Fluoxetine과 Haloperidol의 병합투여시 정신병리 및 추체외로 증상의 변화

이민수,한창수,김제원,원경식,곽동일,Lee, Min-Soo,Han, Chang-Su,Kim, Jae-Won,Won, Kyung-Sik,Kwak, Dong-Il 대한생물정신의학회 1997 생물정신의학 Vol.4 No.1

본 연구는 정신분열증 환자 38명을 대상으로 하여 haloperidol과 fluoxetine을 8주간 병합투여 하였고, PANSS, CGI, Simpson-Angus 척도를 투여전과 투여후 2, 4, 6, 8주에 시행하여 임상증상 및 추체외로 부작용을 평가하였다. 결과는 다음과 같다. 1) 8주간의 연구기간동안 양성, 음성증상의 유의한 변화가 없었다. 2) 8주의 연구기간동안 추체외로 부작용의 증가가 나타나지 않았다. 이는 기존 연구에서 fluoxetine에 의해 haloperidol의 혈중농도가 증가하여 효과 및 부작용이 증가한다는 연구보고와는 다르며, 이 결과는 haloperidol과 fluoxetine의 병합사용을 안전하게 할 수 있다는 것을 의미한다고 하겠다. Objectives : The authors have intended to know the drug interaction of fluoxetine and haloperidol when coadministering two drugs to the chronic schizophrenics by assessing the changes of positive, negative symptoms and extrapyramidal symptoms. Method : We selected 38 patients, the chronic schizophrenics with no physical problems. they are randomly assigned to placebo group and drug group. And then, placebo or fluoxetine 20mg were administered to the subjects of each group during 8 week period. We have assessed their psychopatholgy and extrapyramidal symptoms using Positive and Negative Syndrome Scale(PANSS), Clinical Global Impression(CGI), Simpson-Angus Scale at 0, 2, 4, 6, 8 week during the period. Results : 38 patients have completed the study during 8 weeks. 1) PANSS, CGI : no significant difference between groups and no significant change according to the times. 2) Simpson-Angus Scale : no significant changes. Conclusion : When co-administering fluoxetine and haloperidol, there were no significant changes of psychopathology and extrapyramidal symptoms. These results suggest that it is safe to coadminister fluoxetine to schizophrenic patients with haloperidol treatmemt.

취장 외분기능에 대한 체내 Amines의 역할

곽정재,김예식,명창선,김경환 연세대학교 의과대학 1987 연세의대논문집 Vol.20 No.2

In Vitro 고삼투압이 정자 원형질막의 Protein Tyrosine Phosphorylation에 미치는 영향

오영근,장재호,최인호,정노팔,신형철,곽병주 대한의생명과학회 2000 Journal of biomedical laboratory sciences Vol.6 No.4

정자의 원형질막은 삼투압에 의해서 영향을 받는다고 보고되고 있다. 이중 세포막내 분자구조의 변화 특히 막지질 구조의 변화와 동반되는 이온채널의 변화 그리고 Ca2+과 HCO-3의 유동성과도 밀접한 관련이 있는 것으로 보고되고 있다. 지금까지의 연구보고에 의하면, 정자의 첨체반응 (acrosome reaction)이 일어날 경우 protein tyrosine phosphorylation이 증가되는데 이것은 cAMP, protein kinase A 등을 통하여 작용되는 것으로 보고되고 있다. 막의 지질변화를 유도하는 물질로 일종의 sterol acceptor인 BSA가 알려져 있는 바, 실제로 BSA가 막지질 성분에 미치는 영향을 관찰한 결과 cholesterol이 유출되고 이온 등의 유동성 변화가 일어나, 이 유동성 변화가 정자의 adenylyl cyclase를 활성화시켜 cAMP를 증가시키고, PKA가 활성화되어 결과적으로 Protein tyosine phosphorycation이 유도된다고 보는 것이다. 침체반응과 protein tyrosine phosphorylation과는 밀접한 관계가 있는 것으로 사료되고 있다. 본 연구는 정자 원형질막에서 cholesterol이 유출되어 protein tyrosine phosphorylation이 유도될 때, BSA와 같은 sterol acceptor가 작용할 것이라는 전제하에, 고삼투압 하에서 탈수로 인해 원형질막이 위축되더라도 sterol acceptor가 존재한다면 막지질 성분의 구조적 변화가 억제 될 수 있을 것이라는 가설을 설정하였다. 실험결과, 저온 및 고삼투압 하에서 정자운동은 감소되지만 원형질막의 구조적 변화는 없고, 삼투압에 대한 반응정도는 원형질막을 통한 수분이동과 세포용적 변화에 따라 비례적으로 일어난다고 하는 사실을 발견하였다. 이 결과는 정자보존에 있어서 저온변화에 영향을 미치는 여러 인자들 특히 protein fgrosine phosphorylation의 증가와 밀접한 관계가 있음을 시시해 준다. 또한 sterol acceptor로 알려진 BSA는 삼투압이 변화되더라도 역시 중요한 인자로 작용할 수 있음을 알 수 있었으며, 특히 고삼투압으로의 변화는 cAMP와 protein kiname A를 거치는 신호전달과정에 있어서 중요한 요인이라는 사실을 확인할 수 있었다. It has been reported that plasma membrane activity of the spermatozoa may be susceptible to be influenced by extracellular osmolality and such membranous changes involve intracellular molecular changes, special regard to the structure of membranous lipids, and the accompanying ion-channel of which are closely related with their fluidity of Ca2+ and HCO-3. It is of common recognition that a certain kind of sterol acceptor player an important to induce lipid fluctuation of the sperm plasma membrane which have been influenced by BSA administration and came in effect to outflow of cholesterol from the spermatozoa and resulted in changes of ionic fluidity to facilitate adenylyl cyclase, and to induce protein tyrosine phosphorylation by increase of cAMP and activation of PKA. Thus it seems likely that an augmentation of the acrosomal reaction is closely related with protein tyrosine phosphorylation. The following experimental results were obtained in the present study; Under the high osmolality conditions, the spermatozoa motility declined significantly and the structural change of the plasma membrane diminished to confirm that the response degrees to the osmolality depended upon the water transfer volume through the plasma membrane and the changes of cellular volume. Those experimental results suggest that a physiological parameter such as low temperature condition played an important role for presentation of spermatozoa and that inducement of spermatozoa activation for reinforcement of protein tyrosine phosphorylation. On the other hand, it seemed likely that the BSA administration as one of sterol acceptors might represent a key role also under the high osmolality condition and their result also suggests that osmolality change, special regard to high osmolality condition may play an important role also in the processes of signal transmission

상수도관로의 주변 지반침하 위험도 평가를 위한 안전감시 센서

곽필재 ( Pill Jae Kwak ),박상혁 ( Sang Hyuk Park ),최창호 ( Chang Ho Choi ),이현동 ( Hyun Dong Lee ) 한국센서학회 2015 센서학회지 Vol.24 No.5

IoT(Internet of Things) based underground risk assessment system surrounding water pipeline enables an advanced monitoring and prediction for unexpected underground hazards such as abrupt road-side subsidence and urban sinkholes due to a leak in water pipeline. For the development of successful assessment technology, the PSU(Water Pipeline Safety Unit) which detects the leakage and movement of water pipes. Then, the IoT-based underground risk assessment system surrounding water pipeline will be proposed. The system consists of early detection tools for underground events and correspondence services, by analyzing leakage and movement data collected from PSU. These methods must be continuous and reliable, and cover certain block area ranging a few kilometers, for properly applying to regional water supply changes.

중증 고혈압증의 임상적 관찰

육동민(Dong Min Yook),곽시영(Si Young Kwak),김성식(Seong Sik Kim),이성숙(Seong Sook Lee),홍관표(Kwan Pyo Hong),최창필(Chang Pil Choi),이재우(Jae Woo Lee),이시래(Si Rhae Lee) 대한내과학회 1987 대한내과학회지 Vol.33 No.2

N/A Clinical studies were carried out in the 110 cases of severe hypertension who had been admitted from January 1979 to August 1985 and the following results were obtained: 1) Underlying diseases of severe hypertension were essential hypertension in 67 cases, renal parenchymal hypertension in 36 cases, and renovascular hypertension in 7 cases. 2) Plasma renin activity was the highest in the group of renovascular hypertension which was 22.07±9.20 ng/ ml/hr, and as a whole, the higher diastolic blood pressure, the higher plasma renin activity was. Plasma renin activity in the group of K-W grade IV retinopathy was higher than those of the other groups. 3) The incidence of ventricular hypertrophy fullfilling voltage criteria and with accompanying ST-T changes on electrocardiolgram was 81.5% in the group of essential hypertension and there was no difference in relation to the level of pressure or fundoscopic changes. 4) The serum creatinine level was the highest in the group of renal parenchymal hypertension (7.93±2.98 mg/dl), and in the group of K-W grade IV retinopathy (6.86±3.50mg/dl), but there was no significant difference in relation to the level of diastolic blood pressure, 5) There were no significant difference in cardiothoracic ratio on chest X-ray in relation to underlying diseases, diastolic blood pressure or fundoscopic changes. 6) The major complications were congestive heart failure (49.1%), hypertensive encephalopathy (17.3%), and cerebrovascular accident (8.2%). 7) In the group of essential hypertension blood pressure was controlled by conservative treatment in 81.0% but in 35.7% in the group of renal hypertension. The patients of chronic renal failure who were treated with dialysis blood pressure was controlled in 87.0%. In all 6 cases with renal transplantation, nephrectomy or renal angioplasty blood pressure was well controlled. 8) In cases refractory to triple antihypertensive regimen blood pressure was controlled by minoxidil in 66.7% and by captopril in 75.0%. 9) In 45 cases who were followed up for more than 6 months diastolic blood pressure was controlled under 100mmHg in 77.8% and there were improvement of renal function, fundoscopic findings and electrocardiographic findings in 20.0%, 33.3% and 16.7%, respectively.

원추형 회전체-자기베어링의 능동 진동 제어

석창욱,양승준,곽병철,이재응 중앙대학교 기술과학연구소 2000 기술과학연구소 논문집 Vol.30 No.-

기존 접촉식 베어링과 비교할 때 능동 자기 베어링(AMB)는 많은 장점을 가진다. 자기 베어링 시스템은 주축을 자기력을 이용하여 부상시켜 기계적인 마찰이 없는 상태에서 회전시키기 때문에 윤활을 하지않고도 작동시킬 수 있다. 따라서 이 베어링은 우주에서의 진공상태와 같은 극한상황에서도 사용할 수 있다. 특히 원추형 자기 베어링은 4조의 전자석으로 구성되어 래디얼 타입 자기 베어링보다 소형, 경량화할 수 있는 장점을 가진다. 본 논문에서는 먼저 원추형 자기베어링에 대한 운동방정식을 유도하고, 이 시스템의 진동 제어를 위해 비연성인 디지털 PD, PID 제어기를 설계하였다. 컴퓨터 모의실험을 통해 제어기의 성능을 평가하여 만족할 만한 성능을 얻었다. There are many advantages of the Active Magnetic Bearing(AMB) system, compared with conventional contacting bearing systems. Since the spindle in the AMB system is levitated by electro-magnetic forces and rotates without mechanical friction, it can run without lubrication. So, it can run in the extreme circumstances, e.g. a vacuum condition in the space. Particularly, the cone-type AMB system consists of only 4 couples of magnet, it can be smaller and lighter than radial-type AMB system. In this thesis, the equations of motion of the cone-type AMB system is derived first, and the digital PD and PID controllers are designed for the vibration control of the system. The controllers are designed based on the decoupled equations of motion, and the performance of the controllers are evaluated through the computer simulations. The results of the simulation show good performance of the controllers.

이동 클립을 이용한 건축물 외장재의 구조적 성능에 관한 연구

곽의신(Kwak, Eui-Shin),기창군(Ki, Chang-Gun),이상호(Lee, Sang-Ho),손수덕(Shon, Su-Deok),이승재(Lee, Seung-Jae) 대한건축학회 2017 大韓建築學會論文集 : 構造系 Vol.33 No.12

A recent global trend in the increase of earthquake-related disasters has become so frequent as to cause various damages to a wide range of mid- to high-rise buildings. Particularly, more attention is being paid to the effect of horizontal load in high-rise buildings not only on the key structural elements of the structures, but also on the possibility of the secondary damages to them due to the failure of exterior panels, which are non-structural elements, but such damages are difficult to cope with as they may be caused by unexpected changes. The present study examined exterior panels using moving clips to prevent such secondary damages on the non-structural elements and analyzed the structural performance of these exterior panels through the finite element analysis and the shaking table test. The analysis results showed that the exterior panels using moving clips satisfied the structural performance against the allowable story drift of KBC2009 and the safety of the exterior panels was verified by the shake table test.

단안 카메라 기반 3차원 물체 인식 기법 및 6축 머니퓰레이터 경로계획을 이용한 탁구 로봇의 구현

윤재성(Jae-Seong Yoon),곽창희(Chang-Hee Kwak),김영현(Young-Hyeon Kim),김원호(Won-Ho Kim),옥승호(Seung-Ho Ok) 한국정보기술학회 2018 한국정보기술학회논문지 Vol.16 No.8

In this paper, we propose a path planning method of a 6-axis manipulator and a monocular camera-based detecting method of a ball coordinate in 3D space for a table tennis robot. In the path planning, we plan the path by using kinematic analysis and searching minimal joint change. One of two monocular cameras detects the coordinate of the ball and the other estimates hit point by tracking the ball speed and trajectory. In order to measure hit rate of the proposed table tennis robot, we compared the existing model without ball position coordinate calibration system to the proposed model. As a result of the performance evaluation, hit rate of the table tennis robot with the proposed ball position coordinate calibration system is increased to 50% hit rate from the 10% hit rate of the existing model.

젊은 성인에서 발생한 고환주위 횡문근육종 1예

김소리,곽재용,임창열 대한내과학회 2004 대한내과학회지 Vol.66 No.3

저자들은 좌측 음낭 부종을 주소로 내원한 17세 남자 환자에서 고환주위에 발생한 IRS 분류 group Ⅰ, IRS-Ⅳ에 따른 stage 1, 저 위험군의 태생기성 횡문근육종을 서혜부 절개를 통한 근치적 고환 적출술 및 음낭 절제술 후 1년여에 걸쳐 매 9주 마다 5차까지의 VA 항암화학요법으로 치료 완료하였고, 치료 중 추적검사한 복부 컴퓨터 단층 촬영상 진행 소견이나 전이 소견 관찰되지 않았으며, 항암화학요법 종료 후 6개월 후 추적검사 예정으로 현재 항암화학요법 종료 후 4개월까지 특이소견 관찰되지 않고 있다. This paratesticular rhabdomyosarcoma is more frequent in children than in adult. Paratesticular rhabdomyosarcoma accounts for approximately 7% of all rhabdomyosarcomas and is the most common soft tissue sarcoma in childhood, with an annual incidence of four to seven cases per million. The rhabdomyosarcoma originated from paratedsticular region is considered to have a good prognosis in comparison with othe rhabdomyosarcomas, despite of the high frequency of retroperitoneal lymph node invasion. this superficial site allows rapid diagnosis and consequently often complete resection of the tumor. The multidisciplinary treatment of paratesticular rhabdomyosarcoma has improved control of the disease with a 2-year survival of 80%. Especially, The outcome for patients with localized paratesticular rhabdomyosarcoma is excellent with the use of the new regimen rather than traditional regimen composed of alkylating agent: an alkylating-free and anthracycline-free regimen is adequate treatment for low-risk patients. We report a case of paratesticular rhabdomyosarcoma of embryonal type in a 17-year-old male who presented left scrotal swelling without tenderness. The diagnosis was confirmed by biopsy. After left radical orchiectomy and hemiscrotectomy, he received VA (Vincristine/Actinomycin-D) chemotherapy.

鐵道騷音에 의한 影響과 實態에 關한 硏究 : 湖南線을 中心으로

이병윤,윤해동,곽광수,장영휴,김재수 順天靑巖大學 1998 論文集-順天靑巖大學 Vol.22 No.2

Rail noise and vibration is one of the major problem for the residents living nearby railway tracks. The rail noise may inflict a considerable damage to physiological, spiritual, mental and discomfort to neighboring peoples. Therefore, residents living nearby railway were appeal many troubles. Nevertheless, in our country, adequate guidelines for the rail noise are not yet established because of the lack of basic data and insufficient research works. In this point, this study attempts to surveys the influence of rail noise in urban area using questionnaire. This study also present a basic data in establishing effective plans for rail noise in the future.