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새로운 의약품의 합성에 관한 연구 : 6-Thiocyanopenicillanic Acid 유도체의 합성
李英行,李寀浩,崔元植 원광대학교기초자연과학연구소 1992 基礎科學硏究誌 Vol.11 No.3
6-Aminopenicillanic acid의 diazo화 반응과 sodium thiocyanate와 반응으로 새로운 β-lactam 화합물인 6-thiocyanopenicillanic acid(1a)를 합성하고 p-nitrobenzyl bromide, chloromelthylpivalate 및 1-chlorodiethylcarbonate들과의 반응에 의해 각각에 해당하는 ester(1b~d)를 합성하였다. A new β-lactam compound, 6-thiocyanopenicillanic acid(1a) was prepared by the reaction of diawnium salt of 6-aminopenicillanic acid with sodium thiocyanate. Reaction of 6-thiocyanopenicillanic acid(la) with p-nitrobenzyl bromide, chloromethylpivalate and l-chlorodiethylcarbonate, respectively, afforded the corresponding esters(1b~d).
MSPD법과 HPLC를 이용한 계란내 플루오로퀴놀론계 항균물질의 동시 다성분 정량분석
서계원,이재일,이채용,김은선,이정치 한국수의공중보건학회 2002 예방수의학회지 Vol.26 No.4
A multi-residue matrix solid-phase dispersion extraction and the liquid chromatographic determination of enrofloxacin, ciprofloxacin, norfloxacin and ofloxacin in eggs is described. Blank and fluoroquinolones fortified egg samples (0.5 g) containing oxalic acid 0.05 g and sodium sulfate (anhydrose) 0.5 g were blended with octadecylsilyl (C_(18), 40 m, 18% load, endcapped, 2 g) derived from silica. After homogenization, C_(18)/egg matrix was transferred to column made of 10 ml plastic syringe and filter paper, and compressed 4.0 4.5 ml volume. A column was washed with 8 ml of hexane followed by 8 ml of ethylacetate and dried under N2 gas. Fluoroquinolones were eluated with 8 ml of methanol under gravity. The eluate contained fluoroquinolones, was free from interferences when analyzed by high performance liquid chromatography with fluorescence detection. Correlation coefficients for the fluoroquinolones standard curves (linear regression analysis, n = 5) ranged from 0.99918 (± 0.0035) to 0.99985 (± 0.0002). Aveage recoveries of fortified samples were between 89.4 and 103.5%. The method comparared favorably with the classical method in terms of the sample size, analysis time and overalls costs.
산란계에 투여된 플루오로퀴놀론계 합성항균제의 계란내 이행 잔류 연구
서계원,이재일,이채용,김은선,이정치 한국수의공중보건학회 2002 예방수의학회지 Vol.26 No.4
In the past few years the use of four fluoroquinolones such as of ofloxacin(OF), norfloxacin(NORE), ciprofloxacin(CIP), enrofloxacin(ENR) in veterinary practice has increased. The aim of this study was to determine the elimination of fluoroquinolones into eggs, by intramuscular injection of laying hens(2.5mg of ENR/kg, 5mg of CIP/kg, 5mg of NOR/kg, 5mg of OF/kg). The treatment of fluoroquinolones was carried out in 3 stages with 9 laying hens (Isabrown), with mean weight 1.8kg, which were housed in individual cages. Four fluoroquinolones were administered to 9 laying hens through intramuscular injection at 1 day, 2 days, 5 days trial respectively. Sample (Albumen, Yolk, Whole egg) were analysed by high performance liquid chromatography (HPLC) with a fluorescence programmable detector and matrix solid phase despersion (MSPD) extraction. Residues of fluoroquinolones were much higher in the yolk than in the albumen. Detectable residues persisted for 12 days, 14 days, 16 days, respectively, in albumen and yolk after the injection was discontinued. The increase of the fluoroquinolones concentration in yolk was very rapid and reached a plateau after 3 days of dosing. In albumen, the fluoroquinolones concentration increased during intramuscular injection. As soon as the injection was discontinued, residues decreased in the albumen and the yolk.
α-Sulfamido Acid Alkyl Ester의 합성
宋眞守,鄭起源,李寀浩 원광대학교기초자연과학연구소 1992 基礎科學硏究誌 Vol.11 No.2
A general synthesis for the preparation of α-sulfamido acid alkyl ester has been developed by treatment of α-amino acid alkyl ester with sulfamate ester which was prepared by reaction of catechol sulfate with alkyl amine.
산 촉매에 의한 N- (3,4-Dimethoxybenzyl)sulfonamide 유도체의 C-N 결합의 분해
金善嬉,鄭起源,李英行,李寀浩 원광대학교기초자연과학연구소 1992 基礎科學硏究誌 Vol.11 No.2
Cleavage reaction of N-(3,4-dimethoxybenzyl)sulfonamides has been examined. Treatment of these compounds with trifluoroacetic acid afforded sulfonamides which 3,4-dimethoxybenzyl group was removed.
반월상 연골판 손상을 동반한 내측 측부인대 부분파열 환자의 한방 치료 효과: 증례보고
전용현(Yong-Hyun Jeon),김두리(Doo-Ri Kim),문희영(Hee-Young Moon),박지원(Ji-Won Park),이윤하(Yun-Ha Lee),채지원(Ji-Won Chai1),최동주(Dong-Joo Choi),최효정(Hyo-Jung Choi) 척추신경추나의학회 2019 척추신경추나의학회지 Vol.14 No.2
Objectives : The purpose of this report was to introduce 3 cases of patients diagnosed with both medial collateral ligament tear and meniscal tear that showed clinical improvement after Korean medicine treatment. Methods : These patients received Korean herbal medicine, pharmacopuncture treatment, and acupuncture treatment. We assessed these cases by using the Numeric Rating Scale (NRS), Western Ontario and McMaster Universities’Arthritis Index (WOMAC), and the European Quality of Life-5 Dimension Index (EQ-5D). Results : After Korean medicine treatment, most of the NRS, WOMAC, and EQ-5D scores showed improvement on every discharge date of these 3 cases. The NRS and WOMAC scores of all cases showed a decrease. The EQ-5D of all cases showed an increase. Conclusions : Through this research, we concluded that Korean medicine treatment can be helpful in relieving pain and improving the quality of life and function of knee joint movement in patients with medial collateral ligament tear and meniscal tears.