태변 착색된 태아의 절대혈 산,염기 평형 및 가스분석에 관한 연구

정재현 ( Jae Hyun Chung ),김승욱 ( Syng Wook Kim ) 대한주산의학회 1990 大韓周産醫學會雜誌 Vol.1 No.1

The presence of meconium in the amniotic fluid was said to be a sign of “fetal distress” which may result in the birth of an asphyxiated infants. It was known that umbilical blood gas analysis was an objective index of fetal well-being. Umbilical arterial and venous blood gas analyses were carried out in total 438 infants for the purpose of measuring the acid-base balance of infants at or near term from pregnancies complicated by meconium passage in utero and researching the difference in umbilical blood acid-base and gas status between the meconium and nonmeconium group. About 2ml of umbilical cord blood was collected via doubly clamped cord immediately after the delivery and before the first breath was taken. Cord blood collection was made by a syringe coated with 1000 unit heparin. Immediately after blood collecction, umbilical blood acid-base and gas values were determined with the help of Blood Gas Analyzer Stat Profile 5. When the umbilical arterial and venous blood gases were compared between the meconium and nonmeconium group, there was a significant difference in the mean pH values and bicarbonate concentration. There was a significant increase in the incidence of acidemia(defined as umbilical arterial pH less than 7.2), low I-minute and and 5-minutes Apgar score(<7) in newborns with meconium as compared with those with nonmeconium. The mean carbon dioxide tension of umbilical arterial and venous blood in neonates with thick meconium was significantly higher than those with thin meconium. The frequency of acidemia, low 1-minute and 5-minutes Apgar score(<7)in the thick meconium group increased significantly than those in the thin meconium group. There was a greater incidence of meconium, Apgar score at l-minute or 5 minutes <7 in those neonates with umbilical arterial pH less than 7.2 than in those with higher pH values. It was concluded that the acid-base and gas status of fetal blood was significantly altered when meconium, especially thick meconium is present in amniotic fluid.

한국의 성별, 태수, 분만횟수별 재태연령에 따른 출생체중 유형

이정주 ( Jung Ju Lee ) 대한주산의학회 2007 大韓周産醫學會雜誌 Vol.18 No.1

임신성 고혈압이 합병된 임산부의 태아 흉부하강대동맥 혈류량에 관한 연구

윤보현,은길상,황도영,신희철,김승욱 大韓周産醫學會 1990 大韓周産醫學會雜誌 Vol.1 No.2

주산기 뇌경색에 대한 임상적 연구

정명숙 ( Myung Sook Jeong ),천정미 ( Jung Mi Chun ),김경아 ( Kyung Ah Kim ),고선영 ( Sun Young Ko ),이연경 ( Yeon Kyung Lee ),한병희 ( Byoung Hee Han ),신손문 ( Son Moon Shin ) 대한주산의학회 2005 Perinatology Vol.16 No.2

Objective: Perinatal infarcts are an important cause of neonatal neurologic morbidity accounting up to 10~20% of neonatal seizures and annual incidence rate is about one in 4,000 live births. The purpose of this study is to describe the clinical presentation, course, radiologic and Electroencephlogram (EEG) findings and to evaluate the neurologic outcome of cerebral infarcts. Methods: Between January 2000 to May 2004, 8 of 40,204 delivered newborns (0.02%) were diagnosed as having cerebral infarcts. The clinical presentation, course, radiologic and EEG findings were characterized by retrospective chart review and neurological outcome was evaluated by neurological examination and developmental test (Bayley Scales of Infant Development-II) at out-patient department. Results: There were 5 males and 3 females. Six cases of them were full term, and other 2 cases were near-term neonates. Five cases presented neonatal seizure and 3 presented apnea or respiratory distress. All cases showed abnormal finding in the cranial ultrasonography that was performed immediately after the first symptoms. After then, diagnosis of cerebral infarct was confirmed by computed tomography and magnetic resonance imaging. Abnormal EEG finding was found in the 4 cases and a correlation between the location of these abnormalities and cerebral infarcts existed. The location of infarct was on the left hemisphere in five of the 8 cases and predominantly in the distribution of the middle cerebral artery. 7 cases were followed and the mean duration of follow up was 17 months (range 3~42 months). Neurologic outcome was normal in 3 cases and abnormal in 4 cases. Mild hemiparesis was present in 3 cases and recurrent epilepsy in 1 case. Developmental test was performed in 4 cases, all of them were normal. Conclusion: Neonatal seizure is an important presentation as the first sign of perinatal infarcts and cranial ultrasound can be used for initial evaluation of these perinatal infarcts. Neuological sequelae remains over half of the patients. Performing long term follow-up study of large cohort study is needed.

미숙아 및 저출생체중아의 출생빈도에 관한 통계학적 연구

김미정,손동우,장영표,차한,최중환,윤종구 大韓周産醫學會 1990 大韓周産醫學會雜誌 Vol.1 No.2

임신시 모혈철 Alpha - fetoprotein 치의 변동

김동호 大韓周産醫學會 1990 大韓周産醫學會雜誌 Vol.1 No.2

선택적 제왕절개술로 분만된 신생아 제대혈의 산,염기의 평형 및 가스분압의 정상역의 설정

이병우,김진규,김승욱 大韓周産醫學會 1990 大韓周産醫學會雜誌 Vol.1 No.2

Doppler 초음파에 의한 발육지연 태아에서의 제대동맥과 태아내경동맥 혈류속도파형의 비에 대한 연구

윤보현,노정래,김완영,신희철,김승욱 大韓周産醫學會 1990 大韓周産醫學會雜誌 Vol.1 No.2

Lisuride(Dopergin(R))의 산후 유즙 분비 억제 및 혈중 Prolatine억제에 관한 연구

진정희 ( Jung Hee Chin ),허주엽 ( Chu Yeop Huh ),서병희 ( Byung Hee Suh ),이재현 ( Jae Hyun Lee ) 대한주산의학회 1990 大韓周産醫學會雜誌 Vol.1 No.1

For the suppression of postpartum lactation, natural methods such as discontinuation of breastfeeding or mechanical compression of breast, or hormonal theraphy were used. But its effect was not so satisfactory. Then bromocryptine, a dopamine agonist, was used to suprresion of postpartum lactation and effect was good. But there was limitation of wide use of bromocryptine due to adverse effects, such as nausea, dizziness, postural hypotension and rebound lactation. Lisuride, a semisynthetic dopamine agonist. also suprress postpartum lactation and has less side effect compared with bromocryptine. A comparative study of effectiveness of lisuride with regard to dosage was carried out in 50 puperperal women. 1. The first group of 16 cases recieved 0.2mg of lisuride daily and 2nd group of 34 cases recieved 0.4mg of lisuride daily for 14days. 2. In frist group, milk secretion was found in 43.8% at first day, 56.3% at third day and breast congestion was found in 87.5% at first day, 68.8% at third day and there was no milk secretion or breast congestion at fifteenth days. However, in second group show milk secretion in 20.6% and 20.5% at first and third day each others, and breast congestion at 44.1 % and 32.3% at first and third day and 2cases of breast congestion was found at 15th day. 3. Basal serum prolactin level was 1l0.7±52.4ng/㎖ in first group and 102.5±94.4ng/㎖ in second group and 46.4±29.0ng/㎖, 25.0±29.9 on each group at 15th day and the difference was statistically significant. 4. There was no significant untoward side effect on both group. After discontinuation of medication, rebound lactation was found at 62.5% in first group and 11.8% in second group. These rebound lactation was mild and disappeared in almost cases by further treatment of 7 days.

제대 동맥혈 및 정맥혈 ANP치

김범주 ( Boem Ju Kim ),김행미 ( Heng Mi Kim ),안두홍 ( Doo Hong Ahn ),이원정 ( Won Jung Lee ) 대한주산의학회 1990 大韓周産醫學會雜誌 Vol.1 No.1

Atrial natriuretic peptide(ANP) is a circulating hormone in the human fetus. Human fetus is able to increase ANP release in response to volume expansion and in direct proportion to heart rate. In this study, we attemped to determine the normal range of ANP in umbilical blood and to evaluate the clinical conditions in which the ANP levels may increase. ANP in the umbilical arterial and venous blood obtained at delivery were measured in 21 normal newborns. The ANP concentration in the umbilical arterial blood(mean ±SD, 19.77 ± 14.85 pg/dl) was significantly correlated with that in the umbilical venous blood(17.55 ± 13.70 pg/dl)(r=0.816). The plasma ANP concentration was not correlated with plasma creatine kinase(total, or MB fraction), maternal weight gain during pregnancy or change of hematocrit after birth. There was no difference of ANP concentration according to delivery method or presence of fetal distress. The ANP concentrations in the umbilical arterial, venous and maternal venous blood from mother suffering from pregnancy-induced hypertension were 34.5±15.0 pg/dl, 38.2±16.4 pg / dl and 71.3±37.1 pg/dl respectively. Each of them were significantly hihger than that from normal mother(15.0±11.6 pg/dl, 12.16±7.1 pg/dl and 30.8±18.7 pg/dl)(P<0.05). Our results suggest that cord blood ANP level is influenced by the maternal ANP level by placental transfer.