오약(烏藥)이 토끼의 수축혈관에 미치는 영향

이현주,조학준,김호현,Lee, Hyun-Ju,Jo, Hak-Jun,Kim, Ho-Hyun 한국한의학연구원 2005 한국한의학연구원논문집 Vol.11 No.1

Objectives : This experiments were performed to determine the effect of Linderae Radix extract on norepinephrine-induced arterial contraction in rabbit. Methods : In order to investigate the effect of Linderae Radix extract on contracted rabbit carotid arterial strips, transverse strips with intact or damaged endothelium were used for the experiment using organ bath. To analyze the mechanism of Linderae Radix extract-induced relaxation, Linderae Radix extract infused into contracted arterial strips induced by norepinephrine after treatment of indomethacin, tetraethylammonium chloride, $N{\omega}-nitro-L-arginine$ or methylene blue. Results : Linderae Radix extract relax arterial strip with endothelium contracted by norepinephrine, but in the strips without endothelium, Linderae Radix extract-induced relaxation was significantly inhibited. Linderae Radix extract-induced relaxation was decreased by the pre-treatment of $N{\omega}-nitro-L-arginine$ or methylene blue, but it was not observed in the strips pre-treated with indomethacin or tetraethylammonium chloride. When $Ca^{2+}$ was applied, the strips which were contracted by norepinephrine in a $Ca^{2+}$-free solution, arterial contraction was increased. But pre-treatment of Linderae Radix extract inhibited contractile response to norepinephrine and $Ca^{2+}$. Conclusions : We suggest that Linderae Radix may suppress influx of extra-cellular $Ca^{2+}$ through the formation of nitric oxide, and release of intra-cellular $Ca^{2+}$.

방사성탄소연대측정

이현주,황진주,백현주,Leigh, Hyeon-Ju,Hwang, Jin-Ju,Paek, Hyun-Ju 국립문화재연구소 2002 保存科學硏究 Vol.23 No.-

It is very important to determine the age of the Cultural Properties in archeology. In about 1950, W.F. Libby and a team of scientists at the University of Chicago developed the Radiocarbon Dating technique. Radiocarbon($^14$C) Dating is probably one of the most widely used and best known absolute dating methods. Radiocarbon ages are conventionally specified to the year 1950. This year is 0 BP year. BP is the initial of Before Present. The $^14$C within an organism is continually decaying into stable carbon isotopes. When $^14$C decays, it emits a $\beta$ - particle with an energy content of 156 KeV and becomes 14N. Only the $\beta$ - particle is detected by Liquid Scintillation Counting. $^14$C has a half life of 5730 years. It has been used to date samples as old as 50,000 years. Radiocarbon determinations can be obtained on organic material : wood, charcoal, shell, etc. The results of radiocarbon dating using Benzene Synthesizer and Liquid Scintillation Counter are KCP539 $4030\pm60$BP year, KCP540 $3980\pm60$BP year, KCP575 $4870\pm50$, KCP576 $100\pm50$BP year, KCP577 $130\pm50$BP yea and KCP578 $210\pm70$BP year.

Coated tube를 사용한 CA19-9 측정용 IRMA 시약의 평가

이현주,장현영,신선영,김희선,김태훈,이호영,Lee, Hyun-Ju,Jang, Hyun-Young,Shin, Sun-Young,Kim, Hee-Sun,Kim, Tae-Hoon,Lee, Ho-Young 대한핵의학기술학회 2010 핵의학 기술 Vol.14 No.2

현재 본원은 TFB사의 CA19-9 항체가 bead에 코팅되어있는 CA19-9 IRMA 시약을 사용하고있다. 이번에 TFB사에서 새로 개발된 CA19-9 항체가 polystyrene test tube에 코팅된 CA 19-9 IRMA 시약이 기존 TFB사의 bead를 사용하는 시약을 대체하여 사용할 수 있는지 시약의 성능을 평가하였다. 본원과 서울대학교병원 환자 56명의 검체를 대상으로 하여 TFB사의 기존 bead 방법을 사용한 시약과 새로 개발된 coated tube를 사용한 시약을 비교하여 상관계수와 회귀식을 구하고 coated tube를 사용한 시약의 정밀도, 회수율, 직선성, 민감도, Hook effect 를 확인하였다. 저, 중, 고역가 검체의 검사내 정밀도는 4.1%, 4.0%, 4.2%이고 검사간 정밀도는 7.6%, 4.3%, 7.8%이며 회수율은 모두 $100{\pm}10%$이다. 직선성은 우수하였고 분석적민감도는 0.3U/mL이었으며 9,020,000 U/mL 농도에서는 Hook effect가 나타나지 않았다. 또한 TFB사의 기존 bead를 사용한 방법과 비교하여 상관관계를 분석한 결과, y=0.9185x-0.953, 상관계수 $R^2$=0.9779이었다. 이번 연구를 통해 본원은 TFB사에서 새로 개발된 coated tube CA19-9 IRMA 시약이 검사 시간과 검사 과정에서 간편화되고 검사시 자동화기기를 사용할 수 있으며 기존 bead를 사용한 시약에 대체하여 사용할 수 있다고 판단하였다. Purpose: $TFB^{(R)}$ CA19-9 IRMA kit uses beads coated with CA19-9 antibody. However, this mathod can not use automated equipment, and requires a long time test. Recently, CA19-9 IRMA kit developed by $TFB^{(R)}$ is coated with CA19-9 antibody to the polystyrene test tube and reaction at room temperature, and also reduced test time. This study evaluated the performance of a newly developed $TFB^{(R)}$ CA19-9 IRMA kit. Materials and Methods: This study were measured by using 56 patients sample of Boramae Medical Center and Seoul National University Hospital. We evaluated intra-and inter-assay precision, recovery rate, linearity, sensitivity and high dose hook effect of coated tube CA19-9 IRMA kit developed by $TFB^{(R)}$. The values of CA19-9 measured by $TFB^{(R)}$ bead kit were compared with those measured by $TFB^{(R)}$ coated tube kit. Results: ntra-assay coefficients of variation on three different levels were 4.1%, 4.0% and 4.2%. Inter-assay coefficients of variation were 7.6%, 4.3% and 7.8%. Recovery tests on all three different levels showed within $100{\pm}10%$. Linearity was good and sensitivity was 0.3 U/mL. High dose hook effect is not observed. There was strong correlation between bead kit and coated tube kit by $TFB^{(R)}$ CA19-9 IRMA kit. (y=0.9185x-0.953, $R^2$=0.9779) Conclusion: Coated tube CA19-9 IRMA kit developed by $TFB^{(R)}$ showed satisfactory precision, recovery rate, linearity, sensitivity and high dose hook effect.

가스 하이드레이트 형성 원리를 이용한 연소전 탈탄소화 연구

이현주,이주동,김양도,Lee, Hyun-Ju,Lee, Ju-Dong,Kim, Yang-Do 한국재료학회 2008 한국재료학회지 Vol.18 No.12

The emission of carbon dioxide from the burning of fossil fuels has been identified as a major contributor to green house emissions and subsequent global warming and climate changes. For these reasons, it is necessary to separate and recover $CO_2$ gas. A new process based on gas hydrate crystallization is proposed for the $CO_2$ separation/recovery of the gas mixture. In this study, gas hydrate from $CO_2/H_2$ gas mixtures was formed in a semi-batch stirred vessel at a constant pressure and temperature. This mixture is of interest to $CO_2$ separation and recovery in Integrated Coal Gasification (IGCC) plants. The impact of tetrahydrofuran (THF) on hydrate formation from the $CO_2/H_2$ was observed. The addition of THF not only reduced the equilibrium formation conditions significantly but also helped ease the formation of hydrates. This study illustrates the concept and provides the basic operations of the separation/recovery of $CO_2$ (pre-combustion capture) from a fuel gas ($CO_2/H_2$) mixture.

팔꿉관절과 손목관절 각도가 쥐는 힘과 집는 힘에 미치는 영향

이현주,이승주,Lee, Hyun-Ju,Yi, Seung-Ju 대한물리치료학회 2003 대한물리치료학회지 Vol.15 No.4

The purpose of this study were to determine the effect on grip and pinch strength with elbow and wrist angle change. 112 college students, 88 males, and 24 females aged 19 to 34 years, participated in the study. A Grip and pinch strength was measured in two elbow position($0^{\circ}$ and $90^{\circ}$) and three wrist position($80^{\circ},\;0^{\circ},\;23^{\circ}$). The data were analyzed by mean and deviation, and t-test using the PC/SAS system. These results were obtained as follows; 1. There was a more strength grip and pinch power in $0^{\circ}$ than $90^{\circ}$ elbow flexion at three wrist angle. 2. There was a significant high grip and pinch strength in $23^{\circ}$ dorsiflexion among three wrist angle(p<0.01). 3. The grip and pinch strength power was measured higher in male than female every elbow and wrist angle(p<0.01).

일반논문 : 현덕(1909~?) 문학의 사상적 배경 -가계(家系) 및 거주지 변화와 관련하여-

이현주 ( Hyun Ju Lee ) 한국사상사학회 2008 韓國思想史學 Vol.0 No.30

가방 끈 길이 차이가 상지 근활성도, 압력중심 및 체중분포에 미치는 영향

이현주,김민수,김아연,강현구,태기식,Lee, Hyun Ju,Kim, Min Su,Kim, Ah Yeon,kang, Hyun Gu,Tae, Ki Sik 대한의용생체공학회 2021 의공학회지 Vol.42 No.5

The purpose of this study was to investigate the effect on the activity of the upper trapezius and erector spinae according to the length difference of the backpack using electromyogram (EMG). We also conducted a study comparing the center of pressure (COP) and weight distribution before and after using Wii® balance board. Thirty individuals were randomly assigned to the experimental group (n=14) wearing a backpack with a short right strap length and a control group (n=16) wearing a backpack with the same strap length. Data were collected by dividing into groups, carring a 15% weight backpack and walking for 20 minutes on a treadmill. As a result of analyzing the EMG data, there was no significant change in the upper extremity muscle activity of the control group, but it was significantly decreased in the right upper trapezius activity of the experimental group (p<0.05). In addition, there was a significant change of COP in the experimental group (p<0.05), but there was no significant difference of the weight distribution in both groups. Recognizing mechanical changes in the body that may occur due to the asymmetry of the strap length is thought to be helpful for systematic ergonomic intervention according to changes in the external environment in the future.

보건학 전공 대학생의 회복탄력성이 학업소진에 미치는 영향: 회복탄력성이 낮은 군 대상

이현주,Lee, Hyun-Ju 한국학교ㆍ지역보건교육학회 2019 한국학교지역보건교육학회지 Vol.20 No.1

Objectives: This study is to examine the influences of three sub-factors of resilience on academic burn out among a group of university students, with low resilience, majored in public health. Methods: The survey was made during January 1 to 13, 2017 and after checking the resilience scores of 166 respondents and the questionnaires of 115 respondents, whose scores were less than 195, an average score of Korea, were selected and analyzed using AMOS. Results: The average resilience and academic burn-out scores were 173 and 2.96, respectively. The goodness-of-fit of proposed model showed RMSEA=0.068, GFI=0.916, NFI=0.901, IFI=0.963, CFI=0.962 so, final measurement model was selected. The analysis of the suggested model showed that among three sub-factors of resilience, only self-control ability had a negative(-) effect on academic burnout and two others were shown to have no effects. Conclusion: By researching and introducing a education method that could enhance self-control ability, it would effectively reduce academic burnout in university students with low resilience and majored in public health.

서울지역 공공의료기관 간호사의 병동과 병동 외 구분에 따른 직무스트레스와 피로

이현주,Lee, Hyun-Ju 한국학교ㆍ지역보건교육학회 2018 한국학교지역보건교육학회지 Vol.19 No.1

Objectives: The study was conducted to understand job stress and fatigue conditions by dividing nurses in a polyclinic-level public medical institution, Seoul with more than 600 beds into ward nurses and non-ward nurses and to comprehend sub-areas of job stress that affect fatigue. Methods: A survey was conducted from August 18 2014 to September 12 2014, so 216 cases were analyzed by using PASW statistics 18.0. Results: Job stress of ward nurses is significantly high in the psychological burden of nursing service area and medical limit. Fatigue of ward nurses is also higher. As a result of multiple Linear regression, nursing service area affects fatigue of ward nurses and there is no significant influence factors in non-ward nurses. Conclusion: Therefore, mental health education and interest of hospital in nursing service area are more needed for ward nurses with high job stress and fatigue among nurses.

고구마에 존재하는 mushroom tyrosinase 저해제의 특성

이현주,이민경,박인식,Lee Hyun-Ju,Lee Min-Kyung,Park In-Shik 한국생명과학회 2006 생명과학회지 Vol.16 No.3

고구마(품종: 생미)추출액에 tyrosinase의 활성을 저해하는 저해 물질이 존재함을 확인하였으며, 고구마 추출물의 첨가농도를 증가시킬수록 tyrosinase 활성의 저해도가 증가하였다. 그리고 고구마 추출물에 존재하는 tyrosinase 저해제는 $95^{\circ}C$에서 20분간 열처리에 의하여 37.3%의 활성이 잔존하여 열에 비교적 안정하였으며, pH 5.0-7.0에서 가장 안정하였다. 그리고 고구마 추출물은 투석에 의하여 tyrosinase에 대한 저해활성이 유의적으로 감소하였으며, 따라서 고구마 추출물에 존재하는 tyrosinase의 저해활성은 저분자 물질로 추정된다. Crude extract prepared from sweet potato possessed inhibitory activity toward mushroom tyrosinase. The inhibitory activity was dependent upon the addition amount of sweet potato extract. After heating the sweet potato extract at $95^{\circ}C$ for 20 min, its inhibitory activity retained 37.3%. Its optimum activity was shown at pH ranges of 5.0-7.0. The tyrosinase inhibitory activity was disappeared by dialysis, which suggests the inhibitory activity of sweet potato extract is caused by some compounds of low molecular weight.