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혈소판이 소 폐동맥 내피세포의 Endothelin 생산에 미치는 효과
이상도 ( Sang Do Lee ),심태선 ( Tae Sun Shim ),권석운 ( Seog Woon Kwon ),류진숙 ( Jin Sook Ryu ),이재담 ( Jae Dam Lee ),임채만 ( Chae Man Lim ),고윤석 ( Youn Suck Koh ),김우성 ( Woo Sung Kim ),김동순 ( Dong Soon Kim ),김원동 ( Won 대한결핵 및 호흡기학회 1997 Tuberculosis and Respiratory Diseases Vol.44 No.5
Apple II P.C.를 이용한 Video Image Processing과 인체계측 및 동작분석에의 응용
이상도,정중선,이근부,Lee, Sang-Do,Jeong, Jung-Seon,Lee, Geun-Bu 대한인간공학회 1985 大韓人間工學會誌 Vol.4 No.1
The object of this research is to develop an Interactive Computerized Graphic Program for graphic output of velocity, acceleration and motion range of body-task reference point (e.g., C.O.G., joint location, etc.). Human motions can be reproduced by scanning (rate = 60Hz) the vidicon image, and the results are stored in an Apple II P.C. memory. The results of this study can be extended to simulation and reproduction of human motions for optimal task design.
개선된 thin-layer chromatography를 이용한 바이오디젤 중의 글리세롤 정량분석
이상은(Sang-Eun Lee),최우석(Woo-Seok Choi),강도형(Do-Hyung Kang),이현용(Hyeon-Yong Lee),정경환(Kyung-Hwan Jung) 한국생명과학회 2013 생명과학회지 Vol.23 No.4
Biodiesel 중의 glycerol을 분석하기 위하여 TLC를 이용하여 몇 가지 보고된 이동상에서 glycerol을 분석하였다. 그 중에서 acetonitrile : distilled water (85:15, v/v)를 이동상으로 하여 TLC를 수행하였을 경우에 짧은 시간에 명확한 glycerol band를 확인할 수 있었다. X축의 glycerol 농도를 log scale로 하고, TLC의 glycerol 이미지 면적을 Y축으로 하여 3.0-0.0625 (%, w/v)의 glycerol 농도범위에서 표준곡선을 작성할 수 있었으며, 이를 이용하여 0.2 (%, w/v)의 glycerol을 포함하는 biodiesel 시료에서 유의성 있게 glycerol을 정량분석 할 수 있음을 확인하였다. 이러한 결과는 chemical assay, enzymatic assay를 이용한 glycerol 분석과 비교하여 매우 유사한 결과이며, TLC를 이용한 biodiesel 중의 glycerol 정량법은 특별한 분석기기를 사용할지 않아도 되는 편리하고 간편한 방법으로 생각되어진다. We analyzed glycerol using thin-layer chromatography (TLC) and compared the separation resolution of some mobile phases. When acetonitrile:distilled water (85:15 v/v) was used as a mobile phase, the band of glycerol on the TLC was more distinctly and rapidly separated. Using TLC analysis, we prepared a calibration curve for the glycerol concentration vs. the area of the glycerol band in which the glycerol concentration of the x-axis was converted into a log-scale ranging from 3.0 to 0.0625 (%, w/v). Based on this calibration curve, the residual glycerol concentration (0.2 [%, w/v]) in biodiesel was determined successfully using TLC analysis. When the results of the TLC analysis were compared with those of a chemical and enzymatic assay, the results were fairly similar. We conclude that TLC without additional analytical instruments can be used as an alternative method for the quantitative analysis of the concentration of glycerol in biodiesel.
건강보험 청구명세서 자료를 이용한 제왕절개 분만율 위험도 보정의 효과
이상일,서경,도영미,이광수,Lee, Sang-Il,Seo, Kyung,Do, Young-Mi,Lee, Kwang-Soo 대한예방의학회 2005 예방의학회지 Vol.38 No.2
Objectives: To propose a risk-adjustment model from insurance claims data, and analyze the changes in cesarean section rates of healthcare organizations after adjusting for risk distribution. Methods: The study sample included delivery claims data from January to September, 2003. A risk-adjustment model was built using the 1st quarter data, and the 2nd and 3rd quarter data were used for a validation test. Patients' risk factors were adjusted using a logistic regression analysis. The c-statistic and Hosmer-Lemeshow test were used to evaluate the performance of the risk-adjustment model. Crude, predicted and risk-adjusted rates were calculated, and compared to analyze the effects of the adjustment. Results: Nine risk factors (malpresentation, eclampsia, malignancy, multiple pregnancies, problems in the placenta, previous Cesarean section, older mothers, bleeding and diabetes) were included in the final risk-adjustment model, and were found to have statistically significant effects on the mode of delivery. The c-statistic (0.78) and Hosmer-Lemeshow test ($x^2$=0.60, p=0.439) indicated a good model performance. After applying the 2nd and 3rd quarter data to the model, there were no differences in the c-statistic and Hosmer-Lemeshow $x^2$. Also, risk factor adjustment led to changes in the ranking of hospital Cesarean section rates, especially in tertiary and general hospitals. Conclusion: This study showed a model performance, using medical record abstracted data, was comparable to the results of previous studies. Insurance claims data can be used for identifying areas where risk factors should be adjusted. The changes in the ranking of hospital Cesarean section rates implied that crude rates can mislead people and therefore, the risk should be adjusted before the rates are released to the public. The proposed risk-adjustment model can be applied for the fair comparisons of the rates between hospitals.
Sedimentation Pattern in a Macrotidal Bay (Namhaepo Bay), West coast of Korea
이상도,박수철,LEE, SANG-DO,PARK, SOO-CHUL The Korean Society of Oceanography 1991 韓國海洋學會誌 Vol.26 No.4
The sedimentation pattern in Namhaepo Bay, a macrotidal coastal embayment of western Korea, was investigated by means of analysing high-resolution seismic profiles, sediment samples, and tidal currents. Recent sediments up to 20 m which overlie the irregular surface of the acoustic basement. The sediments consist mainly of sandy silt and silt; the mean grain size of these sediments ranges from 4 to 5.5 phi, showing a shoreward-fining distribution pattern. This distribution pattern agrees are largely reversed during ebb, with a maximum velocity of 39 cm/sec. The calculated shear velocity of the tidal currents at sea bed ranges from 0.5 to 3.3 cm/sec during flood and from 0.7 to 2.5 cm/sec during ebb. The mean values of these velocities exceed the critical shear velocity for the silt particles. The data suggest that the tidal currents play an important role in the transportation and deposition of sediments in the bay and the surface topography of the sea floor is largely deter-mined by tidal sedimentation.
이상화,최백동,정순정,장현선,김병옥,임도선,박주철,왕관림,정문진,Lee, Sang-Hwa,Choi, Baik-Dong,Jeong, Soon-Jeong,Jang, Hyun-Seon,Kim, Byung-Ock,Lim, Do-Seon,Park, Joo-Cheol,Wang, Guan-Lin,Jeong, Moon-Jin Korean Society of Electron Microscopy 2006 Applied microscopy Vol.36 No.3
분비백혈구단백분해효소억제제 (SLPI)는 염증 부위에서 중성구 엘라스타제에 의한 손상 작용에 대해 조직을 보호하는 역할을 한다. SLPI의 새로운 기능에 대한 연구들은 단백질분해효소억제제 역할보다는 선천적 면역반응 작용에 주로 관여 할 것임을 보고하였다. 따라서 본 연구는 섬유모세포 세포주(NIH3T3)에서 박테리아성지질다당류(LPS)자극에 의한 SLPI의 기능을 확인하기 위하여 LPS처리에 따른 여러 성장 인자들과 비교하여 SLPI의 발현을 알아보았다. 역전사효소 중합반응(RT-PCR)과 면역학적 단백질 검출법 (Western blot)은 LPS 처리 후 SLPI와 몇몇 성장 인자들(VEGF, bFGF, PDGF)의 mRNA와 단백질의 검출을 위해 수행하였다. NIH3T3 세포주를 mL당 100ng의 LPS에 각각 30, 60, 90분, 24, 48시간 동안 노출시켰다. RT-PCR 결과 SLPI와 VEGF mRNA는 LPS처리와는 상관없이 강한 발현 양상을 보였다. bFGF mRNA는 대조군과 같이 약하게 발현하였고, PDGF mRNA는 LPS 노출 시간에 따라 점진적으로 증가하는 양상을 나타냈다. 그러나 세포질 용해액과 세포 배양액에서 SLPI단백질의 수준은 LPS처리에 의해 증가하였다. 또한 광학 현미경 관찰과 전자 현미경 관찰은 LPS가 NIH3T3세포주의 형태학적인 변화를 유발시킴을 증명하였다. 따라서 LPS는 NIH3T3세포에서 SLPI의 발현 증가를 조절하며, 분비된 SLPI는 세포분열과 이동을 자극할 것이라는 결론을 얻었다. SLPI가 세포분열과 세포이동에 어떻게 관여하는지는 아직까지 규명되지 않은 실정이므로-추후에 SLPI단백질이나 유전자 도입을 통하여 세포 이동에 관련된 실험이 진행되어야 할 것이다. Secretory leukocyte protease inhibitor (SLPI) involves tissue protection against the destructive action of neutrophil elastase at the site of inflammation. Several studies on new functions of SLPI have demonstrated that SLPI may play a primary role in innate immunity than protease inhibitor, To identify the function of SLPI by lipopolysaccharide (LPS) stimulation in the embryonic fibroblast (NIH3T3) cells. we studied the expression of SLPI compared to other growth factors involving the LPS treatment. To address this, we performed the reverse transcriptase polymerase chain reaction (RT-PCR) and Western blots for the detection of mRNA and protein expression of the SLPI and some growth factors such as VEGF. bFGF, and PDGF-BB after LPS stimulation. NIH3T3 cells were exposed 100 ng/mL Escherichia coli LPS for 30min, 60min, 90min, 24h, and 48h, respectively. The result of RT-PCR showed that SLPI and VEGF mRNA was expressed strongly in NIH3T3 without related to LPS stimulation. mRNA of bFGF was weakly expressed such as the expression of the control. PDGF mRNA expression gradually increased follows at time course. However, SLPI protein level was increased in lysates and culture medium by LPS stimulation. Phase contrast microscopic and scanning electron microscopic observation showed that the increased cell number and cytoplasmic enlargement of the NIH3T3 cells. Therefore, it suggests that the LPS upregulates SLPI expression in NIH3T3 cells. Moreover, secreted SLPI may stimulate cell proliferation and migration.