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( Hye Yeon Chon ),( Han Ah Lee ),( Sang Jun Suh ),( Jung Il Lee ),( Byung Seok Kim ),( In Hee Kim ),( Chang Hyeong Lee ),( Byoung Kuk Jang ),( Hyun Woong Lee ),( Jae Seok Hwang ),( Chang Hun Lee ),( J 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: The modified PAGE-B (mPAGE-B) and PAGE-B models reliably predict the risk of developing chronic hepatitis B (CHB)-related hepatocellular carcinoma (HCC). We investigated whether the addition of liver stiffness (LS) value assessed using transient elastography enhanced the predictive accuracies of these models. Methods: Patients with CHB who started to receive antiviral therapy (AVT) between 2007 and 2017 were enrolled. The training (Yonsei University Hospital) and validation (7 Korean referral institutes) cohorts contained 1,211 and 973 patients, respectively. Results: Based on multivariate analysis, older age (hazard ratio [HR]=1.051, 95% confidence interval [CI]=1.031-1.071), male sex (HR=2.265, 95% CI=1.463-3.506), lower platelet count (HR=0.993, 95% CI=0.989-0.997), and greater LS values (HR=1.015, 95% CI=1.002-1.028) were independently associated with an increased risk of HCC development (all P<0.05). Thus, we developed an mPAGE<sup>LS</sup>-B model (maximum score 34) that included age, male sex, platelet count, and LS value. The integrated area under the curve (iAUC) of the mPAGE<sup>LS</sup> model was greater than those of the PAGE-B and mPAGE-B models (0.760 vs. 0.714 and 0.716, respectively) in the derivation dataset. The cumulative HCC incidence was significantly higher in the high-risk (mPAGE-B<sup>LS</sup> score ≥ 24) group than in the intermediate-risk (mPAGE<sup>LS</sup>-B score 12-24) or low-risk (mPAGE<sup>LS</sup>-B score < 12) group (all P<0.001). Similar results were observed in the validation cohort. Conclusions: The predictive accuracies of the PAGE-B and mPAGE-B models were validated in Korean patients with CHB receiving AVT. However, the mPAGE<sup>LS</sup>-B model featuring the addition of LS value showed higher predictability than the PAGE-B and mPAGE-B models.
Kim, So Hun,Hong, Seong Bin,Suh, Young Ju,Choi, Yun Jin,Nam, Moonsuk,Lee, Hyoung Woo,Park, Ie Byung,Chon, Suk,Woo, Jeong-Taek,Baik, Sei Hyun,Park, Yongsoo,Kim, Dae Jung,Lee, Kwan Woo,Kim, Young Seol The Korean Academy of Medical Sciences 2012 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.27 No.10
<P>The aim of the study was to assess the association between usual dietary nutrient intake and obesity in Korean type 2 diabetic patients. We examined 2,832 type 2 diabetic patients from the Korean National Diabetes Program cohort who completed dietary assessment and clinical evaluation in this cross-sectional study. In men, higher dietary fiber intake was associated with a lower odds of being obese (<I>P<SUB>trend</SUB></I> = 0.003) and in women, higher protein intake was associated with a lower odds of being obese (<I>P<SUB>trend</SUB></I> = 0.03) after adjustment for age, diabetes duration, HbA1c, alcohol drinking, income, education level, and calorie intake. In men, higher fiber intake was associated with lower odds of obesity after further adjustment for diastolic blood pressure, physical activity, and possible confounding nutritional intake and medication. The multivariable adjusted odds ratio for the highest quintile of fiber intake was 0.37 (<I>P<SUB>trend</SUB></I> < 0.001). In women, protein intake was not associated with obesity after further adjustment. In conclusion, higher intake of dietary fiber is associated with lower odds of being obese in type 2 diabetic men, suggesting a role for dietary fiber in the management and prevention of obesity in type 2 diabetes (ClinicalTrials.gov: NCT 01212198).</P>
실험적 성대마비 개에서 자가이개연골의 성대근육내 주입 후 조직학적 변화 : 2년 후 결과
이병주,이진춘,전경명,고의경,노환중,이창훈,왕수건,Lee Byung-Joo,Lee Jin-Choon,Chon Kyong-Myong,Goh Eui-Kyung,Roh Hwan-Jung,Lee Chang-Hun,Wang Soo-Geun 대한후두음성언어의학회 2005 대한후두음성언어의학회지 Vol.16 No.2
Background and Objective : Vocal fold augmentation by injectable material under direct visual control is an easy and simple operation. However, when autologous fat or bovine collagen is used, the resoiption creates a problem. And autologous fascia is debating about absorption now days. We previously reported on the one year results of injected autologous auricular cartilage for volumetric augmentation in paralyzed canine vocal cord. This study evaluates the long-term histomorphologic results of injected autologous auricular cartilage for the augmentation of the paralyzed canine vocal fold at two year. Material and Methods . A prospective trial of autologous cartilage augmentation of vocal cord in animal model. Three dogs were operated upon. A piece of auricular cartilage was harvested from the ear and minced into tiny chips with a scalpel. Fat was harvested from inguinal area and minced with a scalpel. The minced cartilage and fat-paste (0.2ml) was injected using a pressure syringe into the paralyzed thyroarytenoid muscle using direct laryngoscopy. Three animals were sacrificed at 2 years. Each subject underwent laryngectomy and serial coronal sections of paraffin blocks from the posterior vocal fold were made. Results There was no significant complication perioperatively and during follow-up. The injected cartilage which appeared to have lost viability existed in the vocalis muscles until 24 months. Fibrotic change was exhibited in the surrounding injected cartilage. Conclusion : The autologous auricular cartilage graft is well tolerated and may be very effective material for volumetric augmentation on paralyzed vocal cord.
배현옥,임창경,장선일,한동민,안원근,윤유식,전병훈,김원신,윤용갑 대한동의병리학회 2003 동의생리병리학회지 Vol.17 No.3
人蔘, 虎杖根, 常山 등에서 분리한 성분들이 HL60, HL-60, Jurkat, Molt-4에 대한 억제작용이 있는 것으로 조사되었고, 益母草의 Leonunrine, 大靑葉의 Indirubin, 天門冬의 Aspargus polysaccharide A.B.C.D, 百合의 Colchicnamile, 益母草의 Leonunrine, 山豆根, 紫草根 추출물이 여러유형의 백혈병 환자에 대한 백혈병 억제효과가 있는 것으로 조사되었으며, mouse의 P388, L1210, L615, L120, S-180 등에 항 백혈병 효과가 있는 것으로는 莞花, 노회, 遠志, 吳茱萸, 巴豆, 雷公藤, 石蒜, 白朮, 丹蔘, 山藥, 牧丹皮, 靑黛, 甘草, 當歸에서 분리한 성분들이 있으며 白屈菜, 馬錢子, 가시오가피, ??草 축출물들이 동물실험에서 항암작용이 있는 것으로 조사되었다. 또 천연물에서 분리한 성분이 항백혈병 작용이 있는것으로는 ginsenoside Ro, ginsenoside Rh2, Emodin, Yuanhuacine, Aleemodin, phorbocdiester, Triptolide, Homolycorine, Atractylol, Colchicnamile, Paeonol, 당귀다당체, Aspargus, polysaccharideABCD, Indirubin, Leonunrine, Acinosohic acid, Trichosanthin, Ge 132, Schizandrin, allicin, Indirubin, cmdiumlactone chuanxiongol, 18A glycyrrhetic acid, Kansuiphorin A, 13 oxyingenol Kansuiphorin B 등이 조사되었고 추출물이 항 백혈병 작용이 있는 것으로는 遠志, 吳茱萸, 白屈菜, 大黃, 山豆根, 馬錢子, 가시오가피, 천초 등이 조사되었다. According to the Leukemia and Lymphoma Society, leukemia is a malignant disease (cancer) that originates in a cell in the marrow. It is characterized by the uncontrolled growth of developing marrow cells. These are two major classifications of leukemia: myelogenous or lymphocytic, which can each be acute or chronic. The terms myelogenous or lymphocytic denote the cell type involved. Thus, four major types of leukemia are: acute or chronic myelogenous leukemia and acute or chronic lymphocytic leukemia. Leukemia, lymphoma and myeloma are considered to be related cancers because they involve the uncontrolled growth of cells with similar function and origins. The diseases result from an acquired (not inherited) genetic injury to the DNA of a single cell, which becomes abnormal (malignant) and multiplies continuously. In the United States, about 2,000 children and 27,000 adults are diagnosed each year with leukemia. Treatment for cancer may include one or more of the following: chemotherapy, radiation therapy, biological therapy, surgery and bone marrow transplantation. The most effective treatment for leukemia is chemotherapy, which may involve one or a combination of anticancer drugs that destroy cancer cells. Specific types of leukemia are sometimes treated with radiation therapy or biological therapy. Common side effects of most chemotherapy drugs include hair loss, nausea and vomiting, decreased blood counts and infections. Each type of leukemia is sensitive to different combinations of chemotherapy. Medications and length of treatment vary from person to person. Treatment time is usually from one to two years. During this time, your care is managed on an outpatient basis at M. D. Anderson Cancer Center or through your local doctor. Once your protocol is determined, you will receive more specific information about the drug(s) that will be used to treat your leukemia. There are many factors that will determine the course of treatment, including age, general health, the specific type of leukemia, and also whether there has been previous treatment, there is considerable interest among basic and clinical researchers in novel drugs with activity against leukemia, the vast history of experience of traditional oriental medicine with medicinal plants may facilitate the identification of novel anti leukemic compounds. In the present investigation, we studied 31 kinds of anti leukemic medicinal plants, which its pharmacological action was already reported through many experimental articles and oriental medical book: 「pharmacological action and application of anticancer traditional chinese medicine」 In summary : Used leukemia cellline are HL60, HL-60, Jurkat, Molt-4 of human, and P388, L-1210, L615, L-210, EL-4 of mouse. 31 kinds of anti leukemic medicinal plants are Panax ginseng C.A Mey; Polygonum cuspidatum Sieb, et Zucc; Daphne genkwa Sieb, et Zucc; Aloe ferox Mill; Phorboc diester; Tripterygium wilfordii Hook .f.; Lycoris radiata(L Her)Herb; Atractylodes macrocephala Koidz; Lilium brownii F.E. Brown Var; Paeonia suffruticosa Andr; Angelica sinensis (Oliv.) Diels; Asparagus cochinensis (Lour.)Merr; Isatia tinctoria L; Leonurus heterophyllus Sweet; Phytolacca Roxb; Trichosanthes kirilowii Maxim; Dioscorea opposita Thumb; Schisandra chinensis (Rurcz.)Baill; Auium Sativum L; Isatis tinctoria, L; Ligustisum Chvanxiong Hort;Glycyrrhiza uralensis Fisch; Euphorbia Kansui Liou; Polygala tenuifolia Wild; Evodia rutaecarpa (Juss.) Benth; Chelidonium majus L; Rumax madaeo Mak; Sophora Subprostmousea Chunet T.ehen; Strychnos mux-vomical; Acanthopanax senticosus (Rupr.et Maxim.)Harms; Rubia cordifolia L. Anti leukemic compounds, which were isolated from medicinal plants are ginsenoside Ro, ginsenoside Rh2, Emodin, Yuanhuacine, Aleemodin, phorbocdiester, Triptolide, Homolycorine, Atractylol, Colchicnamile, Paeonol, Aspargus polysaccharide A.B.C.D, Indirubin Leonunrine, Acinosohic acid, Trichosanthin, Ge 132, Schizandrin, allicin, Indirubin, cmdiumlactone chuanxiongol, 18A glycyrrhetic acid, Kansuiphorin A 13 oxyingenol Kansuiphorin B. These investigation suggest that it may be very useful for developing more effective anti leukemic new dregs from medicinal plants.