Feasibility of Intraoperative Radiotherapy Tumor Bed Boost in Patients with Breast Cancer after Neoadjuvant Chemotherapy

조연아,양고운,김준원,이익재,정준,안성귀,배숭준,김지형 연세대학교의과대학 2024 Yonsei medical journal Vol.65 No.3

Purpose: This study aimed to assess the feasibility and safety of administering intraoperative radiotherapy (IORT) as a boost dur ing breast-conserving surgery (BCS) following neoadjuvant chemotherapy for patients at high risk of breast cancer recurrence. Materials and Methods: Patients who underwent neoadjuvant chemotherapy received a single 20-Gy dose of IORT during BCS, followed by external beam radiotherapy 4–6 weeks after surgery. Results: The median follow-up duration was 31.0 months (range, 18.0–59.0 months). Initial tumor sizes had a median of 2.6 cm (range: 0.8–5.3 cm), reducing to 0.3 cm (range: 0–4.0 cm) after neoadjuvant chemotherapy. The most common neoadjuvant che motherapy regimen was doxorubicin and cyclophosphamide, followed by paclitaxel (n=42, 73.7%). Among 57 patients who re ceived neoadjuvant chemotherapy before BCS and IORT, 2 patients (3.5%) required secondary surgery to achieve negative resec tion margins due to initially positive margins. Regional lymph node irradiation was performed in 37 (64.9%) patients. There was no grade 3 or higher adverse events, with 4 patients (7.0%) experiencing grade 2 acute radiation dermatitis and 3 (5.3%) having less than grade 2 breast edema. Binary correlation analysis did not reveal statistically significant associations between applicator size or radiation therapy modality and the risk of treatment-related toxicity. Furthermore, chi-square analysis showed that the grade of treatment-related toxicity was not associated with the fractionated regimen (p=0.375). Conclusion: Most patients successfully received IORT as a tumor bed boost after neoadjuvant chemotherapy. Thus, IORT may be a safe and feasible option for patients with advanced-stage breast cancer receiving neoadjuvant chemotherapy.

Intraoperative Radiotherapy for Resectable Pancreatic Cancer Using a Low-Energy X-Ray Source: Postoperative Complications and Early Outcomes

조연아,김준원,김형선,박준성,이익재 연세대학교의과대학 2022 Yonsei medical journal Vol.63 No.5

Purpose: We evaluated the safety, feasibility, and early treatment outcomes of intraoperative radiotherapy (IORT) using a lowenergyX-ray source. Materials and Methods: Patients with resectable pancreatic cancer were enrolled in this single-institution, prospective, singlearm,phase II trial. Patients underwent surgery and IORT with 10 Gy prescribed at a 5-mm depth from the tumor bed using a 50 kVX-ray source (Intrabeam, Carl Zeiss). Six cycles of adjuvant gemcitabine-based chemotherapy were administered 8–12 weeks aftersurgery. Results: A total of 41 patients were included. Thirty-one patients (75.6%) underwent wide R0 resection, while 5 (12.2%) underwentR1 resection and 5 (12.2%) underwent narrow R0 resection (retroperitoneal margin <1 mm). Grade 3 postoperative complicationswere reported in only one patient (4.9%) who needed additional surgery due to ulcer perforation. At a median follow-up of 9 months,four patients showed local-only recurrence, nine had distant metastases, and two showed both local and distant recurrence. The1-year local control rate was 76.4%. Conclusion: Our preliminary report suggests that IORT is well-tolerated and feasible in patients with resectable pancreatic cancer. Further follow-up is needed to confirm the clinical benefits of IORT in terms of local control and overall survival. Trial Registration: Clinical trial registration No. (NCT03273374).

Ruthenium-106 Brachytherapy with or without Additional Local Therapy Shows Favorable Outcome for Variable-Sized Choroidal Melanomas in Korean Patients

조연아,장지석,윤진숙,이성철,김용배,김주호,금기창 대한암학회 2018 Cancer Research and Treatment Vol.50 No.1

Purpose The purpose of this study was to report clinical outcomes of ruthenium-106 (106Ru) brachytherapy with or without additional local therapy for choroidal melanomas in Korean patients. Materials and Methods A total of 88 patients diagnosed with choroidal melanomas were treated with 106Ru brachytherapy between 2006 and 2012. Patients were divided into two groups according to their tumor height: a large group (! 6 mm, n=50) and a small group (< 6 mm, n=38). Most patients in the large group received combined therapy with local excision and/or transpupillary thermotherapy. In general, 85-95 Gy was administered to the apex of the tumor, while 100 Gy was administered to the point 2-6 mm from the outer surface of the sclera for patients undergoing combined therapy. Results The median follow-up duration was 30 months. The 3-year local control rate was significantly higher in the small group than in the large group (94% vs. 70%, p=0.047). The free from distant metastasis (FFDM) rate and the overall survival (OS) rate were also higher in patients in the small group (3-year FFDM, 97% vs. 76%; p=0.031 and 3-year OS, 97% vs. 72%; p=0.036). A total of 13 patients underwent enucleation. The eye-preservation rate was also higher in the small group (3-year eye-preservation rate, 94% vs. 70%; p=0.050), and tumor height was a significant prognostic factor for eye-preservation. Conclusion 106Ru brachytherapy showed favorable outcomes in small choroidal melanomas in Korean patients. Although additional local treatment could improve eye-preservation rate for large tumors, other strategies should be considered for disease control.

기업가정신과 외국시장 성과간의 경로에 관한 연구 - 동적 역량과 경쟁우위를 중심으로 -

조연성,원동환 한국국제경영관리학회 2011 국제경영리뷰 Vol.15 No.4

본 연구는 기업가정신이 외국시장 성과에 영향을 미치는 경로를 살펴보기 위해 동적 역량과 경쟁우위를 기업가정신과 성과 사이에 배치해 분석하였으며, 동적 역량과 경쟁우위가 어떠한 역할을 하는지 세부적으로 살펴보는 것에 목적을 두었다. 실증분석을 위해 외국시장에서 판매활동을 하는 386개 기업을 표본으로 하였으며, 선행연구 고찰을 통해 기업가정신, 동적 역량, 경쟁우위, 외국시장 성과에 대한 9개의 가설을 설정하여 분석하였다. 분석결과 기업가정신은 동적 역량과 경쟁우위에 긍정적 영향을 주는 것으로 나타났으나 성과에는 영향이 없는 것으로 파악되었으며, 동적 역량은 경쟁우위와 성과에 모두 유의한 영향을 미치고, 경쟁우위도 성과에 긍정적인 영향을 주는 것으로 확인되었다. 또한 동적 역량과 경쟁우위의 역할을 효과분해를 통한 매개 효과 검정으로 살펴보았는데, 효과분해 결과 동적 역량은 기업가정신과 경쟁우위의 관계에 긍정적인 매개역할을 하고 있었다. 더불어 경쟁우위도 동적 역량과 성과 사이에 유의한 매개 효과를 가지는 것으로 나타났으며, 동적 역량과 경쟁우위는 기업가정신을 성과에 매개하고 있음도 확인되었다. 이러한 결과는 외국시장 진출기업에 기업가정신을 통한 동적 역량과 경쟁우위 구축이 외국시장 성과를 높이는데 도움을 준다는 점을 시사한다. The aim of this study is to empirically examine the influence of entrepreneurship, dynamic capability and competitive advantage factors on foreign market performance of enterprise and to examine the mediated effect of dynamic capability and competitive advantage factor as well. To achieve the aim above, the research framework has been developed with entrepreneurship factor, dynamic capability and competitive advantage and foreign market performance. Nine hypotheses have been proposed and tested on 386 enterprise using LISREL. Research findings suggest that entrepreneurship factor influences positively on dynamic capability and competitive advantage, except of foreign market performance of enterprise. Also, dynamic capability has positive impacts on competitive advantage and foreign market performance as well. And competitive advantage has significant impacts to foreign market performance. About the test of mediated effect, the dynamic capability has a mediated impact to entrepreneurship on competitive advantage and the competitive advantage has same impact to dynamic capability on performance. Also, dynamic capability and competitive advantage factors have a full mediated effect on the relationship entrepreneurship and foreign market performance.

티오요소와 염산 혼합 용액에서 사이클론 전해에 의한 은(Ag) 회수

조연철,소홍일,이주은,안재우,류호진,Cho, Yeon-Chul,So, Hong-Il,Lee, Joo-eun,Ahn, Jae-Woo,Ryu, Ho-Jin 한국자원리싸이클링학회 2017 資源 리싸이클링 Vol.26 No.4

A cyclone type electrolytic method was used to recover silver from thiourea-hydrochloric acid mixed solutions. The electrowinning behavior of silver was investigated in different systems, such as the flow rate, current density, silver concentration, thiourea concentration and hydrochloric acid concentration. As the increase of the flow rate, current density and hydrochloric acid concentration, the recovery rate of silver was increased. Whereas, as the increase of silver concentration, the recovery rate of silver was decreased. The thiourea concentration did not affect the Ag recovery and current efficiency. Above 99% of Ag was recovered at the flow rate of 12 L/min., current density of $0.75A/dm^2$, silver concentration of 1.0 g/L, 0.5 M thiourea and 0.1 M hydrochloric acid. In most experimental conditions, silver was recovered as a powder form. 티오요소와 염산 혼합 용액 중 은(Ag)을 금속으로 회수하기 위해 사이클론 전해법을 이용하였다. 유속, 전류밀도, 은 농도, 티오요소 농도, 염산 농도를 주요 변수로 하여 은의 전해회수 거동을 살펴보았다. 유속, 전류밀도와 염산 농도가 증가할수록 은의 회수속도가 증가하였으며, 은 농도가 증가함에 따라 은의 회수 속도는 감소하였고, 티오요소 농도는 은 회수율과 전류효율에는 큰 영향이 없었다. 유속 12 L/min., 전류밀도 $0.75A/dm^2$, 1 g/L Ag, 0.5 M Thiourea, 0.1 M HCl에서 실험하였을 경우 99% 이상의 은 회수율을 보였다. 대부분의 실험 조건에서 은(Ag)은 분말 형태로 회수되었다.

경희토류(La, Ce, Pr, Nd, Sm) 혼합용액에서 Cyanex 572에 의한 추출·분리 거동 고찰

조연철,이주은,소홍일,안재우,김홍인,이진영,Cho, Yeon-Chul,Lee, Joo-Eun,So, Hong-Il,Ahn, Jae-Woo,Kim, Hong-In,Lee, Jin-Young 한국자원리싸이클링학회 2017 資源 리싸이클링 Vol.26 No.4

Cyanex 572에 의한 경희토류 다성분 혼합 용액에서 La, Ce, Pr, Nd, Sm의 분리특성에 대해 연구하였다. 5성분계 혼합 용액에서 추출제 농도가 증가할수록 5성분 모두 $pH_{50}$(추출율이 50%인 pH) 값은 감소하였다. 추출제 농도 0.6 M 이상에서 La과 Ce, Nd와 Sm 는 10 이상의 분리계수 값을 보인 반면, Ce과 Pr, Pr과 Nd 사이의 분리계수는 0.5~2.2로 낮았다. 분리계수 개선을 위해 0.6 M Cyanex 572에 TBP를 첨가하였으나 상 분리 속도나 분리계수 개선 효과는 나타나지 않았다. 실험 결과를 고찰한 결과, La/(Pr, Nd, Sm) 그룹과 (Pr, Nd)/Sm 의 경우는 그룹 별 분리는 가능할 것으로 보이나, (La, Ce) 과 (Pr, Nd)의 그룹분리는 Ce와 Pr 사이의 분리계수가 낮아 어려울 것으로 사료된다. Extraction and separation behaviors of La, Ce, Pr, Nd and Sm from light rare earth multi - component mixed solutions by Cyanex 572 were studied. As extractant concentration increased, the $pH_{50}$ values of all the five components decreased. When extractant concentration was larger than 0.6 M, the separation factor of La and Ce, Nd and Sm was higher than 10, while the separation factor between Ce and Pr, Pr and Nd was as low as 0.5~2.2. Addition of TBP to the 0.6 M Cyanex 572 had little synergistic effect on the phase separation rate and separation factor. From the analysis of experiment results, group separation of [La]/[Pr, Nd, Sm] and [Pr, Nd]/[Sm] could be possible, but in case of the group separation between [La, Ce] and [Pr, Nd] was not available because of the low separation factor between Ce and Pr.

기존 부적격 건출물의 특례제도에 관한 연구 (한일간의 비교법적 고찰을 통한 우리 특례 규정의 정비방안을 중심으로)

조연팔 법학연구소 2016 法學論集 Vol.20 No.4

초고층 공동주택의 환기방식에 관한 연구

조연효(Cho Yeon-Hyo),이지원(Lee Ji-Won),이성(Lee Sung) 한국건축친환경설비학회 2008 한국건축친환경설비학회 학술발표대회 논문집 Vol.- No.-

Indoor air quality at ultra-high apartment houses becomes worse with the improvement of airtightness performance of windows and the use of the building materials contained chemical substances. As a result, these cause to have injurious effects on occupant health. The most effective solution to improve the air quality is to encourage the use of a green building material ventilation with outdoor air. The purpose of this study is to suggest the effective ventilation methods indoor air quality in ultra-high apartment houses. To evaluate the natural ventilation and the mechanical ventilation methods can be applied, C.F.D simulation was carried out. Consequently, to apply the natural ventilation method which uses both the mechanical method would be a lot better than to apply the ventilating method of electric heat exchange for indoor thermal comfort and energy conservation.

뇌교육 명상수련 경험 유무에 따른 심리적 안녕감 및 우울감 비교: 20~30대 미혼 성인을 중심으로

조연비 ( Yeon Bee Cho ),오미경 ( Mi Kyoung Oh ) 국제뇌교육종합대학원대학교 뇌교육연구소 2012 뇌교육연구 Vol.9 No.-

This study investigated the relationship between Brain Education meditation experienced and inexperienced in psychological well-being and depression among adults in their 20s and 30s. Results showed that those with Brain Education meditation experience scored higher on the Purpose of life and Personal growth scales of Psychological well-being as compared to those with no experience. Meditators scored lower in symptoms of depression than non-meditators. While Psychological Well-being did not vary for meditators according to gender, inexperienced meditators`s scores did vary according to gender on the Environmental mastery, Purpose in life, and depression scales. Psychological well-being and depression scores were divided into three groups based on amount of experience in Brain Education meditation: no experience, less than one year experience, and more than that. Those with no experience in Brain Education meditation showed a significant difference on the Self-acceptance and Purpose in life scales of Psychological well-being as compared to those with more than one year experience. Those with less than one year experience showed a significant difference on the Autonomy and Purpose in life scales as compared to those with more than one year experience. On the Personal growth and depression scales, non-meditators showed a significant difference as compared to both groups of meditators. This research suggests that Brain Education meditation may contribute to positive changes in one`s Purpose in life and Personal growth and may also help to alleviate the symptoms of depression in their 20s and 30s.

카페인 投與가 持久力 運動 遂行에 미치는 影響

趙衍澈,李源才 최신의학사 1991 最新醫學 Vol.34 No.4