Genome-wide investigation of a Korean synthetic breed, Woori-Heukdon using the Illumina PorcineSNP60K BeadChip

Yong‑Min Kim,Ha‑Seung Seong,Jung‑Jae Lee,Da‑Hye Son,Jin‑Su Kim,Soo‑Jin Sa,Young‑Sin Kim,Tae‑Jeong Choi,Kyu‑Ho Cho,Joon‑Ki Hong,Jung‑Woo Choi,Eun‑Seok Cho 한국유전학회 2020 Genes & Genomics Vol.42 No.12

Background: Woori-Heukdon (KWH) is a Korean synthetic pig breed generated using Chookjin-Duroc (KCD), Chookjin-Chamdon (KCC), and their crossbreds. Currently, there is a severe lack of studies investigating the Korean breed populations including wild boars (KWB) throughout the genome. Objective: This study was performed to investigate the genetic characteristics of Korean pig populations at the genome-wide level. Methods: Using the SNP dataset derived from genotyped and downloaded datasets using the Illumina PorcineSNP60K BeadChip, we compared the genomes of 532 individuals derived from 23 pig breeds to assess the genetic diversity, inbreeding coefficient, genetic differentiation, and population structure. Results: KWB showed the lowest average expected heterozygosity (HE = 0.1904), while KWH showed the highest genetic diversity (HE = 0.02859) among Korean populations. We verified that the genetic composition of KWH, showing USD of 74.8% and KCC of 25.2% in ADMIXTURE analysis. In population structure analyses, KCC was consistently shown to be separated from other pig populations. In addition, we observed gene flow from Western pigs to a part of Chinese populations. Conclusion: This study showed that Korean native pigs, KCC have genetic differences in comparison with Chinese and Western pigs; despite some historical records and recent genetic studies, we could not find any clear evidence that KCC was significantly influenced by Chinese or Western breeds in this study. We also verified the theoretical genomic composition of KWH at the molecular level in structure analyses. To our knowledge, this is the first genomic study to investigate the genomic characteristics of KWH and KCC.

병렬파이프라인 다중인식기를 이용한 무제약 필기체 숫자인식

최용호,조범준 朝鮮大學校 電子情報通信硏究所 2003 電子情報通信硏究所論文誌 Vol.6 No.2

Parallel combination, little significance is given on performance of Recognizer but its performance depends on how to combine. In the serial combination, the results of the Recognizer are ignored and different results can be produced. And, performance even after combination is not much improved compared with that of a single Recognizer. Therefore, this study aims to make up for methods of combination of multi recognizer shortcomings menthioned above. That is, we use an advantage of parallel Recognizers, using two or more resultant values, and those of Recognizers of the serial combination, considering supplements of recognizers and a point of several steps of verification. Therefore, this study tend to suggest the results of research and experiments on methods of recognize the combination of the results from three nodes of recognizers which in parallel are linked in the form of total three pipeline.

6주간의 淸暑益氣湯 經口投與가 에너지대사 및 호르몬 변화에 미치는 영향

최용어,강명신,유종만,이규성,오재근,조준용 韓國體育大學校附屬 體育科學硏究所 1994 韓國體育大學校附屬 體育科學硏究所論文集 Vol.13 No.1

The purpose of this study was to investigate the effects of chung-seo-ik-gi -tang administration on the metabolic responses and hormones in 18 healthy-male elite boxes. All subjects were divided randomly with two groups, Chung-sea-ik-gi-tang Group(N=18) and placebo group(N=18) and perfored with 70% of HR max using bycicle ergometer unfil exhaustion. During the submaximal exercise, heart rate was maesured every two min. The blood samples were collected from antecubital vein by 10ml syranges(6ml/each) before immediately after exhaustion, recover-10 min, recover-20 min and recover-30 min. The samples were to analyzed for the level of glucose, lactate, TG, TC, HDL-C, insulin and catecholamine. The results of various blood parameters were summarized as follow; l. Energy substrates (plasma glucose, TG, TC, HDL-C) changes in group C were significantly different from group P. Plasma glucose in group C was significantly lowered at recover-10 min compared to group P (P<0.05). and also TG, TC and HDL-C in group C were significantly increased after 3 weeks compared to group P (P<0.05) whereas. Lactate accumulation in group C was significantly decreased after 3 weeks compared to group P (P<0.05). 2. Plasma insulin level was not showed significant difference between two groups. But insulin depression tendency after 3, 6 weeks in group C was allevated compared to group P. Increasing rate of norepinephrine in group C at Post-exhaustion after 3weeks lowered compared to group P. Norepinephrine in group C at rest periods after 3 weeks showed significant difference compared to group C. The results indicated that Chung-seo-ik-gi-tang had the effects of ergogenic aids on fatigue resistance and recovery from exhaustive exercise at the level of 70% HR max.

韓國 東海沿岸海(注文津)에서 風成海流 影響下의 海洋汚染 樣相

崔孝,朴榮濟,崔俊 강릉대학교동해안지역연구소 1993 東海岸硏究 Vol.4 No.3

本 硏究에서는 東海의 注文津港口와 連谷川河口에서 沿岸海域으로 流入된 汚染水의 COD와 DO의 농도를 分析하여 沿岸海域에서의 汚染狀態를 調査하였다. 海水의 COD분포의 일반적인 樣相은 注文津 港口의 入口와 河川水의 流入이 많은 連谷川 河口에서 高濃度의 分布를 나타내며 沿岸에서 外海로 갈수록 低濃度의 分布樣相을 보여준다. 그러나 注文津港의 入口에서 海水가 低鹽分度를 나타내지만 COD의 濃度分布는 高濃度이고, 反面에 連谷川 河口에서는 다소 高鹽水이고 COD도 高濃度를 나타낸다. COD의 濃度가 漲潮流時에 注文津港의 入口에서 高濃度를, 落潮流時에 低濃度를 보여주며, 反對로 連谷川 河口에서는 漲潮流時에 低濃度를, 落潮流時에 高濃度를 보여준다. 外海로 갈수록 漲潮流時와 落潮流時에 큰 差異를 보이지 않는다. DO의 濃度分布는 汚染物質이 많이 排出되는 注文津 港口의 入口에서는 DO의 量이 減少함에 따라 海水의 汚染狀態가 심해감을 알 수 있으며 連谷川 河口 역시 生活汚水와 廢水의 放流에 依해 水質이 좋지 못함을 알 수 있다. 그러나 沿岸에서 外海로 갈수록 DO量이 增加하여 水質이 養好해져감을 볼 수 있다. 따라서 沿岸海域에서의 汚染狀態는 DO量이 가장 적은 注文津 港口의 入口가 가장 심하고 連谷川 河口에서 다소 덜 심하며 沿岸에서 3km밖의 外海側에서는 汚染이 되지 않은 海域임을 알 수 있다. By analyzing the concentrations of COD and DO of polluted waters flowed into the East Sea from the Chumunchin harbor and the Yunkok Stream estuary the pollution state in the coastal sea was investigated in this reseach. The general aspect of COD distribution of sea water showed that the concentrations were high in the mouth of the Chumunchin harbor and the eastuary of Yunkok Stream, which the fresh waters flowed in, but low in the open sea at the distance far away from the coast. In the mouth of Chumunchin harbor the salinity of sea water was low and the COD concentration was high, while in the eastuary of Yunkok Stream the salinity was also high and the COD was high. The distributions of COD in the mouth of Chumunchin harbor showed especially high concentrations during the flood, but low concentrations during the ebb. On the other hand, the COD concentrations in the estuary of Yunkok Stream were low for the flood and high for the ebb, but their concentrations in the open sea for both flood and ebb were not much different. Since the concentrations of DO decreased in the mouth of Chumunchin harbor, where a great amount of the pollutants were released, the pollution state became serious, and the water qualities in the estuary of the Yunkok Stream were also in the bad situation due to discharging sewage and waste water. However, the amount of DO increased as the distance from the coast to the open sea increased and the quality of sea water became in the good state. Thus, the pollution state in the coastal sea was worst in the mouth of Chumunchin harbor, where the concentration of DO was low, and relatively not much serious in the eastuary of the Yunkok Stream, but the sea the outside of 3km still contained clean waters.

지역사회 엘리트의 행태에 관한 연구 : 대구지역 엘리트의 정책참여태도를 중심으로

조용상,최봉기,김옥준 계명대학교 사회과학연구소 2000 한국사회과학연구 Vol.19 No.1

한양학원 폐수의 미생물학적 처리에 관한 연구

최용,최영길,이희준,안연준 漢陽大學校 環境科學硏究所 1994 環境科學論文集 Vol.15 No.-

한강수계인 안양천에서 유출되는 산업페수에서 카드뮴과 납에 내성을 지니며 이들 중금속을 축적하는 균주 HYM 2., HYM 40을 분리하여 동정한 효모인 Torulopsis inconspicua로 밝혀졌다. 납의 경우 180mg/g dried cell, 카드뮴의 경우 147.5mg/g dried cell까지 축적한는 것을 확인하였다. 전자현미경으로 관찰한 결과 이들 중금속은 주로 세포막에 축적되는 것으로 나타났다. 이 균주를 한양학원 폐수를 재료로 하여 pilot system에 적용한 결과 원폐수만을 적용했을 때보다는 활성슬러지를 첨가했을 때 (MLSS를 2000∼3000mg/ㅣ로 보정), 특히 분리된 균주를 적용시켰을 때 중금속의 제거 효율이 훨씬 더 증가하였다. 이는 환경오염원을 제어하는 균주를 직접 실공정에 적용할 수 있는 가의 가능성을 타진할 수 있었다. Two strains of yeasts, HYM 20 and HYM 40, which have resistance against heavy metals such as cadmium and lead and have ability to accumulate the heavy metal were isolated in the industrial sewage drained from Anyang stream. These strains of yeasts were identified as Torulopsis inconspicua. This yeast accumulated lead upto 180mg/g dried cell and cadmium 147.5mg/g dried cell. In the electron microscopic analysis, it was observed that the heavy metals were accumulated within the cell membrane. In the application of wastewater from Hanyang University to the A₂/0 system, increased accumulation was observed when the original sewage was added with active slvge by comparison with the sewage alone. particulaly, when added with sluge and isolated strains, higher increasemant of accumulation was boserved than in the former cases. These results showed the possibilities for the practical elimination of heavy metal pollutants.

북한 고등중학교 「지리」 교과서 분석 연구

최석진,남상준,류재명,손용택,이동엽 한국사회과교육연구회 2000 사회과교육 Vol.- No.33

이 연구는 남북한 통일을 대비하여 북한 고등중학교 지리 교육과정 및 교과서를 비교·분석한 것이다. 남북한의 학제와 지리과 영역의 교육과정상의 위치가 다르고 북한의 교육과정을 입수할 수 없었기 때문에, 입수한 북한의 고등중학교 1학년부터 5학년의 지리교과서 5종(1991년도부터 1993년도 발행분)을 대상으로 분석하여, 남한 6차 교육과정의 중학교 사회와 고등학교 공통사회(한국지리) 및 세계지리 내용을 비교 분석하였다. 연구 결과는 다음과 같다. 첫째, 남북한 중등학교 지리교육은 교육과정상의 편제에서 북한은 고등중학교 전학년에 걸쳐서 지리가 독립과목으로 편제되어 있으나, 남한은 중학교 사회과에 통합되어 있고, 고등학교에서는 공통사회에 포함되었으며 세계지리가 선택과목으로 되어있는 등 지리교육 내용계열과 조직체계도 차이가 난다. 둘째, 지리 교육의 이념과 목표에서, 남한은 민주시민 양성을 목표로 하여 개인의 지리교육적 성취가 주된 것이나, 북한은 집단 구성원으로서의 개인 양성에 중점을 두고 있다. 이러한 차이점은 정치체제의 차이에서 비롯된 것이며 지리교육 내용의 구성과 강조점등에서 많은 차이점을 나타내게 하고 있다. 셋째, 지리교육 내용 구성과 서술 등에 차이가 있다. 국토지리와 세계지리 및 계통지리와 지지의 배열과 비중 등이 다르며, 내용의 서술에서도 차이점을 볼 수 있다. 특히, 북한에서는 국토지리와 자연지리의 비중이 높으며, 주요 개념과 용어 설명에서 남한과 다른 점이 보인다. 넷째, 교과서의 구성과 교수-학습 방법 및 자료 사용에서 차이점이 보인다. 북한에서는 실습, 실험 등이 강조되면서 실제적인 기능 향상에 많은 비중을 두고 있으며, 사진에 비해서 그림을 사용하는 삽화의 비중이 높다. 교과서의 외형적 체제와 지질 등에서 차이가 큰데, 이 점은 경제력의 차이에서 비롯된다. 본 연구 결과 남북한은 모두 지리교육을 중등학교에서 중요시하고 있으며, 지리교육을 통하여 소기의 목표 달성에 노력하고 있으나, 서로간에 상당한 차이점도 발견할 수 있었다. The purpose of this study is to understand the similarity and differences of the geography textbook between north and south Korea in preparation for the unification. Five geography textbooks for the first through fifth grade in secondary school were used in the analysis of the geography curriculum for secondary schools in North Korea. The major findings of the study are as follows: First, South Korea takes an integration approach to teach geography as part of the social studies education whereas North Korea treats geography as an independent subject throughout secondary school. Second, South Korea aims at nurturing democratic citizen, emphasizing individual achievement, whereas North Korea puts emphasize nurturing citizenship within community. Third, difference is noted in the organization and content of the geography curriculum between the two Koreas. North Korea puts more emphasis on national geography and natural geography than does South Korea. Forth, North Korean textbook is different from that of South Korea in that the former emphasizes on performance skills through hands-on practice and training. Also North Korean textbook uses more drawings than pictures. Despite differences in various aspects of curriculum and textbooks, there are a great deal of overlap in essential concepts and contents covered in two Koreas' geography textbooks. Both Koreas value geography education in the secondary schools and make efforts to fulfil the educational objectives in geography.

T cell epitope 차폐에 의한 b_(4) peptide 면역응답방응에 대한 연구

최정순,이희종,공수강,리투,류용구,김효준 한양대학교 이학기술연구소 2005 이학기술연구지 Vol.8 No.-

Apo B-100 is a constitutive component of low density lipoprotein (LDL) of which functions in packaging, transport and absorption of lipids Extortive binding of anti B_(4)-antibody onto the Apo B-100 should inhibited the functions of Apo B-100 Previously we had showed that the peptide B_(4) induced antibodies recognized Apo B-100 and thus elicited anti-obesity effect In this study we compared the efficacy of antibody inducing immune responses by introducing additional peptides fused to the C-termninal of B_(4) peptide We constructed TB_(4) hybride peptide of B_(4) with preS2 of HBV and B_(4)N another epitope orientation of chimeric TB_(4) Among these three artificial peptides B_(4)N was the most efficient inducer of the antibody against B_(4) These result explains that the B cell epitope and T-helper cell epitope orientation is very important factor to determine the antigenicity to humoral immunity. Apo B-100은 LDL에서 지방을 포장, 흡수, 운반하는 기능을 수행하는 단백질이다. Apolipoprotein B-100(Apo B-100)에 대한 특이 항체의 결합은 LDL의 정상 기능을 방해한다. 선행 실험에서 Apo B-100의 모조 펩타이드인 B_(4)가 Apo-B-100을 교차 인식하는 항체를 유도하고, 비만 억제 효과를 나타내는 것으로 밝혀졌다. 본 연구에서 B_(4)펩타이드의 C-terminal부분에 펩타이드를 융합, 첨가하므로 면역반응에서 항체유도의 면역응답반응에 어떠한 효과를 나타내는지 비교해 보고자 하였다. B_(4)펩타이드의 N-말단에 HBV의preS2 펩티드를 융합시킨 B_(4)T의 N-말단데 또다른 B세포 에피도프 펩티드를 융합시킨 B_(4)N을 작성하였다, 세종류의 하이브리드 펩타이드 중에서 B_(4)N이 B_(4)에 대한 항체유도능이 가장 효율적이다,. 이상의 결과로 B cell epitope과 T-helper cell epitope의 방향성이 체액성 면역 반응에서 항원유도능을 결정하는 중요한 요소임을 확인하였다.

위내시경에 의한 칫솔제거

최성곤,권영오,김성국,최용환,정준모 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.1

최근 내시경술의 발전으로 진단적인 측면 뿐 아니라 그 치료적인 면에서도 많이 이용되고 있는 실정이다. 저자들은 오심을 해결하기 위해 칫솔로 설근부를 자극하여 구토를 유발하던 중 우발적으로 연하되어 식도·위 접합부 및 위내에 있다가 내시경으로 제거된 칫솔 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. With the improvement of the technique and instrument, the gastroduodenal endoscope has been used not only in diagnostic purpose but in therapeutic approach. In this case, we removed a swallowed toothbrush in esophagus and stomach with gastroduodenal endoscope and snare without complication.

GPS측량에 의한 차량주행지도작성

최철웅,장용구,강인준 釜山大學校 都市問題硏究所 1996 都市硏究報 Vol.4 No.-

In Pusan city, more and more efficient car management is needed for insufficience of accomdating road abilitys. GPS being a global navigation and positioning system works under any kind of weather and no visibility requirement in addition to highly accurate three dimensional positioning information, so tremendous impact from GPS has occureed. Using the position and time data of GPS, we can analyze the velocity of car and utilize GPS data for monitoring statistics and traffic capability of the road. Because of storing capacity the position of car GPS data, we can analyze the navigation path of car. Therefore we will effectively use road resource by GPS data. In this study, we developed programs that could monitor the map of car-navigation, analyze distribution of velocity and traffic management by GPS.