人蔘 Total Saponin, Protopanaxadiol 및 Protopanaxatriol의 消炎作用에 關한 硏究

조태순,이선미,정국현,이범구,이석용,박종대 성균관대학교 약학연구소 1999 成均藥硏論文集 Vol.11 No.-

Abstract-In an attempt to elucidate the anti-inflammatory action of ginseng total saponin, protopanaxadiol and protopanaxatriol, the anti-inflammatory activity of three compounds was investigated under various acute and chronic inflammatory models. The blood vessel permeability was slightly inhibited by total saponin and protopanaxatriol treatments. Granuloma formation induced by 2% carrageenan was inhibited by total saponin and protopanaxatriol. The cotton-pellet granuloma formation was significantly inhibited by intraperitoneal injection of total saponin. Total saponin and protopanaxadiol inhibited leukocyte emigration and protein exudation in CMC-induced pouch but protopanaxatriol increased leukocyte emigration. The swelling of rat hind paw induced by 1% carrageenan was significantly inhibited by total saponin, protopanaxadiol and protopanaxatriol both single and 2 weeks treatments. Total saponin, protopanaxadiol and protopanaxatriol decreased the anti-inflammatory activity in adrenalectomized rat. Our results suggest that total saponin, protopanaxadiol and protopanaxatriol have potent anti-inflammatory activity, this may be mediated in part through stimulation of adrenal glands.

선천성 심장병 수술의 최근 경향

趙範九 대한의학협회 1993 대한의학협회지 Vol.36 No.5

도재용 금속 코핑의 처리 방법에 따른 변연 적합도에 관한 연구

구범모,조인호 단국대학교 치의학연구소 1996 논문집 Vol.8 No.1

The effect of thermocycling and surface finishing on the marginal fidelity of copings for a metal ceramic crown was examined. Methods for minimizing the loss of marginal fidelity were evaluated. The results were as follows ; 1. Thermocycling of ceramic metal copings resulted in increased marginal gap. 2. The greatest marginal gap occurred during the first thermocycling of the copings. 3. No additional distortion of marginal fidelity occurred when surface finishing and second thermocycling were completed after initial thermocycling. 4. The gap increases according to various treatment methods showed group 1 to be the highest values. 5. There was no significant difference between group 2 and group 3(p>0.05). 6. There was significant difference between group 1 and group 2, 3(p<0.05). 7. There was no significant difference among the measurement sites.

심방 전위술의 장기 성적

박영환,조범구 한국소아심장연구회 2003 소아심장 Vol.7 No.2

글래스비드 방법과 분말프레스 방법을 이용한 지르코니아 분말시편의 반정량 엑스선형광분석

강종봉,조범래,양성구 경남대학교 신소재연구소 1999 論文集 Vol.11 No.-

XRF는 시편의 종류에 따라 벌크, 분말 등 여러 가지 형태의 시료를 간단한 전처리 조작에 의해 빠른 시간에 분석할 수 있다는 장점으로 파인세라믹스의 원소분석으로 이용되고 있다. 그러나 시편들의 전처리 방법에 따라 분석의 결과가 달리 나타나고 있어, 본 실험험에서는 분말프페스형 시편과 글래스비드형 시편에서의 분석결과 차이를 밝히고자 하였으며, 분석결과에 미치는 영향들을 살펴보고자 하였다. 글래스비드형 시편인 경우 첨가하는 10배 이상의 플럭스 때문에 측정시편에 포함된 실제 분석하고자하는 시료의 양이 적어 오차의 범위가 크게 나타났다. 미량원소의 분석일 경우 글래스비드형 시편이 분말프레스형 시편의 시편보다 측정결과에서 많은 오차를 나타낸다. 이것은 X-선이 조사되는 영역에서 실제 시편내의 시료의 양이 미량 원소 분석의 오차를 나타냄을 알 수 있었다. XRF(X-ray Fluorescence Spectrometer) is one of the element analyzing instruments. which can be used to analyze ceramic materials of bulk, powder and various forms. The advantage of XRF is rapid analysis of elements in ceramics with simple sample preparation. In this study, the difference in results between pressed powder method and glass bead method were evaluated and the effects of sample preparation the final results were examined. The flux included in glass bead method, which is more than 10 times of samples, affected the final analyzing result. Trace element analysis in XRF could be affected by the sample amount because the region of X-ray beam is related the sample amount.

개심술후 정신의학적 합병증

임기영,조범구,민성길,이홍식,유계준 大韓神經精神醫學會 1985 신경정신의학 Vol.24 No.1

Pre-and post operative psychiatric evaluations were done using semi-structured interview with Hamilton scales for anxiety and depression in 57 open heart surgery receipients to assess post-operative psychiatric complications. Conspicuous post-operative psychiatric complications were observed in 16 (23%) of 57 patients after open heart surgery. Postcardiotomy delirium occurred in seven patients; acute psychotic reaction with paranoid ideation in one; and neurotic reaction in eight. Factors that tended to influence postoperative psychiatric complications were older age, unempolyment, previous medical/psychiatric history, and high level of preoperative anxiety. By analysis of the preoperative psychiatric evaluation, patients could be largely divided in 3 groups; anxiety group, denial group, and adjusted group. Excessive anxiety and massive denial seemed to be signficant in the postoperative psychiatric compliactions. With these findings, the author's impression was that the consultation psychiatrist should give comprehensive psychiatric evaluation and psychiatric preparation in pre-and post-open heart surgery for the possible prevention of postopertive psychiatric complications.

酢漿草가 황달렛드의 혈청비리루빈에 미치는 영향

金順愛,李範九,趙台淳 成均館大學校 科學技術硏究所 1992 論文集 Vol.43 No.1

Oxalis corniculata Linne is a perennial plant which exists all over the country. Although Oxalis has been used to treat the jaundice, the action mechanism is not clear. Thus, this study was performed to determine whether Oxalis altered the bile flow and the levels of serum bilirubin in α-naphthylylisothiocyanate (ANIT)-induced jaundiced rats. The results are summarised as follows. 1) The bile flow and cholate concentration were not changed in ANIT(100mg/kg)-treated rats compared with that of normal control rats. 2) Total serum bilirubin levels were significantly decreased by Oxalis treatment in ANIT (20mg/kg + 100mg/kg consecutive p.o.)treated rats. 3) The levels of total serum bilirubin and conjugated bilirubin were markedly reduced in Oxalis fed rats for 4 days after ANIT(100mg/kg) administration

심초음파로 결정된 응급 심낭천자술의 천자부위

김성환,황성오,이강현,조준휘,강구현,문중범,이승환,윤정한,최경훈,김영식 대한응급의학회 2000 대한응급의학회지 Vol.11 No.3

Background: The aim of this study was to determine whether the conventional subcostal approach is suitable for emergency pericardiocentesis in patients with cardiac tamponade or impending cardiac tamponade. Methods: This study was a prospective, observational study conducted at the emergency department of a tertiary hospital, Patients who had symptomatic pericardial effusion and who needed emergency pericardiocentesis in the emergency department were included in this study. We measured the epicardium-to-pericardium distance at the subcostal, parasternal, and apical area with two-dimensional echocardiography to determine the appropriate puncture site for pericardiocentesis. An epicardium-to-pericardium distance of more than 1.0 cm was considered as the primary safety factor in determining the Puncture site for pericardiocentesis. The skin-to-pericardium distance was considered as secondary safety factor. Results: Ninety-five consecutive patients(55 males and 40 females; total mean age: 53 year old) with cardiac tamponade or impending cardiac tamponade were enrolled in this study. The puncture site for pericardiocentesis, as determined by echocardiography, was the subcostal area in 43 patients(45%), the apical area in 40 patients(42%), the left parasternal area In 11 patients(12%), and the right parastemal area in one patient(1%). Pericardiocentesis failed in 2 patients(2%) with the subcostal approach and in one patient(1%) with the apical approach. The average epicardium-to-pericardium distance was 31 ±21 mm in patients with the subcostal approach and 21±8 mm in patients with other approaches. There were no differences in the amount of pericardial fluid and in the intraperical pressure among patient groups according to puncture site. There were two procedure related complications: a puncture of the right ventricle with the subcostal approach and a ventricular tachycardia with the apical approach.

선천성 양측성 폐정맥 협착증의 심초음파 및 심도자 및 혈관조영술 소견

정남식,하종원,윤정한,김병옥,장양수,조승연,조범구 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.4

간내담석증의 임상적 고찰

조범구(Cho Bum Koo),박응범(Park Eung Bum),황규철(Whang Kyu Chul),허경발(Hur Kyung Bal) 대한외과학회 1972 Annals of Surgical Treatment and Research Vol.14 No.4