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- 저자 : 박병엽(Byeung Yeub Park) (검색결과 4 건)
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정주섭(Ju Sup Jung),박병엽(Byeung Yeub Park),이강희(Kang Hi Lee),나산균(San Gyun Rha),유방현(Bang Hyung Liu) 대한소화기학회 1986 대한소화기학회지 Vol.18 No.1
N/A Twenty-seven patients with alcoholic liver disease who had had a habbit of excessive alcohol consumption and had had a characteristic liver biopsy findings and had been diagnosed as alcoholic liver disease at Pusan National University Hospital during the period of March 1980 to August 1985 were studied. Their epidemiologic, laboratory, histologic and imaging studies were summarized as follows; 1) When the amount of daily alcohol intake is larger, or the duration of alcohol intake is longer, the incidence of alcoholic cirrhosis is more common. 2) The twenty-seven cases were 17 cases with fatty liver, 10 cases with alcoholic cirrhosis. 3) On the chemical liver function test, the value of rGPT & SGOT were elevated nearly all cases and the mean ratio of SGOT/SGPT was above 2. 4) On 99mTC liver scanning, 2 cases with alcoholic cirrhosis showed characteristic scanning change and 6 cases out of 9 cases of fatty liver showed minor non-homogeneity of hepatic uptake and hypertrophic pattern of the liver. 5) On CT scanning, 7 cases with fatty liver showed lower CT numbers than that of control(p<0.01)
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Chloroquine 내성 유입 말라리아 14 예에 대한 Halofantrine 의 치료효과
조현장(Hyun Jang Cho),노성민(Sung Min Noh),이상도(Sang Do Lee),부철수(Cheol Su Poo),김성일(Sung Il Kim),김두형(Du Hyeong Kim),김승영(Seung Young Kim),박병엽(Byeung Yeub Park) 대한내과학회 1997 대한내과학회지 Vol.53 No.4
N/A Objectives: The prevalence of malaria is increasing in recent years and also multidrug resistant malaria is increasing around the world and there is an increasing concern about imported malaria in nonendemic areas. Now many drugs are tried to find out effect on multidrug resistant malaria. We performed this study to investigate the thrapeutic effect of halofantrine in the treatment of chloroquine resistant imported malaria. Methods: From Feb. 1992 to May 1995, we experienced 35 patients infected with malaria and treated 14 patients among 35 patients with halofantrine. Results: 1) All 14 patients were sailor with a mean age of 39.4 years and infected with malaria. 2) The majority of patients were infected with malaria at Africa. 3) 10 patients were infected with Plasmodium falciparum and the remainder were undetermined. 4) In the 11 cases of chloroquine resistant malaria treated with quinine plus tetracycline combination therapy or Fansidar, 4 cases could not be tolerable due to side effects and resistance to the therapy, we substituted halofantrine for above regimens. 5) In the 10 cases, treated after May 1994, halofantrine was the first choice of treatment because they were the cases of malaria infected in the mid-Africa where the prevalence of chloroquine resistant malaria is high. 6) With halofantrine, all 14 cases were treated with minimal side effects suc4 as nausea, vomiting, anorexia, abdominal pain and fatigue. Conclusion: We think halofantrine is a simple and effective regimen against chloroquine resistant malaria and consider this agent as an alternative therapeutic regimen on chloroquine resistant malaria.
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Chloroquine저항성 유입 말라리아 14예에 대한 임상적 고찰
이재홍,노성민,이상도,이일두,박병엽,정주섭 대한감염학회 1994 감염 Vol.26 No.4
Recently the prevalence of malaria and chloroquine-resistant malaria has been increasing around the world and there is an increasing concern about exogenous malaria in non-endemic areas. We reported 14 cases of chloroquine-resistant imported malaria seen at the Hae Dong Hospital from 1992 to May 1994 with a review of the literatures. The following is a summary of the findings. 1) All cases were physically active men with a mean age of 38.6 years and were infected with chloroquine-resistant species. 2) The 11cases were Plasmodium falciparum infection and the other cases were undetermined. 3) The majority(93%) of patients had malaria imported from Africa. 4) All patients had fever, chill, generalized malaise. Gastrointestinal symptoms and hepatosplenomegaly were developed in 50% of patients. 5) About 20% of the patients had serious complications such as hemolytic anemia, acute renal failure and jaundice. 6) In the 3cases of severe malaria, intravenous quinine therapy was attempted and treated successfully. The other cases of chloroquine-resistant malaria were treated with quinine plus tetracycline combination therapy and Fansidar. In the cases, which can not be tolerable because of side effects and resist to above therapy, therapy was substituted to halofantrine. 7) Halofantrine is effective against chloroquine-resistant malaria and recommended the alternative therapy of multidrug resistant malaria.
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