저 품위 철광석을 사용한 식생용 투수 콘크리트의 중성화 및 제작에 관한 연구

은희창,이민수,배충열 강원대학교 산업기술연구소 2007 産業技術硏究 Vol.27 No.A

Recently produced concrete has a tendency to overcome environmental defects. Porous and planting Eco-concrete requires the neutralization process and enough void in concrete to contain water, to pass air freely, and provides necessary nutrients to vegetation roots. The biological environment in concrete is not suitable for planting because the concrete possesses strong alkali constituent of pH 11-13. This study evaluated the strength and serviceability of concrete as well as the chemical characteristics of concrete mixed by low-grade iron ore left in the abandoned mine and treated by Ammonium monohydrogen phosphate, (NH_(4))_(2)HPO_(4). Test variables include two kinds of coarse aggregates such as crushed stones and low-grade iron ore, the duration time and the period for neutralization treatment by Ammonium monohydrogen phosphate, (NH_(4))_(2)HPO_(4), and the proportion ratio of cement, blast furnace slag and silica fume.

B 세포 활성화 유도물질이 proto-oncogene 발현에 미치는 영향 : B 세포 증식효과와의 관련성 분석 No direct correlation with B cell proliferation response

이충은 성균관대학교 기초과학연구소 1995 論文集 Vol.46 No.1

인체 B세포 활성화 과정의 분자적기전을 조사하기 위하여 IL-4. anti-IgM 및 anti-CD40같은 B세포 활성화 물질이 B세포의 proto-oncogene 발현유도에 미치는 영향을 분석하였다. 휴지기 B세포에 anti-IgM의 자극을 가하였을 때 c-myc과 c-fos의 발현이 현저하게 유도되었으나, IL-4의 자극을 가하였을때는 c-fos만이 유도되었다. 또한 anti-IgM과 IL-4를 동시처리 하였을시는 각각을 단독처리하였을때보다 B세포의 증식효과가 크게 상승하였으나, c-myc 또는 c-fos의 발현에는 이러한 상승작용이 관찰되지 않았다. 한편 B세포 활성화 분자인 CD40를 통한 자극에 의하여 c-myc의 발현이 뚜렷이 유도되었는데, 이때에 B세포 증식효과는 나타나지 않았다. 이 결과들은 IL-4, anti-IgM 및 anti-CD40에 의하여 B세포의 증식이 유도되는 과정에서 c-fos나 c-myc과 같은 proto-oncogene의 작용이 직접적으로 관여하지 않음을 시사하며, 아마도 다른 proto-oncogene이나 이들이 down-stream effector들의 작용이 관여하여 이들 B세포 활성화물질에 의한 B세포 증식의 상승효과를 유발할 가능성을 제시한다. To investigate the molecular mechanism of human B cell activation by interleukin-4(IL-4), anti-IgM, and anti-CD40, effects of these B cell activating agents on the induction of proto-oncogene expression were examined. Anti-IgM stimulation of resting B cells induced both c-myc and c-fos expression, while IL-4 induced c-fos but not c-myc. Although the combined treatment of anti-IgM plus IL-4 caused a synergistic effects on B cell proliferation, there was no concomittant enhancement of c-myc or c-fos transcript levels. Interestingly, a soluble anti-CD40 Ab (5C3) strongly induced c-myc proto-oncogene. Yet this soluble Ab alone or even together with IL-4 induced no apparent proliferation of B cells. These data suggest that there is no direct correlation between proto-oncogene, c-fos or c-myc expression and human B cell proliferation induced by IL-4, anti-IgM or anti-CD40. It appears that the reported synergistic effect of IL-4 and anti-IgM or anti-CD40 on B cell proliferation, results from the regulation of other B cell proto-oncogene expression and/or from the action of further down-stream effectors.

B 림프구 활성화 자극에 따른 Interleukin-4 수용체와 Type II IgE 수용체 발현조절양상의 상호관련성

이충은,윤석란,변광호,소의영 大韓免疫學會 1995 大韓免疫學會誌 Vol.17 No.3

Interleukin-4(IL-4) specifically induces the expression of its own receptor, IL-4R and type II IgE receptor, FceR1l in a dose-dependent manner in human B lymphocytes. We observed that the IL-4-induced expression of IL-4R and Fce Rll were both down-regulated by interferon-T(IFN-T) at mRNA as well as surface protein levels in normal B lymphocytes. Such co-ordinated regulation of the IL-4-induced IL-4R and FceRlI also occurred by anti-CD40 and steroid, each regulating the IL-4-induced response in an opposite direction. While anti-CD40, which is re-ported to agument the IL-4-induced B cell activation, further enhanced the IL-4-induced IL-4R and Fee RU expression, methylprednisolon(MPD) strongly inhibited the level of these receptors. The anti-CD40 or MPD-induced modulation of the IL-4-induced IL-4R and FceRII was further subject to the down-regulation by lFN-T. As compared to normal B lymphocytes, a differential regulation of IL-4R and FceRII was noted in a transformed B cell line, where IFN- Tup-regulated the IL-4-induced responses. Still, there was a co-ordinated regulation of the IL-4R and FceRII in these cells. Taken together, these results suggest that modulation of IL-4R expression and FccRII induction are closely correlated events during the IL-4-induced cellular activation

TLD를 사용한 고층건물의 수치해석

홍은호,이충렬 부천대학 2004 論文集 Vol.25 No.-

現代의 高層建物設計는 强風이나 地震荷重으로부터 構造物의 安全性 및 使用性과 居住者의 便安함을 提供하는 問題들을 包含한다. 現代 高層建物의 剛性과 質量은 더 강한 材料와 複合 構造시스템을 使用하여 줄이고 있다 剛性과 質量의 減少는 과도한 水平振動으로부터 構造物에 발생할 수 있는 問題의 가능성을 줄여 준다. 居住者의 便安함과 安全性을 增加시키는 效果的인 方法을 硏究하는 革新的인 엔지니어들은 2가지 形態의 振動制御시스템을 사용한다. 하나는 受動制振시스템이고 다른 하나는 能動制振시스템이다. 이 論文은 受動制振시스템중에 同調液體댐퍼(Tuned Luquid Damper)에 대해 다루고자 한다. 선박에서 널리 사용되어진 TLD는 最近 構造物의 振動制御를 위해 사용되고 있다. TLD는 움직이는 質量으로서 물 또는 다른 液體를 사용하고 復原力은 重力을 사용한다. 에너지 吸收는 液體와 容器의 摩擦과 液體流動시의 출렁거림으로 한다. 構造物의 運動에너지를 吸收하는 TLD의 基本 原理는 TMD와 같다. The design of modern tall buildings involves certain problems, such as safety and serviceability of the structure and comfort of occupants result from strong wind or earthquake loads. The stiffness and mass of modern tall buildings have been reduced by using higher strength materials and better integrated structural systems. These decreases in stiffness and mass have increased the possibility of structural problems arising from excessive lateral vibration. Innovative engineers in their search for effective ways of increasing the comfort and safety of occupants make use of two types of vibration control system. One is passive control system and the other is active control system. This thesis deals with the tuned liquid damper of passive control systems Tuned liquid dampers which have been widely used in ships are recently implemented for vibration control of structures. A TLD uses water or other liquids as the moving mass and restoring force is generated by gravity. Energy absoption comes from boudaries between liquid and containers and turbulence in the liquid flow. The basic principle of TLD to absorb kinetic energy of the main structure is the same as TMD.

인체 B 림프구 활성화의 신호전달과정에서 IL-4 수용체와 CD40 분자간의 상호작용

이충은,윤석란,변광호 大韓免疫學會 1995 大韓免疫學會誌 Vol.17 No.3

Stimulation of B cells through CD40 antigen has been reported to agument the interleukin-4(IL-4)induced B cell proliferation and differentiation. In order to elucidate mechanisms underlying the synergistic action, we examined the effect of CD40-mediated signal on the IL-4-induced B cell activation. Treatment of dense, resting tonsillar B cells with agonistic anti-CD40 mAb caused a noticeable induction of IL-4 receptor(IL-4R) mRNA expression within hours, which was followed by a significant enhancement of the IL-4-induced surface IL-4R and CD23 expression, suggesting a role of CD40 in amplifying the IL-4-induced signal. Signal interplay between the IL-4 and the CD40 system was further supported by the observation that, in tonsillar B cells, IL-4 plus anti-IgM induced CD40 expression and tyrosine phosphorylation of IL-4R, and that anti-CD40 co-immunoprecipitated the IL-4R and the IL-4R associated tyrosine kinase activity, which implies a possible molecular interaction between IL-4R and CD40. Together these results suggest that there is a cross-talk between CD40-and the IL-4R-mediated signal transduction system during the T cell-dependent B cell activation.

國際 小貨物 運送業體의 競爭 戰略에 관한 硏究

이충배,홍은경 중앙대학교 산업경영연구소 1999 산업경영연구 Vol.8 No.2

고객요구의 변화에 따른 생산체제의 변화, JIT 시스템의 중요성 증대, 무역의 증가, 고부가가치 산업의 발달, 전자상거래 도래에 따른 유통체제의 변화 등으로 인해 국제 소화물 운송에 대한소요가 계속적으로 증가하고 있다. 본 연구는 국제소화물 운송업체들 중 선두주자인 FedEx, UPS, DHL의 경쟁우위 전략을 분석하는 데 있다. 이들 업체들은 최근 정보화, 서비스 지역의 확대 및 사업영역의 확장 등의 부문에서 경쟁업체들에 비하여 우위를 점하기 위한 전략을 적극적으로 추진하고 있다. 이들 업체들은 전세계를 대상으로 고도의 물류서비스를 제공하기 위하여 정보화, 통합화를 가속화시키고 있으며, 지역적으로는 현지 업체들과의 제휴를 통해 해당 지역의 시장을 공략하고 있다. 물류환경의 변화와 국제소화물 운송업체들의 대응전략은 우리 운송업체들의 향후 진로에 많은 시사점을 제공해 줄 수 있을 것이다. Demand for international express delivery service is rapidly growing by changes of commercial environments such as production method. JIT system, high-value added industries and distribution structure. electronic commercial transactions. In response international express delivery service companies such as FedEx, UPS and DHL are introducing and adopting new strategies i.e. enhancing information technologies, diversification for comprehensive logistics service, market expansion. This study aims to compare and analyze the strategies of international express delivery service companies. In conclusion, most companies are making aggressive investment plans for IT, diversification market expansion in order to cope with new business environments such as electronic commerce. This study suggests that Korean express companies mostly small-scale, hold a Korean market with establishing joint venture, strategic alliance with international express companies.

자궁경부암 선별검진을 위한 PapSure 검사에서 Spiral Brush의 유용성에 관한 연구

송언호,김어진,명나혜,박충학 대한부인종양 콜포스코피학회 2002 Journal of Gynecologic Oncology Vol.13 No.4

2001년 12월 1일부터 2002년 6월 30일까지 만 7개월 간 단국대학교의료원 산부인과 부인종양 Clinic에서 자궁경부암 선별검진을 위한 PapSure 검사를 시행한 환자 중 SpiraBrush Cx_® 검사를 실시한 33예를 대상으로 하여, 기존의 Papanicolaou 세포진 검사의 진단과 SPiraBrush Cx_®)에 의한 Papanicolaou 세포진 검사의 진단 및 최종적인 병리조직학적 진단을 비교, 분석하여 SpiraBrush Cx_®에 의한 세포진 검사가 생검에 의한 조직검사를 대체할만한 유용성이 있는지 그 여부를 조사하기 위하여 본 연구를 시행하여 다음과 같은 결과를 얻었다. 1. 환자의 연령별 분포는 21세에서 70세까지였으며 40-49세 군이 42%로 가장 많은 분포를 보였고, 평균 연령은 45.7세였다. 2. 환자의 평균 임신횟수는 3.6회였으며, 평균 출산횟수는 2.0회였다. 3. 기존의 자궁경부 세포진 검사(Conventional Papanicolaou cytology)상 진단이 음성으로 나온 경우가 19예(57.6%)였고, ASC를 포함하여 양성으로 나온 경우가 14예(42.4%)였다. 자궁경부 형광경진 검사(Speculoscopy)에서는 음성이 13예(39.4%)였고, Suspicious 진단을 포함하여 양성으로 나온 경우가 20예(60.6%)였다. SpiraBrush Cx®에 의한 세포진 검사(SpiraBrush Cx_® Papanicolaou cytology)에서는 진단이 음성인 경우가 8예(24.2%)였고, ASC를 포함하여 양성으로 나온 경우가 25예(75.8%)였다. 4. 병리조직학적 검사의 진단은 음성 12예(52.2%), 저등급 편평상피내병변(Low-grade Squamous Intraepithelial Lesion: 이하 LSIL이라 함) 2예(8.7%), 고등급 편평상피내병변(High-grade Squamous Intraepithelial lesoin: 이하 HSIL이라 함) 3예(13.0%), 편평세포암(Squamous Cell Carcinoma: 이하 SCC라 함) 6예(26.1%)였다. 5. 검사 결과의 양성판정 기준을 세포진 검사의 경우는 ASC 이상으로 하고 조직학적 검사의 경우는 LSIL이상으로 정할 경우, 기존의 Papanicolaou 세포진 검사의 민감도는 63.6%이고 특이도는 66.7%였으며, SpiraBrush Cx_®세포진 검사의 민감도는 90.9%이고 특이도는 33.3%였다. 이상의 결과로 미루어 볼 때 연구 대상의 숫자가 적어서 통계학적인 유의성은 찾을 수 없으나 SpiraBrush Cx_®가 자궁경부암 선별검진에서 생검에 의한 자궁경부의 조직학적 진단을 대체하지는 않는다고 판단된다. 그러나 기존의 Papanicolaou 세포진 검사의 민감도가 63.6%인데 반하여 SpiraBrush Cx_® 세포진 검사의 민감도는 90.9%로 훨씬 더 높았으며 이로 인해 SpiraBrush Cx_® 세포진 검사의 특이도는 33.3%로 훨씬 낮았는데 이는 매우 흥미있는 사실로서 향후 많은 Data로 더욱 연구하여 진위를 구분함이 필요하리라 사료된다. 또한 본 연구에서는 SpiraBrush Cx_® 기구의 강모들이 단단하고 날카로워서 기저막층까지의 조직과 상피층 세포들을 탈락시키면서 많은 출혈을 초래하여 슬라이드 판독에 어려움을 주었고 이는 연구 결과에 지대한 영향을 미쳤으리라고 생각되는 바, 이러한 출혈로 인한 요인을 최대한 배제하기 위하며 향후 SpiraBrush Cx_® 세포를 채취한 후 최신의 자궁경부 세포진 검사법인 ThinPrep Pap Test를 이용하거나 조직표본을 만들기 위한 Cellblock 기법을 사용하여야 한다고 판단된다. Objective : The purpose of this study was to investigate the clinical efficacy of a new stiff bristled spiral shaped brush (SpiraBrush Cx_(??))∼in) PapSure Test for cervical cancer screening, by comparing SpiraBrush Cx_(??) cytologic diagnoses with conventional Papanicolaou cytologic diagnoses and final histologic diagnoses. Methods : This study was performed in Gynecologic Oncology Clinic of Department of Obstetrics and Gynecology at Dankook University Medical Center from December I, 2001 to June 30, 2002. Thirty three cases who underwent PapSure Test (Pap cytology t Speculoscopy) were analyzed. SpiraBrush Cx_(??) Papanicolaou cytologic diagnoses were compared with conventional Papanicolaou cytologic diagnoses and histologic diagnoses as a reference standard. Results : Followings are the results summarized. 1. Age distribution was between 21 and 70. The mean age was 45.7 years. 2. The mean gravidity was 3.6 and the mean parity was 2.0. 3. There were 19 (57.6%) conventional Papanicolaou cytologic diagnoses of Negative, and 14 (42.4%) of Positive including ASC. There were 13 (39.4%) Speculoscopy diagnoses of Negative, and 20 (60.6%) of Positive including Suspicious. There were 8 (24.2%) SpiraBrush Cx_(??) cytologic diagnoses of Negative and 25 (75.8%) of Positive including ASC. 4. There were 12 (52.2%) histologic diagnoses of Negative, 2 (8.7%) of LSIL, 3 (13.0%) of HSIL, and 6 (26.1%) of SCC, according to the criteria of TBS, 2001. 5. For detecting LSIL or worse lesions, conventional Papanicolaou cytologic test yielded sensitivity of 63.6% and specificity of 66.7%. On the other hand, SpiraBrush Cx_(??) cytologic test yielded sensitivity of 90.9% and specificity of 33.3%. Conclusion : SpiraBrush Cx_(??) cytologic diagnosis does not seem to have clinical efficacy replacing the histologic diagnosis by punch biopsy in cervical cancer screening in this study. But further studies using ThinPrep Pap Test or Cellblock techniques with large data will be required and anticipated.

대학 전산 정책의 방향설정 및 추진계획에 관한 연구

홍상은,이병수,조충호,이상정,주경수,안종근,황순기 순천향대학교 1994 논문집 Vol.17 No.1

It has been rapidly given to the importance of the embodiment of the efficient computer systems in university education. Since the recent trend of the adoption of the openess policy in university education systems significantly affects on the realization of the embodiment of the efficient computer systems which is very essential to promote the international competition in many areas of university education. So it is greatly needed that our Soonchunhyang university must have the following principles for the embodiment of the efficient computer systems. (1) It is required that the appropriate computer education and the good quality of research environment must be given. (2) The establishment of the synthetic computer network system for efficient the university administrations is needed. (3) It is needed to establish the computer system for the consideration of the future performance. (4) It is also needed to improve the organization and the administration systems of the university computer center. (5) It is required on the establishment of the local area network(LAN) systems in the Soonchunhyang university, and the LAN must be connected to other outer national and international computer systems. And we propose the following requirement for the establishment of the convienent computer systems in our university and we have been greatly though about the significant change of the environment in university computer system. [1] The subject of the basic computer must become as the required subject for the all students in the curriulum. [2] The new computer systems both in hardware and software must be introduced. [3] It is needed to the change of the present name of the university computer center into the university information and computer center. And its organizations must be furthur developed [4] The training center for the university emploee is also needed. [5] The establishment of the database systems for the automtion of the university administation is needed. [6] It is strongly required on the establishment of the local area network system in the Soonchunhang university to connect the Bitnet and the Internet through the Hankook communication. [7] The computerization for the central library is needed. The indepent local area network system for the library is also needed to establish the own database system. Finally we hope that the LAN will be connected to the national wide library computer system.

스포츠 관광 활성화 개선방안에 관한 연구

조충현,김홍식,박은석,강성찬,이동헌 圓光大學校 附設 體力科學硏究所 2003 體力科學硏究 Vol.26 No.1

This study was conducted to investigate the effects of the marketing strategy based on the traditional wrestling, which affects the tour industry. The study used the simple random sampling method in the group of the Kwang-Ju district citizens. The group representatives were directly interviewed, and 277 interviewees replied with concern. The rest of the interviewees were not interested in the survey. The general characteristics of the interviewees -- gender, age, education, job, monthly salary. -- were used to analyze the items related to Sports Tourism in general. Sport Tourism in general Male interviewees had higher recognition over females in the interview. The rate of experience was low for both genders. According to their education, the satisfaction of sport tourism showed low rate. However, there were many answers where the interviewees, not depending on the age or gender, indicated that they will participate in the future. The policy recommended based upon the results of the study is as follows. There is a need for setting up a new strategy in order to increase participation of sports. Also, it is urgent to set up a sports theme center to raise professional sportsmen and to supply them to where they are needed.

鼻結核症의 一例

金充恩,洪晋杓,金正坤,文一榮 中央醫學社 1964 中央醫學 Vol.6 No.6

Acase of primary tuberculosis of the nose and nasopharynx was reported: The nasal lesion that was suggestive of chronic atrophic rhinitis complicated by chronic: maxillary sinusitis was proved to be tuberculosis of the nose, following biopsy with tissue examinations. And etiology, pathology, symptoms, prognosis and treatment of tuberculosis of the nose were discussed.