만성 B형 간염 환자에서 3년간 라미부딘 투여 후 간의 조직학적 변화

정은선 ( Eun Sun Jung ),배시현 ( Si Hyun Bae ),장정원 ( Jeong Won Jang ),최종영 ( Jong Young Choi ),윤승규 ( Seung Kew Yoon ),정규원 ( Kyu Won Chung ),선희식 ( Hee Sik Sun ),박두호 ( Doo Ho Park ),김병기 ( Byung Ki Kim ) 대한소화기학회 2003 대한소화기학회지 Vol.41 No.3

Background/Aims: The aim of this study was to examine the histological changes of the liver after a 3-year lamivudine therapy in patients with chronic hepatitis B. Methods: Seven patients with sustaining virological and biochemical response were enrolled in this study. The patients were given lamivudine orally at a dose of 100 mg for 3 years, and then, the second liver biopsy was performed. The liver biopsies were evaluated using the conventional histological assessment scale and the quantification of fibrosis by an image analysis. Results: All patients showed a reduction in the hepatic necro-inflammatory activity after 3 years of lamividine therapy compared to the pretreatment value as follows: the mean grade of lobular activity, 1.14 vs. 2.28; porto-periportal activity grade, 1 vs. 2.57; fibrosis stage 1.14 vs. 2.14. The quantification by the image analysis showed a significant reduction of the fibrotic area in the mean portal, periportal, and septal portions (17,985 vs. 7,082 um2, p<0.05). The intrahepatic expression of HBcAg turned negative in the liver tissues of five patients. Conclusions: The improvements in liver histology, especially in porto-periportal activity and fibrosis, can be obtained in patients with sustained viral and biochemical response after a long-term lamivudine treatment. (Korean J Gastroenterol 2003;41:204-210)

Aloe재배품의 형태와 이화학적연구

도정애(Chung Ae Toh),정은선(Eun Sun Jung) 한국생약학회 1985 생약학회지 Vol.16 No.1

There are about 180 species of Aloe which is a fleshy plant growing wild in the tropic regions. Among six species recorded in Pharmacopoeia., Aloe ferox Mill (Cape Aloe), Aloe barbadenis Mill (Aloe vera L.) (Curacao Aloe), Aloe perrxi Baker (Socotra Aloe) are being currently used, Main components are aloin, barbaloinn, aloeside, aloesin, aloctin, aloe ulcin and alomicin, etc. There are reports that Aloe is effective for the treatment of circulatory a digestive and skin diseases, diabetes, tumor, cancer, allergy, antibiosis and inflammation. In this study, three species of Aloe, Aloe arborescence, Aloe vera and Aloe saponaria, which are cultivated in this country, were compared with their morphological, histological and cytological aspects and investigated their physico-chemical properties. Especially the authors examined on skin disease of Aloe juices with Aspergillus niger`s hyphae.

이형성결절에서 발행한 소간세포암종

김창욱 ( Chang Wook Kim ),정은선 ( Eun Sun Jung ),최종영 ( Jong Young Choi ),장정원 ( Jeong Won Jang ),배시현 ( Si Hyun Bae ),윤승규 ( Seung Kew Yoon ),이창돈 ( Chang Don Lee ),정규원 ( Kyu Won Chung ),선희식 ( Hee Sik Sun ) 대한간암학회 2004 대한간암학회지 Vol.4 No.-

흰쥐에서 간의 허혈-재관류 손상에 대한 Tacrolimus와 Prostaglandin E1의 보호효과

김동구(Dong Goo Kim),김용귀(Yong Gui Kim),정은선(Eun Sun Chung) 대한외과학회 1999 Annals of Surgical Treatment and Research Vol.57 No.4

소간세포암의 외과적 치료

김재철(Jae Chul Kim),김동구(Dong Goo Kim),정은선(Eun Sun Chung) 대한외과학회 2000 Annals of Surgical Treatment and Research Vol.58 No.5

1930~40년대 중국목판화에 미친 서구미술의 영향

鄭恩先 미술사연구회 2004 미술사연구 Vol.- No.18

What we cannot omit in the discussion of Chinese modern art history is the discussion on modern woodcuts. The undergraduates of the college of fine art who participated in the movement of woodcuts during the 1930s and 1940s continue to act as wood-block artists, oil painters and chrysanthemum artists in the later generations, and the formation of modern woodcuts distinguished from traditional wood-block prints was made in the thirties as a starting point Also, because the point of time making a stroke between duplicated wood carving and created wood engraving in the history of wood-block prints is this period It is necessary to pay attention to the thirties and forties in the history of Chinese wood-block prints. The revival of woodcuts can be said to gear into the situation existent China was located in, that is, the social situation of the twenties and thirties. Globally, this is not irrelevant to the rediscovery of created woodcuts in German movement of woodcuts and the West. Therefore, what is noteworthy among all the phenomena of the thirties is Western influences In view of the history of negotiating with the West in the history of China, China has maintained its closing attitude toward Occidental cultures since it was communized in 1949 and has disconnected also its exchanges with Soviet since the period of cultural revolution The exchanges with foreign countries and positive acceptance of Western cultures in the thirties are said to be meaningful in such points. Between 1919 and 1929, the books dealing with on Western art theories and aesthetics were published in more than hundreds of pieces In the modes of fine art, impressionism, neo-impressionism, Fauvism and German expressionism were brought in by the students studying abroad in Paris and Germany However, students in the college of fine art including Luxun were more interested in social critical art rather than performing art. Chinese woodcuts during the thirties to forties seems to have been developed mainly centering on exhibitions and collections of wood-block prints In the thirties, there were exhibitions and brief courses of woodcuts that held total thirty-odd times, and it was through Yewonjohwa" series that foreign wood-block artists and their works were introduced into China Through this book of paintings were Carl Meffert, Kathe Kollwitz, Franz Masereel, Pavorsky, Pisakarev and Kravchenko introduced. These artists considerably popular to Chinese woodcut artists, were wood-block artists favoring for expressionism and realism Their thoughts and modes were formed through the process of popularization of modem woodcut movement It was the acceptance of Western wood-block prints that made a great contribution to the initial stage of forming such Chinese modern woodcuts. Luxun introduced Soviet and European wood-block printing works through exhibitions and books of wood-block prints between 1930 and 1936. Eventually, the acceptance of Western wood-block prints must have been selected according to Luxun's understanding of Western wood-block prints and evaluating them Luxun paid attention to artists' artistic qualities and talents, artists' senses and experiences and messages conveyed by their works in introducing Western artists to Chinese woodcut artists One of the great characteristics of Western woodcuts selected on these foundations was on relevancy with literature and realistic modes. This is related to the revolution of books in Russia, and Russia encouraged consecutive works and illustrations as artistic forms and adopted them as popular forms. Luxun introduced the works of Western artists as an example of consecutive paintings. Kathe Kollwitz's consecutive works of "Peasants' War" and "Workmen", Karl Mefert' s illustration of "Cement", Piskarev' s "The Stream of Iron" and Alexeev' s illustration of "A Mother" are commonly consecutive works and have having one story in common. Also, Franz Maasereel's consecutive works of "A Man's Passion" and "The Sun" as novels without characters can be taken as an example of introducing the artisticality of consecutive works to Chinese woodcut artists Another great characteristics of Western woodcuts which was popular in China are realistic elements. Also, in the line of German expressionists, Kathe Kollwitz is a wood-block artist commanding more realistic description and also Franz Masereel is a wood-block artist evaluated as an artist of realistic description. Also, as for the works of Soviet wood-block artists, the works of wood-block artists describing reproductively and realistically rather than cubism or futuristic works were popular to Chinese woodcut artists in the later generations

Aloe 植物의 化學分類學的 硏究

都貞愛,鄭殷先 梨花女子大學校 韓國生活科學硏究院 1985 韓國生活科學硏究院 論叢 Vol.36 No.-

한국에서 재배되는 Aloe에 종의 구별없이 混用되고 있는 Aloe arborescence Mill., Aloe vera L., Aloe saponaria Haw.의 세 종에 관해 外部형태, 내부조직의 관찰과 理化學的 성질을 비교 분석하였으며, 皮膚眞菌症에 응용의 일환으로 검체의 단백질 抽出物, methanol, ethanol추출물과 自家分解에 의한 추출물이 Aspergillus niger van Tieghem (IMI 41873)에 미치는 抗眞菌 效果를 연구하였다. 연구 결과는 다음과 같다. 1. 내부조직 상에 A.arborescence에 Ca-oxalate 속침정이 많이 분포되어 있었으며, A. vera와 A. saponaris의 조직내에 未知結晶體物質이 관찰되었다. 2. 이화학적 성질과 단백질, Ca鹽의 함량, 미량 금속성분의 함량에 현저한 차이가 나타났다. 3. Aloe 세 종 각각의 단백질 추출물과 A. arborescence의 methanol 추출물, A. vera의 ethanol 추출물이 A. niger에 대해 抗眞菌 效果를 나타내었다. Three s ecies of cultivated Aloe, Aloe arborescence Mill., Aloe vera L., Aloe saponaria Haw. were compared with their morphological, physicochemical properties, analysis of components and mineral contents. Antifungal effects of protein extracts, methanol extracts and ethanol extracts were investigated against Aspergillus niger. The results were as follows: 1. Much raphides of Ca-oxalate in A. arborescence and unknown crystal in central zone parenchyma tissue in A. vera, A. saponaria were observed. 2. From the result of physicochemical analysis of components, the highest contents were protein in A. vera; viscosity in A. saponaria; Ca-salt, oxalic acid, mineral contents in A. arborescence. 3. Methanol extract of A. arborescence, protein extracts of three Aloe species and ethanol extract of Aloe vera inhibited the growth of A. niger. Therefore, the difference of interspecies of Aloe showed in antifungal effect against A. niger.

간세포암의 조직학적 분화도 및 임상적 특징에 따른 E-cadherin과 β-catenin의 발현 양상

배시현,정은선,박영민,장정원,최종영,조세현,윤승규,안병민,차상복,정규원,선희식,박두호,김병기,김동구 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.3

배경/목적: E-cadherin과 β-catenin은 하나의 복합체를 형성하여 세포간 접착을 유지하는데 중요한 기능을 하고, 이들의 돌연변이는 세포간 접착기능의 상실로 종양의 발생과 세포전이를 유도한다. 본 연구의 목적은 간세포암 조직에서 E-cadherin과 β-catenin의 발현 양상과 빈도를 조사하고, 간세포 암의 임상적, 병리학적 인자들 사이에 상호관련성을 알아보고자 하였다. 방법: 간세포암으로 진단받은 36 명의 환자로부터 수술후 얻은 파라핀 포매된 조직을 대상으로 E-cadherin과 β-catenin에 대한 면역조직화학적 염색을 시행하였다. E-cadherin의 발현은 세포질막의 염색유무로 분류하였고, β -catenin의 발현은 세포질형과 핵형으로 분류하였다. 간세포암의 발생 원인, 혈청 AFP 수치, TNM stage, 간세포암의 크기, 형태적 유형, 다른 장기 전이, 간세포암의 분화도 및 간문맥 혈전 유무 등에 대해서도 분석하였다. 결과: 간세포암 부위에서 E-cadherin의 발현은 세포질막 발현이 58% (21/ 36), 발현이 안되는 경우가 42%(15/36) 였다. β -catenin의 발현은 세포질형 83%(30/36)와 핵형 14%(5/36), 그리고 염색이 안된 경우가 3%(1/36) 였다. 간세포암의 고, 중, 저 분화도에 따른 E-cadherin, β-catenin 의 발현 양상 사이에 상호 관련성은 관 찰할 수 없었다 결론: 간세포암에서 주변 비간암 조직에 비교해서 E-cadheirn의 발현감소를 관찰할 수 있었으며, β-catenin의 핵내 발현이 증가되어 E-cadherin, β-catenin system이 간세포암 발생 과정에 관련이 있음을 알 수 있었다. 간세포암 분화도, 간세포암의 임상적인 특징에 따른 E-cadherin 및 β-catenin의 발현 양상차이는 없었다. Background/Aims: E-cadherin is involved in intercellular binding and cellular polarity formation. β-catenin plays a fundamental role in regulation of the E-cadherin cell adhesion complex. The abnormalities of the components of the complex may disrupt this adhesive function. We investigated the expression patterns of E-cadherin and β-catenin to determine the clinical significance of these proteins in hepatocellular carcinoma. Materials/Methods: Thirty-six hepaticellular carcinoma tissues and adjacent non-tumor specimens were analyzed. Subcellular distribution of E-cadherin and β-catenin was examined by immunohistochemistry staining. We evaluated the patterns of the expression, and investigated the relationship with the cause of HCC; level of AFP; TNM stage; tumor size; growth types; metastasis; differentiation grade of HCC; and presence of portal vein thrombosis. Results: Immunohistochemistry showed that all non-tumor tissues had membranous type staining of E-cadherin. All non-tumor tissues showed cytoplasmic type staining of β-catenin, but no β -catenin accumulation in nuclei was found. 58% (21/36) of HCC showed positive expression of E-cadherin in cytoplasmic membrane. The cytoplasmic expression of β-catenin in HCC was 83% (30/36); nuclear expression in 14% (5/36); and no staining in 3% (1/36). Nuclear β-catenin expression was observed in none (0/4) of the well-differentiated HCC; 17%(3/9) of moderate-differentiated HCC; and 17%(2/6) of poorly-differentiated HCC. There were no relationships between E-cadherin and β-catenin expression with other clinicopathologic factors. Conclusions: Loss of cytoplasmic staining of E-cadherin and nuclear accumulation of β-catenin were observed in HCC. Nuclear accumulation of β-catenin was not found in well differentiated HCC but was found in poorly differentiated HCC. (Korean J Hepatol 2002;8:297-303)