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다발성 간종괴의 형태로 나타난 특발성 과호산구 증후군 치험1예
최승오,연규민,이승민,김순제,왕준호,박형석,이재동,진춘조,이창훈,신현준,김정은 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-
Hypereosinophilic syndrome is characterized by persistent blood eosinophilia of 1,500/ul or more in the absence of known causes and multiorgan dysfunction by eosinophil-related tissue damage. In Korea, some cases of hypereosinophilic syndrome with hepatic involvement have been described with prolonged benign clinical courses. Most of them were diffuse or multifocal lesions in imaging studies, and a few case presenting as a single mass has been described. Here we report a case of hypereosinophilic syndrome with hepatic involvement in a 65-year-old man who presented with multifocal mass lesions. By abdominal US and CT scan, multiple, ill-defined nodules were detected in throughout the liver. Liver biopsy revealed severe eosinophilic hepatitis, suggestive of hypereosinophilic syndrome. Hepatic mass lesions improved after steroid administration for several weeks.
Risk Factors for Anxiety in Major Depressive Disorder Patients
Li-Min Xin,Lin Chen,Zhen-Peng Ji,Suo-Yuan Zhang,Jun Wang,Yan-Hong Liu,Da-Fang Chen,Fu-De Yang,Gang Wang,Yi-Ru Fang,Zheng Lu,Hai-Chen Yang,Jian Hu,Zhi-Yu Chen,Yi Huang,Jing Sun,Xiao-Ping Wang,Hui-Chun 대한정신약물학회 2015 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.13 No.3
Objective: To analyze the sociodemographic and clinical factors related to anxiety in patients with major depressive disorder (MDD). Methods: This study involved a secondary analysis of data obtained from the Diagnostic Assessment Service for People with Bipolar Disorders in China (DASP), which was initiated by the Chinese Society of Psychiatry (CSP) and conducted from September 1, 2010 to February 28, 2011. Based on the presence or absence of anxiety-related characteristics, 1,178 MDD patients were classified as suffering from anxious depression (n=915) or non-anxious depression (n=263), respectively. Results: Compared with the non-anxious group, the anxious-depression group had an older age at onset (t=−4.39, p<0.001), were older (t=−4.69, p<0.001), reported more lifetime depressive episodes (z=−3.24, p=0.001), were more likely to experience seasonal depressive episodes (χ2=6.896, p=0.009) and depressive episodes following stressful life events (χ2=59.350, p <0.001), and were more likely to have a family history of psychiatric disorders (χ2=6.091, p=0.014). Their positive and total scores on the Mood Disorder Questionnaire (MDQ) and the 32-item Hypomania Checklist (HCL-32) (p<0.05) were also lower. The logistic regression analysis indicated that age (odds ratio [OR]=1.03, p<0.001), a lower total MDQ score (OR=0.94, p=0.011), depressive episodes following stressful life events (OR=3.04, p<0.001), and seasonal depressive episodes (OR=1.75, p=0.039) were significantly associated with anxious depression. Conclusion: These findings indicate that older age, fewer subclinical bipolar features, an increased number of depressive episodes following stressful life events, and seasonal depressive episodes may be risk factors for anxiety-related characteristics in patients with MDD.
( Yan-jun Wang ),( Xiu-qiong Lang ),( Dan Wu ),( Yu-qin He ),( Chun-hui Lan ),( Xiao-xiao ),( Bin Wang ),( Duo-wu Zou ),( Ji-min Wu ),( Yong-bin Zhao ),( Peter W Dettmar ),( Dong-feng Chen ),( Min Yan 대한소화기 기능성질환·운동학회 2020 Journal of Neurogastroenterology and Motility (JNM Vol.26 No.1
Background/Aims To determine the value of salivary pepsin in discriminating sub-types of gastroesophageal reflux disease (GERD) and GERD-related disorders. Methods Overall, 322 patients with different sub-types of GERD and 45 healthy controls (HC) were studied. All patients took Gastroesophageal Reflux Disease Questionnaire (GerdQ) and underwent endoscopy and 24-hour esophageal pH monitoring and manometry. Salivary pepsin concentration (SPC) was detected by using colloidal gold double-antibody immunological sandwich assay. Oral esomeprazole treatment was administrated in the patients with non-erosive reflux disease (NERD) and extra-esophageal symptoms (EES). Results Compared to HC, patients with erosive esophagitis, NERD, EES, EES plus typical GERD symptoms, or Barrett’s esophagus had a higher prevalence of saliva and SPC (all P < 0.001). There was no significant difference in the positive rate for pepsin in patients with functional heartburn or GERD with anxiety and depression, compared to HC. After esomeprazole treatment, the positive rate and SPC were significantly reduced in NERD (both P < 0.001) and in EES (P = 0.001 and P = 0.002, respectively). Of the 64 NERD patients, 71.9% (n = 46) were positive for salivary pepsin, which was significantly higher than the rate (43.8%, n = 28) of pathological acid reflux as detected by 24-hour esophageal pH monitoring (P = 0.002). Conclusions Salivary pepsin has an important significance for the diagnosis of GERD and GERD-related disorders. Salivary pepsin and 24-hour esophageal pH monitoring may complement with each other to improve the diagnostic efficiency.
Chang-Liang Shih,Quei-Min Liao,Ya-Yuan Wang,Wu-Chun Tu 한국응용곤충학회 2019 Journal of Asia-Pacific Entomology Vol.22 No.4
The abundance and host-seeking activity of the biting midge, Forcipomyia taiwana (Shiraki), were measured in Central Taiwan at 418 locations with low, medium, and high densities using a human-bait method. Abundance estimates at 10 min after sampling commenced were comparable to longer sampling periods of 20 min, allowing a shorter 10 min sampling period to be used throughout. Host-seeking F. taiwana females were only active during daylight and biting activity did not occur after sunset. The diurnal activity of host-seeking females changed seasonally, beginning at around 07:00–08:00 during the spring equinox, summer solstice, and autumnal equinox, whereas activity began an hour later in winter. Most females were collected during 10:00–16:00, with a peak abundance during 13:00–15:00. Blood-sucking activity of female F. taiwana were positively correlated with ambient temperature with a minimum threshold of 18 °C. When different years, seasons, trapping times, environmental factors, and female adults trapped were analyzed using multiple regression model, the results showed that all these factors contributed to the regression model and the determination coefficient (R 2 ) of this multiple regression model was 0.81.
Auto-tuning SOS Algorithm for Two-Dimensional Orthogonal Cutting Optimization
Min-Yuan Cheng,Yi-Cho Fang,Chun-Yao Wang 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.10
Minimizing the loss of raw materials is an important issue in the construction industry. The construction material often encounters two-dimensional cutting problems such as steel plates and wooden plates. Reducing material waste by using building information modeling (BIM) and artificial intelligence methods has received considerable attention. Thus, this study focused on two-dimensional cutting stock problems (2D-CSP), and employed the auto-tuning Symbiotic Organisms Search algorithm (SOS) to establish residual material optimization model. The results considering the placement strategy with the rotation of the cutting plates, showed that, compared to other heuristic algorithms such as Genetic Algorithm (GA) and Particle Swarm Optimization (PSO), the SOS algorithm obtained superior solutions to the two-dimensional cutting operation. Therefore, the proposed model possesses a certain application value for solving the optimization problem in the construction industry, and helps reducing the material waste and budget cost.
Chun-Jen Huang,Hui-Min Hsieh,Herng-Chia Chiu,Peng-Wei Wang,Mei-Hsuan Lee,Chih-Yi Li,Ching-Hua Lin 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.6
Objective: The study investigated to compare health care utilization and expenditures between diabetic patients with and without depression in Taiwan. Methods: Health care utilization and expenditure among diabetic patients with and without depression disorder during 2000 and 2004 were examined using Taiwan’s population-based National Health Insurance claims database. Health care utilization included outpatient visits and the use of inpatient services, and health expenditures were outpatient, inpatient, and total medical expenditures. Moreover, general estimation equation models were used for analyzing the factors associated with outpatient visits and expenditures. Multiple logistic regression analysis was applied for identifying the factors associated with hospitalization. Results: The average annual outpatient visits and annual total medical expenditures in the study period were 44.23–52.20; NT$87,496–133,077 and 30.75–32.92; NT$64,411–80,955 for diabetic patients with and without depression. After adjustment for covariates, our results revealed that gender and complication were associated with out-patient visits. Moreover, the time factor was associated with the total medical expenditure, and residential urbanization and complication factors were associated with hospitalization. Conclusion: Health care utilization and expenditures for diabetic patients with depression were significantly higher than those without depression. Sex, complications, time, and urbanization are the factors associated with health care utilization and expenditures.
Control of macrophage responses on hydrophobic and hydrophilic carbon nanostructures
Chun, Young Wook,Wang, Wenping,Choi, Jungil,Nam, Tae-Hyun,Lee, Yong-Hee,Cho, Kwon-Koo,Im, Yeon-Min,Kim, Minsoo,Gwon, Yong-Hwan,Kang, Sang Soo,Lee, Jong Duk,Lee, Keunwook,Khang, Dongwoo,Webster, Thomas Elsevier 2011 Carbon Vol.49 No.6
<P><B>Abstract</B></P><P>This study monitored the expression of cytokines by macrophages and synaptic antigens on macrophages in contact with hydrophobic (water contact angle was 140°) and hydrophilic (water completely adsorbed within 5s) carbon nanostructures. Results indicated that hydrophilic carbon nanofibers (CNFs) generated the smallest inflammatory response from macrophages compared to hydrophobic CNFs and titanium (which is a conventional prosthetic implant material). Specifically, hydrophilic CNFs triggered less pro-inflammatory cytokine (e.g., tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6)) secretion from macrophages than hydrophobic CNFs. Results further revealed that hydrophobic CNFs activated macrophage cytoskeleton changes in a time dependent manner, whereas hydrophilic CNFs did not. Lastly, although additional tests are needed, the net analysis of macrophage expression of co-stimulatory molecules (e.g., CD80 and CD86) demonstrated that hydrophobic CNFs may ultimately lead to increased T-cell activation than hydrophilic CNFs. In summary, this study suggests that the wettability of carbon nanostructured materials may be potentially linked to macrophage behavior to induce or minimize inflammation.</P>
Wang, Lian-Zhou,Guo, Chun-Yu,Su, Yu-Min,Wu, Tie-Cheng The Society of Naval Architects of Korea 2018 International Journal of Naval Architecture and Oc Vol.10 No.2
The characteristics of the relationship between the evolution of propeller trailing vortex wake and skew angle are numerically examined based on four different five-blade David Taylor Model Basin (DTMB) model propellers with different skew angles. Numerical simulations are based on Reynolds-averaged Naviere-Stokes (RANS) equations combined with SST $k-{\omega}$ turbulence model. Results show that the contraction of propeller trailing vortex wake can be restrained by increasing skew angle and loading conditions, and root vortices fade away when the propeller skew angle increases. With the increase of the propeller's skew angle, the deformation of the hub vortex and destabilization of the tip vortices are weakening gradually because the blade-to-blade interaction becomes weaker. The transition trailing vortex wake from stability to instability is restrained when the skew increases. Furthermore, analyses of tip vortice trajectories show that the increasing skew can reduce the difference in trailing vortex wake contraction under different loading conditions.
Chun Liu,Hengbo Yin,Chen Ge,Aili Wang,Min Ren,Yunsheng Zhang,Longbao Yu,Tingshun Jiang 한국화학공학회 2011 Korean Journal of Chemical Engineering Vol.28 No.6
Uniform sized and integrated hollow silica spheres with porous shells were prepared by using sulfuric and carboxylic acid-functionalized polystyrene latex spheres as templates, sodium silicate as a precursor, and cetyltrimethylammonium bromide as a shell structure-directing agent. When polystyrene-methyl acrylic acid latex spheres were used as the templates, the pores in the shells of the resultant hollow silica spheres were composed of both micropores and mesopores. The pores in the shells of the hollow silica spheres were mainly composed of mesopores when sulfonated polystyrene-methyl acrylic acid latex spheres were used as the templates. The shell thickness and the specific surface area of the hollow silica spheres increased with the increase in the surface acidity of the latex spheres.