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효소보충치료(ERT)를 받고 있는 뮤코다당증 환자의 경험
권은경,정소영,최유진,조성윤,진동규,Kwon, Eun Kyung,Jung, So-Young,Choi, Eu Jin,Cho, Sung Yoon,Jin, Dong Kyu 대한산업경영학회 2021 산업융합연구 Vol.19 No.4
본 연구는 효소보충치료(ERT)를 받고 있는 뮤코다당증 환자들의 경험을 파악하기 위한 목적으로 수행되었다. 본 연구는 질적 연구방법을 적용하였고, 효소보충치료를 받고 있는 7명의 뮤코다당증 성인환자를 대상으로. 2018년 7월 1일부터 2018년 7월 22일까지 심층 인터뷰를 통해 자료를 수집하였다. 수집된 개별 면담 자료는 필사하여 귀납적 내용 분석 방법으로 분석하였다. 연구결과, 효소보충치료를 받고 있는 뮤코다당증 환자의 경험은 최종 4개의 범주(효소보충치료를 통한 신체·심리적 변화, 효소보충치료라는 계속되는 터널, 치료에 대한 현실 받아들이기, 조심스러운 희망)와 15개의 하위범주로 도출되었다. 따라서, 의사 및 간호사는 효소보충치료를 받고 있는 뮤코다당증 환자의 이러한 경험을 고려하여 돌봄을 제공해야 할 것이고, 정부 또한 뮤코다당증 환자의 신체적 증상 뿐 아니라 효소보충치료로 인한 어려움을 고려한 실질적인 정책을 마련할 필요가 있다. 본 연구는 희귀질환인 뮤코다당증 환자의 경험을 확인하였다는 점에서 의의가 있다. The purpose of this study was to explore the meaning of the experience of Mucopolysaccharidosis patients receiving Enzyme Replacement Therapy(ERT). A qualitative research design was adopted. The participants were 7 patients diagnosed with MPS who is receiving ERT for several years. Data were collected through in-depth interviews from 1 July 2018 to 22 July 2018 for seven adult patients with MPS receiving ERT. Individual interviews were recorded, and transcribed data were analyzed using the inductive method of content analysis. The final 4 categories and 15 subcategories were identified. The 4 categories of the experience of Mucopolysaccharidosis patients receiving ERT were "Physical and psychological changes through ERT", "Continuous tunnel called ERT", "Accepting the reality" and "Cautious hope". This study provides deep insight into the experience of Mucopolysaccharidosis patients receiving ERT. Medical staff including nurses and related organizations should concern their distress during ERT as well as physical symptoms.
배 에탄올 추출물이 난황에 의하여 유발된 생쥐의 천식에 미치는 영향
정희진 ( Hee Jin Chung ),정영민 ( Young Min Joung ),최유진 ( Eu Gene Choi ),신동선 ( Dong Sung Shin ),김형우 ( Hyung Woo Kim ),조수인 ( Su In Cho ) 대한본초학회 2012 大韓本草學會誌 Vol.27 No.1
Objectives: In the theory of Korean medicine, Pear has long been considered to protect throat, bronchus and lung. Pear has been believed to remove sputum in Korean people. This study was conducted to investigate the effect of pear ethanol extract (PEE) on asthma induced by ovalbumin in mice. Methods: We investigated the effects of PEE on airway hyperresponsiveness to methacholine, production levels of ovalbumin (OVA) specific total immunoglobulin G (IgG), IgG1, IgG2a and IgE in serum and histopathological changes of lung tissues in asthamtic mice. Results: PEE decreased airway hyperresponsiveness to methacholine significantly compared to non-treated asthmatic mice (P<0.05). Level of OVA specific IgE in serum was lowered by oral administration of PEE effectively (P<0.05). In histopathological observation, administration of PEE reduced infiltration of immune cells into lung tissue. Conclusion: These results suggest that pear has anti-asthmaitc action and related mechanims are involved in anti-inflammatory action such as reducing level of OVA specific IgE and immune cell infiltration.
당귀(當歸)가 Estradiol valerate에 의하여 유발된 다낭성난소에 미치는 영향
김형우 ( Hyung Woo Kim ),최유진 ( Eu Gene Choi ),정희진 ( Hee Jin Chung ),정영민 ( Young Min Joung ),신동선 ( Dong Sung Shin ),조수인 ( Su In Cho ) 대한본초학회 2011 大韓本草學會誌 Vol.26 No.1
Objective: This study was designed to investigate the effects of Angelicae Gigantis Radix (AGR) on Polycystic Ovary (PCO) induced by Estradiol valerate (EV) in female rats. Methods: We investigated the effects of AGR on Changes in body weights and food and water uptake for 5 weeks. In addition, we examined the effects on ovary weights. Finally, we also observed histopathological changes in PCO rats. Results: Treatment with AGR did not affect body weights, amount of food and water uptake. Administration group of AGR restored body/ovary weight ratio to normal levels, which were lowered by induction of PCO. In histopathological observation, formation of cysts was suppressed in AGR group compared with non-treated control group. Conclusion: These results suggest that AGR can be used for patients with PCO to prevent formation of cystic follicles and malfunction of ovary.
TGF-${\beta}1$으로 자극한 사람중피세포주에서 조직플라스미노겐 활성제가 미치는 영향
이정림,전수진,유영춘,김지혜,이유미,권선중,손지웅,최유진,나문준,Lee, Jung-Lim,Jeon, Soo-Jin,Yoo, Young-Choon,Kim, Ji-Hye,Lee, Yu-Mi,Kwon, Sun-Jung,Son, Ji-Woong,Choi, Eu-Gene,Na, Moon-Jun 대한결핵및호흡기학회 2011 Tuberculosis and Respiratory Diseases Vol.70 No.5
Background: In an effort to find alternative therapeutic agents to prevent excessive fibrosis as a sequela to complicated parapneumonic effusion or empyema, we examined the effect of tissue plasminogen activator (tPA) as a fibrinolytic agent combined with talc or transforming growth factor (TGF)-${\beta}1$ in a human pleural mesothelial cell line, MeT-5A. Methods: MeT-5A cells were stimulated with various doses of talc, doxycycline or TGF-${\beta}1$ for 24 h and then were treated with tPA for an additional 24 h. Cell viability was measured by MTT assay. The production of interleukin (IL)-8 and vascular endothelial growth factor (VEGF) in the culture supernatants was measured by ELISA. Real-time PCR was carried out for measurement of type I collagen mRNA. Results: MeT-5A cells treated with talc showed a dose-dependent increase in production of IL-8. Talc also increased production of type I collagen mRNA at low doses, but talc did not influence the induction of VEGF. Addition of tPA to talc-stimulated cells showed further increases in the production of IL-8, but tPA did not influence the production of VEGF or type I collagen mRNA. TGF-${\beta}1$ increased the production of both VEGF and collagen type I mRNA, both of which were effectively inhibited by additional tPA treatment in MeT-5A cells. Conclusion: TGF-${\beta}1$ is a potent inducer of collagen synthesis without induction of IL-8 in MeT-5A cells. Addition of tPA after TGF-${\beta}1$ stimulation inhibited further fibrosis by direct inhibition of collagen mRNA synthesis as well as by inhibition of VEGF production.
TGF-β1으로 자극한 사람중피세포주에서 조직플라스미노겐 활성제가 미치는 영향
이정림 ( Jung Lim Lee ),전수진 ( Soo Jin Jeon ),유영춘 ( Young Choon Yoo ),김지혜 ( Ji Hye Kim ),이유미 ( Yu Mi Lee ),권선중 ( Sun Jung Kwon ),손지웅 ( Ji Woong Son ),최유진 ( Eu Gene Choi ),나문준 ( Moon Jun Na ) 대한결핵 및 호흡기학회 2011 Tuberculosis and Respiratory Diseases Vol.70 No.5
Background: In an effort to find alternative therapeutic agents to prevent excessive fibrosis as a sequela to complicated parapneumonic effusion or empyema, we examined the effect of tissue plasminogen activator (tPA) as a fibrinolytic agent combined with talc or transforming growth factor (TGF)-β1 in a human pleural mesothelial cell line, MeT-5A. Methods: MeT-5A cells were stimulated with various doses of talc, doxycycline or TGF-β1 for 24 h and then were treated with tPA for an additional 24 h. Cell viability was measured by MTT assay. The production of interleukin (IL)-8 and vascular endothelial growth factor (VEGF) in the culture supernatants was measured by ELISA. Real-time PCR was carried out for measurement of type I collagen mRNA. Results: MeT-5A cells treated with talc showed a dose-dependent increase in production of IL-8. Talc also increased production of type I collagen mRNA at low doses, but talc did not influence the induction of VEGF. Addition of tPA to talc-stimulated cells showed further increases in the production of IL-8, but tPA did not influence the production of VEGF or type I collagen mRNA. TGF-β1 increased the production of both VEGF and collagen type I mRNA, both of which were effectively inhibited by additional tPA treatment in MeT-5A cells. Conclusion: TGF-β1 is a potent inducer of collagen synthesis without induction of IL-8 in MeT-5A cells. Addition of tPA after TGF-β1 stimulation inhibited further fibrosis by direct inhibition of collagen mRNA synthesis as well as by inhibition of VEGF production.