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- 검색키워드
- 저자 : Ghi Su Kim (검색결과 84 건)
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Kim, Beom-Jun,Kim, Shin-Yoon,Cho, Yoon-Shin,Kim, Bon-Jo,Han, Bok-Ghee,Park, Eui-Kyun,Lee, Seung-Hun,Kim, Ha-Young,Kim, Ghi-Su,Lee, Jong-Young,Koh, Jung-Min Korean Society for Biochemistry and Molecular Bion 2011 Experimental and molecular medicine Vol.43 No.2
There is increasing evidence of a biochemical link between lipid oxidation and bone metabolism. Paraoxonase 1 (PON1) prevents the oxidation of low-density lipoprotein (LDL) and metabolizes biologically active phospholipids in oxidized LDLs. Here, we performed association analyses of genetic variation in $PON1$ to ascertain its contribution to osteoporotic fractures (OFs) and bone mineral density (BMD). We directly sequenced the $PON1$ gene in 24 Korean individuals and identified 26 sequence variants. A large population of Korean postmenopausal women ($n$ = 1,329) was then genotyped for eight selected $PON1$ polymorphisms. BMD at the lumbar spine and femoral neck was measured using dual-energy X-ray absorptiometry. Lateral thoracolumbar (T4-L4) radiographs were obtained for vertebral fracture assessment, and the occurrence of non-vertebral fractures (i.e., wrist, hip, forearm, humerus, rib, and pelvis) was examined using self-reported data. Multivariate analyses showed that none of the polymorphisms was associated with BMD at either site. However, +$5989A>G$ and +$26080T>C$ polymorphisms were significantly associated with non-vertebral and vertebral fractures, respectively, after adjustment for covariates. Specifically, the minor allele of +$5989A>G$ exerted a highly protective effect against non-vertebral fractures (OR = 0.59, $P$ = 0.036), whereas the minor allele of +$26080T>C$ was associated with increased susceptibility to vertebral fractures (OR = 1.73, $P$ = 0.020). When the risk for any OFs (i.e., vertebral or non-vertebral) was considered, the statistical significance of both polymorphisms persisted ($P$ = 0.002-0.010). These results suggest that $PON1$ polymorphisms could be one of useful genetic markers for OF risk in postmenopausal women.
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한국인 여성에서 비타민 D 수용체 유전자 , 에스트로겐 수용체 유전자 및 제 1 형 콜라겐 α1유전자의 다형성과 최대골량의 연관성에 관한 연구
김은숙,김상욱,김기수,김홍규 대한내분비학회 2001 Endocrinology and metabolism Vol.16 No.1
Background: Genetic suggest that strongest effect is observed in the premenopausal peak bone mass, which become less with age. However, the evaluation of candidate genes polymorphisms has been most frequently done in postmenopausal women and the results have been controversial. Therefore, we studied the possible association of the peak bone mass and candidate for osteoporosis genes polymorphism in premenopausal women. Methods: The associations between BMD and polymorphisms of the vitamin D receptor (3'-end region by BsmI restriction enzyme and start codon by FokI restriction enzyme), estrogen receptor (by PvuII and XbaI restriction enzyme), and type I collagen al (Spl binding site by MscI and Ball restriction enzyme) genes were examined in 100 healthy young Korean women who had a peak bone mass (age 20 35 years). Bone mineral densities were measured by dual energy X-ray absorptiometry (DEXA). Dietary calcium intake was also measured using a food frequency questionnaire. Results: The frequencies of the B allele of the vitamin D receptor gene BsmI polymorphism and the X allele in the estrogen receptor gene, XbaI polymorphisms were lower in Koreans than those in Caucasians. The allelic frequencies of the vitamin vitamin D receptor gene Fokl polymorphism and the estrogen receptor gene PvuII polymorphism were similar to those of Caucasians. No significant association was found between BMD and the vitamin D receptor genotype according to Bsml or FokI polymorphisms. There was also no significant relation between the PvuII or XbaI polymorphisms of the estrogen receptor gene and BMD. The associations between BMD and cross-genotypes combining the vitamin D receptor gene (BsmI and FokI) and estrogen receptor gene (PvuII and XbaI) polymorphisms were also analyzed. Among the subjects who lacked the Bf haplotype of the vitamin D receptor gene, the BMD of the femoral neck area was significantly higher in subjects lacking Px haplotypes of the estrogen receptor gene than in those having Px haplotype (p $lt; 0.05). When dietary calcium intake was taken into consideration, there were significant differences in BMD according to the cross-genotype in the group having a low calcium intake ($lt; 500 mg/day). The subjects that lacked the Bf and Px haplotypes had a significantly higher BMD in the femoral neck (p $lt; 0.01), Wards triangle (p $lt; 0.0~5), and in the trochanteric area (p $lt; 0.05) than those who lacked Bf but a Px haplo~type. We did not find a polymorphism in the Spl bindi~ng site of the type I ~collagen ~al gene in our subjects. Conclusion: These data suggest that a complex interaction of vitamin D and the estrogen receptor gene with the dietary calcium intake, rather than a polymorphism of a sing~le gene, may influence peak bone mass in healthy young Korean women (J Kor Soc Endocrinol 16:97-114, 2001).
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Kim, Beom-Jun,Ahn, Seong Hee,Bae, Sung Jin,Kim, Eun Hee,Lee, Seung-Hun,Kim, Hong-Kyu,Choe, Jae Won,Koh, Jung-Min,Kim, Ghi Su Mary Ann Liebert, Inc 2012 Journal of Bone and Mineral Research Vol.27 No.11
<P>Despite extensive experimental and animal evidence about the detrimental effects of iron and its overload on bone metabolism, there have been no clinical studies relating iron stores to bone loss, especially in nonpathologic conditions. In the present study, we performed a large longitudinal study to evaluate serum ferritin concentrations in relation to annualized changes in bone mineral density (BMD) in healthy Koreans. A total of 1729 subjects (940 postmenopausal women and 789 middle-aged men) aged 40 years or older who had undergone comprehensive routine health examinations with an average 3 years of follow-up were enrolled. BMD in proximal femur sites (ie, the total femur, femur neck, and trochanter) was measured with dual-energy X-ray absorptiometry using the same equipment at baseline and follow-up. The mean age of women and men in this study was 55.8 6.0 years and 55.5 7.8 years, respectively, and serum ferritin levels were significantly higher in men than in women (p < 0.001). The overall mean annualized rates of bone loss in the total femur, femur neck, and trochanter were -1.14%/year, -1.17%/year, and -1.51%/year, respectively, in women, and -0.27%/year, -0.34%/year, and -0.41%/year, respectively, in men. After adjustment for potential confounders, the rates of bone loss in all proximal femur sites in both genders were significantly accelerated in a dose-response fashion across increasing ferritin quartile categories (p for trend = 0.043 to <0.001). Consistently, compared with subjects in the lowest ferritin quartile category, those in the third and/or highest ferritin quartile category showed significantly faster bone loss in the total femur and femur neck in both genders (p = 0.023 to <0.001). In conclusion, these data provide the first clinical evidence that increased total body iron stores could be an independent risk factor for accelerated bone loss, even in healthy populations.</P>
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2 - Bromopropane 에 노출된 여성에서 집단적으로 발생한 원발성 난소 기능 부전증
김철희,김기수,김효정,김영탁,고정민,신은석,조경식,윤길숙 대한내분비학회 1997 Endocrinology and metabolism Vol.12 No.2
Background: Primary ovarian failure is reportedly increasing in recent years. Environmental factors have been frequently implicated as responsible for this increase, However, only a few of the environmental factors have been proven to cause the ovarian failure in human. Methods: In June 1995, 24 female laborers, who worked in a factory which used Solvent #5200(with a main chemical component being 2-bromopropane), developed symptoms of amenorrhea or irregular menstruation. All subjects underwent laboratory tests including measure- ment of serum LH, FSH, and estradioL Magnetic resonance imaging and ultrasonography of the pelvis were performed in all subjects. Laparoscopic examination was performed in 6 out of 24 patients after obtaining informed consent and 4 of 6 underwent ovarian biopsy. Results: One subject was excluded because she had undergone hysterectomy previously. Among the remaining 23 subjects, 14 and 9 complained of amenorrhea and irregular menstrual periods, respectively. When we defined primary ovarian failure as FSH$gt;30mIU/mL, all of those 14 patients with amenorrhea could be classified as primary ovarian failure. On the other hand, those 9 patients with irregular menstruations had normal FSH levels. Pathologic examination of ovaries showed interstitial fibrosis, loss of primordial follicles, and development arrest of follicles in the group with amenorrhea, similar to what is found in those who received chemotherapy or were exposed to radiation. Conclusion: The female laborers who were exposed to the solvent with 2-bromopropane developed primary ovarian failure. This failure was associated with longer duration of exposure. To our knowledge, this is the first report in the world indicating 2-bromopropane as a possible agent for ovarian failure. (J Kor Soc Endocrinol 12:255-264, 1997)
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Sheehan 증후군과 동반된 Extrapontine Myelinolysis 1 예
김영일,이성진,홍성관,김철희,김기수,박형주,한정희,김승규 대한내과학회 2000 대한내과학회지 Vol.59 No.3
Since the first descriptions of central pontine myelinolysis(CPM) were put forth it has become evident that myelinolysis may not be exclusively restricted to the pons. In many cases myelinolysis may share other brain regions, while in still others the pons may not be affected at all as in the present case of pure basal ganglia myelinolysis. Regardless of geographic location, too rapid correction of hyponatremia has been invoked as the triggering mechanism which leads to both CPM and extrapontine myelinolysis(EPM). This case of EPM is that a 51-year-old female who was healthy. Following vomiting and poor oral intake, a low serum sodium(110 mEq/L) developed and was corrected to normal(140 mEq/L) within 36 hours. Seven days later altered mental status ensued and the patient was transferred to our hospital. Clinical manifestation and hormonal study were compatible with panhypopituitarism (Sheehan's syndrome). T2 weighted MRI showed symmetrical, bilateral high intensity foci in the putamen, caudate nucleus. The pons was spared. This case illustrates that extrapontine, basal ganglia myelinolysis may occur in the absence of CPM or alternate areas of myelinolysis. MRI is uncovering many new cases in EPM and CPM. This permits one to follow the evolution of the myelinolytic lesions and to correlate their progression or regression with treatment modalities and the neurological findings.(Korean J Med 59:300-304, 2000)
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정읍지역 폐경후 여성에서 혈청 렙틴 농도와 골초음파지표와의 상관관계
김하영,김덕재,김기수,김상욱,고정민 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.1
Background: Obese postmenopausal women usually have a tend to have greater bone mineral density than lean women. This has been attributed to either the mechanical effects of their excessive weight on bone tissue or to their high body fat content. A recent study demonstrated that leptin, the hormone produced in adipocytes, acts on bone metabolism. These findings have prompted speculations on the possible role of leptin in the protective effect of obesity on bone. Methods: We studied the relationship between serum leptin levels and quantitative ultrasound (QUS) values of calcaneus in 94 postmenopausal Korean women who were randomly selected from the population of the Chung-Up osteoporosis prevalence study. QUS values, broadband ultrasound attenuation and speed of sound; were measured at the calcaneus. Results: Leptin values were strongly correlated with body mass index (r = 0.478, p < 0.001), confirming a positive relationship between leptin levels and fat mass. In contrast, no significant correlations were observed between serum leptin levels and calcaneal QUS values. Conclusion: Our results suggest that circulating plasma leptin does not have a significant influence on QUS values of calcaneus in Korean postmenopausal women
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