hae-jung ),신자경 ( Shin Ja-kyeong ),김해경 ( Kim Hai-gyoung ) 한국도서(섬)학회 2018 韓國島嶼硏究 Vol.30 No.1

이 연구는 전남 신안군 상태도에 위치한 상서고분군 축조에 사용된 석재들에 대한 암석학적 특성과 채석 등 유통과정에 대해 고찰하고자 하였다. 고분 축조에 사용된 석재들에 대한 암석학적 특성 연구는 외관적 관찰에 의한 암석기재적 연구와 편광현미경 하에서 암석의 광물조성과 조직특성에 대한 연구 및 암석의 주성분 함량조성을 통한 지구화학적 연구를 수행하였다. 이 연구들과 함께 주변지질들과 관련하여 고분석재들의 채석과 이송 등에 대한 연구도 병행하였다. 고대로부터 신안군 일대는 한국-중국-일본을 연결하는 고대 해상교통로에 중요한 위치를 점하는 것으로 알려져 고분 축조에 사용되었던 석재 연구는 고대 해양사 측면에서 의미를 지닌다고 할 수 있다. 기재적 관찰에서 석재들은 중성암맥 기원인 안산반암을 제외하고는 대부분이 응회암류에 해당한다. 이들은 라필리응회암과 세립질 응회암으로 구분되는데 대부분 세립질 응회암에 속한다. 응회암 구성입자들은 각상에서 초각상이고 분급도는 불량하다. 세립질 응회암들은 매우 치밀한 조직을 보유하고 특히 라필리응회암의 불규칙한 이탈흔들은 타포니(tafoni)와 관련될 가능성이 있다. 응회암의 입자들은 사장석편과 암편 등이 주를 이루며 크기 범위가 광범위하다. 사장석들은 알바이트 쌍정이 잘 나타나고 격자쌍정을 이루는 미사장석들도 출현한다. 응회암의 치밀한 조직은 부분적으로 속성작용과 관련되는 것으로 여겨지며 다양한 풍화정도를 보인다. 또한, 미세한 석영맥들이 응회암들을 종횡으로 관통하고 있다. 상기한 상서고분군 석재들에 대한 주성분 원소 함량에 대한 지구화학적 연구에 의하면, 이들 응회암은 화산암류 관점에서 산성암계열에 근접한 중성암 계열 및 산성암계열에 해당시킬 수 있다. 이러한 함량분포 특성 상, 이 응회암들은 두 가지 군으로 나눌 수 있다. 그리고 TAS(total alakali vs silica) 분류에서 이 응회암들은 저알칼리암 계열에 도시된다. 고분축조에 사용된 응회암들은 주변의 암석과 매우 유사하며 석재들 자체도 광물조상과 조직특성에서 서로 유사정도가 높다. 일반적으로 응회암들은 판상특성, 가공의 용이성 및 상대적인 견고성으로 고분과 건축 등에 많이 이용되어 왔다. 이러한 결과들을 기반으로 고분축조에 사용된 응회암들은 산성암계열에 근접한 중성암계열 및 산성암계열 기원을 가지며 주변 암석에서 채석·이송된 것으로 추정된다. This study considers on petrological characteristics and distribution to building stones of Sangseo tumuli in Santae Island, Shin-an, Jeonnam. The petrological study on the stones includes visually petrographical descriptions, textural study by polarized microscope and geochemical analysis. Along with the study, distribution routes of the stones were traced based on the regional geology of the island. Since ancient times, the study area is important as a base on international maritime traffic route. Therefore, studies on the tumuli are meaningful for ancient maritime history. In visual observation, above building stones are of tuffs except for an andesitic porphyry considered as intermediate dyke. The tuffs are assigned to lapilli and fine ones. Their grains are poorly sorted and angular to very angular in roundness. In particular, the fine tuffs show very dense textures and take up the most part of the building stones. In addition, the stones have irregularly removed depressions inferred as the linkage to tafoni, in lapilli tuffs particularly. The tuffs are mainly of plagioclases laths, rock fragments and matrices and ranges widely in grain size. The plagioclases show mostly unambiguous albite twin. And, microcline crystals are observed in the tuffs too. Matrices in the tuffs are considerably dense and weathered. Dense texture in the rocks are related to diagenesis in part. In addition, thin quartz veins irregularly intruded the rocks vertically and horizontally. According to the geochemical analysis of building stones of above tumuli, the stones might be intermediate rock series near acidic rock ones and acidic rock ones in the correspondence of volcanics. Therefore, the tuffs probably grouped as two types and are assigned to subalkaline rock series by TAS diagram. Most the building stones mutually resemble in visual and textural characteristics. Tuffs are generally platy, easy in use and relatively hard. In addition, rocks very similar to the building stones are widely distributed in surrounding area. Synthesizing above results, it is considered that tuffs used in tumuli building are corresponded to intermediate rock series near acidic rock ones and acidic rock, and got from surrounding rocks.

충남대학교병원 마취발전의 경향에 관한 분석 : 1967년부터 - 1996년까지 from 1967 to 1996

최세진,김상수,정규돈,윤석화,신용섭,손수창,이원형,김혜자,이정은 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.2

To evaluate the specificity and historical trends of the anesthesia in Chungnam National University Hospital, anesthetic experiences of 83,572 in total performed at Chungnam National University Hospital from January 1967 to December 1996 were analyzed statistically and clinically according to age, sex, surgical department, physical status, elective and emergency surgery, premedicants, IV anesthetics, anesthetic methods, inhalational anesthetics, muscle relaxants. The results were as follows : 1. The number of cases has been steadily increased year by year. 2. The ratio of male to female was 52.8% : 47.2%. 3. According to the age, There were 44,905 cases (54%) in the group of 13-45 years. 4. According to the ASA classification of physical status, most of the cases were belonged to the class 1 & 2 (72.5%). 5. The ratio of elective to emergency was 79.4% to 20.6%. 6. Recently, glycopyrrolate has been used increasingly. 7. Thiopental sodium has been mainly used for intravenous induction agent. 8. General anesthesia has been used mainly. 9. Enflurane is the most common inhalational anesthetic agent. but Isoflurane has been used increasingly. 10. Most of muscle relaxants are Pancuronium & Vecuronium(84.5%).