측두하악관절 내장증에서의 관절원판의 형태 및 골 변화에 관한 연구

박철우,황의환,이상래 대한구강악안면방사선학회 2001 Imaging Science in Dentistry Vol.31 No.1

Purpose : To investigate bone and disc configuration on MR images in internal derangement related to age. Materials and methods : MR images of 150 TMJs in 107 patients were analyzed to determine the morphologic changes. Two groups were distinguished to be correlated with age. Group 1 consisted of TMJs that were diagnosed as having anterior disc displacement with reduction (ADDwR), and Group 2 consisted of TMJs that were diagnosed as having anterior disc displacement without reduction (ADDwoR). We assessed the configuration of the articular disc, degree of anterior disc displacement, and osseous changes of TMJs. Results : The third decade (83 of 150 joints) was most frequent in this study. In the ADDwR group biconcave discs was most frequent at all ages except fifth decade, but in the ADDwoR group deformed discs was most frequent at third and forth decades. In the ADDwR group slightly displaced discs was most frequent at all ages, but in the ADDwoR group severely displaced discs was most frequent at second decade, and the degree of disc displacement was increased with aging over 30 years of age. TM joints showed osseous changes in 17% of the ADDwR group, and in 30% of the ADDwoR group. MR findings of osseous changes of the TMJ were not found to be significantly correlated with age. Conclusion : The prevalence of deformation of disc, displacement of disc, and osseous changes of TMJ was higher in the ADDwoR group than in the ADDwR group. MR findings of disc configuration and degree of disc displacement were found to be correlated with age.(Korean J Oral Maxillofac Radiol 2001;31:9-16)

사무직 근로자에서 직무스트레스 및 VDT작업과 목·어깨 근골격계 증상과의 관련성

이의철,김환철,정달영,김동현,임종한,박신구 대한산업의학회 2007 대한직업환경의학회지 Vol.19 No.3

황색포도구균의 균혈증에서 초기 항생제 치료가 예후에 미치는 영향

김성한,박완범,이기덕,강철인,최영주,김홍빈,박상원,김의석,오명돈,김의종,최강원 대한감염학회 2002 감염 Vol.34 No.5

직무스트레스와 감기와의 관련성

김동현,박신구,김환철,이의철,김정훈,임종한 大韓産業醫學會 2008 대한직업환경의학회지 Vol.20 No.2

목적: 국내외를 통해 직무스트레스와 감기 등과 같은 감염질환과의 관련성에 대한 연구는 많지 않으며, 특히 국내에서의 연구는 거의 전무한 실정이다. 이에 직무스트레스와 감기와의 관련성을 확인하고자 한다. 방법: 일개 대학병원의 산업의학과에서 보건관리대행을 이행하고 있는 83개의 사업장, 근로자 6,699명에 대해 한국형직무스트레스-단축형(KOSS-SF) 설문지를 배부하였고 회수된 4,637명의 설문지 중 부적절한 응답과 다른 호흡기와 관련한 폐질환을 앓고 있는 237명을 제외한 최종분석 근로자 4,400명(65.7%)의 설문자료를 근거로 연구를 시행하였다. 결과: 감기 경험과의 단변량분석에서 유의한 차이를 보인 요인들과 일상생활 스트레스를 보정한 후 시행한 직무스트레스와 감기 경험과의 로지스틱 희귀분석 결과 직무 자율성 결여를 제외한 직무스트레스 하부 영역 전반(직무요구, 관계갈등, 직무불안정, 조직체계, 보상부적절, 직장문화)에 걸쳐 통계적으로 유의한 차이를 보여주었다. 또한 직무스트레스와 감기 경협 첫수와의 관련성을 확인하기위한 다중회귀분석에서도 비슷한 양상을 보였다. 결론: 직무자율성 결여를 제의한 한국형 직무스트레스 요인 전체가 감기와 관련성을 나타내었다. Objectives: To investigate the relationship between job stress and the common cold which is one of the most common infectious disease. Methods: A KOSS (Korean Occupational Stress Scale)-based questionnaire survey was conducted targeting 6,699 workers, of which 4,637 questionnaires were returned and the data for 237 were excluded due to poor response and having pulmonary disease other than common cold. Consequently, 4,400 (65.7%) returned questionnaires were analyzed. Multiple logistic regression analysis and multiple linear regression, adjusted for daily life stress, confounding variables and both, were used to evaluate the relationship between job stress and the common cold. Results: After adjustment for confounding variables and daily life stress, most of the subscales of job stress contributed to an increased risk of common cold. Conclusions: These results indicated that job stress may play a significant role in increasing the risk of the common cold and that further preventive efforts and studies are needed to reduce job stress and address infectious disease caused by job stress among Korean employees.

중소규모 사업장 근로자의 직무스트레스로 인한 결근, 조퇴 현황과 한국형직무스트레스 하부요인과의 관련성

김정훈,박신구,김동현,김환철,임종한,이의철,이동훈,이지영 大韓産業醫學會 2009 대한직업환경의학회지 Vol.21 No.2

목적: 중소규모 사업장 근로자들의 직무 스트레스로 인한 결근, 조퇴의 현황과 한국형 직무 스트레스 하부 요인과의 관련성을 알아보고자 하였다. 방법: 중소규모 사업장 83곳 근로자들에 대해 한국형 직무스트레스요인 평가도구-단축형(KOSS-SF)과 사회 일반적 특성, 직업적 특정 및 직무스트레스로 인한 결근이나 조퇴 경험여부 등을 묻는 구조화된 자가 기입식 설문을 실시하였고, 응답한 4,350명에 대해 최종 분석을 시행하였다. 직무스트레스로 인한 결근, 조퇴와 한국형 직무스트레스 하부 요인들과의 관련성을 확인하기 위하여 로지스틱 회귀분석을 시행 하였다. 결과: 직무 스트레스로 인한 결근, 조퇴를 한 근로자는 남자에서 7%(196명), 여자에서 8%(113명) 로 조사되었고 한국형 직무 스트레스 하부요인과의 관련성에서는 남, 여 모두 직무요구, 관계갈등, 조직체계, 보상부적절, 직장문화 영역의 스트레스가 높은 군에서 통계적으로 의미있게 직무스트레스로 인한 결근, 조퇴율이 증가하였다. 결론: 중소규모 사업장 근로자들의 직무 스트레스로 인한 결근, 조퇴와 한국형 직무 스트레스 하부요인과의 관련성은 남자에서는 조직체계 영역이 가장 높았고, 여자는 직장문화 영역에서 가장 높은 관련성을 보였다. Objective: The aim of this study was to examine the actual conditions of absence and early leave due to job stress of 4,350 workers in 83 small and medium scale industries, and its relationship to job stress factors using Korean Occupational Stress Scale-Short Form (KOSS-SF). Methods: A structured self-reported questionnaire was used to assess each respondent's Sociodemographics, job stress, experience of absence and early leave due to job stress. Seven KOSS-SF domains of job stress were used. We estimated the relation of absence and early leave due to job stress and job stress factors using logistic regression analyses. Results: Absence or early leave due to job stress occurred in 7% of male workers and 8% of female workers. Multiple regression analysis revealed a significantly positive association job stress-related absence/early leave and job demand, interpersonal conflict, organizational system, lack of rewards and occupational climate. Conclusions: Absence and early leave due to job stress is significantly attributed to organizational System and lack of reward for men, and occupational climate and organizational system for women.

Sargassum serratifolium suppresses RANKL-induced osteoclast differentiation and oxidative stress through inhibition of NF-κB and activation of the Nrf2/HO-1 signaling pathway

Cheol Park,Hong Jae Kim,Gi-Young Kim,Eui Kyun Park,You-Jin Jeon,Yung Hyun Choi 한국실험동물학회 2018 한국실험동물학회 학술발표대회 논문집 Vol.2018 No.7

Protective effects of fermented oyster extracts against oxidative stress-induced- DNA damage and apoptosis through activation of the Nrf2/HO-1 signaling pathway in MC3T3-E1 osteoblasts

Cheol Park,Hyesook Lee,Joung-Hyun Park,Gi-Young Kim,Bae-Jin Lee,Eui Kyun Park,You-Jin Jeon,Yung Hyun Choi 한국수산과학회 양식분과 2020 한국수산과학회 양식분과 학술대회 Vol.2020 No.7

Dermatofibrosarcoma protuberans: A retrospective study of clinicopathologic features and related Akt/mTOR, STAT3, ERK, cyclin D1, and PD-L1 expression

Park, Sunyoung,Cho, Soyun,Kim, Minji,Park, Ji Ung,Jeong, Eui Cheol,Choi, Euno,Park, Jeong Hwan,Lee, Cheol,Chang, Mee Soo Elsevier 2018 JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY - Vol.79 No.5

<P><B>Background</B></P> <P>Little is known regarding oncoproteins other than platelet-derived growth factor subunit B in dermatofibrosarcoma protuberans (DFSP). Moreover, the risk factors for worse prognosis are controversial.</P> <P><B>Objective</B></P> <P>We sought to determine the clinicopathologic features and key factors for adverse outcome in DFSP, including the implication of expression of protein kinase B (Akt)/mammalian target of rapamycin (mTOR), signal transducer and activator of transcription 3 (STAT3), extracellular signal regulated kinase (ERK), cyclin D1, and programmed death ligand 1 (PD-L1).</P> <P><B>Methods</B></P> <P>Clinicopathologic and immunohistochemical analyses were performed for 44 DFSPs having wide local excision and 92 dermatofibromas as controls.</P> <P><B>Results</B></P> <P>Compared with the 35 nonrecurrent DFSPs, the 9 recurrent DFSPs exhibited larger tumor size, deeper invasion beyond the subcutis, and more diverse histologic subtype. The fibrosarcomatous subtype revealed frequent mitotic figures and a high cyclin D1–positive index. The 2 metastatic DFSPs (1 each of the fibrosarcomatous and myxoid subtypes) demonstrated 4 and 11 instances of local recurrence, respectively, as well as larger tumor size, deeper invasion beyond the subcutis, and high expression of cyclin D1. Expression of Akt/mTOR, STAT3, ERK, and PD-L1 ranged from none or low in the primary skin lesions to high in the corresponding metastatic sites. Akt/mTOR and ERK were expressed more frequently in DFSP than in dermatofibroma.</P> <P><B>Limitations</B></P> <P>Lack of information on patients before hospital evaluation.</P> <P><B>Conclusion</B></P> <P>Complex factors beyond fibrosarcomatous subtype may portend local recurrence or metastasis. Akt/mTOR, STAT3, ERK, and PD-L1 may be associated with development and/or progression of DFSP.</P>

Aging process is accompanied by increase of transglutaminase C

Park, Jeong Soo,Kwak, Sahng June,Choi, Jee Young,Yeo, Eui Ju,Kim, Kyung Ok,Seong, Sang Cheol,Hwang, Yong Chul,Park, Sang Chul,Park, Yong Hoon,Han, Jeong A 한림대학교 한림과학원 부설 환경ㆍ생명과학연구소 1998 국제학술회의 Vol.1998 No.-

Crosslinking has been suggested as one of the mechanisms involved in the aging process. Among the various random or enzyme-mediated crosslinking reactions, transglutaminase (TGase)-catalyzed crosslinking activity has been proposed for its possible involvement in cell proliferation, differentiation, carcinogenesis, programmed death and aging. Moreover, recent findings of TGase C as a putative signal transducer and cell cycle regulator has renewed interest in the study of TGase C in relation to aging phenomena. The ubiquitous presence of TGase C compared to the organ-specific localization of other types of TGases has attracted special attention as a cellular aging device. In the present study, for in vitro studies we have analyzed the comparative pattern of TGase C in young and old human red blood cells, separated by density defferentiation, and in early and late-passage of hydrogen peroxide-treated human primary fibroblasts. For in vivo study, we monitored the age-dependent changes of TGase C in the liver and brain tissues of 4, 12, 18, and 24-month-old Sprague-Dawley rats. We obtained evidence that both the activity and protein levels of TGase C were high in old RBC and late-passage of hydrogen peroxide-treated vibroblasts. Similar findings were seen in liver and brain tissue such as age-dependent increases in TGase activity and protein level in an organ-specific pattern. These data suggest that TGase C might play an active role in the cellular process with age.

Size-tunable mesoporous spherical TiO₂ as a scattering overlayer in high-performance dye-sensitized solar cells

Park, Yoon-Cheol,Chang, Yong-June,Kum, Byung-Gon,Kong, Eui-Hyun,Son, Jong Yeog,Kwon, Young Soo,Park, Taiho,Jang, Hyun Myung Royal Society of Chemistry 2011 Journal of materials chemistry Vol.21 No.26

<P>Size-tunable mesoporous spherical TiO<SUB>2</SUB> (MS TiO<SUB>2</SUB>) with a surface area of ∼110 m<SUP>2</SUP> g<SUP>−1</SUP> have been prepared through combination of “dilute mixing”-driven hydrolysis of titanium(iv) tetraethoxide and solvothermal treatment. The hierarchically structured MS TiO<SUB>2</SUB> are characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and nitrogen sorption analysis. Using three different MS TiO<SUB>2</SUB> (587, 757, and 1554 nm in diameter) as a scattering overlayer on a transparent nanocrystalline TiO<SUB>2</SUB> film, bi-layered dye-sensitized solar cells (DSCs) have been fabricated. Since the MS TiO<SUB>2</SUB> particles are comprised of ∼10 nm nanocrystallites that cluster together to form large secondary spheres, they can function as light scatterers without sacrificing the surface area for dye-uptake. As a result, the present MS TiO<SUB>2</SUB>-based cells perform a noticeable improvement in the overall efficiency: maximum 9.37% <I>versus</I> 6.80% for the reference cell made of a TiO<SUB>2</SUB> nanocrystalline film. This extraordinary result is attributed to the dual effects of enhanced dye loading and light scattering.</P> <P>Graphic Abstract</P><P>Dye-sensitized solar cells made with the size-tunable mesoporous spherical TiO<SUB>2</SUB> as a scattering overlayer exhibit a noticeable improvement in the overall efficiency: maximum 9.37%. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1jm11043h'> </P>