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한국산망개나무 추출액이 비알코올성 지방간 쥐에 미치는 효과
최석철,주미하,이길현 사단법인 인문사회과학기술융합학회 2015 예술인문사회융합멀티미디어논문지 Vol.5 No.3
This study was designed to examine effects of Korean Berchemia berchemiaefolia (Makino) Koidz (BBK) on diet induced-fatty liver. 45 male SD rats were divided into three groups: normal diet (control group, n=15), 40% fat diet-induced obese rats (fat group, n=15), and BBK extract diet with 40% fat diet-induced obese rats (BBK group, n=15). Hematological and biochemical variables were measured. Total leukocyte, neutrophil, neutrophil/lymphocyte ratio, erythrocyte, platelet, hemoglobin, and red distribution width levels were significantly lower than in BBK group than in fatty group. Glucose, total cholesterol, triglyceride, LDL-cholesterol, and BUN levels in BBK group were significantly lower than those of fatty group. BBK group showed significantly lower liver fatty degeneration (steatosis). These results suggest that Korean Berchemia berchemiaefolia (Makino) Koidz exerts anti-inflammatory, anti-obesity and ameliorative liver fatty degeneration effects. 본 연구는 한국산 망개나무(BBK)가 식이로 유도된 지방간에 미치는 영향을 알아보기 위하여 실행되었다. 총 45마리의 SD 쥐를 다음 3개의 그룹으로 분류하였다: 정상 식이 rat(n=15), 40% 지방 식이로 유도된 비만 rat(n=15), 비만 rat에 BBK 투여군(n=15). 혈액학적 분석에서는 BBK 투여군에서 총 백혈구, 호중구, 호중구/림프구 비율, 적혈구, 혈소판, 헤모글로빈, RDW의 값이 비만그룹에 비하여 유의하게 낮았으며 생화학적 분석에서는 포도당, 총 콜레스테롤, 트리글리세라이드, LDL-콜레스테롤, BUN의 농도가 비만그룹에 비하여 BBK 투여군에서 유의하게 낮은 수준을 보였다. 그리고 BBK 투여군은 다른 군들에 비하여 현저히 낮은 지방간화 진행을 보여주었으며 이러한 결과를 종합하여 볼 때 한국산 망개나무는 항염증, 항비만, 지방간 개선효과를 가지고 있다고 사료된다.
Correlation between the time elapsed after liposuction and the risk of fat embolism: An animal model
임광열,조정민,윤청민,이근철,이상윤,주미하 대한성형외과학회 2018 Archives of Plastic Surgery Vol.45 No.1
Background Liposuction has become one of the most frequently performed procedures in the field of aesthetic surgery. Fat embolism syndrome after liposuction can easily be overlooked or underestimated; however, occasionally, fulminating fat embolism syndrome can develop and lead to a critical situation within 2–3 days after lipoplasty. Changes over time in the amount of circulating fat particles and the histology of major organs have not yet been studied. Methods This study was conducted using 18 male Sprague-Dawley rats aged 12 weeks and weighing 500–628 g (average, 562 g). Fifteen rats were used as the experimental group and 3 as the control group. Under general anesthesia, tumescent-technique liposuction was performed at the lateral flank areas and abdomen for 1 hour. Blood, lung, and brain tissue specimens were obtained at 1 hour, 1 day, and 2 days after the liposuction procedure. Results The average number of fat particles in the blood samples was 25,960/dL at 1 hour, 111,100/dL at 24 hours, and 21,780/dL at 48 hours. The differences between study groups were statistically significant. Both intravascular and extravascular fat particles with inflammation were seen in all 15 rats, as were inflammatory cell infiltration, hemorrhage, and consolidation with shrinkage of the lung alveoli. Conclusions These results imply that there is a strong possibility of fat embolism syndrome after liposuction in real clinical practice, and the first 24–48 hours after the operation were found to be the most important period for preventing pulmonary embolism and progression to fulminating fat embolism syndrome.
변경도,황효준,박기재,김민찬,조세헌,주미하,이진화,정진숙 한국유방암학회 2018 Journal of breast cancer Vol.21 No.4
Purpose: T-cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3) is an emerging immune response molecule related to T-cell anergy. There has been tremendous interest in breast cancer targeting immune checkpoint molecules, especially in the triple-negative breast cancer (TNBC). This study was designed to investigate TIM-3 expression on tumor infiltrating lymphocytes (TILs), its relationships with clinicopathological parameters and expression of programmed death receptor 1 (PD-1)/ programmed death receptor ligand 1 (PD-L1), and its prognostic role. Methods: Immunohistochemistry on tissue microarray blocks produced from 109 samples of invasive ductal carcinoma type TNBC was performed with antibodies toward TIM-3, PD-1, PD-L1 and breast cancer-related molecular markers. Associations between their expression and clinicopathological parameters as well as survival analyses were performed. Results: TIM-3 was expressed in TILs from all 109 TNBCs, consisting of 17 cases (<5%), 31 cases (6%–25%), 48 cases (26%–50%), and 13 cases (>51%). High TIM-3 was significantly correlated with younger patients (p=0.0101), high TILs (p=0.0029), high tumor stage (p=0.0018), high PD-1 (p=0.0001) and high PD-L1 (p=0.0019), and tended to be associated with higher histologic grade, absence of extensive in situ components and microcalcification. High TIM-3 expression was significantly associated with a combinational immunophenotype group of high PD-L1 and high PD-1 (p<0.0001). High TIM-3 demonstrated a significantly better disease-free survival (DFS) (p<0.0001) and longer overall survival (OS) (p=0.0001), together with high TILs and high PD-1. In univariate survival analysis, high TIM-3 showed reduced relapse risk (p<0.0001) and longer OS (p=0.0003), together with high PD-1 expression. In multivariate analysis, high TIM-3 was statistically significant in predicting prognosis, showing better DFS (hazard ratio [HR], 0.0994; 95% confidence interval [CI], 0.0296–0.3337; p=0.0002) and longer OS (HR, 0.1109; 95% CI, 0.0314–0.3912; p=0.0006). Conclusion: In this study, we demonstrate that TIM-3 expression is an independent positive prognostic factor in TNBC, despite its association with poor clinical and pathologic features.