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Vascular Protective Role of Samul-Tang in HUVECs: Involvement of Nrf2/HO-1 and NO
Choi, Eun Sik,Lee, Yun Jung,Seo, Chang Seob,Yoon, Jung Joo,Han, Byung Hyuk,Park, Min Cheol,Kang, Dae Gill,Lee, Ho Sub Hindawi Publishing Corporation 2016 Evidence-based Complementary and Alternative Medic Vol.2016 No.-
<P>Samul-Tang (Si-Wu-Tang, SMT), composed of four medicinal herbs, is a well-known herbal formula treating hematological disorder or gynecologic disease. However, vascular protective effects of SMT and its molecular mechanisms on the vascular endothelium, known as the central spot of vascular inflammatory process, are not reported. The aim of this study was to investigate vascular protective effects of SMT water extract in human umbilical vein endothelial cells (HUVECs). Water extract of SMT was prepared and identified by HPLC-PDA analysis. Expression of cell adhesion molecules (CAMs) and heme oxygenase-1 (HO-1) and translocation of nuclear factor-kappa B (NF-<I>κ</I>B) and nuclear factor-erythroid 2-related factor 2 (Nrf2) were determined by western blot. Nuclear localization of NF-<I>κ</I>B and Nrf2 was visualized by immunofluorescence and DNA binding activity of NF-<I>κ</I>B was measured. ROS production, HL-60 monocyte adhesion, and intracellular nitric oxide (NO) were also measured using a fluorescent indicator. SMT suppressed NF-<I>κ</I>B translocation and activation as well as expression of CAMs, monocyte adhesion, and ROS production induced by TNF-<I>α</I> in HUVECs. SMT treated HUVECs showed upregulation of HO-1 and NO which are responsible for vascular protective action. Our study suggests that SMT, a traditionally used herbal formula, protects the vascular endothelium from inflammation and might be used as a promising vascular protective drug.</P>
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崔秉昊 成均館大學校 科學技術硏究所 1984 論文集 Vol.35 No.2
國際平均海面資料管理機構로부터 1982年 12月까지의 世界各國港灣의 月平均海面資料가 磁氣테이프의 形態로 利用可能케 되었다. 이 刮目할만한 最近까지의 海面의 月平均資料로서 氣象 및 海洋資料를 倂用하면 汎世界的 또는 局地的인 海面의 季節的, 經年的인 變化에 對한 傳統的인 硏究가 可能하다. 初期段階의 硏究로 上記 dataset으로부터 中共의 Amoy港 및 우리나라 沿岸의 主要港의 月平均海面을 抽出하여 Vanicek이 提示한 最小子乘스펙트럼分析을 遂行하였다. 初期硏究結果가 提示되었으며 追後의 硏究事項이 討議되었다. 本 硏究는 交通部 水路局의 海面變化調査事業 및 建設部 國立地理院의 一等水準網調整事業의 初期作業으로 遂行되었는데 우리나라 沿岸의 地殼의 變動을 調査하는 地球動力學的 硏究를 爲한 初步作業이기도 하다. Monthly mean values of sea level at a mumber of sites around the world were available from global bank of the mean sea level data of the Permanent Service for Mean Sea Level (PSMSL), with the latest values being for December, 1982. This latest noteworthy compilation of mean monthly height of sea level makes it possible to view the seasonal and annual oscillation of sea level on a global or regional scale with the aid of meteorological and oceanographic data. As a fundamental step monthly mean values of sea level at Xiamen (Amoy) in China and several ports in Korea were extracted and spectral analysis technique by Least Square (Vanicek, 1971) were performed. Some of initial results are present and discussions for further developments are also described. This study has been undertaken in association with the programme of sea level research at Korea Hydrographic Office and the programme of adjustment of first order levelling network at National Geographic Institute.
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崔秉昊 成均館大學校 科學技術硏究所 1985 論文集 Vol.36 No.1
洛東江 感潮區間의 潮汐傳播 現象을 1次元 動水力學的 數値 모델을 利用하여 調査하였다. 첫 段階로서 樹立된 潮汐모델은 平均大, 中, 小潮時의 感潮區間의 潮汐傳播를 算定하는데 利用되었으며 또한 洪水時의 水位 算定을 爲하여 利用되었다. 이 硏究의 目的은 洛東江河口의 締切堰工事가 始作되기 前의 潮汐力學을 糾明하는데 있다. The progression of the tide in the lower reaches of the Nakdong River was investigated by the use of a simplified one-dimensional hydrodynamic numerical model. As a first step the developed tidal model was used to compute tidal distribution for average spring, mean and neap conditions and further utilised to investigate the waterlevel response by combined tide and flood discharge effects. The objective of this inital study is to investigate the tidal dynamics of the lower reaches of the Nakdong River under the condition of before-cross-channel barrage condition.
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최병철,정호용 여수대학교 2002 論文集 Vol.17 No.-
The various science fair have the objection and the role in cultivating diverse experiences and dreams for science to students in the scientific education of the middle school. As the results in his study, it is discovered through this investigation there to be estrangements between the contents of programs for various items executed on the spot and the science teacher's recognitions. According to the analysis I will find the previewing points of the solving-methods for revealed problems to make narrow between the poles of estrangements.
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Modified Free Wrap-around flap을 이용한 수무지 재건술
최영화,황치원,정병훈,한명호 대한성형외과학회 1992 Archives of Plastic Surgery Vol.19 No.3
The thumb is the most important part in the hand and its loss results in severely diminished function of the hand for pinch and grasp. There are several microsurgical and other methods to reconstruct and amputated or lost thumb such as toe-to-thumb transfer1)2)9) as well as several varieties of flaps. Among them, a free wrap around flap taken from the big toe, including the nail and an iliac bone graft as the cone of the reconstruction was a quite satisfactory procedure, but there were some problems. We performed a free wrap around flap on traumatically missing thumb with modification to include all part of the distal phalanx without iliac bone graft. The resorption and atrophy of a grafted iliac bone, a constant problem with Morrison's original procedure8), could be prevented by the modified method. The donor site defects were covered by remained medial flap for weight bearing area first, and full thickness skin graft for remained defected area. The results were good cosmetically and functionally without significant problems.
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崔秉昊 成均館大學校 科學技術硏究所 1990 論文集 Vol.41 No.1
A two-dimensional hydrodynamics-numerical model was established to investigate the hydraulic process in the vicinity of large steel mill cnstructed on the reclaimed platform at the estuary of Sumjin River, Kwang Yang Bay. The developed model was first used to simulate M_2 tide in the estuary. The computed results were presented in the form of tidal ellipses, maximum bottom stress and energy dissipation and discussions were also made for furture development of the model.
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최연옥,정병호,조금배 조선대학교 전자정보통신연구소 2002 電子情報通信硏究所論文誌 Vol.5 No.1
In this paper, a direct torque control(DTC) method of an induction motor is proposed which enables constant switching frequency. The switching strategy of a conventional direct torque control scheme which is based on hysteresis comparator results in a variable switching frequency which depends on the speed, flux, stator voltage and hysteresis band of the comparator. This paper proposes a new switching strategy which determine the effective switching time on each switching period by comparing the ascending and descending torque slopes. The simulation results are presented to verify this proposed scheme.
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