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변경도,황효준,박기재,김민찬,조세헌,주미하,이진화,정진숙 한국유방암학회 2018 Journal of breast cancer Vol.21 No.4
Purpose: T-cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3) is an emerging immune response molecule related to T-cell anergy. There has been tremendous interest in breast cancer targeting immune checkpoint molecules, especially in the triple-negative breast cancer (TNBC). This study was designed to investigate TIM-3 expression on tumor infiltrating lymphocytes (TILs), its relationships with clinicopathological parameters and expression of programmed death receptor 1 (PD-1)/ programmed death receptor ligand 1 (PD-L1), and its prognostic role. Methods: Immunohistochemistry on tissue microarray blocks produced from 109 samples of invasive ductal carcinoma type TNBC was performed with antibodies toward TIM-3, PD-1, PD-L1 and breast cancer-related molecular markers. Associations between their expression and clinicopathological parameters as well as survival analyses were performed. Results: TIM-3 was expressed in TILs from all 109 TNBCs, consisting of 17 cases (<5%), 31 cases (6%–25%), 48 cases (26%–50%), and 13 cases (>51%). High TIM-3 was significantly correlated with younger patients (p=0.0101), high TILs (p=0.0029), high tumor stage (p=0.0018), high PD-1 (p=0.0001) and high PD-L1 (p=0.0019), and tended to be associated with higher histologic grade, absence of extensive in situ components and microcalcification. High TIM-3 expression was significantly associated with a combinational immunophenotype group of high PD-L1 and high PD-1 (p<0.0001). High TIM-3 demonstrated a significantly better disease-free survival (DFS) (p<0.0001) and longer overall survival (OS) (p=0.0001), together with high TILs and high PD-1. In univariate survival analysis, high TIM-3 showed reduced relapse risk (p<0.0001) and longer OS (p=0.0003), together with high PD-1 expression. In multivariate analysis, high TIM-3 was statistically significant in predicting prognosis, showing better DFS (hazard ratio [HR], 0.0994; 95% confidence interval [CI], 0.0296–0.3337; p=0.0002) and longer OS (HR, 0.1109; 95% CI, 0.0314–0.3912; p=0.0006). Conclusion: In this study, we demonstrate that TIM-3 expression is an independent positive prognostic factor in TNBC, despite its association with poor clinical and pathologic features.
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Preparation and properties of thermoplastic polyurethane nanocomposites containing nanosilica
이단비,한동훈,황효준,이창근,김영민 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1
Display 산업이 발전함에 따라 LCD, OLED 등의 생산 공정에 점착 패드를 필요로 한다. Nano-composite pad는 편광 필름, 특수 필름 등의 자동 합지를 위한 공정용 점착패드로 공정 시 필요한 부착기술이 부착 방식에 따라 발전해 왔다. 기존 제품의 경우 Liner/점착제/아크릴 폼/PET 구조로 되어있는데 아크릴 폼의 경우 반복 사용 시에 형태 변형으로 인한 내구성 약화가 문제되고 있다. 본 연구에서는 Nano-composite 기술을 도입하여 안정적인 점착력과 높은 반복 사용 횟수를 위해 thermoplastic polyurethane (TPU) nanocomposite 적용 연구하였다. 극성 고분자 조성 및 표면 처리된 나노실리카 함량에 따른 Nano-composite pad의 기계적 강도, 표면 특성, 점착력 및 반복 내구성 변화를 측정하여 최적의 TPU nanocomposite 조성물을 확인하였다. 또한 TPU nanocomposite 조성물의 컴파운딩 공정 및 blending 조건 확보를 통해 Nano-composite pad 조성물 및 제조 기술 개발 연구하였다.
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