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번계전탕액 投與가 생쥐의 腫瘍致死細胞 및 抗炎症細胞의 活性度에 미치는 影響
李長泉,辛民敎,宋昊埈 圓光大學校 韓醫學硏究所 1991 원광한의학 Vol.1 No.1
This study carried out to know the effects of Tetragonia on tumor immunities and the inflammatory responses. The tumor immunities were measured by checking the antibody dependent on cellular cytotoxicity(ADCC) and natural killer(NK) cell activity. The effects of Tetragonia on inflammatory responses were measured by evaluating the amount of reactive oxygen intermediate(ROI) in the neutrophils and macrophages. The innate immunity was evaluated by measuring the phagocytic activity of macrophages. The results obtained were as follows : 1. Tetragonia increased the antigen specific ADCC without affecting antigen non specific NK cell activity in tumor immunities. 2. Tetragonia severely decreased such ROI as O^-_2 and H_2O_2 in both neutrophils and macrophages. 3. Tetragonia increased the phagocytic activity of macrophages. The results of this study suggest that tetragonia might be effective on tumor immunity and such inflammatory diseases as rheumatoid arthritis and allergic diseases.
백창렬,이동건,최정현,정현화,조유경,박훈준,이승훈,박윤희,이교영,민우성,김춘추,신완식 대한감염학회 2001 감염 Vol.33 No.4
As a result of the enlarging pool of unvaccinated children and young adults, there has been an increase in measles in our countries. In these situation, it has been reported that measles associated pneumoinia is easily complicated with fatal respiratory failure, espycially in immunocompromised patients. Herein we report the case of lethal measles pneumonia after allogenic hematopoietic stem cell transplantation in adults proven by autopsy. Recently, one case of measles was encountered in 39-year-old female patients after allogenic bone marrow transplanted case (chronic myelogenous leukemia), who progressed into interstitial pneumonia pattern, despite treatment including antibiotics, immunoglobulin. The patient died of giant cell pneumonia compatible with that of measles which was comfirmed in the section of necropsy lung specimen. (Korean J Infect Dis 33:301∼309, 2001)
Predictors of Neurodevelopmental Outcomes in Newborns Undergoing Hypothermia Therapy
Min-Kyo Chun,Hyun Jung Sung,Joo Hyung Park,임계연,김소영 대한신생아학회 2019 Neonatal medicine Vol.26 No.1
Purpose: This study aimed to identify the early predictors of neurodevelopmental outcomes in infants undergoing therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy. Methods: The medical records of 24 neonates who underwent hypothermia therapy for hypoxic ischemic encephalopathy at the neonatal intensive care unit of Yeouido St. Mary's Hospital of the Catholic University of Korea between August 2013 and May 2016 were reviewed. Patients were divided into two groups according to their neurological outcome at the age of 18 to 24 months: a normal group (n=14), which included patients with normal neurological function, and an abnormal group (n=10), which included patients with neurological deficits. The clinical characteristics, clinical outcomes, and laboratory findings before and after hypothermia treatment were compared between the groups. Results: There were no significant differences in the demographic characteristics between the two groups. With regard to clinical outcomes, only brain magnetic resonance imaging (MRI) findings showed significant differences between the normal and abnormal groups (21.4% vs. 100.0%, P<0.001). With regard to laboratory findings, there were significant differences in the white blood cell (WBC) count after hypothermia treatment between the normal and abnormal groups (9.78±3.52 vs. 14.90± 3.48, P=0.003). However, logistic regression analysis showed that the WBC count was not an independent risk factor for abnormal neurodevelopment (P>0.05). Conclusion: The presence of abnormal lesions on MRI was the most useful predictor of poor neurodevelopmental outcome in infants treated with therapeutic hypothermia after perinatal asphyxia.
만삭전 조기양막파열 산모에서 양수과소증이 주산기 예후 및 분만 잠복기에 미치는 영향
구천회 ( Chun Hoe Ku ),박교훈 ( Kyo Hoon Park ),우헌탁 ( Hun Tack Woo ),김문영 ( Moon Young Kim ),김유미 ( You Mi Kim ),이철민 ( Chul Min Lee ),조용균 ( Yong Kyoon Cho ),최훈 ( Hoon Choi ),김복린 ( Bok Lin Kim ),이홍균 ( Hong Kyo 대한주산의학회 2002 Perinatology Vol.13 No.2
연구목적:본 연구의 목적은 만삭전 조기양막파열 산모에서 양수과소증이 주산기 예후 및 분만 잠복기에 미치는 영향을 살펴보고자 한다. 방법:조기양막파열로 입원한 임신 26주에서 35주의 단태임신 98명을 대상으로 후향적 관찰 연구를 시행하였다. 모든 대상 환자에서 입원 직후 경복부 초음파를 시행하여 양수 지수를 측정하였으며 모든 산모와 신생아 의무 기록을 검토하여 양수과소증이 주산기 예후 및 분만 잠복기에 미치는 영향을 조사하였다. 양수과소증은 양수지수가 5 이하일때로 정의하였고 분만 잠복기의 정의는 양막파열부터 분만까지의 시간으로 하였다. 통계 처리는 비율의 비교는 Chi-spuare test 또는 Fisher`s exact test를 사용하였으며, 연속형 변수의 비교는 변수의 특성에 따라 Student-t test 또는 Mann-Whitney U test를 사용하였다. 결과:1) 총 98명의 연구 대상자 중 양수과소증이 존재하지 않은 군이 59명(60%)이었고 양수과소증 군은 39명(40%)이었다. 조기양막파열 산모에서 분만 주수, 분만시 신생아 체중은 양수과소증이 존재한 군에서 양수과소증이 존재하지 않은 군보다 유의하게 낮았으나 1분 아프가 점수 7점 미만의 빈도, 5분 아프가 점수 7점 미만의 빈도, 신생아 이환율 및 주산기 사망률은 두 군 사이에 유의한 차이가 없었다. 2) 조기양막파열 산모에서 양수과소증이 분만 잠복기에 미치는 영향을 알아보기 위하여 산모 및 태아적응증으로 유도분만이나 제왕절개술을 시행한 산모 73명을 제외한 25명을 대상으로 하였다. 분만 잠복기는 양수과소증이 존재하지 않은 군의 중앙값이 41.5시간으로 양수과소증이 존재한 군의 중앙값 44시간과 유의한 차이를 나타내지 않았다. 결론:만삭전 조기양막파열 산모에서 양수과소증은 불량한 주산기 예후 및 분만 잠복기와는 유의한 관련성을 나타내지 않았다. Objectives:To examine the effects of the oligohydramnios on perinatal outcome and latency period in patients with preterm premature rupture of membranes. Methods:We performed a retrospective analysis of 98 singleton pregnancies complicated by preterm premature rupture of membranes, with delivery between 26 and 35 weeks` gestation. Amniotic fluid index was determined using transabdominal ultrasound at admission. All medical records of mothers and neonates were reviewed. Oligohydramnios was defined as amniotic fluid index less or equal to 5.0cm and latency period was defined as time interval from membrane rupture to delivery. Chi-spuare test, Fisher`s exact test, Student-t test, Mann-Whitney U test were used for statistical analysis. Results:1) Of the 98 patients, 59 patients(60%) were oligohydramnios group(AFI≤5.0) and 39 patients(40%) were non-oligohydramnios group(AFI>5.0). Both groups were similar with respect to selected dermographics, gestational age at rupture of the membranes, chorioamnionitis, 1 min Apgar score and 5 min Apgar score. Patients with oligohydramnios demonstrated a lower gestatoinal age at birth and lower birth weight. There were no statistically significant correlations in neonatal morbidity and perinatal mortality between both groups. 2) For comparing latency period, we excluded deliveries of Cesarean section or induction. Comparing the remained group(25 patients), median of latency period in oligohydramnios group were 41.5 hours and median of latency period in non-oligohydramnios group were 44 hours. There were no statistically significant correlations in oligohydramnios and latency period. Conclusion:There were no significant effects of the oligohydramnios on poor perinatal outcome and latency period in patients with preterm premature rupture of membranes