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      • P-24 : 최근 3년간 AFB Culture 양성 검체 중 NTM의 비율 증가 추이

        홍영주 대한임상병리사협회 2012 임상미생물검사학회 발표자료집 Vol.2012 No.-

        배경: 흔히 결핵은 주로 병원성과 위험도가 매우 높은 MTB (Mycobacterium tuberculosis)가 이전부터 주요한 관리대상이 되어왔으나 최근 들어서는 면역력 저하 환자에서 NTM (Non-tuberculous Mycobacteria)의 위험도가 높은 것으로 알려지고 있어 주의를 요하고 있다. 이에 본 검사실에서 실시하고 있는 AFB culture 양성 검체 중 MTB와 NTM의 양성률을 비교해 보았다. 방법: 최근 3년간(2009~2011년) 본원에 의뢰된 AFB culture 양성 검체를 대상으로 조사하였으며, 검사 방법은 NALC-NaOH 용액을 사용하여 처리한 검체를 3% Ogawa 배지에 접종한 뒤8주 동안 배양하며 판독하는 방법으로 실시하였다. MTB와 NTM의 감별검사로는 MPT64 Ag test를 실시하였다. 검사 시약은 SD사의 TB Ag MPT64 Rapid를 사용하여 검사하였고 필요 시MTB & NTM PCR로 감별하였다. 결과: 조사해 본 결과 2009년에는 전체 양성 검체 1806건 중 MTB가 1563건(86.54%), NTM이243건(13.46%), 2010년에는 전체 양성 검체 1984건 중 MTB가 1629건(82.10%), NTM이 355건(17.90%), 2011년에는 전체 양성 검체 1582건 중 MTB가 1287건(81.35%), NTM이 295건(18.65%)으로 조사되었다. 고찰: 본원에서 조사된 AFB culture 양성 검체 중 NTM의 비율은 2009년에 13.46%, 2010년에 17.90%, 2011년에 18.65%로 점차적으로 증가하고 있음을 볼 수 있었다. NTM 감염률이 계속증가하고 있고 실제 증가 추세이기도 하지만 그밖에 여러 가지 관련요소들이 있다. 진단률이 높아져서 증가할 수도 있고, 항산균 검사 건수 자체가 증가한다거나, 검사실에서의 기술의 발달로 NTM 감별과 확인이 더 정확해지고 있는 것도 증가 추세에 기인하고 있다. 또한 NTM 질환에 대한 관심과 인식이 높아지고 있는 것도 한 요소가 될 수 있다.

      • KCI등재
      • KCI등재

        자연언어에 나타나는 공백현상에 관한 연구

        홍영주 대한일어일문학회 2018 일어일문학 Vol.77 No.-

        Empty category is called PRO and means some element of the sentence which must exist in the sentence does not appear. In this paper, we try to present the interpretation of the empty category sentence. Especially, we aim to describe the complement clause type depending on the type of the main clause predicate and the circumstances in which the interpretation of the empty category appear in each case. And in order to achieve this goal, we proceed the research in three step down below. First, we classified the type of the complement clause which is selected in simple verb sentence and the feature of the verb predicate sentence. In this study we particularly focus on the complement marker [-koto][-to] and [-no] in Japanese. Also we represent the subtype of the verb predicate which appears in the complement clause by its grammatical and semantic features. As a result, we figure out that the complement clause type can change according to main clause verb. On the other hand, we can identify that although they are correspond to each other in both languages, they can take the different complement clause marker. These phenomena can come from the differences of the range of the semantic feature in each verb. Second, we pick up the empty category phenomena appear in accordance with the complement clause type which is classified in the first step above and the feature of the predicate. Then we describe their interpretations. In this step, we research the empty category phenomena which can appear in each clause complement type and each sub-predicate, and represent the possible interpretations in each element. Then, we analyze the interrelationships between these interpretations and the predicate verb along with the tense of the complement clause. As a result of the analysis, the interpretation of the empty category can change by the tense of the complement clause. we can clarify that while in case of the non-past tense, the interpretation of the empty category appears to object [-ni] and [-ga], in case of the past tense, it appears irregularly. Third, through this comparative study, we represent the common feature and the condition that the verb predicate in each complement clause type is concerned with the empty category interpretation, and also present the similarities and the differences between the two languages.

      • KCI등재
      • KCI등재

        Analysis of Interactive E-Health Tools on United Arab Emirates Patient Visited Hospital Websites

        홍영주,김정은 대한의료정보학회 2019 Healthcare Informatics Research Vol.25 No.1

        Objectives: This study is to scrutinize the website of Seoul National University Hospital in Korea, Clinique Valmont in Switzerland, Medical Center of the University of Munich in Germany, Cleveland Clinic Abu Dhabi in the United Arab Emirates (UAE) to suggest successful communication factors to the medical service providers who deal with Middle Eastern patients. Methods: Using content analysis and in-depth interviews, this research examines four hospitals commonly visited by Middle East patients. The four hospitals approaches to implementing interactive e-health tools on their web sites are reviewed. Four hospitals selection criterion was process by focus group interview of government officials in UAE health sectors. Results: The way of providing medical information differed by hospitals that used e-health tools. The analysis of each website shows a different way providing medical information, services and education. There are important differences among hospitals. These include decision-making, planning processes and outcomes of implementing e-health tools online, as well as potential obstacles to such implementation. Thus, hospitals can learn and design effective interactive tools by applying e-health tools on their websites. Conclusions: Each website showed different interactive tools such as traditional functional tools, core ebusiness tools, patient support tools, visitor related tools, emerging functional tools. By applying the interactive e-health tools sets an objective view for e-health strategy and vision for the hospitals conveying information through the website. According to the type of hospitals and its location different methods of strategy should be applied. Targeting not only the patients but also the general website users will eventually improve health information accessibility.

      • KCI등재

        The Relationship between Working Memory and Metaphor Comprehension in School-Age Children with Specific Language Impairments

        홍영주,임동선 한국언어청각임상학회 2014 Communication Sciences and Disorders Vol.19 No.2

        배경 및 목적: 본 연구에서는 단순언어장애아동 및 일반아동을 대상으로 작업기억 능력과 은유 이해능력을 비교하고, 작업기억 능력과 은유 이해능력 간의 관련성을 살펴보고자 하였다. 방법: 본 연구에서는 초등학교 4-6학년에 재학 중인 10-12세 단순언어장애 15명, 일반 15명, 총 30명을 대상으로 작업기억 과제(문장기억폭, 매트릭스)와 은유 과제(은유문장, 은유광고)를 실시하고, 이원혼합분산분석(two-way mixed ANOVA) 및 Pearson 적률상관계수를 구하였다. 결과: 작업기억 과제(문장기억폭, 매트릭스)에서 두 집단 간 유의한 차이가 있었고, 과제 간 유의한 차이를 보였다. 은유 과제(은유문장, 은유광고)에서 두 집단 간 유의한 차이를 보였다. 단순언어장애 아동은 은유 과제 간 유의한 상관을 보였고, 일반아동은 작업기억 과제(문장기억폭)와 은유 과제(은유문장, 은유광고) 간 유의한 상관을 보였으며, 은유 과제 간에도 유의한 상관을 보였다. 논의 및 결론: 단순언어장애아동은 일반아동과 비교해 작업기억 능력과 은유 이해능력 모두에서 어려움을 보였다. 비록 단순언어장애아동이 작업기억 능력과 은유 이해능력 사이에 유의한 상관을 보이지는 않았지만, 두 집단이 작업기억 능력에 차이를 보인다는 결과는 단순언어장애아동이 보이는 언어적 결함이 작업기억과 관련이 있을 수 있다는 점을 시사한다. Objectives: The present study investigated the relationship between working memory and metaphor comprehension in children with specific language impairment (SLI) and typical development (TD). Methods: A total of 30 children between 10 to 12 years old, 15 children with SLI and 15 children with TD participated in the study. The experiments consisted of two working memory tasks (Competing Language Processing Task [CLPT] and Matrix) and two metaphor comprehension tasks (sentence and advertisement). Performance on the two working memory tasks and two metaphor comprehension tasks were analyzed by using two-way mixed ANOVA and correlational analyses. Results: Results were summarized as follows: There were significant differences between the groups on working memory tasks (CLPT and Matrix), and metaphor tasks (sentence and advertisement), showing that the SLI group had lower accuracy than TD group. There was a significant difference within conditions in which verbal working memory task performance had lower accuracy than the nonverbal working memory task. The correlational analyses were significant between metaphor tasks (sentence and advertisement) for both groups. However, correlational analyses among working memory tasks (CLPT), and metaphor tasks (sentence and advertisement) were significant for children with TD but not for children with SLI. Conclusion: The study results indicate that children with SLI have more difficulties in working memory and metaphor comprehension then children with TD. Although the working memory ability and metaphor comprehension ability were not significantly correlated for children with SLI, the differences between two groups of working memory abilities showed that difficulties in the metaphor comprehension for children with SLI may be involved with working memory difficulties.

      • KCI등재

        추출방법에 따른 소목 심재의 항산화 및 항당뇨 활성 평가

        홍영주,정경한,정윤희,김태훈,Hong, Young Ju,Jeong, Gyeong Han,Jeong, Yun Hee,Kim, Tae Hoon 대한본초학회 2017 大韓本草學會誌 Vol.32 No.6

        Objectives : The heartwood of Sappan Lignum has been used since ancient times as an ingredient in folk medicines against anti-bacterial and anti-anemia purposes. Many bioactive constituents have been derived from this biomass such as chalcones and homoisoflavonoids. In the current investigation, the antioxidant and anti-diabetic properties using DPPH and $ABTS^+$ radicals scavenging, ${\alpha}-glucosidase$, and advanced glycation end products (AGEs) inhibition assays were evaluated by different extraction methods of Sappan Lignum. Methods : In our continuing investigation for bioactive natural ingredients, the antioxidant and ${\alpha}-glucosidase$ inhibitory properties of Sappan Lignum extracts were prepared from different extraction methods and the biological efficacies were investigated in vitro. The antioxidant properties were evaluated employing radical scavenging assays using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) ($ABTS^+$) radicals. In addition, the anti-diabetic effects of Sappan Lignum extracts were tested via ${\alpha}-glucosidase$ and AGEs formation inhibitory assay. The total phenolic contents were determined using a spectrophotometric method. Results : All the tested samples showed dose-dependent radical scavenging and ${\alpha}-glucosidase$ inhibitory activities. Among the tested extracts, the 80% methanolic extract of Sappan Lignum was showed the most potent activity with an $IC_{50}$ value of $82.3{\pm}1.7{\mu}g/m{\ell}$ against DPPH radical scavenging assay. While, $ABTS^+$ radical scavenging activity of 80% methanolic extract was higher than those of other extracts. Also, ${\alpha}-glucosidase$ inhibitory and AGEs formation effects of each extacts and total phenolic contents were evaluated. Conclusions : These results suggested that Sappan Lignum can be considered as a new effective source of natural antioxidant and anti-diabetic materials.

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