당뇨망막병증 환자에서의 망막지혈증

최성원,김유철.Sung Won Choi. MD. Yu Cheol Kim. MD 대한안과학회 2014 대한안과학회지 Vol.55 No.4

Purpose: To report a case of lipemia retinalis in a patient with diabetes. Case summary: A 27-year-old female with type 2 diabetes visited our clinic with visual disturbance in her left eye while being followed up from a pars plana vitrectomy in her right eye for proliferative diabetic retinopathy. On fundus examination of both eyes, the retinal vessels were creamy white and the retinal veins were undistinguishable from the retinal arteries. The serum triglyceride level was 2,676 mg/dL. The patient was asymptomatic except for visual impairment due to vitreous hemorrhage in her left eye. The patient was diagnosed with lipemia retinalis and chylomicronemia syndrome. After controlling the triglyceride level, funduscopic findings in the both eyes were improved. However, the visual acuity in her right eye remained unchanged. Conclusions: Lipemia retinalis can be a sign of a systemic condition although it may not affect visual acuity. Fundus examination may be a useful tool in the early diagnosis of hyperlipidemia. J Korean Ophthalmol Soc 2014;55(4):623-627

예측알고리즘 적용을 위한 데이터세트 구성이 근적외선 분광광도계를 이용한 옥수수 품질평가에 미치는 영향

최성원,이창석,박창희,김동희,박성권,김법균,문상호,Choi, Sung-Won,Lee, Chang-Sug,Park, Chang-Hee,Kim, Dong-Hee,Park, Sung-Kwon,Kim, Beob-Gyun,Moon, Sang-Ho 한국축산환경학회 2014 한국축산시설환경학회지 Vol.20 No.3

The objectives were to assess the use of near-infrared reflectance spectroscopy (NIRS) as a tool for estimating nutrient compositions of corn kernel, and to apply an NIRS-based indium gallium arsenide array detector to the system for collecting spectra and analyzing calibration equations using equipments designed for field application. Partial Least Squares Regression (PLSR) was employed to develop calibration equations based on representative data sets. The kennard-stone algorithm was applied to induce a calibration set and a validation set. As a result, the method for structuring a calibration set significantly affected prediction accuracy. The prediction of chemical composition of corn kernel resulted in the following (kennard-stone algorithm: relative) moisture ($R^2=0.82$, RMSEP=0.183), crude protein ($R^2=0.80$, RMSEP=0.142), crude fat ($R^2=0.84$, RMSEP=0.098), crude fiber ($R^2=0.74$, RMSEP=0.098), and crude ash ($R^2=0.81$, RMSEP=0.048). Result of this experiment showed the potential of NIRS to predict the chemical composition of corn kernel.

40세 이하에서 발생한 열공망막박리의 고찰

최성원,김광수,김유철,Sung Won Choi,MD,Kwang Soo Kim,MD,Yu Cheol Kim,MD 대한안과학회 2014 대한안과학회지 Vol.55 No.12

Purpose: To investigate the risk factors and the factors affecting surgical and visual outcomes of rhegmatogenous retinal detachment in patients under 40 years of age. Methods: This retrospective study included 88 patients (96 eyes) diagnosed with rhegmatogenous retinal detachment that were followed up for more than 3 months postoperatively. Patients were categorized into 3 groups according to age. The etiologic risk factors and the primary anatomical and functional success rates were analyzed. Preoperative factors that could affect postoperative visual acuity and primary anatomical outcome, such as subretinal strands and proliferative vitreoretinopathy (grade C or worse), were analyzed. Results: Myopia more severe than -4.0 diopters was the most common predisposing factor in all 3 groups. Anatomical success rates and functional success rates were not significantly different among the groups. Prevalence of macular detachment and proliferative vitreoretinopathy were highest in group 1. The presence of subretinal strands was highest in group 2 and proliferative vitreoretinopathy was highest in group 1. Patients with preoperative subretinal strands showed a lower primary anatomical success rate in group 1 and poor postoperative visual acuity in groups 1 and 2. Patients with proliferative vitreoretinopathy had poor postoperative visual acuity however there was no significant difference in primary anatomical success rate among the groups.Conclusions: Proliferative vitreoretinopathy did not affect the anatomical success rate but did affect visual outcome in rhegmatogenous retinal detachment in patients under age 40. Subretinal strands contributed to a lower anatomical success rate and poorer visual outcome in such patients that were under age 18. J Korean Ophthalmol Soc 2014;55(12):1808-1813

비후성 반흔 각질세포와 정상 각질세포의 유전자 비교분석

최성원,정호윤,임영국,김훈남,오지원,김문규,전세화,홍용택,Choi, Sung-Won,Chung, Ho-Yun,Lim, Young-Kook,Kim, Hoon-Nam,Oh, Ji-Won,Kim, Moon-Kyu,Jeon, Sae-Hwa,Hong, Yong-Taek 대한성형외과학회 2010 Archives of Plastic Surgery Vol.37 No.4

Purpose: There is no clear evidence of the original cause of hypertrophic scar, and the effective method of treatment is not yet established. Recently the steps of searching in gene and molecular level are proceeding. we are trying to recognize the difference between keratinocytes of hypertrophic scar and normal skin. Then we do support the comprehension of the scar formation mechanism and scar management. Methods: Total RNAs were extracted from cultured keratinocytes from 4 hypertrophic scars and normal skins. The cDNA chips were prepared. A total of 3063 cDNAs from human cDNA library were arrayed. And the scanning data were analyzed. Results: On microarray, heat shock protein, pyruvate kinase, tumor rejection antigen were more than 2 fold intensity genes. Among them, heat shock 70 kd protein showed the strongest intensity difference. Conclusion: In this study, it can be concluded that heat shock proteins play an important role in the process of wound healing and scar formation. This study provides basic biologic information for scar research. The new way of the prevention and treatment of scar formation would be introduced with further investigations.

단안 상사근 마비와 동반된 수평 사시의 특징 및 치료 예후

최성원,정세환,라상훈,Sung Won Choi,Se Hwan Jung,Sang Hoon Rah 대한안과학회 2007 대한안과학회지 Vol.48 No.3

Purpose: To review the clinical characteristics and treatment outcomes in horizontal strabismus combined with unilateral superior oblique palsy (SOP). Methods: A retrospective review of medical records was conducted in 21 patients with unilateral SOP treated between January 2001 and December 2005. Patients had more than 6 months of follow-up at the Department of Ophthalmology, Wonju College of Medicine. Results: Among 21 patients (11 male, 10 female) with unilateral SOP, 57.1% of patients had horizontal strabismus. The mean vertical deviation was 12.56±3.81 (8~24) PD. All patients with horizontal strabismus had exotropia and the mean deviation was 10.57±4.58 (6~20) PD. A standard 10mm inferior oblique (IO) recession was performed uniformly at the paretic eye in all patients. In 7 of the patients (58.3%, exotropia greater than or equal to 10PD), horizontal rectus muscle recession was performed simultaneously. In these 7 cases, vertical and horizontal deviation less than or equal to 4PD was achieved (one patient with 10PD remaining hypertropia excluded). In 5 cases with exodeviation less than 10PD, isolated IO recession without horizontal rectus recession on the ipsilateral side achieved orthophoria in the primary position. In 9 cases of isolated SOP, all patients showed orthophoria in the primary position. Conclusions: This study demonstrates horizontal strabismus is combined with unilateral SOP in a high percentage of patients. Additionally, in all cases, all the incidents of horizontal deviation was involved exotropia. A standard 10 mm recession of the IO in combination with horizontal rectus recession is an effective surgical technique. It has an especially high success rate in patients with unilateral SOP (≤14PD vertical deviation) with exodeviation greater than 10PD. In patients with exodeviation less than 10PD, an isolated IO recession is sufficiently effective.

효소 , 대사물질 Streptomyces endus YP - 1 이 생산하는 항암활성 물질의 분리 및 정제

최성원,김병찬,최선진,김동섭,여익현,문순옥,오두환 ( Sung Won Choi,Byoung Chan Kim,Sun Jin Choi,Dong Seob Kim,Ick Hyun Yeo,Soon Ok Moon,Doo Hwan Oh ) 한국미생물생명공학회 1997 한국미생물·생명공학회지 Vol.25 No.5

캐니스터를 사용한 LPLi 엔진의 누설연료 저감에 관한 연구

최성원(Seongwon Choi),명차리(Cha-Lee Myung),박심수(Simsoo Park),한도(Doh Han),김현기(Hyun-Kee Kim) 한국자동차공학회 2005 한국자동차공학회 춘 추계 학술대회 논문집 Vol.2005 No.11_1

Liquid Phase LPG injection (LPLi) system has several advantages in more precise fuel metering and higher engine performance than those of the conventional type. On the other hands. leakage problem of LPLi system at the injector tip is a main obstacle for meeting more stringent future emission regulations because this phenomena might cause excessive amount of THC emission during cold and hot restart phase. The main focus of this paper is the development of leakage fuel recirculation system with activated carbon canister to eliminate the leaked fuel at intake system. Leaked fuel level was quantified using fast response THC analyzer. Finally, to confirm the adsorption efficiency of recirculation system in real LPLi vehicle, THC emission level was measured through FTP-75 mode. Vehicle test results shows that 70% of THC emission was reduced and stable engine operation was possible through suitable duty control.

〈코코〉를 통해 본 3D 디지털 애니메이션의 미학적 고찰

최성원(Choi, Sung-Won) 한국만화애니메이션학회 2018 만화애니메이션연구 Vol.- No.52

3D 디지털 애니메이션 "코코(Coco)"는 멕시코 공휴일인 망자의 날을 기반으로 ‘애드리안 몰리나가’가 각본을 ‘리 언크리치’가 집필·감독한 장편 3D 애니메이션으로 픽사(Pixar) 애니메이션 스튜디오가 제작하고 ‘월트 디즈니 픽쳐스’가 배급한 뮤지컬 영화이다. 이 장편 3D 애니메이션은 제90회 아카데미 장편 애니메이션 부문에서 작품 및 주제가상을 수상 하였다 3D 디지털 애니메이션 `코코(Coco)`가 가상현실 속에서 일어난 영화이고, 전통적 예술 형식과는 달리 시 · 공간의 범주를 동시에 포함하고 있지만 ‘코코’는 관객을 가상의 세계로 몰입시키고 감동 주었다. 그 이유는 작가와 감독이 현실의 ‘총체성’을 인식하고 이를 담고자 하는 확고하고도 생기 넘치는 세계관 때문이다. `코코(Coco)`가 관객에게 충족감을 준 이유는 영화 자체의 총체성을 기준으로 대상의 묘사와 스토리텔링의 서사 형식이 적용되어 있고 이 모든 과정 하나하나가 관찰자의 심리를 기준으로 전체적인 스토리의 서사와 묘사가 이루어졌으며, ‘코코’는 작품 그 자체로 충족한 자율성을 지니고 있음을 의미하디. 즉 작품을 보는 수용자는 자신의 지각행위 가운데 ‘코코’의 잠재적인 의미를 이해하게 되고 그 결과 관객은 ‘코코’를 가상의 캐릭터가 아닌 내 앞에 존재하는 캐릭터 즉 현실적인 의미 존재로 완성 시켰음을 증명하고 있다. 따라서 ‘코코’와 같은 3D 디지털 애니메이션은 형식적 특성에만 얽매이지 말고, 대상의 묘사와 대상들과의 관계라는 측면에서의 ‘서사’라는 상호 연계성 속에서 그리고 총체적 의미 내에서 이러한 단위들이 설명되어야 할 것이다. 즉 3D 애니메이션은 아직도 그 매체의 특성 때문에 예술로서 많은 논란이 있지만 3D 디지털 애니메이션의 형식적 특성과 더불어 예술의 근본적 문제인 상상력을 통해 질료적 형태로 어떻게 재현되는지를 밝힌다면 독자적인 예술의 한 장르로서 정립될 수 있다. 따라서 본 논문은 예술의 한 장르로서 승화시키기 위해 타자의 예술 양식이 되어버린 3D 디지털 애니메이션을 어떠한 방식으로 정의해야 하는지에 대해서 논해 보고자 한다. Coco is a 2017 American 3D computer-animated fantasy film produced by Pixar Animation Studios and released by Walt Disney Pictures. Based on an original idea by Lee Unkrich, it is directed by him and co-directed by Adrian Molina. The film`s voice cast stars Anthony Gonzalez, Gael García Bernal, Benjamin Bratt, Alanna Ubach, Renée Victor, Ana Ofelia Murguía, and Edward James Olmos. The story follows a 12-year-old boy named Miguel who is accidentally transported to the Land of the Dead, where he seeks the help of his deceased musician great-great-grandfather to return him to his family among the living. Coco, 3D animation, was said to be movie in virtual reality, and differed from traditional art to include time and space and to let spectator devote to virtual world. This was because `Coco` had autonomy of the work. The one who watched work could understand potential value of digital animation and to complete realistic existence. Therefore, digital animation like Coco should not be adhered to formal characteristics and should be described from point of view of mutual relation between description and object. After aesthetic reflection, 3D animation could be defined to be a genre of independent art. This study investigated definition of 3D animation being third party"s art form in order to make a genre of the art.

가열처리가 칡 이소플라본의 열 안정성에 미치는 영향

최성원(Sung-Won Choi),김경선(Kyung-Seon Kim),허남윤(Nam-Yun Hur),김동섭,안순철(Soon-Cheol Ahn),박천석(Cheon-Seok Park),김병용(Byung-Yong Kim),백무열(Moo-Yeol Baik),김대옥(Dae-Ok Kim) 한국생명과학회 2008 생명과학회지 Vol.18 No.10

열처리 조건 및 농도의 차이에 따른 칡 이소플라본인 daidzin과 genistin의 열 안정성에 대하여 조사하였다. Daidzin과 genistin 두 종류의 이소플라본은 처리방법에 상관없이 140℃이상의 열처리 조건에서 초기 30분 동안 급격히 열 안정성이 떨어지고 그 이후 변화가 적게 나타나 처리온도가 높을수록 열 안정성의 변화가 큰 것으로 나타났으며, genistin은 daidzin에 비해 농도차이 에 따른 변화의 차이가 크지 않은 것을 알 수 있었다. 또한 열처리 조건에 따른 반응속도는 모두 두 단계로 나타났는데, daidzin과 genistin 모두 2단계보다 1단계에서 빠른 반응속도를 보여 주었고, daidzin은 고농도 일 수록 더 빠른 반응속도를 나타내는 것을 알 수 있었으나, genistin은 농도에 따른 유의차가 적은 것을 알 수 있었다. Daidzin은 1단계의 고농도에서 온도 의존성이 높게 나타났으며 2단계는 농도에 따른 온도 의존성에 유의차가 없었다. Genistin의 경우 1단계에서는 농도에 의한 온도 의존성이 작게 나타났지만 2단계의 저농도에서 온도 의존성이 높은 것을 알 수 있었다. 농도에 따른 변화를 보면 genistin은 고농도와 저농도 모두 1단계에서 온도 의존성이 큰 것으로 나타났으며 반면 daidzin은 고농도, 저농도 모두 2단계에서 온도 의존성이 높은 것을 알 수 있었다. 또한 daidzin과 genistin 모두 140℃ 이상의 열처리에 의해 이소플라본 glucosidic group이 열에 의해 가수분해되어 daidzein, genistein, glycitein, malonyl-glycitin, acetyl-genistin 등의 중간 유도체 및 aglycone이 생성되며 140℃, 15 min의 처리 조건에서 대부분 가장 많은 양이 생성되는 것을 알 수 있었고, 농도 변화에 따른 함량의 증가는 유의차가 적은 것을 알 수 있었으나 그 중 malonyl daidzin의 경우 열처리 조건에 의해 따른 생성량의 차이가 큰 것을 알 수 있었다. 열처리 후 농축조건이 농축 후 열처리보다 더 많은 daidzin, genistin 유도체들을 생성시킨 것으로 보아 칡 이소플라본의 각 열처리 조건에 따른 열 안정성은 농축 후 열처리보다 열처리 후 농축이 훨씬 더 열에 안정하다는 것을 알 수 있었다. 따라서 칡 이소플라본의 열안정성은 콩 이소플라본과 유사하게 140℃ 이상 열처리에 의해 가수분해반응을 보였고, 이소플라본의 중간 유도체들과 aglycone이 140℃ 이상의 열처리 시 생성되었다. 따라서 칡 이소플라본의 열 안정성은 가열온도와 농도에 의해 큰 영향을 받으며, 콩 이소플라본의 열 안정성과 매우 유사한 특성을 나타내었다. Effect of heat processing on thermal stability of kudzu root isoflavone was investigated for future use such as various processed foods and functional foods. Kudzu root extracts were heated at 80, 100, 121, 140, 165, and 180℃ for up to 90 minutes before and after concentration, respectively. Changes in the amount of isoflavones were monitored using HPLC and thermal stability was investigated using Arrhenius equation. The amount of both daidzin and genistin decreased slightly during heating at 80, 100 and 121℃ but decreased significantly above 140℃. This indicated that daidzin and genistin are stable at temperatures near the boiling point of water. The degradation of both daidzin and genistin occurred in two steps and each step showed typical first order kinetic. The degradation rates were faster in the first step than the second step in both daidzin and genistin. Additionally, the degradation was accelerated when they heated after concentration compared to the sample heated before concentration. These results suggested that degradation of kudzu root isoflavone was highly dependent on both their concentration and heating temperature. This study provides the basic information on thermal stability of kudzu root isoflavones, which can be used for future processing of functional foods.

목회자 리더십의 방향과 개발에 관한 연구

최성원(Sung Won Choi) 개혁주의교회성장학회 2017 개혁주의 교회성장 Vol.- No.10