우리나라 대도시지역 암 사망자에 대한 분석 -서울, 부산, 대구, 인천을 중심으로-

이채언,김준연,Lee, Chae-Un,Kim, Joon-Youn 대한예방의학회 1987 예방의학회지 Vol.20 No.1

For the purpose of preparing the basic data for further cancer epidemiologic study and cancer patients control, we conducted the analysis on the degree and structure of deaths from cancer in metropolitan areas of Korea with 7,934 certified cancer deaths records of Seoul, Pusan, Taegu and Incheon in 1982. The analyzed results were as follows: 1) The total number of cancer deaths in metropolitan areas were 7,934 (male: 4,749, female: 3,185) as 14.1% of deaths from all causes in the same area. 2) The rate of physician's certification on cancer deaths was 77.4% and most of cancer deaths (84.4%) occured at their home. 3) Cancer specific death rate was 51.7 per 100.000 population (male: 62.9, female: 41.9) and age-adjusted cancer death rate was 82.4 in male and 51.6 in female per 100,000 population. And the difference was statistically significant (p< 0.01). 4) Age-specific cancer death rate was generally increased with age and most of cancer deaths (male: 75% , female: 65%) occurred from 45 to 74 years old. 5) The first three orders of cancer site were stomach (32.7%), liver (28.8%), lung (11.7%) in male and stomach (30.6%), uterus (18.4%), liver (13.8%) in female. And the relative frequency of these three cancer sites among total cancer deaths was corresponded to 73.2% in male and 62.8% in female. 6) The ratio of male to female cancer death rate was 1.5:1. And the ratio was aboye 3.0 in esophagus, liver, larynx, bladder cancer and the ratio was similar to 1.0 in stomach, pancreas, leukemia, brain, colon cancer, but the ratio was reversed in gall bladder and bile duct, and thyroid cancer.

톨루엔 폭로 근로자들의 요중 마뇨산 배설량

이채언,신해림,조병만,문덕환,손혜숙,조규일,김성천,김용완,Lee, Chae-Un,Shin, Hai-Rim,Cho, Byung-Mann,Moon, Deog-Hwan,Shon, Hae-Sook,Cho, Kyu-Il,Kim, Sung-Chun,Kim, Yong-Wan 대한예방의학회 1988 Journal of Preventive Medicine and Public Health Vol.21 No.2

In order to prepare the fundamental data for preventing the hazardous effects at toluene exposure in many kinds of industry, the authors determined the level of urinary hippuric acid on 592 toluene exposed women(exposed group) and 102 unexposed women(control group) in Pusan area, from April. 1 to October 31, 1986. Hippuric acid was measured by high performance liquid chromatography. The results were summarized as follows; 1. The mean value of urinary hippuric acid concentration of the control group was $0.44{\pm}0.21g/l$(0.11-0.89g/l). The distribution of urinary hippuric acid concentration of the control group was not fit to the normal distribution. 2. The mean value of urinary hippuric acid concentration of the exposed group was $1.56{\pm}0.95g/l$(0.44-4.57g/l). The distribution of urinary hippuric acid concentration of control group was not fit to the normal distribution. 3. The urinary hippuric acid concentration by age group was not statistically significant in the control group, but in the exposed group the urinary hippuric acid concentration was highest in women between 20-29 years old($1.71{\pm}0.95g/l$) and was statistically significant(p<0.01). 4. The urinary hippuric acid concentration by duration of working hours was not statistically significant (p>0.1).

6가 크롬 폭로가 랫트의 태반 기능과 출산에 미치는 영향

이헌,문덕환,이채언,강성구,손병철,김대환,이창희,김정원,이채관,전진호,Lee, Heun,Moon, Deog-Hwan,Lee, Chae-Un,Kang, Sung-Goo,Son, Byung-Chul,Kim, Dae-Hwan,Lee, Chang-Hee,Kim, Jung-Won,Lee, Chae-Kwan,Chun, Jin-Ho 대한예방의학회 2004 예방의학회지 Vol.37 No.2

Objectives : This study aimed to investigate the toxic effects of chromium (VI) on the placental function and reproduction in rats. For the study, the placental prolactin-growth hormone (PRL-GH) gene expression, placental trophoblast cell differentiation and reproductive data were analyzed. Methods : The pregnancies of F344 Fisher rats were checked by the presence of a copulatory plug or sperm in the vaginal smear, which was defined as day 0 of the pregnancy. Pregnant rats were divided into the three groups. The control group was given tap water (chromium level < 0.001 ppm) and the remaining groups were given 250 or 750 ppm of chromium (VI) [as potassium dichromate], from day 7 to 19 of the pregnancy. Rats were sacrificed at days 11 and 20 of pregnancy. The mRNA levels of PRL-GH and Pit-1a and b isotype genes were analyzed by Northern blot hybridization and reverse transcription-polymerase chain reaction (RT-PCR). The hormonal concentration was analyzed by radioimmunoassay, and the differentiation of placental trophoblast cells were observed by histochemical studies. Reproductive data, such as placental and fetal weights, pregnancy period, and litter size, were surveyed at day 20 of pregnancy and after birth. A statistical analysis was carried out using the SAS program (version 8.1). Results : The mRNA levels of the prolactin-growth hormone (PRL-GH) family of genes were dose dependently reduced by chromium exposure. The mRNA levels of Pit-1a and b isotype genes that induce the expression of the PRL-GH family of genes were also reduced by chromium exposure. The PRL-GH hormonal concentration in the rat placenta, fetus and maternal blood were decreased by chromium exposure. In the middle stage of pregnancy (day 11), a high dose of chromium suppressed the differentiation of spongiotrophoblast cells that secret the PRLGH hormones. In the last stage of pregnancy (day 20), a high dose of chromium induced apoptosis of placental cells. Reproductive data, such as placental and fetal weights, litter size, were reduced, but the pregnancy period was extended in the group exposed to chromium compared with the controls. Conclusion : Chromium (VI) disrupts the ordered functions of the placenta, which leads to reproductive disorders in rats.

실내외 $NO_2$농도 및 $NO_2$개인폭로량과 이들에 영향을 미치는 요인에 관한 연구 -도시지역 주택 및 주부를 대상으로-

전진호,이채언,김준연,정요한,Chun, Jin-Ho,Lee, Chae-Un,Kim, Joon-Youn,Chung, Yo-Han 대한예방의학회 1988 Journal of Preventive Medicine and Public Health Vol.21 No.1

This study was conducted to establish the control program for preventing unfavorable health effects of nitrogen dioxide($NO_2$) exposure in homes by preparing the fundamental data for evaluation of relation-ships between $NO_2$ levels and influencing factors through measurements of indoor-outdoor $NO_2$ levels and personal $NO_2$ exposures for housewives with questionnaire survey on 172 homes in Pusan area from April to June, 1987 $NO_2$ measurements were made by using diffusion tube samplers(Palmes tube $NO_2$ sampler) for one week at 4 sites in homes ; kitchen(KIT), bedroom(BED), living room(LIV), outdoor(OUT) and near the collar of housewives(personal exposure livel, PNO). The details of questionnaire were number of household members(FAM), number of regular smokers (SMOKER), daily number of meals eaten(MEAL), type of housing units(HOUSE), location of house with distance from the heavy traffic roads as walking time(DIST), and of kitchen(KAREA), kind of cooking fuels(FUEL), cooking time of each meal(CTIME), usage of kitchen fan for cooking(FAN), type of heating facilities(HEAT) and so on of subject homes. The Obtained results were as fellows : 1) The mean $NO_2$ level was significantly higher at indoors than outdoors(p<0.01) and the kitchen $NO_2$ level was the highest with $33.7{\pm}13.6ppb$(9.5-81.5ppb). The mean personal exposure level of $NO_2$ for housewives was $20.6{\pm}8.8ppb$(3.1-46.9ppb). 2) The mean indoor $NO_2$ level was significantly higher in the group of household members above 5 than below 4(p<0.05), in detached dwellings than apartments(p<0.001), within 5 minutes of distance than over 5 minutes(p<0.001), in the group of unusing fan(p<0.001), in the group of longer cooking time(p<0.001), and it was in order of coal briquette, gas, electricity and oil by kind of cooking fuels(p<0.05). 3) Variables showing significant correlation(p<0.001) with indoor $NO_2$ level were kitchen $NO_2$ level(r=0.8677), cooking time(r=0.5921), outdoor $NO_2$ level(r=0.5192), personal $NO_2$ exposure level(r=0.4615), usage of kitchen fan(r=0.3573) and location of house(r=-0.2988) 4) As a result of multiple regression analysis, the most significant influencing variable to the kitchen $NO_2$ level was cooking time[KIT=$-0.378{\pm}11.772$(CTIME)+0.298(OUT)+3.102(FAN)], it was kitchen $NO_2$ level to the indoor $NO_2$ level[IND=6.996+0.458(KIT)+0.230(OUT)-1.127(KAREA)], and it was indoor $NO_2$ level to the personal $NO_2$ exposure level[PNO=15.562+0.729(IND)-4.542(DIST)-0.200(KIT)] 5) It was recognized that aritificial ventilation in the kitchen, suppression of unnecessary combustion and replacement of cooking fuel, as much as possible, were effective means for decreasing indoor $NO_2$ levels in homes.

제조업 산업장의 소음 작업환경 실태에 관한 조사 연구

김준연,김병수,이채언,전진호,이종태,김진옥,Kim, Joon-Youn,Kim, Byung-Soo,Lee, Chae-Un,Jun, Jin-Ho,Lee, Jong-Tae,Kim, Jin-Ok 대한예방의학회 1986 예방의학회지 Vol.19 No.1

산업장내의 소음작업 환경개선과 소음폭로 근로자에 대한 효과적인 청력 보호대책을 마련할 기초작업의 일환으로 1985년 4월부터 7월까지의 4개월간 부산시내 12개 제조업종 56개 산업장을 대상으로 작업공정을 파악하고 소음발생 작업공정별 소음수준을 측정하여 얻은 성적은 다음과 같다. 1) 평균 소음수준이 가장 높은 산업장은 선박건조 및 수선업(95.6dB(A))이었고, 다음으로는 철강압연업(94.0dB(A)), 자동차 제조업(93.1dB(A)), 어망 제조업(92.9dB(A)), 섬유제품 제조업(92.5dB(A)), 주조업 (89.3 dB(A)), 금속제품 제조업(89.1dB(A)), 수산물 처리 가공업(87.0dB(A)), 고무제품 제조업(85.3dB(A)), 합판 제조업(84.9dB(A)), 페인트 제조업(84.5 dB(A))의 순이었다. 2) 총 50개 조사대상 소음공정 가운데 21개 공정(42%)의 평균 소음수준이 1일 8시간 소음폭로 허용기준(90 dB(A))을 초과하였다. 3) 전 주파수역 평균음압(A특성)에 대한 1일 소음폭로 허용시간은 선박건조 및 수선업의 코킹과 철강압 연업의 도금(CGL) 공정이 30분으로 가장 짧았고, 다음으로는 자동차 제조업의 조립 (리벳트)공정이 1시간, 섬유 제조업의 직조와 선박건조 및 수선업의 숏트, 기계, 배관공정이 2시간의 순이었다. 4) 평균 음압수준이 90dB(A)를 초과한 작업공정에 대한 소음의 주파수 분석에서 모든 공정 공히 2,000Hz 혹은 4,000Hz의 음압이 가장 높았다. 5) 산업장의 소음수준 평가시 전 주파수역(overall)음압의 측정 역시 주파수 분석에 못지 않은 방법의 하나로 인지되었다. In order to prepare the fundamental data for the improvement of noisy working environments and the effective hearing conservation program on workers exposed to industrial noise, the authors surveyed the working processes and evaluated the noise levels on 56 manufacturing industries in Pusan area from April to July in 1985. The results were summarized as follows : 1. The noise level was the highest in shipbuilding and repairing(95.6 dBA), and followed by steel rolling(94.0 dBA), manufacture of motor vehicles(93.1 dBA), manufacture of fishing nets(92.9 dBA), manufacture of testiles(92.5 dBA), iron and steel foundries(89.3 dBA), manufacture of metal products(89.1 dBA), preserving and processing of marine foods(87.0 dBA), manufacture of rubber products(85.3 dBA), manufacture of plywood(84.9 dBA) and manufacture of paints(84.5 dBA). 2. Among fifty surveyed working processes, the noise level of twenty-one processes (42%) exceeded the threshold limit value for 8 hours per day. 3. As the allowable exposure times by governmental threshold limit values to industrial noise level(dBA), cocking of shipbuilding and repairing and plating(CGL) of steel rolling were the shortest(30 minutes), and followed by assembling(rivet) of manufacture of motor vehicles(1 hour) weaving of manufacture of textiles and shot, machine, pipe laying of shipbuilding and repairing(2 hours). 4. By the result of octave band analysis on noisy working processes in excess of 90 dBA, the sound level was the highest at 2,000 Hz or 4,000 Hz. 5. It was recognized that the measurement of overall sound pressure level was also effective as octave band analysis in evaluating the industrial noise.

경남지역 일부 산업간호사의 업무수행에 관한 연구

김영숙,손혜숙,강정학,이창희,이채언,Kim, Young-Sook,Shon, Hae-Sook,Kang, Jeong-Hak,Lee, Chang-Hee,Lee, Chae-Un 대한예방의학회 1995 Journal of Preventive Medicine and Public Health Vol.28 No.3

Authors purposed to observe activities of occupational health nurses and it's related factors, and to suggest the way that induct better occupational health nurses' activities with questionaire to 87 occupational health nurses who individually work as health manager in the plant. The questionaire included type of plant and number of workers, general characteristics, work conditions, activities, etc. Major findings are as follows. 1. 82.8% of occupational health nurses were third decade. 93.1% graduated junior college or college. And 82.8% were not married. 2. General work conditions: 40.2% were belonged to safety-health section, 98.85% were mere clerks. 60.9% worked less than weekly 44 hours, and an annual salary of 50.6 % was between 10 million and 14 million won. 3. Work condition related to health manager work: there was separated health care room in 94.3%, working period as health manager(occupational health nurse) was less than 5 years in 70.1%, 49.4% had the out-of-health manager work. In 87.4%, occupational physician was appointed, only 6.9% of them were full time, 52.9% of them worked little in the plants. The problems related to workers' health were discussed with industrial nurses in 88.5%. 4. Attitude for their work: 88.5% were thought that their work is important for workers' health care, 57.5% satisfied to work as health manager. In 51.7%, motive to being industrial nurse were the appropriate aptitude. 5. Activities: General medical care in 100% were carried out, in 97.7% works related to general health examination, in 100% works related to special health examination were carried. But works related to use of protective apparatus were carried out in 20.8%. 6. Factors related to level of activities: In cases who solved the health related problems by themselves, the level of activites was significantly higher than in others. In cases there were full time occupational physician, the level of activities was significantly lower. 7. Occupational health nurse's needs: 100% wanted regular education, 89.7% wanted the qualifying examination. As the results, author suggests that the right of self-control is given to occupational health nurses and the work of occupational physician is clearly defined for the induction of the better activities of occupational health nurses.

임부들을 대상으로 한 산전교육의 효과

박춘화 ( Choon Hwa Park ),이채언 ( Chae Un Lee ) 여성건강간호학회 2002 여성건강간호학회지 Vol.8 No.1

鉛取扱勤勞者의 血中 鉛濃度와 聽力損失에 關한 硏究

이남희(Nam-Hee Lee),이종태(Jong-Tae Lee),신해림(Hae-Lim Shin),박인근(In-Guen Park),이채언(Chae-Un Lee) 대한직업환경의학회 1995 대한직업환경의학회지 Vol.7 No.1

유기용제 폭로가 여성 근로자들의 월경에 미치는 영향

양칠용 ( Chil Yong Yang ),이채언 ( Chae Un Lee ),문덕환 ( Deog Hwan Moon ),김대환 ( Dae Hwan Kim ),이채관 ( Chae Kwan Lee ) 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.3

Organic solvent is one of the most prevalent sources of chemical exposure among female workers. In previous studies, higher rates of spontaneous abortion, reduced fertility and menstrual disorder among women have been associated with a wide variety of chemical agents. This study was conducted to evaluate the effects of occupational organic solvents exposure on the menstrual function of female workers. Rates of menstrual disorders were studied in 187 female workers with exposure to organic solvent including the shoes manufacturing industry and compared with 183 control female workers who had no exposure to organic solvents. Detailed menstrual and reproductive histories were obtained by personal interview using structured questionnaire, and plasma concentrations of progesterone and estrogen were analyzed by radioimmunoassay (RIA). The rates for menstrual irregularity was higher in organic solvent exposure group than non-exposure group. However, menstrual duration, blood clot in menstrual flow and dysme-norrhea were not significantly difference in both groups. Number of using menstrual pad was significantly higher in the exposed group than non-exposed group (P<0.05). Plasma level of progesterone during 6-11th, 17-28th day of menstrual cycle was significantly lower in the exposed group than non-exposed group (P<0.05). Plasma level of estrogen during 17-22th day of menstrual cycle was also significantly lower in the exposed group than non-exposed group (P<0.05). All of these results suggest that occupational organic solvents exposure decreased the progesterone and estrogen levels. And these effects can leads to the menstrual disorder in female workers. But this fact is contestable because other behavioral, psychological and work related factors may also affect to the menstrual function.

부산지역의 대기 중 중금속 농도

송인혁,조규일,문덕환,이창희,강정학,김종갑,한용수,이채언,Song, In-Hyeok,Cho, Gyu-Il,Moon, Deog-Hwan,Lee, Chang-Hee,Kang, Jung-Hak,Kim, Jong-Gab,Han, Yong-Soo,Lee, Chae-Un 대한예방의학회 1995 Journal of Preventive Medicine and Public Health Vol.28 No.3

This study was carried out to assess the present level of atmospheric metals. Five metals - lead, cadmium, chromium, manganese, vanadium - were checked on the industrial(Sasang) and residental area(Daeshindong) in the city of Pusan. Sampling period was the year of 1986, 1990 and 1994, and the sampling time was 2 days of each site. As the result of comparison with the atmospheric standard of ASHRAE(1980), the average concentrations of lead was above the standard, the average concentrations of chromium was around the standard, and the average concentrations of cadmium and vanadium was below the standard. The average concentrations of manganese was above the standard of industrial environment. And the average concentrations of five metals was higher in the industrial area than the residental area. The average concentrations of lead, cadmium and chromium showed the increase tendency by the year, and the average concentrations of vanadium showed no change, and the average concentrations of manganese showed the decrease tendency. As a result of correlation analysis, lead and cadmium(r=0.31), vanadium and manganese(r=0.24), vanadium and chromium(r=0.19) showed significance.