19개월 여아에서 metofluthrin 살충제 섭취 후 발생한 급성 호흡곤란

최다연,김경원,윤서희 대한소아응급의학회 2023 대한소아응급의학회지 Vol.10 No.3

Metofluthrin is a volatile pyrethroid insecticide. Despite being widely used as a safe household insecticide, it could cause severe systemic symptoms. A 19-month-old girl was taken to the emergency department after ingesting 1 mL of a mosquito repellent containing metofluthrin. After the arrival, the girl developed respiratory distress, which worsened progressively despite the administration of oxygen with nebulized salbutamol and budesonide. Additionally, she underwent application of high-flow nasal cannula, and administration of activated charcoal and systemic steroids. Her dyspnea gradually improved, and she was thus discharged on day 4 with oral prednisolone. All medications were discontinued 10 days after the discharge without any complication. Respiratory distress can develop after the ingestion of even a small amount of metofluthrin. Symptomatic and adjunctive steroid therapies can be effective therapeutic options.

ESG 경영과 유한킴벌리의 ESG 실천 사례 : 자원순환경제 중심으로

최다연,김승진,이인석 한국국제문화교류학회 2024 문화교류와 다문화교육 Vol.13 No.1

In the 21st century, environmental and climate challenges become essential issues. This study aims to respond to the global climate crisis and spread carbon neutrality through the case study of ESG management practices of Yuhan- Kimberly. The circular economy is an alternative economic model that pursues a sustainable environment through resource conservation and recycling. Despite its reputation for reducing carbon emissions and plastic use and practicing environmental management to achieve carbon neutrality, the questions have been raised about resource circulation issues in its major products and ESG washing in its actual environmental performance in terms of ESG management. In terms of circulator economy for sustainable development of Yuhan-Kimberly, the following suggestions were made. First, economic benefits such as improving competitiveness, reducing operating costs, and increasing sales will be achieved. Second, in terms of environmental benefits, sustainable resource utilization and greenhouse gas reduction can contribute to reducing resource consumption, minimizing waste, and protecting ecosystems. Third, the social benefits can increase through the cooperation and participation of stakeholders. Fourth, it is necessary to activate the policy of circulator economy with ESG management. Key words

상사의 비인격적 감독이 부하의직장-가정 갈등에 미치는 영향 : 부하의 회복탄력성과 감성지능, 조직지원인식의 조절효과를 중심으로

최다연,이형석,정무관,이현규,이인석 경남대학교 산업경영연구소 2021 지역산업연구 Vol.44 No.4

The purposes of this research are (a) to examine the main effect of abusive supervision on work-family conflict, and (b) to examine whether employee’s individual factors (resilience, emotional intelligence) and organizational factor (perceived organizational support) moderate the main effect empirically. To verify the hypothesis empirically, 136 validate data was used as the analysis data of this study. As a result, abusive supervision has a significant positive effect on work-family conflict. Regarding the moderator testing, subordinate’s resilience has a buffer effect on the relationship between abusive supervision and work-family conflict. However, emotional intelligence and perceived organizational support have no significant moderating effects on the main relationship. 상사의 비인격적 감독이 부하에게 미치는 영향에 관한 연구들이 활발하게 이루어지고 있지만, 관리적 측면에서 비인격적 감독의 부정적 효과를 감소시키는 방안에 관한 연구는 부족하였다. 이에 따라, 본 연구에서는 상사의 비인격적 감독과 직장이 직장-가정 갈등에 어떤 영향을 미치고, 이를 조절하는 개인 특성(회복탄력성, 감성지능) 및 조직 특성(조직지원인식)의 변수의 효과를 파악하고자 하였다. 136명의 종업원을 대상으로 실증적 검증을 한 결과, 비인격적 감독은 직장-가정 갈등에 유의한 정(+)의 영향을 미치는 것으로 밝혀졌다. 조절효과 검증에서는 회복탄력성이 비인격적 감독과 직장-가정 갈등의 관계를 완충 효과로써 조절하는 것으로 밝혀졌다. 그러나 감성지능과 조직지원인식은 예상과 달리 유의한 조절변수가 되지 못하는 것으로 나타났다.

지역난방 시스템 배관 부식방지를 위한 기체분리막 탈산소 성능 및 파일럿 플랜트 적용 평가

최다연,진용쉰,손아섬,백수민,박성수,홍석원 대한환경공학회 2018 대한환경공학회 학술발표논문집 Vol.2018 No.11

삼종염(Potassium monopersulfate)을 주성분으로 하는 소독제의 주요 수산 병원체에 대한 살균소독 효과

최다연,최희재,조아현,서정우,박지원,나정현,이병윤,김준환,강예재 한국어병학회 2023 한국어병학회지 Vol.36 No.1

Infectious diseases are a major cause of death at the fish farm. Therefore, various disinfectants are used in aquaculture to sterilize pathogens. In this study, the disinfectant efficacy of triple salt was evaluated against Salmonella typhimurium and important aqua pathogens. In the case of bacteria under the conditions of distilled water (DW), hard water (HW), and organic matter (OM), S. typhimurium was inactivated with 0.56, 0.5 and 100 parts per thousands (ppt), V. parahaemolyticus (AHPND) was inactivated with 0.17, 0.13 and 20 ppt and V. anguillarum was inactivated with 0.25, 0.17 and 33.3 ppt. Also, in the case of the virus under the conditions DW, HW and OM, VHSV was inactivated with 0.1, 0.1 and 0.5 ppt and SVCV was inactivated with 0.5, 0.5 and 1 ppt. In addition, this study investigated the disinfection effect of triple salt against WSSV by bioassay using Litopenaeus vannamei. Investigating the antiviral effect of disinfectants under DW, HW, and OM conditions, WSSV was inactivated with 0.05, 0.05, 0.8 ppt. The results from this study showed that the triple salt was a highly effective disinfectant against aqua pathogens. Therefore, we can provide basic data for establishing the standards for use of triple salt in aquaculture.

Conjugation strategies of DNA to gold nanoparticles

최다연,김수현,오정욱,남좌민 대한화학회 2022 Bulletin of the Korean Chemical Society Vol.43 No.12

DNA-modified gold nanoparticles (NPs) have been extensively explored in vari- ous applications including the construction of three-dimensional (3D) assembly architectures and biomedical applications. As ligand molecules, DNA strands can facilitate the building block function of gold NPs due to the inherent nature of DNA bonding, that is, Watson–Crick base pairing. In addition, the negative electrostatic character of DNA backbones renders colloidal gold NPs stability and robustness under various aqueous environments. Therefore, DNA conjugation to gold NP surfaces is a key step for stabilizing, controlling, and uti- lizing DNA-modified gold NPs, and the working conjugation strategy should be employed and implemented for a specific application. This review covers vari- ous DNA conjugation strategies to gold NPs with fundamental binding features of DNA strands with varying functional groups to gold NP surfaces. DNA graft- ing density and directional grafting strategies on gold NPs are also discussed, which is a key factor to construct 3D NP assembly architectures via DNA hybridization.

DNA topoisomerase 억제제인 β-lapachone에 의한 인체 간암 및 방광암세포 증식억제에 관한 연구

최다연,이재일,정협섭,서한결,우현주,최영현,Choi Da Yean,Lee Jae Il,Chung Hyun Sup,Seo Han Gyeol,Woo Hyun Joo,Choi Yung Hyun 한국생명과학회 2005 생명과학회지 Vol.15 No.3

남미지역에서 자생하는 Tabebuia avellanedae라는 나무의 수피에서 동정된 quinone계 물질이며, DNA topoisomeras억제제로 알려진 $\beta-lapachone$의 항암작용에 관한 부가적인 자료를 얻기 위하여 인체 간암(HepG2) 및 방광암(T24)세포를 대상으로 조사한 결과 다음과 같은 결과를 얻게 되었다. MTT assay 및 flow cytometry 분석 등의 결과에서, $\beta-lapachone$의 처리에 따라 조사된 두 가지 암세포에서 $\beta-lapachone$처리 농도의존적으로 암세포의 심한 형태적 변형이 동반되면서 암세포의 증식이 억제되었으며, 생존율이 저하되었고 이는 apoptosis유발과 상관성이 있음을 알 수 있었다. $\beta-lapachone$처리에 의한 두 암세포의 증식억제는 종양억제 유전자 p53 및 Cdk inhibitor p21의 발현과는 큰 연관성이 없음을 RT-PCR 및 Western blot analysis를 통하여 확인하였다. 그러나 전사조절인자 Sp-1 및 세포증식 주요조절인자인 PCNA의 단백질 발현은 $\beta-lapachone$처리에 따라 매우 감소되었으며, telomere조절에 중요한 인자들의 선택적 발현 저하 현상도 관찰되었다. 이상의 결과들은 인체 암세포에서 $\beta-lapachone$의 항암작용을 이해하는 중요한 자료가 될 것이며, $\beta-lapachone$과 유사한 화학적 구조 및 성질을 가지는 항암제 후보물질들의 항암기전 비교 및 항암제 개발을 위한 기초 자료로서 응용될 것이다. The objective of the present study was to investigate the effect of $\beta-lapachone$, a quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) in South America, on the cell growth of human hepatoma (HepG2) and bladder (T24) carcinoma cells. Exposure of cancer cells to $\beta-lapachone$ resulted in growth inhibition, morphological changes and apoptosis in a concentration-dependent manner, which could be proved by MTT assay and flow cytometry analysis. Reverse transcription-polymerase chain reaction (RT-PCR) and Western blot analyses revealed that $\beta-lapachone$ did not affect the levels of tumor suppressor p53 and cyclin-dependent kinase (Cdk) inhibitor p21 (WAFl/CIPl) expression. However, the transcriptional factor Sp-l and proliferating cell nuclear antigen (PCNA) protein levels were significantly down-regulated by $\beta-lapachone$ in both cell lines. Moreover, $\beta-lapachone$ treatment caused a dose-dependent inhibition of the expression of telomere regulatory gene products such as human telomere reverse transcriptase (hTERT) and telomerase-associated protein-l (TEP-l). Taken together, these findings suggest that $\beta-lapachone$-induced inhibition of human hepatoma and bladder carcinoma cell proliferation is associated with the induction of apoptotic cell death via modulation of several major growth regulatory gene products, and provide important new insights into the additional mechanisms of the anti-cancer activity of $\beta-lapachone$.

물리치료사의 고용의 질이 직무자율성과 직무스트레스에 미치는 영향

최다연,황지민,심재훈 한국신경근육물리치료학회(구 한국신경근육재활학회) 2020 한국신경근육재활학회지 Vol.10 No.3

The purpose of this study was to investigate how the physical therapists’ employment quality is affecting job autonomy and job stress. Through this study, we hope to provide physical therapists with basic data for improving working conditions in the future. 355 physical therapists who are currently working in clinical setting completed the survey. The questionnaire used in this study consists of 60 questions in total, which include questions about the general characteristics of the study subjects, quality of work, job autonomy, and job stress. The collected data were analyzed using independent t-test, one-way ANOVA, pearson correlation analysis, and multiple regression analysis. The mean score of quality of employment was 58.30 points. Job autonomy was 69.56 points, and job stress was 45.72 points. There was a positive correlation between the quality of employment and job autonomy, and a negative correlation between quality of employment and job stress. A negative correlation between job autonomy and job stress. Therefore, the results of this study suggest that higher the physical therapists’ quality of employment, more autonomy they have to work and less stress.

직장-가정 갈등 발생의 원인 및 해결방안에 대한 연구: 구성원들의 회복탄력성, 조직지원인식을 중심으로

최다연,이형석,이인석,이현규,김승진 대한산업경영학회 2023 산업융합연구 Vol.21 No.5

We examine the relationship between abusive supervision and work-family conflict, and the moderating effects of employee’s resilience and perceived organizational support. We collected the employees’ sample(n=136) and conducted multiple hierarchical regression analysis. Abusive supervision has a significant positive effect on work-family conflict. Subordinate’s resilience has a buffer effect on the main relationship, but perceived organizational support has no significant moderating effect. This study will be helpful for employees who are suffered from work-family conflict. 본 연구는 직장-가정 갈등의 직장 차원의 원인 중 하나를 비인격적 감독으로, 해결방안이 될 개인 특성을 회복탄력성, 조직적 조치를 조직지원인식으로 보고 자원보존이론의 자원 손실, 자원 투자, 자원 대체 차원에서 실증연구를 실시하였다. 수도권 소재의 기업에 근무하는 직장인 136명을 대상으로 위계적 회귀분석을 실시한 결과, 비인격적 감독은 직장-가정갈등에 정(+)의 영향을 미치는 것으로 밝혀졌다. 조절효과 분석의 경우, 회복탄력성이 비인격적 감독과 직장-가정 갈등의 관계를 완화하는 방향으로 조절하는 것으로 밝혀졌다. 그러나 조직지원인식은 조절하지 못하는 것으로 나타났다. 본 연구는 비인격적 감독처럼 가정에도 영향을 미치는 직장 스트레스요인에 쉽게 노출되는 국내 직장인들에게 유용할 것이다. 기업은 직원이 겪는 직장문제가 가정문제에 지장이 되지 않도록 상사와 관련된 스트레스요인을 해결하고 직원의 회복탄력성을 함양하되, 향후에 일방적인 조직지원보다 다른 사회적 지원 및 조직적 조치를 찾아야 한다.

냉·난방순환수 배관 내 부식방지를 위한 중공사막의 산소제거 성능평가

최다연 ( Dayeon Choi ),진용쉰 ( Yongxun Jin ),홍승관 ( Seungkwan Hong ),홍석원 ( Seok Won Hong ),박찬혁 ( Chanhyuk Park ) 한국물환경학회(구 한국수질보전학회) 2018 한국물환경학회·대한상하수도학회 공동 춘계학술발표회 Vol.2018 No.-