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Ciprofloxacin 제제의 생물학적 동등성에 관한 연구
최철희,신재국,신완균,유호진,이경훈,정원석,장인진,신상구 대한화학요법학회 1991 대한화학요법학회지 Vol.9 No.1
국내 시판중인 ciprofloxacin 제제인 Citopcin®(250㎎ tablet)의 동등성을 검토하기 위해 제조원인 Bayer사의 Citopcin®(250㎎ tablet)를 기준제제로 하여 18명의 건강한 남성 피험자를 대상으로 500㎎ 1회 교차 경구 투여후 약동학적 성상을 분석비교한 결과는 다음과 같다. 시험제제의 생체 이용율의 지표인 AUC, C_(mao), T_(max) 및 MRT들의 평균치는 백분율차이에 있어 모든 기준제제 지표의 ± 20% 이내였으며, 이들 생체 이용율 지표들은 분산분석 검정에서 차이를 인지할 수 없었다.생체 이용율 지표들의 기준제제에 대한 백분율 90% 대칭 신뢰구간 검토시 모든 경수들에서 ± 20% 이내의 조건을 만족하였으며 AUC의 경우에는 대칭형 신뢰구간으로 변환시 95% 신뢰구간에서도 동등성의 조건을 만족하였다, 이상의 시험결과로 시험제제인 Citopcin®은 기준제제인 Ciprobay®와 생물학적 동등한 제제로 판단되었다. The pharmacokinetics of ciprofloxacin was studied for the evaluation of the bioequivalence of the generic ciproflocacin products. Two single doses of 500㎎ each of ciprofloxacin(Ciprobay® 250㎎ tablet as a reference compound and Citopcin® 250㎎ tablet s a test compound) were administered orally to ighteen male volunteers in a balanced, randomized crossover design. Pek plasma levels of ciprofloxacin were observed about 1 hour after the doses and the peak concentrations of both products were similar(Ciprobay®, 3.18㎍/㎖; Citopcin®, 2.89㎍/㎖). The values of other pharmacokinetic parameter of ciprofloxacin computed for Ciprobay® are presented in that order: AUC=13.53:12.47㎍·h/㎖, T_(max)=1.28:1.14 hours; MRT=5.30:5.08 hours; t_(1/2)β=3.65:3.47 hours. No satistically significant, differences were detected when AUC and the other parameters were compared with the method of ANOVA. Using the criteria of 90% confidence interval for the assessment of bioequivalence al the parameters were acceptable. The products were found to be equivalent on the premise that no significant difference was detected when the relevant pharmacokinetic parameters were compared, and the confidence limit analysis showed acceptable results.
이영신,조용균,박철휘 한서대학교 산학협력연구원 부설 환경연구소 2000 환경연구소 논문집 Vol.3 No.-
Seosan city is facing fast industrialization, urbanization, and populization growth. It speedy changes into engineering oriented area around Dae-San engineering district causefuuture increase of general sewages and industrial waste water. the environmentally hazardous materials will also aggravate water quality of neighboring rivers and ocean. Thus, this study has been performed to investigate current lever of industrial waste water, and then project future level of those environmental damages.
분해도 및 작업시간 산정을 통한 균형잡힌 조립공정계획에 관한 연구
신철균(Chul Kyun Shin) Korean Society for Precision Engineering 2007 한국정밀공학회지 Vol.24 No.7
This paper presents a method of a line balanced assembly sequence generation based on the verification of a disassemblability and a work time. To derive the disassemblability for a part to be disassembled, first we inference collision free assembly directions by extracting separable directions for the part. And we determine the disassemblability defined by the separability and stability cost. The separability cost represents a facility of the part disassembly operation, and the stability cost which represents a degree of the stability for the base assembly motion. Based upon the results, we propose a new approach of evaluating work time using neural networks. The proposed assembly sequence generation provides an effective means of solving the line balancing problem and gives a design guidance of planning assembly lay-out in flexible manufacturing application. Example study is given to illustrate the concepts and procedure of the proposed schemes.
Park, Chul-Min,Ahn, Won-Ju,Jo, Woong-Kyu,Song, Jin-Hun,Oh, Chang-Yeop,Jeong, Young-Shin,Chung, Min-Chul,Park, Kwon-Pil,Kim, Ki-Joong,Jeong, Woon-Jo,Sohn, Bo-Kyun,Jung, Sang-Chul,Lee, Do-Jin,Ahn, Byeon American Scientific Publishers 2015 Journal of Nanoscience and Nanotechnology Vol.15 No.1
<P>The greenhouse effect of carbon dioxide (CO2) has been recognized as one of the most serious problems in the world. Conversion of CO2 to methyl alcohol (CH3OH) was studied using catalytic chemical methods. Honeycomb-typed monolith used as catalyst support was 400 cell/inch2. Pretreatment of the monolith surface was carried out by thermal treatment and acid treatment. Monolith-supported nanosized CuO-ZnO catalysts were prepared by wash-coat method. The prepared catalysts were characterized by using SEM, TEM, and XRD. The catalytic activity for CO2 hydrogenation to CH3OH was investigated using a flow-type reactor with varying reaction temperature, reaction pressure and contact time. Conversion of CO2 was increased with increasing reaction temperature, but selectivity to CH3OH was decreased. Optimum reaction temperature was about 250 degrees C under 20 atm. Because of the reverse water gas shift reaction.</P>