간장 및 담도 : 알콜성 간상해에 관한 연구

정주섭(Ju Sup Jung),박병엽(Byeung Yeub Park),이강희(Kang Hi Lee),나산균(San Gyun Rha),유방현(Bang Hyung Liu) 대한소화기학회 1986 대한소화기학회지 Vol.18 No.1

N/A Twenty-seven patients with alcoholic liver disease who had had a habbit of excessive alcohol consumption and had had a characteristic liver biopsy findings and had been diagnosed as alcoholic liver disease at Pusan National University Hospital during the period of March 1980 to August 1985 were studied. Their epidemiologic, laboratory, histologic and imaging studies were summarized as follows; 1) When the amount of daily alcohol intake is larger, or the duration of alcohol intake is longer, the incidence of alcoholic cirrhosis is more common. 2) The twenty-seven cases were 17 cases with fatty liver, 10 cases with alcoholic cirrhosis. 3) On the chemical liver function test, the value of rGPT & SGOT were elevated nearly all cases and the mean ratio of SGOT/SGPT was above 2. 4) On 99mTC liver scanning, 2 cases with alcoholic cirrhosis showed characteristic scanning change and 6 cases out of 9 cases of fatty liver showed minor non-homogeneity of hepatic uptake and hypertrophic pattern of the liver. 5) On CT scanning, 7 cases with fatty liver showed lower CT numbers than that of control(p<0.01)

위선암 중 Signet - ring cell type 의 임상적 연구

허윤(Yoon Huh),정주섭(Ju Sup Jung),윤명순(Meung soon Yoon),박병엽(Byung Yeub Park),김무현(Moo Hyun Kim),나산균(San Gyun Rha) 대한소화기학회 1986 대한소화기학회지 Vol.18 No.1

To investigate the clinical characteristics about signet-ring cell type of gastric adenoca- rcinoma, the authors has evaluated 176 cases of gastric adenocarcinoma that had been diagnosed by gastrofiberscopic biopsy during 5.5 years. Of these, 21.6%(38/176) were signet-ring cell type. At the time of diagnosis, the average age of patients with signet-ring cell type was younger and the sex ratio showed equal male: female(1.1: 1) distribution. The location of signet-ring cell type was mainly the gastric body 45%(17/38) and more wides- pread 26%(10/38) than non-signet ring cell type 9%(13/138). The macroscopic features pre-dominantly detected in signet-ring cell type. For staging gastric adenocarcinoma preoperati- vely, 63 patients were examined with abdominal Computerized Tomography scan. The group of patients with signet-ring cell type was often composed by stage 4 50%(7/14) that could not be performed with curative surgery. To study the invasiveness of cancer cell, the microscopic examination on the resected margin was designed in 36 specimens that curative operation had been done. Malignant cells were found in 33%(2/6) in the group of signet-ring cell type and this result was statistically significant(p<0.05), as compared with the group of non-signet ring cell type, 3%(1/30). These data suggest that signet-ring cell type of gastric adenocarcinoma may result in a worse outcome.

자연 생리 주기에서 발생한 병합 임신에서의 만기 분만

김소희 ( So Hee Kim ),정명수 ( Myeong Su Jung ),정주섭 ( Ju Sup Jung ),문태식 ( Tae Sik Mun ),이상언 ( Sang Eon Lee ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.5

후천성 면역 결핍증 환자 ( AIDS ) 의 혈액면역학적 특성과 기회감염에 대한 임상적 고찰

남태수(Tae Su Nam),서경수(Keung Su Seo),이경인(Kyong In Lee),김윤성(Yun Seong Kim),홍진희(Jin Hee Hong),김광하(Gwang Ha Kim),정준훈(Joon Hoon Jeong),주형준(Hyung Jun Chu),박승근(Seung Keun Park),성낙현(Nak Hean Seoung),정주섭(Ju Sup 대한내과학회 1997 대한내과학회지 Vol.52 No.1

N/A The number of persons with HIV infection in Korea have increased steadily, total number of HIV infection in Korea were 478 on August, 1995. To investigate the clinicoimmunologic manifestation of AIDS in Korea, we reviewed complete blood counts (CBC), CD4 counts, serum β2-microglobulin level, opportunistic infections and cause of death for 19 AIDS patients who had been admitted or visited at Pusan national university hospital during the period of January, 1990 to August, 1995. 1) The predominant mode of HIV transmission was heterosexual contact(18), other modes of transmission were homosexual contact(1). Clues of diagnosis of HIV infection were routine occupational health examination(14), and opportunistic infection symptoms such as fever, coughing(4). 2) Mean CD4 cell counts(/mm3) were 53±72 totally, 22±27 for 8 dead patients at mean 2 month before, 91±87 for 7 living patients. There were not significant difference(p>0.05). 3) Serum β2-microglobulin(MG;ug/ml) was measured at 12 patients, mean serum β2-MG level was4.8±7.3 totally, 7.1±10.3 for 6 dead patients at mean 1.3 month before, 2.5±0.4 for 6 living patients. There were not significant(p>0.05). 4) At CBC examination, WBC(/mm3) was 5,932±2,899 totally, 5,452±3,436 for 10 dead patients, 6,500 ±2,221 for 9 living patients(p>0.05). Hb(g/dl) was 11,4±2.8 totally, 9.4±1.8 for dead patients, 13.6±1.8 for living patients(p<0.05). Lymphocyte count(/mm) was 1,255±800 totally, 731±424 for dead patients, 1,838716 for living patients(p<0.05). ESR(mm/h) was 72±47 totally, 97±33 for dead patients, 47±47 for living patients(p<0.05). 5) Opportunistic infections had developed at 14 patients, candidiasis 7, pneumocystis carinii pneumonia 5, tuberculosis 3, cytomegalovirus infection 2, herpes zoster 3, toxoplasmosis 1, cryptococcal infection 2, bacterial pneumonia 5, and herpes simplex l. Malignant lymphoma had developed in 1 patient. 6) Mean survival interval from diagnosis of HIV infection to death was 32.8±19.1 months, and the most common cause of death was pneumocystis carinii pneumonia, and other causes of death were meningitis, bacterial pneumonia and AIDS-wasting syndrome. Based on these results, We concluded that CD4 counts, serum β2-microglobulin level, Hb, total lymphocyte count and ESR in AIDS patients are specific laboratory markers of progression and prognosis of AIDS, the most common opportunistic infection was candidiasis, and the most common cause of death in AIDS patients was pneumocystis carinii pneumonia.

Chloroquine저항성 유입 말라리아 14예에 대한 임상적 고찰

이재홍,노성민,이상도,이일두,박병엽,정주섭 대한감염학회 1994 감염 Vol.26 No.4

Recently the prevalence of malaria and chloroquine-resistant malaria has been increasing around the world and there is an increasing concern about exogenous malaria in non-endemic areas. We reported 14 cases of chloroquine-resistant imported malaria seen at the Hae Dong Hospital from 1992 to May 1994 with a review of the literatures. The following is a summary of the findings. 1) All cases were physically active men with a mean age of 38.6 years and were infected with chloroquine-resistant species. 2) The 11cases were Plasmodium falciparum infection and the other cases were undetermined. 3) The majority(93%) of patients had malaria imported from Africa. 4) All patients had fever, chill, generalized malaise. Gastrointestinal symptoms and hepatosplenomegaly were developed in 50% of patients. 5) About 20% of the patients had serious complications such as hemolytic anemia, acute renal failure and jaundice. 6) In the 3cases of severe malaria, intravenous quinine therapy was attempted and treated successfully. The other cases of chloroquine-resistant malaria were treated with quinine plus tetracycline combination therapy and Fansidar. In the cases, which can not be tolerable because of side effects and resist to above therapy, therapy was substituted to halofantrine. 7) Halofantrine is effective against chloroquine-resistant malaria and recommended the alternative therapy of multidrug resistant malaria.

위암 환자에 있어서 말초혈의 T 세포 Subset 와 Natural Killer(NK)세포에 관한 연구

김순호,허윤,정주섭 대한소화기학회 1992 대한소화기학회지 Vol.24 No.3

To elucidate alteration of peripheral T cell susbsets and NK cells in patients with stomach cancer, the authors examined CD3^+, CD4^+, CD8^+, and Leu 7^+ cells and NK cell activity in 25 cases of preoperative patients and 26 cases of postoperative patients with stomach cancer as well as 23 case of adult healthy subjects as control. Diagnoses were confirmed histopathologically in all the patients. All blood samples were obtained from veins of the patients and control subjects on Pusan national University hospital during the period of January to August, 1990. The results obtained were summarized as follows: 1) The percentage of CD4^+ cells and CD4/CD8 ratio were significantly decreased in the preoprative patients with the stage Ⅳ in stomach cancer as compared with adult healthy subjects and the stage Ⅰ + Ⅱ or stage Ⅲ, respectively, and tended to be decreased as the stage was advanced. 2) The percentage of CD8^+ cells was significantly increased in the preoprative patients with the stage Ⅳ oin stomach cancer as compared with adult healthy subjects, and the stage Ⅰ+Ⅱ or stage Ⅲ respectively. 3) The percentage of Leu 7^+ cells was not different between the adult healthy subjects and the preoperative patients in al stages of stomach cancer. 4) The activity of NK cells was significantly decreased in the preoperative patients on all stages of stomach cancer, and tended to be decreased as the stage was advanced. 5) The percentage of CD4^+, CD8^+ and Leu 7^+ cells and the activity of NK cells were not different between the preoprative and postoperative patients in all stages of stomach cancer. On the basis of this results, it can be suggested that the cellular immunosuppression in the preoperative patients with advanced stomach cancer is due to the decreased helper/inducer T cells and increased suppressor/cytotoxic T cells, and that the activity of NK cells is decreased on all the patients with stomach cancer.

간성 방선균증 1 예

이재홍,이상도,이일두,정주섭,노성민,박병엽,조현장,김승영 대한내과학회 1996 대한내과학회지 Vol.51 No.1

Actinomycosis is chronic suppurative and granulomatous disease caused by anaerobic, gram positive filamentous bacterium, The most common sites of involvement are the cervicofascial area, thorax, abdomen and pelvis. Primary hepatic actinomycosis is rare and presents a diagnostic challenge. A 57-year old man was admitted because of right upper quadrant abdominal pain and fever for 1 month. abdominal ultrasonography, computed tomography examination showed mass lesion in liver. Primary hepatic actinomycosis was confirmed by identification of sulfur granule, ultrasonography-guided percutaneous needle aspiration. We report a case of primary hepatic actinomycosis, emphasizing the role of imaging study followed by percutaneous liver biopsy in a condition which frequently requires laparotomy for diagnosis.

말라리아의 경구 Quinine 치료중 발생한 저혈당 1 예

김병국,이재홍,이상도,정주섭,노성민,황병욱,박병엽 대한내과학회 1995 대한내과학회지 Vol.49 No.1

Quinine-induced hypoglycemia may be the fatal complication during the treatment of P. falciparum, especially in the severe form of malaria and pregnant patient. A 32 year old male was admitted for high fever. Abdominal CT scan showed marked hepatosplenomegaly with normal pancreatic structure and the trophozoites and gamatocytes of P. falciparum were detected on peripheral blood smear. He was improved with oral medication of quinine and tetracycline. But confused mentality and cold sweating were suddenly developed on the 3rd day of quinine medication, so we examined the blood sugar and insulin level. In correlation between hypoglycemia and clinical course of patient, this attack was considered as quinine-induced hypoglycemia. He was improved thereafter, and treated with halofantrine completely. We report one case of quinine-induced hypoglycemia that is complicated with oral medication in P. falciparum patient.

후천성 면역 결핍증(AIDS) 환자에서 발생한 뇌톡소플라즈마증 2 예

이우철,이재승,김영민,최영근,조군제,신호진,정주섭,서경수,홍진희 대한내과학회 1998 대한내과학회지 Vol.55 No.3

Toxoplasmosis of the central nervous system occurs in 3 to 40 percent of all patients with the acquired immunodeficiency syndrome(AIDS), and it is the most common opportunistic infection to cause encephalitis or focal intracerebral lesions. We experienced two cases of cerebral toxoplasmosis in AIDS patients presenting as high fever, seizure and general weakness.

카포시 육종, 주폐포자층 폐렴 등을 동반한 특발성 CD4+ T 림프구감소증 1 예

김준홍,김병진,정영태,고원욱,김사웅,조군제,정주섭,남태수,서경수,성낙현,김부웅 대한내과학회 1996 대한내과학회지 Vol.51 No.4

The recently recognized immunodeficiency syndrome of idiopathic CD4+ T-lymphocytopenia was defined by the Centers for Disease Control and Prevention (CDC) to include depressed numbers of circulating CD4+ T-lymphocytes ($lt;300 cells/㎣ or $lt;20% of total T cells) on more than one occasion, no laboratory evidence of infection with human immunodeficiency virus type 1(HIV-1) or type 2 (HIV-2), and the absence of any defined immunodeficiency or therapy associated with depressed levels of CD4+ T cells. We had experienced one case of Idiopathic CD4+ T-lymphocytopenia without HIV infection, combined with Kaposi's sarcoma and Pneumocystis carinii pneumonia. She had visited to emergency room due to moderate dyspnea and fever for about three months. On physical examination, multiple purple colored mass lesions were detected on lower back, both upper and lower extremities and right tonsillar area. Skin biopsy on mass of right lower extremity revealed Kaposi's sarcoma. On HRCT of the chest, patch bilateral, symmetric reticulonodular infiltration were founded. So, we performed sputum cytology repeatedly, we identified pneumocystis carinii cysts. Idiopathic CD4+ T-lymphocytopenia is rare and represents various clinical and immunologic states. It is perhaps more important to work harder to track the epidemiologic feature of this syndrome closely, to define the associated immune deficits carefully, and to search broadly for the cause. Further epidemiologic, immunologic, and virologic studies will aid in the characterization of this newly recognized condition.